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The benefits of PCSK9 inhibitors in patients with acute coronary syndrome:a systematic review and meta-analysis

Emergency and Critical Care Medicine 2024年第1期4卷 28-34页

作者： guanzhao zhang Shuting Chang Faming Zhao Xiangfeng Guan Zifan Nie Wenhao Liu Bo Li Department of Cardiology Binzhou Medical UniversityZibo Central HospitalZiboShandongChina Weifang Medical University WeifangShandongChina Department of Infectious Disease Zibo Infectious Disease HospitalZiboShandongChina.

Background:Proprotein convertase subtilisin/kexin 9(PSCK9)inhibitors have been beneficial for many patients with *** objective of this study was to investigate the benefit of PSCK9 inhibitors in patients with acute coronary syndrome(ACS).Methods:We systematically searched PubMed,EMBASE,and Cochrane Clinical Trials(published before January 2023;no language restriction)to compare the treatment of patients with ACS using PCSK9 inhibitors and *** primary end points were major adverse cardiovascular events,nonfatal myocardial infarction,cardiogenic death,stroke,hospitalization for recurrent ACS,and coronary ***-or random-effects models were used to assess the aggregated ***:Of the 1686 identified studies,5 were eligible and included in our analysis(of a total of 38,005 participants,18,609 cases were placed in the PCSK9 inhibitor treatment group and 19,396 cases in the placebo group).Compared with the placebo group,PCSK9 inhibitors significantly reduced the major adverse cardiovascular events(odds ratio[OR]:0.83;95%confidence interval[CI]:0.77–0.88;P<0.00001)for patients following *** incidence of nonfatal myocardial infarction(relative risk:0.80;95%CI:0.74–0.87;P<0.00001),cardiovascular death(OR:0.96;95%CI:0.83–1.10;P=0.56),stroke(OR:0.74;95%CI:0.63–0.88;P=0.0007),hospitalization for recurrent ACS(OR:0.57;95%CI:0.40–0.83;P=0.003),or coronary revascularization(OR:0.82;95%CI:0.76–0.88;P<0.00001)all demonstrated a significant decrease in the comparison between the 2 ***:This meta-analysis demonstrated that treatment with PCSK9 inhibitors in patients with ACS reduced the probability of multiple cardiovascular events and improved patient prognosis.

关键词： Acute coronary syndrome Cardiovascular disease PCSK9 inhibitors

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Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment

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Emergency and Critical Care Medicine 2022年第4期2卷 225-232页

作者： Jing Yang Shuting Chang Jing Liu guanzhao zhang Yue Wang Baixue zhang Zifan Nie Yuanbao Dong Bo Li Binzhou Medical University YantaiShandongChina Department of Cardiology Shandong University Zibo Central HospitalZiboShandongChina Zibo Key Laboratory of Atherosclerosis and Vascular Calcification ZiboShandongChina Weifang Medical University WeifangShandongChina Department of Intravenous Drug Dispensing Shandong University Zibo Central HospitalZiboShandongChina Shandong First Medical University JinanShandongChina Weifang Fangzi District People’s Hospital WeifangShandongChina.

