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Piezoelectric composite hydrogel with wireless electrical stimulation enhances motor functional recovery of spinal cord injury

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Journal of Materials Science & Technology 2024年第5期172卷 228-239页

作者： Zehao li guanlin li Xinyu Wang Zheng Zhao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China

Electrical stimulation(ES)can restore motor function after spinal cord injury(SCI).However,traditional intraspinal ES has many disadvantages,such as the need for a complex circuitry device,an external power source,and a second surgery to remove the implant.Piezoelectric materials have received increasing at-tention due to their potential to convert ambient mechanical energy into ES without an external power source or implantation of electrodes.Herein,a novel polydopamine(PDA)coated barium titanate(BaTiO_(3))nanoparticles(BaTiO_(3)@PDA)incorporated silk fibroin(SF)hydrogel(SFBT)was established.The SFBT hy-drogel was crosslinked by horseradish peroxidase(HRP)/hydrogel peroxide(H_(2)O_(2))to integrate the piezo-electric potency of BaTiO_(3)with the thermal sensitivity of HRP/H_(2)O_(2)for SCI recovery.The hydrogel con-taining 5%(w/v)BaTiO_(3)@PDA nanoparticles(SFBT-5),which was selected for in vivo study,exhibited a short gelation time(5 min),suitable storage modulus(925±35 Pa),and wireless ES(average current of 124 nA).Moreover,Basso-Beattie-Bresnahan(BBB)scores test and footprint analysis demonstrated that the SFBT-5 hydrogel successfully enhanced motor functional recovery of SCI.In histopathological assess-ments,the SFBT-5 hydrogel significantly accelerated spinal cord healing,as indicated by smaller lesion cavities(∼16.7%of the SCI group).Meanwhile,the SFBT-5 hydrogel accelerated neurogenesis,facilitated axon regrowth and synapse formation,and promoted remyelination.Overall,this study highlights the potential of piezoelectric hydrogels for SCI regeneration.

关键词： Silk fibroin Barium titanate Piezoelectric hydrogel Spinal cord injury Electrical stimulation

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Patterns of crop-specific fertilizer-nitrogen losses and opportunities for sustainable mitigation:A quantitative overview of 15N-tracing studies

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Soil Ecology Letters 2024年第2期6卷 71-81页

作者： Cong Xu Hanshen Zhu Haokuang liu Cheng Ji Jie Yuan guanlin li Jidong Wang Yongchun Zhang National Agricultural Experimental Station for Agricultural Environment LuheInstitute of Agricultural Resources and EnvironmentJiangsu Academy of Agricultural SciencesNanjing210014China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang212013China

Pattern and mitigation potential of crop-specific fertilizer-N losses were assessed.China showed high fertilizer-N losses due to high N application rates and low SOC.MAP,SOC,and soil pH are key parameters affecting fertilizer-N losses.At a given application rate,soils with higher SOC have lower fertilizer-N losses.Optimal N rate combined with SOC improvement could cut 34.8%-59.6%of N losses.

关键词： fertilizer-nitrogen loss crop-specific 15N tracing soil organic carbon meta-analysis

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Modified rolling guidance law for single moving mass controlled reentry vehicle against maneuvering target with impact angle constraints

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Chinese Journal of Aeronautics 2022年第6期35卷 226-239页

作者： guanlin li Ming YANG Songyan WANG Tao CHAO Control and Simulation Center Harbin Institute of TechnologyHarbin 150001China

This paper deals with the problem of guidance law design for the single moving mass controlled reentry vehicle when impact angle constraints and maneuvering target are taken into consideration.More specifically,a modified rolling guidance law is proposed with the interactive virtual target and the landing point prediction strategy.First,considering the fact that the roll channel can be controlled directly,the relative motion between the single moving mass controlled reentry vehicle and the target is described by the error angle between the relative velocity and the line-ofsight.Second,a nonlinear error angle command is given to reduce the rotation rate.To satisfy impact angle constraints,an interactive virtual target is presented and the‘‘S”formed velocity of the virtual target is given to abate the error angle tracking difficulty at the final stage of the reentry phase.Then,the landing point prediction strategy is employed and the motion variation trend is also taken into consideration.As the maneuvering target is replaced with the predicted landing point,the error angle tracking difficulty caused by the target velocity decreases,which is helpful to meet impact angle constraints and improve guidance accuracy at the same time.Finally,the finite-time rolling guidance law is proposed and proved via Lyapunov stability theorem.Compared with the existing method,lower-speed rotation,smaller missing distance and less impact angle errors are obtained,which can be demonstrated by numerical simulations.

