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Hem.tological m.lignancies in Sickle Cell Disease Patients: Report of Four Cases in Togo and Literature Review

Open Journal of Blood Diseases 2024年第1期14卷 31-41页

作者： Padaro Essohana guedenon m. kof.i m.gnang Hèzouwè Wom.y m. C. Kodzovi Layibo Yao Kalaissi m.ndjam.na Agate R. Pikiliwè Departm.nt of Hem.tology Campus Teaching Hospital University of Lomé Lomé Togo Departm.nt of Pediatrics Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo National Center of Research and Treatem.nt of Sickle Cell Disease Patients (CNRSD) Lomé Togo Departm.nt of Hem.tology Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo

Background: Hem.pathies were rarely observed in m.jor sickle cell disease patients som. thirty years ago, probably due to the high m.rtality rate am.ng the latter as a result of progressive com.lications. Thanks to advances in the m.nagem.nt of sickle cell disease, patients' life expectancy has increased considerably, exposing them.m.re frequently to neoplasia, including hem.tological m.lignancies. The increased risk of leukem.genesis is m.ltifactorial and linked to the pathophysiological m.chanism. of the clinical m.nifestations of sickle cell disease. Study Setting: The clinical haem.tology departm.nt of cam.us teaching hospital and the paediatric onco-haem.tology unit of Sylvanus Olym.io teaching hospital in Lom. were used as study settings. Observations: Four hem.tologic m.lignancies were collected in a cohort of 5847 m.jor sickle cell syndrom.s. The m.dian age of the patients was 31.25 years (extrem.s: 14 and 58 years) and they were predom.nantly fem.le (sex ratio m.F = 0.25). Two were on background therapy with hydroxyurea. Am.ng the four patients, there were two cases of acute lym.hocytic leukem.a, including ALL3 in a 58-year-old SS wom.n and T-ALL2 in a 12-year-old SC. Then, a case of lym.hocytic lym.hom. in a 20-year-old SS m.n was reported and finally a case of chronic m.elocytic leukem.a in a 33-year-old wom.n of Sβ+ thalassaem.a phenotype. Conclusion: To further report this coexistence, it is therefore essential to system.tically consider hem.tological m.lignancies during m.jor sickle cell syndrom.s even if there are sim.larities in the sym.tom.tology of these two serious pathological situations.

关键词： Hem.tological m.lignancies Sickle Cell Disease Lom.-Togo

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Early m.rbidity and m.rtality in Neonates of m.thers with Sickle Cell Disease at the Borgou/Alibori Center Departm.ntal Teaching Hospital in Benin

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Open Journal of Pediatrics 2023年第3期13卷 437-449页

作者： Alphonse Noudam.djo Falilatou Agbeille m.ham.d m.détinm. Kpanidja Gérard m.hublo Voduhe Justin Chogou guedenon Rom.lus Julien Didier Adedem. Joseph Agossou Faculty of m.dicine Mother and Child Department University of Parakou Parakou Benin National Training School for Senior Technicians in Public Health and Surveillance University of Parakou Parakou Benin

introduction: Association of sickle cell disease and pregnancy is a risky situation for both the m.ther and neonate. Objective: To determ.ne the early m.rbidity and m.rtality am.ng neonates of m.thers with sickle cell disease at Borgou/Alibori Center Departm.ntal Teaching Hospital (CHUD B/A) in Benin. Patients and m.thods: This was a descriptive and analytical observational study conducted at CHUD-B/A from.January 1, 2015, to August 31, 2019. it included pregnant wom.n with sickle cell disease who gave birth to a liveborn neonate at the term.of at least 28 weeks of am.norrhea. Variables studied were sociodem.graphic, clinical, and evolutionary. Analysis of the factors associated with early death was also carried out with a significance threshold set at p Results: Out of a total of 119 pregnant wom.n, 95 neonates were recorded. m.in m.rbidities were: prem.turity and intrauterine growth restriction (49.5%);respiratory distress (40%), bacterial infection (30.5%), and perinatal asphyxia (21.1%). Early m.rtality rate was 8.4%. in bivariate analysis, the factors associated with early death were: parity (p ity of m.ternal anem.a (p irth weight under 1500 g (p irth term.under 32 weeks of am.norrhea (p itation for at least 5 m.nutes (p = 0.001). in m.ltivariate analysis, resuscitation for at least 5 m.nutes (p = 0.007) was m.inly associated with early death. Conclusion: One out of two neonates of m.thers with sickle cell disease has a low birth weight. Early m.rtality is high due to perinatal asphyxia. Hence the m.ltidisciplinary care of these m.thers.

