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慢性病患者限制饮食负担量表的汉化和信效度检验

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护士进修杂志 2024年第6期39卷 594-598,604页

作者：董蓉琳方艳春李雄志蒋冠华宗旻阳付伟乐南华大学护理学院湖南衡阳421200 邵阳市中心医院湖南邵阳422000 浙江大学医学院附属第四医院护理部浙江义乌322000

目的汉化慢性病患者限制饮食负担量表(BIRD),并检验其信效度。方法采用Brislin翻译模式对BIRD量表进行翻译、回译,再进行文化调试和预试验后形成中文版BIRD量表。采用便利抽样法选取2023年4-6月邵阳市多所三级甲等医院的343例慢性心力... 详细信息

目的汉化慢性病患者限制饮食负担量表(BIRD),并检验其信效度。方法采用Brislin翻译模式对BIRD量表进行翻译、回译,再进行文化调试和预试验后形成中文版BIRD量表。采用便利抽样法选取2023年4-6月邵阳市多所三级甲等医院的343例慢性心力衰竭患者进行信效度检验。结果中文版BIRD量表共1个维度,11个条目,量表每个条目的内容效度指数(CVI)均处于0.82~1.00,问卷平均CVI值为0.983;量表的效标关联效度r=-0.323(P<0.001);验证性因子分析χ^(2)/df=2.797,RMSEA=0.073,整体模型拟合度较好;量表的折半信度为0.79;总量表的Cronbach′sα系数为0.870。结论中文版BIRD量表具有良好的信度和效度,可作为我国慢性病患者限制饮食负担的测评工具。

关键词：慢性病限制饮食负担量表信度效度护理

Xiaohong Cheng’s Clinical Experience in Treating Membranous Nephropathy

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Journal of Clinical and Nursing Research 2022年第1期6卷 26-29页

作者： guanhua jiang Yu Wang Xiaohong Cheng Shaanxi University of TCM Xianyang 712046China Shaanxi Provincial Hospital of TCM Xi’an 710003China

Membranous nephropathy is the most common pathological type of nephrotic syndrome in adult *** recent years,the incidence of membranous nephropathy has been increasing year by *** pathogenesis of membranous nephropathy has not been completely clear *** Xiaohong Cheng has accumulated a lot of clinical experience in the treatment of membranous nephropathy,and believes that the main pathogenesis of membranous nephropathy is“spleen and kidney deficiency,kidney blockage.”The main treatment method is“invigorating spleen and kidney,promoting blood circulation and clearing collaterals,”which has achieved remarkable clinical efficacy.

关键词： Membranous nephropathy TCM therapy Xiao-hong Cheng Doctors experience

Electrocatalytic NAD(P)H regeneration for biosynthesis

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Green Chemical Engineering 2024年第1期5卷 1-15页

作者： Yaoxuan Li guanhua Liu Weixi Kong Suoqing Zhang Yuemei Bao Hao Zhao Lihui Wang Liya Zhou Yanjun jiang National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin300401China North China Pharmaceutical Group Corp Shijiazhuang050015China Tianjin Food Research Institute Tianjin301609China

The highly efficient chemoselectivity,stereoselectivity,and regioselectivity render enzyme catalysis an ideal pathway for the synthesis of various chemicals in broad *** the cofactor of an enzyme is necessary but expensive,the conversed state of the cofactor is not beneficial for the positive direction of the *** regeneration using electrochemical methods has the advantages of simple operation,low cost,easy process monitoring,and easy product separation,and the electrical energy is green and ***,bioelectrocatalysis has great potential in synthesis by combining electrochemical cofactor regeneration with enzymatic *** this review,we detail the mechanism of cofactor regeneration and categorize the common electron mediators and enzymes used in cofactor *** reaction type and the recent progress are summarized in electrochemically coupled enzymatic *** main challenges of such electroenzymatic catalysis are pointed out and future developments in this field are foreseen.

