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定量足跟超声和临床危险因素对老年女性骨质疏松骨折危险性的评估

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国际医学放射学杂志 2008年第5期31卷 393-393页

作者： i. guessous J. Cornuz C. Ruffieux P. Burckhardt M.A. Krieg. 白荣杰（译）唐光健（校） Department of internal Medicine Lausanne University Hospital Lausanne Switzerland. 不详

目的根据前瞻性临床和骨超声资料形成确定老年女性骨质疏松骨折危险性的预测方法。方法本研究经瑞士伦理学委员会批准。对6174名瑞士女性，年龄70～85岁．行足跟骨定量超声检测，经3a的多中心研究，利用计算机将获得数据进行评估预测。... 详细信息

目的根据前瞻性临床和骨超声资料形成确定老年女性骨质疏松骨折危险性的预测方法。方法本研究经瑞士伦理学委员会批准。对6174名瑞士女性，年龄70～85岁．行足跟骨定量超声检测，经3a的多中心研究，利用计算机将获得数据进行评估预测。定量超声仪可计算跟骨的强硬指数。其基线特征、已知可致骨质疏松和跌倒的危险因素以及定量US强硬指数均可作为推演骨质疏松性骨折的预测指标。利用单因素Cox回归方法确定预测值并用多变量分析方法校正。结果骨质疏松性骨折的发生有5个危险因素：

关键词：骨质疏松性骨折临床危险因素定量超声检测骨折危险性老年女性足跟骨评估预测指标

肾长度的遗传性、决定因素和参考值:一项基于家庭的群体研究

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国际医学放射学杂志 2013年第6期 613-613页

作者： M.Pruijm B.Ponte D.Ackermann P.Vuistiner F.Paccaud i.guessous 卢暄郭琪 institute of Social and Preventive Medicine (iUMSP) Lausanne University Hospital (CHUV) Route de la Corniche 101010 Lausanne Switzerland

摘要目的在这项基于群体的研究中,评估肾长度的参考值,以及与肾长度相关的遗传性和相关因素。方法在随机选取的欧洲血统(瑞士)的家庭中,对人体测量参数和肾脏超

关键词：肾脏长度肾脏体积肾脏超声一般人群遗传性

Combined Nodal Method and Finite Volume Method for Flow in Porous Media

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Wireless Sensor Network 2010年第3期2卷 227-232页

作者： Abdeslam Elakkad Ahmed Elkhalfi Najib guessous 不详

This paper describes a numerical solution for two dimensional partial differential equations modeling (or arising from) a fluid flow and transport phenomena. The diffusion equation is discretized by the Nodal methods. The saturation equation is solved by a finite volume method. We start with incompressible single-phase flow and move step-by-step to the black-oil model and compressible two phase flow. Numerical results are presented to see the performance of the method, and seem to be interesting by comparing them with other recent results.

关键词： Saturation Equation Nodal Methods Finite Volume Method Two-Phase Simulation

Enhancing Nuclear Security System of irradiation Facility SiBO iNRA/Tangier Morocco

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Journal of Chemistry and Chemical Engineering 2017年第3期11卷 95-101页

作者： Mouhib Mohammed Chentouf Mouad guessous Amina Rostislav Vlaev iNRA/CRRA/URTNEQ Tangier Morocco iNRA/CRRA Tangier Morocco Faculte des Sciences iBN TOFAiL Kenitra Morocco 3TECH Rabat Morocco

Around the world, radioactive sources have been widely used for decades to benefit humankind; industry food; health, etc. However, the malicious use of radiological sources poses a significant threat globally. As irradiation facility for research the goal of this paper is to show a case study of application of nuclear security and nuclear security culture code of contact in irradiation facility using cobalt 60. And it will show the necessary work done to achieve the goal of protection of radioactive material and continue working in safe conditions. This objective could not be achieved without the collaboration of all department involved in security and nuclear safety. in this work we applied the nuclear security and nuclear security culture procedures in order to define the type of system used to achieve the global objective in accordance with Global Threat Reduction Program to reduce the threat of a RDD （Radiological Dispersion Device） in collaboration with The United States Department of Energy＇s NNSA （National Nuclear Security Administration）. The objective of this paper is to share a local experience in upgrading security with return of experience in practice and very good collaboration with general direction of national security and all departments involved in security and nuclear safety.

关键词： Security nuclear irradiation safety radiological cobalt 60.