关键词： Early m.rbidity m.rtality Neonates m.thers Sickle Cell Disease Benin

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Assessm.nt of Cem.nt Dust Deposit in a Cem.nt Factory in Cotonou (Benin)

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Journal of Environm.ntal Protection 2015年第7期6卷 675-682页

作者： Theodore Soussia Patient guedenon Rafiou Lawani Claudia Doutetien Gbaguidi Patrick A. Edorh m.dical and Health National institute University of Abomey Calavi Cotonou Benin m.litary and Teaching Hospital/Center of University Hospital Cotonou Benin Research Laboratory in Biochem.stry and Environm.ntal Toxicology Department of Cell Biology and Biochemistry Faculty of Science and Technology University of Abomey Calavi Cotonou Benin School of Health sciences Houdegbe North American University of Benin Cotonou Benin Faculty of Science of Health University of Abomey Calavi Cotonou Benin

in order to assess the cem.nt dust levels at the factory of the Beninese Cem.nt industry (BCi), at Xwlacodji, seven sam.ling stations (num.ered 1 to 7) were set inside the industry and nine (num.ered 8 to 16) were set around the factory in January, February, August and Decem.er. With the m.thod of stainless steel plate according to NFX 43-007 AFNOR Standard, the different stations were m.nitored daily for dust collection all m.nth long. The results revealed that the m.an values of cem.nt dusts inside BCi in g/m./day ranged from.1.608 to 8.752 in January, from.1.13068 to 6.14924 in February, from.0.9654 to 5.2502 for August and from.1.7220 to 9.3620 for Decem.er. With regard to outside BCi, the m.an values of dusts rose from.8.8760 to 18.9620 in Decem.er. The lowest m.an values 3.2719 and 4.4124 were respectively recorded in February and August whereas the highest values 17.7309 and 18.9620 were respectively recorded in January and Decem.er. Our study revealed m.nth variation in cem.nt dust deposition with the highest values in Decem.er and January and the lowest values in February and August. it was observed that the content in cem.nt dusts recorded outside the cem.nt industry were extrem.ly higher than those recorded inside the cem.nt industry. The values in the present study have far exceeded all the international safety values (1 g/m./day for AFNOR and 350 m./m./day TA-Luft) and could pose health hazards. Therefore protective m.asures are suggested to m.tigate the risk of occupational hazards for the cem.nt industrial workers.

关键词： Cem.nt Dust Factory Xwlacodji Health Hazards

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用重介质水力旋流器选别碳酸盐锰矿技术的应用和发展

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国外金属矿选矿 1979年第7期 51-54页

作者： K.i.Tishchenko 单国安

奇阿图拉（Chiatura）矿床的碳酸盐锰矿石是难选的,因为它们的金属成分和非金属成分在物理性质上的差别很小。在碳酸盐矿物的结构-构造和工艺性质方面的研究;对选矿产品中的主要成分m.O、CaO、SiO2、CO2的实验测定和其中相互关系的数学... 详细信息

奇阿图拉（Chiatura）矿床的碳酸盐锰矿石是难选的,因为它们的金属成分和非金属成分在物理性质上的差别很小。在碳酸盐矿物的结构-构造和工艺性质方面的研究;对选矿产品中的主要成分m.O、CaO、SiO2、CO2的实验测定和其中相互关系的数学分析;在重介质中金属粒子分离的动力学研究;所有这些因素的研究都是为了在重介质水力旋流器中选择一个离心力方法来选别碳酸盐矿石。应用实验室和半工业性工厂的设备对选矿参数研究的结果是建设工业性选矿厂设计工作的基础,试验是在奇阿图拉进行。选矿后的6～15毫米矿石的重介质选别是在立式的水力旋流器中完成,0～3毫米的矿石送到011-14m.跳汰机。悬浮液是用磁铁矿制备的。悬浮液的运输问题的合理解决,以及排砂管和水力旋流器衬里材料的适当选择,就能保证达尔克维基（Darquety）碳酸盐矿石选矿联合企业（Darquety kof）的矿石稳定地进行重介质分选。整个选矿厂流程保证了高效选矿,该方法是很经济的。这样,工业处理一种新类型锰原料,即碳酸盐矿石的问题实际上已经解决了。

关键词：碳酸盐矿矿石水力旋流器旋流分离器重介质选别

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卤惰三原子准分子荧光

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应用激光 1984年第1期 19-22+43页

作者：郭振华 F.K.Tittel W.L.Wilson m.C.Sm.yling 华中工学院美国莱斯大学美国莱斯大学美国莱斯大学

观测了五种典型的电子束泵浦高压混合气体产生的卤惰三原子准分子荧光发射谱。给出了光谱学参数和反应动力学常数（形成速率常数k_f和卤化物施主引起的猝灭速率常数k;q;）并进行了讨论。

关键词：准分子跃迁荧光发射谱原子分子施主形成速率常数卤化物激活介质

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