关键词： Reentry vehicles Guidance law Impact angle Maneuvering target Finite-time convergence

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Simulated Indonesian Throughflow in Makassar Strait across the SODA3 products

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Acta Oceanologica Sinica 2024年第1期43卷 80-98页

作者： Tengfei Xu Zexun Wei Haifeng Zhao Sheng Guan Shujiang li guanlin Wang Fei Teng Yongchui Zhang Jing Wang First Institute of Oceanography/Key Laboratory of Marine Science and Numerical Modeling Ministry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Qingdao Marine Science and Technology CenterQingdao 266237China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China CAS Key Laboratory of Ocean Circulation and Waves Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of ScienceQingdao 266071China

The Indonesian Throughflow(ITF), which connects the tropical Pacific and Indian oceans, plays important roles in the inter-ocean water exchange and regional or even global climate variability. The Makassar Strait is the main inflow passage of the ITF, carrying about 77% of the total ITF volume transport. In this study, we analyze the simulated ITF in the Makassar Strait in the Simple Ocean Data Assimilation version 3(SODA3) datasets. A total of nine ensemble members of the SODA3 datasets, of which are driven by different surface forcings and bulk formulas, and with or without data assimilation, are used in this study. The annual mean water transports(i.e.,volume, heat and freshwater) are related to the combination of surface forcing and bulk formula, as well as whether data assimilation is employed. The phases of the seasonal and interannual variability in water transports cross the Makassar Strait, are basically consistent with each other among the SODA3 ensemble members. The interannual variability in Makassar Strait volume and heat transports are significantly correlated with El Ni?oSouthern Oscillation(ENSO) at time lags of-6 to 7 months. There is no statistically significant correlation between the freshwater transport and the ENSO. The Makassar Strait water transports are not significantly correlated with the Indian Ocean Dipole(IOD), which may attribute to model deficiency in simulating the propagation of semiannual Kelvin waves from the Indian Ocean to the Makassar Strait.

关键词： Indonesian Throughflow Simple Ocean Data Assimilation(SODA) El Ni?o-Southern Oscillation(ENSO) Indian Ocean Dipole(IOD) data assimilation

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LonP1 links Mitochondria–ER Interaction to Regulate Heart Function

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Research 2024年第1期2023卷 595-609页

作者： Yujie li Dawei Huang lianqun Jia Fugen Shangguan Shiwei Gong linhua Lan Zhiyin Song Juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang liu Xingxu Huang Carolyn K.Suzuki Zhongzhou Yang guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and homeostasis.In particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle dynamics.However,the regulatory mechanisms of MAM formation and their function are still elusive.Here,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering protein.The removal of LonP1 substantially reduces MAM formation and causes mitochondrial fragmentation.Furthermore,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart remodeling.These findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

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Non-invasive tests of non-alcoholic fatty liver disease

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Chinese Medical Journal 2022年第5期135卷 532-546页

作者： guanlin li Xinrong Zhang Huapeng lin lilian Yan liang Grace Lai-Hung Wong Vincent Wai-Sun Wong Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Medical Data Analytics Centre The Chinese University of Hong KongHong KongChina

For the detection of steatosis,quantitative ultrasound imaging techniques have achieved great progress in past years.Magnetic resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic steatosis.Some blood biomarkers correlate with non-alcoholic steatohepatitis,but the accuracy is modest.Regarding liver fibrosis,liver stiffness measurement by transient elastography(TE)has high accuracy and is widely used across the world.Magnetic resonance elastography is marginally better than TE but is limited by its cost and availability.Several blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment response.This article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease(NAFLD).Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD,assess its severity,and predict the prognosis.Further studies are needed to determine the role of the tests as monitoring tools.We cannot overemphasize the importance of context in selecting appropriate tests.