Background:Drug-coated balloons(DCBs)are an up-and-coming tactic in treating in-stent restenosis and coronary artery small vessel disease,but their efficacy in treating acute myocardial infarction needs to be further ***:A meta-analysis of 7 studies was conducted to make a comparison with the results of DCB and drug-eluting stent implantation after a median follow-up of 15 ***:A total of 922 patients were included in this analysis in total,including 375 patients in the DCB group and 547 patients in the stent group.A total of 962 vascular diseases were manifested in the 2 *** 6 to 24 months of follow-up,there was no statistically significant difference with respect to major adverse cardiovascular events(odds ratio[OR]:0.82;95%confidence interval[CI]:0.52–1.29;Z=0.85;P=0.39),cardiac death(OR:0.92;95%CI:0.39–2.12;Z=0.21;P=0.84),target lesion revascularization(OR:1.09;95%CI:0.53–2.25;Z=0.24;P=0.81),late lumen loss(MD:−0.05;95%CI:−0.15 to 0.06;Z=0.85;P=0.40),or dual antiplatelet therapy(DAPT)(OR:1.04;95%CI:0.53–2.05;Z=0.11;P=0.91)between the 2 *** the DCB group,persistent residual stenosis or C-F dissection occurrence necessitated that a total of 30 patients receive extra bailout *** rate of bailout stenting was 11.8%(95%CI:7.1–16).Moreover,the DCB group had a shorter DAPT duration compared with the stent ***:Drug-coated balloons with shorter DAPT durations may be as effective and safe as stent therapy in treating acute myocardial infarction.

关键词： Acute myocardial infarction Drug-coated balloon Dual antiplatelet therapy Paclitaxel-coated balloon

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Prevalence of Congenital Heart Disease at Extremely High Altitudes in Tibet and the Establishment of a New Free Treatment Model

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Congenital Heart Disease 2022年第6期17卷 709-716页

作者： Shuting Chang guanzhao zhang Nengjun Sun Xinpeng Yuan Qingting Wang Lin Zhu Feiyue zhang Yu Xiu Yang Dong Yonghong Chen Zhanpeng Zhao Xiao Liu Qiang Shao Xiaofeng Xu Anshun Wang Mengjiao Li Bo Li Weifang Medical University WeifangChina Department of Cardiology Shandong University Zibo Central HospitalZiboChina Binzhou Medical University YantaiChina Department of Ultrasound Shandong University Zibo Central HospitalZiboChina Department of Anesthesiology Shandong University Zibo Central HospitalZiboChina Department of Anorectal Surgery Shandong University Zibo Central HospitalZiboChina Department of Obstetrics Shandong University Zibo Central HospitalZiboChina Department of Ultrasonography Qilu Hospital Huantai BranchZiboChina Department of Cardiology Zichuan District HospitalZiboChina Department of Cardiology Zhoucun District HospitalZiboChina Department of Cardiology Zhangdian District HospitalZiboChina Department of Cardiology Boshan District HospitalZiboChina Department of Ultrasound Zibo Municipal HospitalZiboChina Department of Ultrasound Zibo First HospitalZiboChina

Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatmentfor the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County,Xigaze City, Tibet from September 2019 to September 2020 were selected for screening. The students were examinedthrough the inquiry of their current medical history and family history, cardiac auscultation and a physicalexamination, in order to screen out the suspected cases of CHD, and then the suspected cases were confirmed bycardiac color ultrasound examinations. After that, positive patients were be transferred to Shandong Province forfree treatment. Results: The prevalence of CHD among children in Ngamring County was 3.70% (83 cases),which is the highest incidence rate ever reported. The most common type of CHD was patent ductus arteriosus(PDA), accounting for 55.42% of the total number of cases screened, followed by atrial septal defect (ASD) andventricular septal defect (VSD), accounting for 28.92% and 12.05%, respectively. The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude. The children with CHD weretransferred to Shandong Province for surgery, the operations were successful and their recoveries went ***: The results show that high altitude is closely related to the prevalence of CHD, and the incidencein Ngamring County is much higher than that in previous reports.

