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Postoperative Delirium in Elderly Patients May be Associated with Perioperative Blood Pressure Fluctuations

Journal of Geriatric Medicine 2021年第1期3卷 6-11页

作者： Daxu Peng Qingchen Liu Xiuyang Cao guanwen deng Shaoguan Shaokang Hospital ShaoguanGuangdong512400China Affiliated Hospital of North China University of Technology TangshanHebei06300China Lechang Traditional Chinese Medicine Hospital ShaoguanGuangdong512400China

Postoperative delirium(PD)is a common complication of surgery in elderly patients,but its pathophysiological mechanism remains *** order to clarify the role of intraoperative hypotension and fluctuation of blood pressure in the development of PD,we conducted a follow-up study in elderly patients with intraoperative hypotension and fluctuation of blood pressure.A total of 237 patients underwent hip surgery between July 2018 and September 2019,and 158 patients who were eligible for inclusion were enrolled in the *** day before the operation,the mentality of patients was evaluated by Mini-mental State Examination(MMSE),and the sex,age,height,and weight of the patients were *** artery puncture was performed in all patients before anesthesia,intraoperative SBP,MAP and DBP were recorded,and the surgical events of the patients was *** markers associated with PD(TNF-α,IL-6 and S-100β)were determined before and after *** delirium(PD)was assessed by the prevailing standard of assessment,Confusion of Consciousness Assessment(CAM).Cognitive assessment was evaluated using the Mini-mental State Examination(MMSE).In addition,the timing and type of delirium were *** were 158 patients which were accorded with the inclusion criteria came into the *** results of our data showed that delirium occurred in 41 patients(25.9%)during the first week after *** the comparison between the PD group and the non-PD group,it was found that the patients with postoperative delirium were older,lower body mass index and higher MMSE score before *** blood pressure is low,usually more than 30%lower than preoperative blood *** levels of TNF-α,IL-6 and Smur100βwere higher after *** increased incidence of postoperative delirium may be related to intraoperative hypotension and intraoperative blood pressure *** pathophysiological mechanism may be that hypotension causes low cerebr

关键词： Perioperative period Blood pressure fluctuation Postoperative delirium

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Evaluation of Light Specific Gravity Ropivacaine Combined with Sufentanil in Hip Arthroplasty at An Advanced Age

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Journal of Advances in Medicine Science 2021年第1期4卷 19-22页

作者： Daxu Peng Qingchen Liu Xiuyang Cao guanwen deng Shaoguan Shaokang Hospital ShaoguanGuangdong512400China Affiliated Hospital of North China University of Technology TangshanHeibei063000China Lechang Traditional Chinese Medicine Hospital ShaoguanGuangdong512400China

combined with sufentanil in elderly patients undergoing hip ***:89 elderly patients with hip arthroplasty from July 2019 to September 2020 were randomly divided into experimental group and control *** experimental group was anesthetized with light specific gravity ropivacaine combined with *** control group was anesthetized with equal specific gravity ropivacaine to compare the effect of anesthesia and the incidence of adverse ***:there was no significant difference in sensory recovery time and motor recovery time between the experimental group and the control group(P>0.05),and the incidence of adverse reactions between the two groups was *** sensory block time in the experimental group was shorter than that in the control group(PP>0.05).Conclusion:ropivacaine combined with sufentanil subarachnoid anesthesia is more effective in elderly patients undergoing hip arthroplasty,and the safety of the anesthesia scheme is higher,which will not lead to serious adverse reactions during ***,the application of the anesthesia scheme can effectively improve the analgesic effect during and after operation,and the clinical application value is high.