关键词： Fatty liver Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis liver fibrosis Cirrhosis Transient elastography FibroScan Magnetic resonance imaging

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Warming and elevated nitrogen deposition accelerate the invasion process of Solidago canadensis L.

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Ecological Processes 2022年第1期11卷 890-901页

作者： Guangqian Ren Bin Yang Miaomiao Cui Zhicong Dai Yan Xiang Haiyan Zhang guanlin li Jian li Qaiser Javed Daolin Du Institute of Environment and Ecology Academy of Environmental Health and Ecological SecuritySchool of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China School of Agricultural Engineering Jiangsu UniversityZhenjiang 212013China School of Inspection and Testing Certification Changzhou Vocational Institute of EngineeringChangzhou 213164China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China

Background:Invasive species can threaten native diversity and alter ecosystem processes while interacting with other components of global environmental change.Invasive plants are becoming increasingly problematic and this can be stimulated by changes in the environment.However,existing studies have primarily investigated the effects of environmental change on a specific stage of plant invasion rather than the continuous invasion process.Methods:A space-for-time substitution experiment was performed to investigate how warming and nitrogen deposition affects the invasion process of a plant.Specifically,different ratios of invasive Solidago canadensis L.to native Artemisia argyi Levl.et Van were employed as a proxy to represent successive levels of invasion.A total of seven treatments were applied in the experiment:ambient(CK),N addition(+5,+12 g m^(−2)year^(−1)),warming(+1.15,+1.86℃)and their interaction(5 g N m^(−2)year^(−1)+1.15℃,12 g N m^(−2)year^(−1)+1.86℃).The growth performance and competitiveness of S.canadensis were investigated.Results:The competitiveness of Solidago canadensis decreased linearly with its invasion degree(plinear regression showed that S.canadensis invasion levels of 53%,53%,68%,55%and 58%were the critical thresholds for shifting the direction or magnitude of chlorophyll,leaf nitrogen,leaf shape index,diameter,and root/shoot ratio,respectively.Compared with the ambient treatment(CK,no warming and no N addition),the diameter,height,bio-mass and relative competitiveness of S.canadensis were each limited by warming,to a certain extent,whereas these and the above parameters were significantly increased by nitrogen deposition.The interaction of increased temperature and nitrogen deposition led to significant increases in the growth and competitiveness of S.canadensis,and this effect was detected in every stage of the invasion,throughout the invasion process.Conclusions:Environmental change might have a continuous,progressive,and augmentative effect on the phenotypic traits of S.canade

关键词： Environmental change Phenotypic trait Competitiveness Solidago canadensis L. Invasion process

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基于浅地层剖面数据和改进地声模型的底质反演方法

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海洋地质与第四纪地质 2024年第1期44卷 170-178页

作者：孙振银王虎李冠霖天津大学海洋科学与技术学院天津300072 自然资源部海洋观测技术重点实验室天津300112

浅地层剖面仪发射的声脉冲能够穿透海底面进入沉积层内部,其回波中携带了丰富的底质信息。地声模型是底质声学与物理性质关系的数学描述,广泛用于海底声学与地声反演研究。本文通过对浅地层剖面数据的处理、解译得到海底反射系数,与考... 详细信息

