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Bioactive Materials 2024年第6期36卷 541-550页

作者： Lanqing Wang Zi Mei guanyu jin Hao Liu Shixian Lv Runjia Fu Muxing Li Cuiping Yao Institute of Biomedical Photonics and Sensing School of Life Science and TechnologyKey Laboratory of Biomedical Information Engineering of Ministry of EducationXi’an Jiaotong UniversityXi’an710049China School of Stomatology School of Materials Science and EngineeringDepartment of General SurgeryThird HospitalPeking UniversityBeijing100871China Department of Oncology The Second HospitalCheeloo College of MedicineShandong UniversityJinan250033China

Systematic administration of small molecular drugs often suffered from the low efficacy and systemic toxicity in cancer *** addition,application of single mode drug usually leads to unsatisfactory therapeutic ***,developing multimodal-drug combination strategy that acts on different pathways without increasing side effects remains great ***,we developed a hydrogel system that co-delivered glycolysis inhibitor apigenin and chemo-drug gemcitabine to realize combination strategy for combating can-cer with minimal systemic *** demonstrated that this system can not only eliminate tumor cells in situ,but also induce abscopal effect on various tumor *** results showed that our study provided a safe and effective strategy for clinical cancer treatment.

关键词： Chitosan-based hydrogel Drug delivery Controlled-release Abscopal effect Polymer carriers

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

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Medical Review 2023年第1期3卷 4-30页

作者： Yuanzhen Su guanyu jin Huicong Zhou Zhaofan Yang Lanqing Wang Zi Mei Qionghua jin Shixian Lv Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina School of Materials Science and Engineering Peking UniversityBeijingChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Chemistry Capital Normal UniversityBeijingChina School of Materials Science and Engineering Peking UniversityNo.5 Yiheyuan RoadBeijing 100871China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026Anhui ProvinceChina

The complexity of the tumor microenvironment(TME)severely hinders the therapeutic effects of various cancer treatment *** TME differs from normal tissues owing to the presence of hypoxia,lowpH,and immunesuppressive *** of the TME to reverse tumor growth equilibrium is considered an effective way to treat ***,polymeric nanomedicines have been widely used in cancer therapy,because their synthesis can be controlled and they are highly modifiable,and have demonstrated great potential to remodel the *** this review,we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME,aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

关键词： cancer therapy polymeric nanomedicines stimuli responsive tumor microenvironment

多元主体参与的韩国农民数字素养教育实践及启示

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图书与情报 2023年第3期 22-28页

作者：金冠妤武汉大学信息管理学院湖北武汉430072

提升农民数字素养是弥合数字鸿沟的重要举措,调查韩国农民数字素养教育实践情况可为我国农民数字素养教育开展提供参考。文章调研了韩国各主体参与农民数字素养教育现状,发现韩国政府机构、公共机构、学校、社会组织等农民数字素养教育... 详细信息

提升农民数字素养是弥合数字鸿沟的重要举措,调查韩国农民数字素养教育实践情况可为我国农民数字素养教育开展提供参考。文章调研了韩国各主体参与农民数字素养教育现状,发现韩国政府机构、公共机构、学校、社会组织等农民数字素养教育主体明确自身责任,取得了良好的教育效果。结合韩国多元主体参与农民数字素养教育的成功经验及我国现状,从完善政策制度、明确各主体职能、构建评价标准三个角度对我国农民数字素养教育提出了一些建议,以期为我国社会各界共同参与农民数字素养教育提供借鉴。

关键词：农民数字素养多元主体数字素养教育韩国

基于色散调控氟碲酸盐玻璃光纤的O-U波段平坦光频梳产生

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发光学报 2024年第3期45卷 458-467页

作者：陈禹先张绪成金冠宇孟凡超贾志旭秦伟平秦冠仕吉林大学电子科学与工程学院集成光电子学国家重点实验室吉林长春130012

光学频率梳(简称光频梳)作为一种优秀的多波长光源在通信领域具有巨大的应用潜力。通过将光频梳光源与波分复用技术(WDM)、空分复用技术结合(SDM),通信系统可以具有百Tbit/s量级的传输速率,在5G/6G通信、物联网、自动驾驶等方面具有重... 详细信息