关键词： Light specific gravity ropivacaine Sufentanil Elderly patients Hip replacement Safety

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岛状皮瓣修复术治疗手外伤患者软组织缺损的效果观察及有效率分析

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中国社区医师 2021年第18期37卷 10-11页

作者：邓冠文游卫福潘海文广东省韶关韶康医院外科广东韶关512000

目的:探究岛状皮瓣修复术治疗手外伤患者软组织缺损的效果及有效率。方法:2017年9月-2020年9月收治存在软组织缺损的手外伤患者40例,均采取岛状皮瓣修复术治疗,分析应用效果。结果:40例患者皮瓣均存活,平均创面愈合时间为(23.10±2.37)d... 详细信息

目的:探究岛状皮瓣修复术治疗手外伤患者软组织缺损的效果及有效率。方法:2017年9月-2020年9月收治存在软组织缺损的手外伤患者40例,均采取岛状皮瓣修复术治疗,分析应用效果。结果:40例患者皮瓣均存活,平均创面愈合时间为(23.10±2.37)d;术后30 d恢复情况优良率为87.50%;抗菌药物使用时间为(7.47±3.24)d,创面愈合时间为(17.98±2.20)d,住院时间为(7.89±1.23)d;术后14 d炎症因子TNF-α、IL-6、IL-8水平,瘙痒评分、VAS疼痛评分均低于术前,差异有统计学意义(P<0.05);术后30 d出现并发症4例,经及时对症处置后,明显好转并基本消失;患者静态两点辨别觉平均为(7.53±1.37)mm;总满意率为90.00%。结论:利用岛状皮瓣修复术治疗手外伤患者软组织缺损的临床效果良好。

关键词：环岛皮瓣修复术手外伤软组织缺损

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Nonparaxial propagation properties of the chirped Airy Gaussian vortex beams in uniaxial crystals orthogonal to the optical axis

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Chinese Physics B 2018年第10期27卷 315-321页

作者： Yizuo Chen guanwen Zhao Feng Ye Chuangjie Xu Dongmei deng Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices South China Normal UniversityGuangzhou 510631China

In this article, we investigate the nonparaxial propagation properties of the chirped Airy Gaussian vortex（CAiGV）beams in uniaxial crystals orthogonal to the optical axis analytically and numerically. We discuss how the linear chirp parameters, the quadratic chirp parameters, and the Gaussian factors influence the nonparaxial propagation dynamics of the CAiGV beams. The intensity, the energy flow, the beam center, and the angular momentum of the CAiGV beams are deeply investigated. It is shown that the Gaussian factors have a great effect on the intensity and the centroid positions of the CAiGV beams. With the Gaussian factors increasing, the intensity of CAiGV beams decreases rapidly. The main lobes of the transverse intensity distribution of the CAiGV beams are similar to triangles.

关键词： Chirped Airy Gaussian vortex beams energy flow angular momentum nonparaxial propagation

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Administrative Urbanization and City-making in Post-reform China: A Case Study of Ordos City, Inner Mongolia

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Chinese Geographical Science 2017年第6期27卷 891-903页

作者： YIN guanwen LIU Yungang College of Geography and Environment Shandong Normal University Guangdong Provincial Key Laboratory of Urbanization and Geo-simulation School of Geography and Planning Sun Yat-sen University

In post-reform China, local governments, instead of the central state, have become major promoters of urbanization. Differing from the existing literature based on Western theories, this article argues that a localized perspective, ‘administrative urbanization', can provide a contextual explanation for the mechanism of urbanization in the reform era. The case study of Ordos indicates that new town construction, especially in the inland area, has become the main strategy for investment attraction and economic development. The local government has played a dominant role in this construction through a series of administrative measures, including avoidance of central state regulations, land leasing, high standard infrastructure construction, relocation policies and industrial attraction. This article also explores the issue of unsustainability in the new town, and identifies that underdeveloped industrialization, slow population agglomeration and real estate bubbles are primary threats to the sustainability of administrative urbanization.

关键词： administrative urbanization local government sustainability Ordos China

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Post-self-repair process of neuron cells under the influence of neutral and cationic nanoparticles

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Chinese Chemical Letters 2019年第12期30卷 2368-2374页

作者： Ting Wang guanwen Qu Yu deng Jing Shang Zhangqi Feng Fengyu Yang Nongyue He Jie Zheng State Key Laboratory of Bioelectronics National Demonstration Centre for Experimental Biomedical Engineering EducationSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China State Key Laboratory of Natural Medicines Department of PharmacologyChina Pharmaceutical UniversityNanjing 210002China Department of Chemical and Biomolecular Engineering The University of AkronOH 44325United States School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Nanjing Daniel New Mstar Technology Ltd.Nanjing 2U200 China