关键词： Tibet high altitude CHD free treatment model

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10kV配网馈线自动化系统研究与应用

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通信电源技术 2021年第21期38卷 42-44页

作者：张冠钊广东电网有限责任公司东莞西北供电局广东东莞523000

电力系统发展对供电可靠性要求逐渐提高,其中配电网馈线自动化作为供电可靠性提升的重要手段,近年来也受到人们的关注。馈线自动化系统在配电网中的科学应用能够实现对整个线路运行情况的实时监控。若配网线路运行中若出现故障,则馈线... 详细信息

电力系统发展对供电可靠性要求逐渐提高,其中配电网馈线自动化作为供电可靠性提升的重要手段,近年来也受到人们的关注。馈线自动化系统在配电网中的科学应用能够实现对整个线路运行情况的实时监控。若配网线路运行中若出现故障,则馈线自动化系统能够对故障信息进行判别,采取自动化措施实现故障区域隔离,保证非故障区的正常稳定供电。针对10 kV配网自动化系统进行研究与分析,阐述馈线自动化技术内涵和其基本功能,并就馈线自动化系统中常用的几大关键技术进行详细对比和分析,解析馈线自动化系统的处理流程,并提出10 kV配网馈线自动化系统构建方案。

关键词： 10kV配网馈线自动化供电可靠性

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面向图书馆数字资源的用户信息行为采集系统设计与实现

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长江信息通信 2024年第6期37卷 155-157页

作者：金光龙张光照贵州财经大学图书馆贵州贵阳550025

随着信息化技术的普及,数字资源已成为图书馆馆藏资源建设的核心部分。选择合适的数字资源供应商和向读者提供定制化、精准的阅读服务显得尤为关键。而获取用户在使用数字资源时的信息行为数据,是实现这一目标的基石。为解决现有研究在... 详细信息

随着信息化技术的普及,数字资源已成为图书馆馆藏资源建设的核心部分。选择合适的数字资源供应商和向读者提供定制化、精准的阅读服务显得尤为关键。而获取用户在使用数字资源时的信息行为数据,是实现这一目标的基石。为解决现有研究在采集用户行为数据时消耗巨大存储空间和算力以及不够及时的局限,文章提出基于Vertx的反向代理机制的用户信息行为采集系统,旨在精准化的进行用户信息行为采集,解决算力、存储和实时性的局限。

关键词：图书馆用户信息行为数据采集反向代理

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澳大利亚翻译人才的培养及其对我国的启示——主要基于翻译硕士人才培养的实践

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内蒙古师范大学学报（教育科学版） 2023年第4期36卷 36-40页

作者：张光召王雅晳赤峰学院外国语学院内蒙古赤峰024099 内蒙古医科大学附属医院科研部内蒙古呼和浩特010010

全球化背景下,翻译人才培养对于开展国际贸易交流和文化共享等具有重要作用。澳大利亚麦考瑞大学在翻译人才培养方面取得成熟经验,其强化翻译人才政策导向及整体规划、提升国家站位把握翻译人才发展需求、立足市场导向推进学校教育体系... 详细信息

全球化背景下,翻译人才培养对于开展国际贸易交流和文化共享等具有重要作用。澳大利亚麦考瑞大学在翻译人才培养方面取得成熟经验,其强化翻译人才政策导向及整体规划、提升国家站位把握翻译人才发展需求、立足市场导向推进学校教育体系变革、将翻译资格认证体系融入学校教育等做法,对我国高校翻译人才培养的实践具有启示意义。

关键词：翻译人才培养文化交流外语教育改革

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Numerical Simulation of Radiation Transport to Improve Microalgae Cultivation in an Air-Lift Photobioreactor

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Journal of Thermal Science 2025年第1期34卷 62-76页

作者： zhang Xianbin LI Mingjia HUNG Tzuchen zhang Zixun Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi'an Jiaotong University School of Mechanical Engineering Beijing Institute of Technology Department of Mechanical Engineering Taipei University of Technology

A comprehensive numerical model is developed to simulate the growth of microalgae under light/dark cycling *** purpose of this study is to predict the growth rate of Chlorella vulgaris cultivated in photobioreactors(PBRs) in order to improve the light conditions for microalgae and enhance the photosynthetic *** fluid dynamics(CFD) is used to simulate its internal hydrodynamic *** Lagrangian method is employed to track the movement of microalgae *** radiative transfer equation(RTE)is used to obtain light intensity *** combination of light radiation field and microalgae cell motions is used to construct the light history and they are integrated into the model of the photosynthetic units(PSU) to calculate the microalgae growth *** numerical results demonstrate that enhanced light/dark cycling frequency with ordered mixing can promote efficient microalgae *** effect of the vortex flow field generated by the baffles in an air-lift PBR is analyzed for increasing microalgae growth *** using the 1:1 baffle spacing,the biomass production of microalgae is increased by 41.8% compared to the original PBR.

