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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 36-37页

作者： guettier c. Sebagh M. Buard J. 李翔 Servic. d'Anatomie Pathologique Université ParisXIHpital Paul Brousse 14 avenue PaulVaillant Couturier 94804 Villejuif Cedex France

Male mic.oc.imerismis frequent in the adult female liver and is attributed to fetal c.lls originating frompreviousmale offspring. It has never been studied in pregnant women, female c.ildren, or fetuses. We examined its frequenc. and c.llular nature in normal and diseased female livers from fetal life to adulthood. Forty-six liver samples from 29 women, 6 female c.ildren, and 11 female fetuses were sc.eened for the Y c.romosome via polymerase c.ain reac.ion (Pc.) assay and fluoresc.nt in situ hybridization (FISH). The X c.romosome was used as an internal c.ntrol. A third Pc. assay was used for Y genotyping. The Y c.romosome was detec.ed in 5 of 6 c.ildren, 7 of 11 fetuses, 3 of 9 women with normal liver, 7 of 10 women with c.ronic.hepatitis c. 5 of 6 women with ac.te liver disease during pregnanc. with male offspring, and 2 of 4 nonpregnant women with fulminant hepatitis. In positive samples, the mean XY/XX ratio was 0.012 (±0.004). In women, male mic.oc.imerism was c.rrelated with previous male offspring. Male hepatoc.tes, detec.ed via FISH c.mbined with anti-hepatoc.te immunohistoc.emistry,were observed only in fetuses (4/9) and in postpartem women (4/6). Y genotypes were different from eac. other in 4 of 5 female livers. In c.nc.usion, male liver mic.oc.imerism is frequent in normal and diseased female livers. The presenc. of male c.lls in the liver of female c.ildren and fetuses is probably due to the transplac.ntal transmission of fetal c.lls preexisting in the mother and ac.uired either from previous pregnanc. with male offspring or during the mother’s own fetal life.

关键词：微嵌合性细胞爆发性肝炎肝细胞慢性丙型肝炎胚胎细胞染色体检测细胞特性女性儿童基因分型

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