The prevalence of functionalized nanoparticles in biological and clinical fields attracts intensive toxicology *** the nanoparticles’ biohazard remains a challenge due to the insufficient understanding on the nanoparticle-induced cell death *** the presented study,we observed the lysosome and genome injuries and so caused cell cycle changes and regulations of retinal ganglion neuron cell 5(RGC-5) induced by aminated and alkylated *** nanoparticles induced malignant lysosome and genome damages followed by severe post-self-repair ***-5 treated with alkylated nanoparticles presented dramatic S phase prolongation resulted from cyclin E accumulation mediated by Fbw7 downregulation,which assisted DNA replication after failed self-repair of the malignantly damaged DNA caused by alkylated ***,aminated nanoparticles in RGC-5 induced moderate lysosome and genome injuries and these damages could be repaired in the p21-involved pathway,so that cells did not induce apparent cyclin E accumulation nor Fbw7 downregulation as post-self-repair *** results helped us to understand the toxicity of analogous nanoparticles on retinal ganglions such as glaucoma *** work provides new insights into nanoparticle functionalization and toxicity in relation to the research on the toxicology and pathology of nerve cells.

关键词： Lysosome S phase Cyclin E p21 Fbw7

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GNSS techniques for real-time monitoring of landslides:a review

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Satellite Navigation 2023年第1期4卷 214-223,I0006页

作者： guanwen Huang Shi Du Duo Wang College of Geology Engineering and Geomatics Chang’an UniversityXi’an 710054ShannxiChina Key Laboratory of Ecological Geology and Disaster Prevention Ministry of Natural ResourcesXi’an 710054ShannxiChina

Currently,Global Navigation Satellite System(GNSS)Real-Time Kinematic positioning(RTK)and Precise Point Positioning(PPP)techniques are widely employed for real-time monitoring of ***,both RTK and PPP monitoring techniques have their limitations,such as limited service coverage or long convergence ***-RTK technique which integrates RTK and PPP is a novel approach for monitoring landslides with the advantages of rapid convergence,high-precision,and a wide service *** study summarizes the limitations of RTK,PPP,and PPP-RTK monitoring techniques and suggests some improved *** performances are compared and analyzed using real monitoring *** experiment results demonstrate that RTK is the best option for small-scale(the baseline distance<15 km)and real-time landslide monitoring without considering the *** technique converges to centimeter-level accuracy in tens of minutes,only suitable for the stability analysis of reference *** a large area(the baseline distance<100 km),PPP-RTK can provide excellent horizontal accuracy and adapt the service range in response to the demand for monitoring accuracy,as the vertical accuracy is signifcantly impacted by the service range and elevation ***,the characteristics of three techniques are integrated to form a comprehensive landslide monitoring technique that considers intelligence,robustness,and real-time.

关键词： Landslide geohazards RTK PPP PPP-RTK Monitoring

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Estimation of fractional cycle bias for GPS/BDS-2/Galileo based on international GNSS monitoring and assessment system observations using the uncombined PPP model

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Satellite Navigation 2021年第1期2卷 130-140页

作者： Jin Wang Qin Zhang guanwen Huang College of Geology Engineering and Geomatics Chang’an UniversityXi’an 710054China

The Fractional Cycle Bias(FCB)product is crucial for the Ambiguity Resolution(AR)in Precise Point Positioning(PPP).Different from the traditional method using the ionospheric-free ambiguity which is formed by the Wide Lane(WL)and Narrow Lane(NL)combinations,the uncombined PPP model is flexible and effective to generate the FCB *** study presents the FCB estimation method based on the multi-Global Navigation Satellite System(GNSS)precise satellite orbit and clock corrections from the international GNSS Monitoring and Assessment System(iGMAS)observations using the uncombined PPP *** dual-frequency raw ambiguities are combined by the integer coefficients(4,−3)and(1,−1)to directly estimate the *** details of FCB estimation are described with the Global Positioning System(GPS),BeiDou-2 Navigation Satellite System(BDS-2)and Galileo Navigation Satellite System(Galileo).For the estimated FCBs,the Root Mean Squares(RMSs)of the posterior residuals are smaller than 0.1 cycles,which indicates a high consistency for the float *** stability of the WL FCBs series is better than 0.02 cycles for the three GNSS systems,while the STandard Deviation(STD)of the NL FCBs for BDS-2 is larger than 0.139 *** combined FCBs have better stability than the raw *** the multi-GNSS FCB products,the PPP AR for GPS/BDS-2/Galileo is demonstrated using the raw *** hourly static positioning results,the performance of the PPP AR with the three-system observations is improved by 42.6%,but only 13.1%for kinematic positioning *** results indicate that precise and reliable positioning can be achieved with the PPP AR of GPS/BDS-2/Galileo,supported by multi-GNSS satellite orbit,clock,and FCB products based on iGMAS.