光学频率梳(简称光频梳)作为一种优秀的多波长光源在通信领域具有巨大的应用潜力。通过将光频梳光源与波分复用技术(WDM)、空分复用技术结合(SDM),通信系统可以具有百Tbit/s量级的传输速率,在5G/6G通信、物联网、自动驾驶等方面具有重要的应用价值。目前实现光频梳的方法主要有以下四种,分别为基于锁模激光器产生飞秒光频梳、基于光学微腔产生光频梳、基于电光调制器产生光频梳以及基于行波四波混频产生光频梳。它们各具特点,但均很难同时实现宽光谱、高信噪比、高平坦度、高的单梳齿功率以及梳齿频率间隔大范围可调,这在一定程度上影响了光频梳在光通信领域的应用。本文提出基于受激布里渊激光腔产生种子梳,采用腔外负色散光纤进行脉冲压缩,进一步利用色散调控的高非线性氟碲酸盐光纤进行扩谱,从而实现光频梳产生。数值计算结果表明,通过该系统,我们可以得到重复频率大范围可调、光谱覆盖整个O-U波段且在O-U波段梳齿强度标准差小于5 dB的平坦光频梳,证明了通过基于布里渊激光腔与色散调控高非线性氟碲酸盐光纤的光学系统产生可用于光通信的平坦光频梳的可行性。

关键词：光频梳色散调控氟碲酸盐玻璃光纤脉冲压缩腔外扩谱 O-U波段平坦

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污泥基生物炭对重金属Cd^2+的吸附性能

安徽建筑大学学报 2020年第4期28卷 21-27,116页

作者：金冠宇李卫华杨厚云安徽建筑大学环境与能源工程学院安徽合肥230601

以剩余污泥为原材料,分别在400、600和800℃高温隔绝氧气的条件下碳化制备成生物炭。利用扫描电子显微镜(SEM)、傅里叶红外光谱仪(FTIR)、拉曼光谱仪(Raman)等对其理化性质进行表征。SEM结果表明随着炭化温度上升,生物炭表面形态结构越... 详细信息

以剩余污泥为原材料,分别在400、600和800℃高温隔绝氧气的条件下碳化制备成生物炭。利用扫描电子显微镜(SEM)、傅里叶红外光谱仪(FTIR)、拉曼光谱仪(Raman)等对其理化性质进行表征。SEM结果表明随着炭化温度上升,生物炭表面形态结构越来越杂乱;红外光谱显示碳化温度升高的过程中,生物炭中大量官能团消失;拉曼光谱阐明碳化温度的升高导致生物炭缺陷程度明显增大。同时研究不同温度制备的污泥基生物炭对溶液中Cd^2+的吸附性能。吸附实验结果表明碳化温度为800℃制备得到的生物炭在pH=7时对Cd^2+的吸附效果最好,其吸附过程均更符合准二级动力学方程。对反应前后生物炭进行X-射线衍射(XRD)、X-射线光电子能谱(XPS)测试,X-射线衍射分析结果表明高温碳化导致生物炭中生成更多无机矿物,其对Cd^2+的吸附机制是表面官能团络合作用;同样的吸附机理也在X射线光电子能谱的分析中被证实。利用剩余污泥制备吸附材料是剩余污泥资源化利用的一种有效途径。

关键词：生物炭剩余污泥 Cd^2+ 吸附

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聚合氯化铁强化生物絮凝一级处理工艺

阜阳师范大学学报（自然科学版） 2020年第2期37卷 34-39页

作者：金冠宇李宇昇李卫华安徽建筑大学环境与能源工程学院安徽合肥230601 中国科学技术大学化学与材料科学学院安徽合肥230026

本研究拟通过聚合氯化铁强化生物絮凝,去除原水中部分总磷(TP)与化学需氧量(COD).研究在污水厂中采用实际废水进行,于中试装置中投加聚合氯化铁絮凝剂,以TP及COD为控制指标水质符合典型的短程硝化-厌氧氨氧化工艺的需求.综合批次试验及... 详细信息

本研究拟通过聚合氯化铁强化生物絮凝,去除原水中部分总磷(TP)与化学需氧量(COD).研究在污水厂中采用实际废水进行,于中试装置中投加聚合氯化铁絮凝剂,以TP及COD为控制指标水质符合典型的短程硝化-厌氧氨氧化工艺的需求.综合批次试验及中试运行的长期试验结果表明,在中试装置中投加30 mg/L聚合氯化铁时对生活污水处理效果最好,对总磷去除率达到83%,为总磷的排放量达标提供了基础.COD去除率达到70%,为后续短程硝化-厌氧氨氧化工艺的运行提供了前提条件.