A Web-Based Cardiovascular Risk Assessment via Pharmacists: A Feasibility and Validation Study

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Open Journal of Preventive Medicine 2015年第8期5卷 348-358页

作者： Alexandra de Toledo Pascal Bonnabry Jean-Michel Gaspoz Jean-Philippe de Toledo idris guessous Division of Primary Care Medicine Department of Community Medicine Primary Care and Emergency Medicine University Hospitals of Geneva Faculty of Medicine University of Geneva Geneva Switzerland PP Pharmacie Principale SA Geneva Switzerland Pharmacy Geneva University Hospitals Geneva Switzerland School of Pharmaceutical Sciences University of Geneva University of Lausanne Geneva Switzerland Community Prevention Unit University Institute of Social and Preventive Medicine Lausanne University Hospital Lausanne Switzerland Department of Epidemiology Rollins School of Public Health Emory University Atlanta USA

Background: involving pharmacists in clinical care could improve the identification of subjects at risk for cardiovascular (CV) disease. Data on web-based approach involving pharmacists for CV disease risk assessment are very limited. Methods: We first developed a web-based CV risk assessment tool to be used by pharmacists that includes demographic, lifestyle, biological and anthropometric information. Biological and anthropometric data were collected in independent laboratories. We then assessed the feasibility and validity of this approach by inviting adults who previously (within 6 months) participated in a Swiss standardized population-based study to fill out the web-based platform. Attrition rates and correlations were used to assess the feasibility and validity, respectively. Proportions were expressed as percentages and continuous variables were expressed as means ± standard deviations (SD). Main Outcomes Measure: Proportions of participants who 1) agreed to participate;2) filled out the questionnaire and had their biological and anthropometric measures taken;3) only filled out the questionnaire;and 4) only had their biological and anthropometric measures taken. Correlations were used to compare continuous variables (body mass index [BMi], waist circumference, systolic blood pressure, fasting blood glucose, total plasma cholesterol, HDL plasma cholesterol, LDL plasma cholesterol, triglycerides) collected via both studies. Results: Overall, 218 (53.2% women) adults of the population-based study were eligible and were contacted to participate, from April to November 2013. Of these, 140 (64.2%) agreed to participate. The majority (67/140, 47.8%) both filled out the questionnaire and had their biological/anthropometric measures taken, whereas only 2.8% and 7.1% only filled out the questionnaire or only had their biological measures taken, respectively. Except for systolic blood pressure, fasting glucose, and triglycerides, the correlations between the measures ob

关键词： Pharmacists Web-Based Cardiovascular Disease Risk Feasibility

Appropriateness of Screening of Angiopathic Complications Prevention in Ambulatory Patients with Diabetes

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Open Journal of Preventive Medicine 2015年第6期5卷 244-258页

作者： Sophie Excoffier Manuel Raphael Blum Nicolas Rodondi Jacques Cornuz Lukas Zimmerli Jean-Michel Gaspoz idris guessous Unit of Population Epidemiology Division of primary care medicine Department of Community Medicine Primary Care and Emergency Medicine Geneva University Hospital Geneva Switzerland Department of General internal Medicine Inselspital University of Bern Bern Switzerland Department for Ambulatory Care and Community Medicine University of Lausanne Lausanne Switzerland Division of internal Medicine University Hospital of Zurich Zurich Switzerland Division of Chronic Diseases Institute of Social and Preventive Medicine Centre Hospitalier Universitaire Vaudois University of Lausanne Lausanne Switzerland Department of Epidemiology Rollins School of Public Health Emory University Atlanta USA

Background: Preventive care of diabetic foot and eye complications is essential. However, data on the prevalence of and factors associated with screening of angiopathic complications in ambulatory patients with diabetes are very limited in Switzerland. We aimed to fill this gap of knowledge. Methods: Cross-sectional data on recommended preventive care using RAND’s criteria in a random sample of patients aged 50-80 years in 2005-2006. Participants were recruited from 4 Swiss university primary care settings (in Lausanne, Geneva, Zürich and Basel). Scores for general preventive care in patients with and without diabetes were calculated by using generalized estimating equation binomial models. Multivariate regression models were used to identify determinants of appropriateness of angiopathic complications prevention. The main outcome measure was appropriateness of screening for angiopathic complications based on the 2005 American Diabetes Association recommendations corresponding to the period of data collection. Results: Among the 1002 patients aged 50 - 80 years, 292 (29.1%) had diabetes (101/292 [34.6%] female, mean BMi 30.7 [SD 5.7]). Fifty-nine percent had appropriate preventive foot care and 55.8% had appropriate preventive eye care. Only 34.6% had appropriate preventive care of both foot and eye. No differences in aggregate scores for general preventive care in patients with and without diabetes were found (67.5% vs. 69.1%, p value 0.39). in multivariate model, obesity was negatively (OR = 0.28, 0.15 - 0.53) and hyperlipidemia positively (OR = 2.29, 1.20 - 4.38) associated with appropriate eye preventive care and with appropriate combined foot and eye preventive care (OR = 0.35, 0.18 - 0.70 for obesity and OR = 2.82, 1.24 - 6.40 for hyperlipidemia). Conclusions: Preventive care of diabetic angiopathic complications is low among ambulatory patients despite universal health care coverage. Particular attention should be paid to obese patients with diabetes.

关键词： Diabetes Appropriateness Angiopathic Complications Prevention Primary Care

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

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中国神经肿瘤杂志 2009年第4期7卷 274-274页

作者： Li Y guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R Departments of Microbiology Neurology and Pathology University of Virginia Charlottesville VA 22908 USA.