关键词： PPP AR Fractional cycle bias Satellite orbit and clock products iGMAS

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Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3

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Chinese Chemical Letters 2019年第5期30卷 1043-1050页

作者： Ting Wang Yu deng guanwen Qu Yaozhong Chen Jing Shang Zhangqi Feng Jie Zheng Fengyu Yang Nongyue He State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Chemical and Biomolecular Engineering The University of AkronAkron OH 44325United States State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Nanjing Daniel New Mstar Technology Ltd. Nanjing 2J1200China National Demonstration Center for Experimental Biomedical Engineering Education Southeast UniversityNanjing 210096China

Breast cancer is one of the most common cancers in the world,survival rates of breast cancer are rising as screening and treatment *** new technologies applied in the biomedical domain have been born for rapid diagnosis and *** this work,visualization cell microarray chip with threedimensional(3 D)embedded cell scaffold for cell diagnosis and treatment was *** segment,targeting on breast cancer cells SK-BR-3,were modified with camptothecin and used as model *** microarray chip system successfully control the diffusion of small molecules and locally introduced the compounds into cells.3 D embedded cell scaffold in the cell array chip afforded an environment with continuous medium supplementary and help controlling the diffusion of small molecules *** cell microarray chip system,SK-BR-3 was targeted screening and killing in one *** microarray chip system can achieve accurate,rapid diagnosis and target treatment of breast cancer cells SK-BR-3 and have a potential to develop to be an effective and accurate drug screen method for evaluating the drug effect of the booming chemicals.

关键词： Cell micro-array chip DNA segment Target SK-BR-3 Camptothecin

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Desulfurization characteristics of slaked lime and regulation optimization of circulating fluidized bed flue gas desulfurization process--A combined experimental and numerical simulation study

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Chinese Journal of Chemical Engineering 2024年第9期73卷 163-175页

作者： Jing Chen Wenqi Zhong guanwen Zhou Jinming Li Shasha Ding Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Nanjing Iron and Steel United Co. Ltd.Nanjing 210035China

Circulating fluidized bed flue gas desulfurization(CFB-FGD) process has been widely applied in recent years. However, high cost caused by the use of high-quality slaked lime and difficult operation due to the complex flow field are two issues which have received great attention. Accordingly, a laboratory-scale fluidized bed reactor was constructed to investigate the effects of physical properties and external conditions on desulfurization performance of slaked lime, and the conclusions were tried out in an industrial-scale CFB-FGD tower. After that, a numerical model of the tower was established based on computational particle fluid dynamics(CPFD) and two-film theory. After comparison and validation with actual operation data, the effects of operating parameters on gas-solid distribution and desulfurization characteristics were investigated. The results of experiments and industrial trials showed that the use of slaked lime with a calcium hydroxide content of approximately 80% and particle size greater than 40 μm could significantly reduce the cost of desulfurizer. Simulation results showed that the flow field in the desulfurization tower was skewed under the influence of circulating ash. We obtained optimal operating conditions of 7.5 kg·s^(-1)for the atomized water flow, 70 kg·s^(-1)for circulating ash flow, and 0.56 kg·s^(-1)for slaked lime flow, with desulfurization efficiency reaching 98.19% and the exit flue gas meeting the ultraclean emission and safety requirements. All parameters selected in the simulation were based on engineering examples and had certain application reference significance.

关键词： Circulating fluidized bed flue gas desulfurization(CFB-FGD) Desulfurization characteristics Computational particle fluid dynamics (CPFD)numerical simulation Operational optimization Gasesolid flow

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