关键词： Biosynthesis Cofactor regeneration Bioelectrocatalysis NAD(P)H Electron mediator

Dendritic mesoporous silica nanoparticles for enzyme immobilization

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Green Chemical Engineering 2024年第2期5卷 173-186页

作者： Shuling Zhang Jing Bai Weixi Kong Haolei Song Yunting Liu guanhua Liu Li Ma Liya Zhou Yanjun jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China College of Food Science and Biology Hebei University of Science&TechnologyShijiazhuang050018China Hebei Yanuo Bioscience Co. Ltd.Shijiazhuang052165China

Dendritic mesoporous silica nanoparticles(DMSNs)are a new class of solid porous materials used for enzyme immobilization support due to their intrinsic characteristics,including their unique open central-radial structures with large pore channels and their excellent *** this review,we review the recent progress in research on enzyme immobilization using DMSNs with different structures,namely,flower-like DMSNs and tree-branch-like *** DMSN synthesis methods are briefly compared,and the distinct characteristics of the two DMSN types and their effects on the catalytic performance of immobilized enzymes are comprehensively *** directions for future research on enzyme immobilization using DMSNs are also proposed.

关键词： Dendritic mesoporous silica nanoparticles Enzyme immobilization Flower-like Tree-branch-like Central-radial structure

Magnetic wrinkled organosilica-based metal-enzyme integrated catalysts for enhanced chemoenzymatic catalysis

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 122-125页

作者： Yunting Liu Na Guo Weixi Kong Shiqi Gao guanhua Liu Liya Zhou Jing Gaoa Yanjun jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China Tianjin Key Laboratory of Chemical Process Safety Hebei University of TechnologyTianjin 300130China

Core-shell structured magnetic wrinkled organosilica-based metal-enzyme integrated catalysts were synthesized,and their catalytic performances were studied in the chemoenzymatic dynamic kinetic resolution of chiral amines in an organic solvent,as well as in the chemoenzymatic synthesis of chiral alcohols in *** studies revealed the important influence of their tunable structure and composition on the optimization of activity,stability,and recyclability in chemoenzymatic catalysis.

关键词： Magnetic wrinkled organosilica Chemoenzymatic catalysis Co-immobilization Asymmetric synthesis Chiral amines/alcohols Dynamic kinetic resolution Nanomaterials

根部内引流技术在A型主动脉夹层手术中的应用

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中华急诊医学杂志 2014年第10期23卷 1146-1150页

作者：张勇梁家立姜冠华济南军区总医院心血管外科济南250031

目的总结在A型主动脉夹层手术中采用主动脉根部内引流技术的经验.方法采用回顾性研究方法,选择2003年3月至2008年3月20例A型主动脉夹层患者（A组）和2008年3月至2013年5月36例A型主动脉夹层患者（B组）在济南军区总医院行升主动脉替... 详细信息

目的总结在A型主动脉夹层手术中采用主动脉根部内引流技术的经验.方法采用回顾性研究方法,选择2003年3月至2008年3月20例A型主动脉夹层患者（A组）和2008年3月至2013年5月36例A型主动脉夹层患者（B组）在济南军区总医院行升主动脉替换＋主动脉弓置换＋降主动脉支架象鼻术,B组手术中在主动脉根部行主动脉壁与右心耳做内引流.分析两组间手术时间、术中出血量、体外循环时间、术中输注红细胞量、术后再次开胸手术止血例数、术后24 h总引流量、术后输红细胞量、术后发生肺部并发症例数、术后死亡病率.数据采用SPSS 10.0统计软件进行统计学方法,采用成组t检验和x2检验进行组间计量资料和计数资料的统计学分析.结果 B组患者在手术时间、术中出血量、体外循环时间、术中输注红细胞量、术后再次开胸手术止血例数、术后24 h总引流量、术后输红细胞量、术后发生肺部并发症例数、术后病死率等方面均明显低于A组（x2或t值分别为2.658,2.381,2.265,3.056,6.862,2.896,2.316,7.215,7.668;P值分别为0.012,0.034,0.007,0.016,0.013,0.032,0.008,0.008）.结论 A型主动脉夹层手术中应用根部内引流技术可以减少术后出血,减少术后并发症,提高手术成功率.