关键词：聚合氯化铁强化一级处理生活污水短程硝化-厌氧氨氧化

Longitudinal Control for Balloon-Borne Launched Solar Powered UAVs in Near-Space

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Journal of Systems Science & Complexity 2022年第3期35卷 802-819页

作者： HU Yanpeng GUO jin MENG Wenyue LIU guanyu XUE Wenchao School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of Knowledge Automation for Industrial Processes Ministry of EducationBeijing 100083China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

Aiming to improve the pull-up control performance in the process of releasing balloonborne solar powered UAVs(Unmanned Aerial Vehicles),this paper establishes the full flight mechanics equations with flexible modes,and proposes the control method suitable for engineering *** be specific,the authors first calculate the real aerodynamic force on horizontal stabilizer by comparing the fuselage deformation in ballooning test with that in static loading ***,considering fuselage elastic deformation,the pitching moment coefficient is obtained and the influence of airspeed and elevator angle on pitching moment coefficient and control surface efficiency are ***,the authors establish a complete flight mechanics model,including elastic structural dynamic model and rigid flight dynamic model,by comprehensively considering the aerodynamic data,the relationship between fuselage deformation and load,as well as the ballooning ***,the authors perform the numerical simulation and comparison study on control performance between rigid model and flexible ***,the authors implement model modification based on the low altitude flight test and steady-state point ***,a scaled UAV is used to complete the balloon-borne launching *** results show that the longitudinal control method can analyse the longitudinal aerodynamics and control characteristics accurately,and could be effectively utilized in the pull-up control of the balloon-borne solar powered UAV.

关键词： Aeroelastic model balloon-borne flight test flight dynamic model longitudinal control numerical simulation solar powered UAV

A duplication-free quantum neural network for universal approximation

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Science China(Physics,Mechanics & Astronomy) 2023年第7期66卷 2-16页

作者： Xiaokai Hou guanyu Zhou Qingyu Li Shan jin Xiaoting Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610051China

Different from the concept of universal computation,the universality of a quantum neural network focuses on the ability to approximate arbitrary functions and is an important guarantee for ***,conventional approaches of constructing a universal quantum neural network may result in a huge quantum register that is challenging to implement due to noise on a near-term *** address this,we propose a simple design of a duplication-free quantum neural network whose universality can be rigorously ***,instead of using multiple duplicates of the quantum register,our method relies on a single quantum register combined with multiple activation functions to create nonlinearity and achieve ***,our proposal requires significantly fewer qubits with shallower circuits,and hence substantially reduces the resource overhead and the noise *** addition,simulations demonstrate that our universality design is able to achieve a better learning accuracy in the presence of noise,illustrating a great potential in solving larger-scale learning problems on near-term devices.

关键词： quantum computing quantum machine learning quantum neural network universality

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中西医结合治疗与单纯西医治疗少精子症的临床疗效对比

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现代中西医结合杂志 2014年第21期23卷 2286-2288,2291页

作者：王志勇卢太坤金冠羽韩玉芬王瑜河南省濮阳市妇幼保健院河南濮阳457000 福建中医药大学附属厦门中医院福建厦门361001

目的比较中西医结合治疗与单纯西医治疗对提高肾精亏虚证少精子症患者精子密度的临床疗效。方法将300例肾精亏虚证少精子症患者随机分为2组,治疗组150例口服补肾益精汤和枸橼酸他莫西芬片、甘草锌胶囊及维生素E胶丸治疗;对照组150例口... 详细信息

目的比较中西医结合治疗与单纯西医治疗对提高肾精亏虚证少精子症患者精子密度的临床疗效。方法将300例肾精亏虚证少精子症患者随机分为2组,治疗组150例口服补肾益精汤和枸橼酸他莫西芬片、甘草锌胶囊及维生素E胶丸治疗;对照组150例口服枸橼酸他莫西芬片及甘草锌胶囊和维生素E胶丸治疗。2组均治疗3个月,不足3个月而其配偶受孕者终止治疗,跟踪随访6个月。结果治疗组治疗后精子密度、活动力、活动率、精子正常形态率明显优于治疗前(P均<0.01),且显著优于对照组(P均<0.01);治疗组在改善临床症状方面明显优于对照组(P<0.01)。结论中西医结合治疗能显著提高肾精亏虚证少精子症患者的精子密度及精液质量其他指标,改善临床症状。

关键词：男性不育症少精子症肾精亏虚证中西医结合疗法

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卢太坤教授辨病辨证相结合治疗血精症经验

光明中医 2014年第10期29卷 2052-2054页

作者：王志勇金冠羽卢太坤韩玉芬王瑜河南濮阳市妇幼保健院生殖中心濮阳457000 福建中医药大学附属厦门市中医院男科厦门361009

血精症是男科常见的、反复发作的男性疾病,生殖系、下泌尿系及全身疾病均可导致其发病。卢太坤教授治疗血精症首先查明病因以辨病治疗,进而辨证论治,同时强调生活方式及排精时间选择的重要性。本文结合病案进一步阐释了卢太坤教授辨病... 详细信息

血精症是男科常见的、反复发作的男性疾病,生殖系、下泌尿系及全身疾病均可导致其发病。卢太坤教授治疗血精症首先查明病因以辨病治疗,进而辨证论治,同时强调生活方式及排精时间选择的重要性。本文结合病案进一步阐释了卢太坤教授辨病辨证相结合治疗血精症的学术思想。

关键词：血精症辨病论治辨证论治卢太坤