浅地层剖面仪发射的声脉冲能够穿透海底面进入沉积层内部,其回波中携带了丰富的底质信息。地声模型是底质声学与物理性质关系的数学描述,广泛用于海底声学与地声反演研究。本文通过对浅地层剖面数据的处理、解译得到海底反射系数,与考虑底质松密影响的改进Biot-Stoll模型相结合,提出底质反演新方法并开展实例验证。研究结果表明:通过对浅地层剖面原始记录的读取、解译,提取反射波振幅,并结合设备声源级,可有效求取海底反射系数。通过引入相对密度改进孔隙度计算公式,进而在基于Biot-Stoll模型构建海底反射系数和底质平均粒径关系过程中进一步考虑了底质松密的影响。基于山东威海某海域及文献的算例均显示,本文提出的改进地声模型可缩小底质反演与实测结果之间的相对误差、提升基于浅地层剖面数据的海底底质地声反演精度。

关键词：浅地层剖面底质反演 Biot-Stoll模型海底反射系数平均粒径

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Stereodivergent Pd/Cu Catalysis for Asymmetric Desymmetric Alkylation of Allylic Geminal Dicarboxylates

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CCS Chemistry 2022年第5期4卷 1720-1731页

作者： Xiaohong Huo ling Zhao Yicong Luo Yue Wu Yuwen Sun guanlin li Tatiana Gridneva Jiacheng Zhang Yong Ye Wanbin Zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 College of Chemistry Zhengzhou UniversityZhengzhou 450052

AstereodivergentPd/Cucatalyst systemforasymmetric desymmetric alkylation of allylic geminal dicarboxylates has been developed,which was successfully applied to the asymmetric synthesis of β-hydroxycarbonylmotifs bearing a versatile carbon-carbon double bond in an enantio-and diastereodivergent manner.A wide scope of substrates including challenging alkylsubstituted,2-substituted,and3,3′-disubstitutedallylic species are compatible with this catalytic system,delivering the substituted products in high to excellent yieldsandwith excellent diastereo-(upto>20:1 dr)and enantioselectivities(up to>99%ee).Furthermore,the mechanism of this dual Pd/Cu catalytic system including:(1)the desymmetrization process ofgeminal dicarboxylates;(2)the origin of regioselectivity(branched or linear);(3)the enantio-and diastereoselectivity observed by changing the combinations of two chiral metal catalysts,have been carefully investigated by theoretical calculations.

关键词： stereodivergent synthesis bimetallic catalysis desymmetrization Pd/Cu dual catalysis asymmetric allylic substitution

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Short-Term Effects of Experimental Warming and Precipitation Manipulation on Soil Microbial Biomass C and N, Community Substrate Utilization Patterns and Community Composition

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Pedosphere 2017年第4期27卷 714-724页

作者： guanlin li Seongjun KIM Minji PARK Yowhan SON Department of Environmental Science and Ecological Engineering Graduate SchoolKorea UniversitySeoul 02841Korea Department of Biological and Environmental Sciences Qatar UniversityDoha 2713Qatar

Soil microorganisms are major drivers of soil carbon(C) cycling;however,the response of these microorganisms to climate change remains unclear.In the present study,we investigated how 18 months of multifactor climate treatments(warmed air temperature by 3℃ and decreased or increased precipitation manipulation by 30%) affected soil microbial biomass C and nitrogen(N),community substrate utilization patterns,and community composition.Decreased and increased precipitation significantly reduced microbial biomass C by 13.5% and 24.9% and microbial biomass N by 22.9% and 17.6% in unwarmed plots,respectively(Plization by 89.8%,20.4%,and 141.4% in the natural,decreased,and increased precipitation plots,respectively.Particularly,warming significantly enhanced the utilization of amine and carboxylic acid substrates among all precipitation manipulation plots.Compared with the natural air temperature with natural precipitation treatment,other treatments affected fungal community richness by -0.9% to 33.6% and reduced the relative abundance of the dominant bacterial and fungal groups by 0.5% to 6.8% and 4.3% to 10.7%,respectively.The warming and/or precipitation manipulation treatments significantly altered Zygomycota abundance(Plimate change drivers and their interactions may cause changes in soil microbial biomass C and N,community substrate utilization patterns,and community composition,particularly for the fungal community,and shifts in the microorganism community may further shape the ecosystems function.

关键词： bacterial community, climate change, community abundance, community diversity, community richness, fungal com-munity

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