关键词：主动脉夹层体外循环深低温人工血管主动脉替换主动脉支架术后出血内引流

联合超滤在合并恶液质的心脏瓣膜置换术体外循环中的应用

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中国现代医学杂志 2009年第15期19卷 2327-2328,2332页

作者：张鲁英姜冠华济南军区总医院心外科山东济南250031

目的总结联合应用平衡超滤加改良超滤在合并恶液质的心脏瓣膜置换术体外循环(ECC)中的经验。方法本组48例心脏恶液质瓣膜置换术患者在ECC中应用平衡超滤加改良超滤。ECC开始血液动力学稳定后即行超滤。结果ECC时间68～215min,主动脉阻... 详细信息

目的总结联合应用平衡超滤加改良超滤在合并恶液质的心脏瓣膜置换术体外循环(ECC)中的经验。方法本组48例心脏恶液质瓣膜置换术患者在ECC中应用平衡超滤加改良超滤。ECC开始血液动力学稳定后即行超滤。结果ECC时间68～215min,主动脉阻断时间41～186min。超滤时间53～175(57±48)min。滤出液量3500～8900(4200±970)mL。术中维持红细胞容积(HCT)0.20～0.25。改良超滤结束HCT为0.30～0.35。死亡3例,1例死于心功能衰竭无法停ECC,2例术后死于多脏器功能衰竭。结论联合超滤应用于合并恶液质的心脏瓣膜置换术ECC中,不仅迅速滤出体内多余水分,提高HCT和血浆胶体渗透压,还可超滤出中小分子炎性介质和乳酸等不良成分,有利于减少术后并发症,促进各脏器功能恢复。

关键词：超滤心脏瓣膜手术体外循环

CARBON NANOTUBE BASED NANOELECTROMECHANICAL SYSTEMS

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CARBON NANOTUBE BASED NANOELECTROMECHANICAL SYSTEMS

神经肌电刺激通过调控炎症因子促进小鼠脊髓损伤修复研究

庆祝中国力学学会成立50周年暨中国力学学会学术大会’2007

作者： ZHENG Quanshui~(*,1)) XU Zhiping~* CHEN guanhua~(**) jiang Qing~+ *(Department of Engineering Mechanics,Tsinghua University,Beijing,100084,China) **(Department of Chemistry,University of Hong Kong) *(School of Engineering,University of California-Riverside,USA)

Since the proposal of caving multiwalled carbon nanotubes(MWNTs) as mechanical oscillator with operating frequencies in the gigahertz range(Zheng & jiang,PRL,2002),there have been extensive studies on the energy dissipation mechanisms,driven and energy supplement techniques,and the inventions,models,and analyses of various other gigahertz oscillators,switches,nano-channels and nanoflows,self-assembly behavior,

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中国临床解剖学杂志 2023年第4期41卷 416-421页

作者：梁银花宋海旺姜冠华罗艺刘国祥杨丹贵州医科大学基础医学院人体解剖学教研室贵阳550025

目的探讨神经肌电刺激(neuromuscular electrical stimulation,NMES)调控炎症因子表达修复脊髓损伤(spinal cord injury,SCI)的机制。方法将60只健康成年小鼠随机分为假手术组(Sham组)、SCI组、1 Hz NMES组、20 Hz NMES组,每组15只,利用Basso Mouse Scale评分和足印分析观察小鼠后肢运动功能恢复情况;免疫荧光观察脊髓损伤前角神经元数目;real-time RT-PCR检测炎症因子TNF-α、IL-6、IL-12 mRNA表达;Western blot测定炎症因子TNF-α、IL-6、IL-12及BDNF、GFAP表达。结果与SCI组相比,神经肌电刺激干预后小鼠后肢运动功能明显改善,损伤处存活的神经元增多,且20 Hz NMES组神经元多于1 Hz NMES组;神经肌电刺激干预可以下调TNF-α、IL-6、IL-12及GFAP表达,促进BDNF表达。结论神经肌电刺激能下调炎症因子抑制GFAP表达,抑制纤维瘢痕形成,同时上调BDNF表达保护神经元数目,促进脊髓损伤后小鼠运动功能恢复。

关键词：脊髓损伤神经肌电刺激炎症因子功能恢复

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