关键词： light distribution particle tracking photobioreactor structure optimization

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题名相似度模型在文献数据质量控制中的应用

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长江信息通信 2024年第2期37卷 120-122页

作者：金光龙张光照张银玲贵州财经大学图书馆贵州贵阳550025

针对特色文献资源建设面临采访预订单中元数据描述不标准、字段不齐全、输入不规范,采访渠道广泛等问题给查重工作带来的难度,本文提出了基于题名相似度的查重模型,将题名经过数据预处理后利用word2vec提取题名的特征向量,计算题名之间... 详细信息

针对特色文献资源建设面临采访预订单中元数据描述不标准、字段不齐全、输入不规范,采访渠道广泛等问题给查重工作带来的难度,本文提出了基于题名相似度的查重模型,将题名经过数据预处理后利用word2vec提取题名的特征向量,计算题名之间的余弦相似度解决文献的查重问题。实验结果表明该查重模型具有较好的效果,为图书馆馆藏特色文献资源建设提供了可行的借鉴。

关键词：特色馆藏元素据题名查重 word2vec 余弦相似度

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Melting Evaluation of Phase Change Materials Impregnated into Cascaded Metal Foams with Regionalized Enhancement

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Journal of Thermal Science 2025年第1期34卷 223-241页

作者： WEI Xinyi zhang Nan zhang Zhaoli CAO Xiaoling YUAN Yanping School of Mechanical Engineering Southwest Jiaotong University

Metal foam promotes the heat transfer of phase change materials(PCMs) in the penalty of reducing the energy storage density of the composite *** this work,the effects of constant porosity(0.96,0.94,0.92,or 0.90) and pore density(PPI) of metal foam on heat transfer of composite PCMs are *** rate could be enhanced by employing with low porosity copper ***,aiming to the right bottom phase changing "dead region",a regionalized enhancement strategy of cascaded metal foams is *** dynamic melting performances of all the composite PCMs are comprehensively *** results reveal that the cascaded configuration is beneficial for *** show that the horizontal strategy enhances melting performance:a maximum of 17.98% reduction in total melting time could be reached when the rear part porosity is 90%.The energy storage density rate could be raised by 5.48%.Besides,the vertical strategy performs with a better average temperature uniformity of 0.441 and brings a lower temperature in the heated *** sum up,the regionalized enhancement of copper foam provides better performance in the phase change *** shows significant potential for solar heat storage and thermal protection.

关键词： copper metal foam heat transfer enhancement phase change materials regionalized enhancement

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The optimal control theory——a scientific approach to fundamentally solving control problems

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Science China(Information Sciences) 2025年第1期68卷 389-391页

作者： Huanshui zhang School of Electrical and Automation Engineering Shandong University of Science and Technology School of Control Science and Engineering Shandong University

The maximum principle has bridged mathematical optimization to optimal control,ushering in significant developments and refinements in optimal control theory,notably during the 1960s with the advent of linear quadratic (LQ)control and linear quadratic estimation (LQE).This progression propelled optimal control theory into further advancements,encompassing stochastic control,robust/H-infinity control,model predictive control (MPC),networked control,and reinforcement learning *** control,established upon a rigorous mathematical foundation,extends static optimization theory to dynamic systems,exhibiting scientific essence,unity,and ***,since its inception,optimal control theory has served as an indispensable core role across all control-related domains,including communication-constrained control in networked systems,consensus control,cooperative control,and reinforcement learning control.

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