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Synergistic Effects of Rotavirus and Co-Infecting Viral Enteric Pathogens on Diarrheal Disease-Guangzhou City,Guangdong Province,China,2019

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China CDC weekly 2023年第33期5卷 725-730页

作者： Shunxian Zhang Liguang Tian Yan Lu Lei Wang Wenwen Lyu Jinxin Zheng Shan Lyu Lili Pang Guobing Yang Hongli Wang Ruitao Liu guanhua chen Jichun Wang Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research On Tropical DiseasesNational Institute of Parasitic DiseasesShanghaiChina School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiChina Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina National Health Commission(NHC)Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Department of Science and Technology Chinese Center for Disease Control and PreventionBeijingChina.

What is already known about this topic?Diarrhea represents a substantial public health issue,contributing globally to a high number of pediatric medical consultations,hospital admissions,and mortality rates.What is added by this report?An increase in diarrheal frequency serves as a critical benchmark for evaluating severity.The predominant pathogens associated with pediatric diarrhea are rotavirus and norovirus,with co-infections exerting a notable compounding effect that leads to more severe diarrhea.What are the implications for public health practice?Implementing sensitive diagnostic techniques and comprehensive monitoring is paramount in identifying co-infections.Such strategies can provide physicians with critical insights into disease progression,thus considerably reducing the burden of diarrhea.

关键词： globally predominant Guangdong

Structure descriptor for surface passivation in the simulation of atomistic models

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Science China(Information Sciences) 2017年第3期60卷 68-77页

作者： Li CAO Siukong KOO Jian SUN guanhua chen Wenping WANG Department of Computer Science The University of Hong Kong Department of Chemistry The University of Hong Kong

Surface passivation is an essential step for atomistic simulations. There can be many possible surface passivation results for a given device model, such as semiconductor devices that consist of Si, Ga As, or other materials because the bonding directions of the surface atoms may not be unique. Based on the structure analysis of the given model, a generation method with structure descriptor(SDG) is proposed for surface passivation.Compared with other existing solutions, the SDG method not only provides trimmer results, but also reduces the torsion angle energy of the model, which is preferred in the simulation of atomistic models. The efficiency of this method was validated through test results from several applications.

关键词： computer aided design structure analysis torsion angle universal force field surface passivation atomistic model

Sandwich Structure Design of a Cooling Fin for Battery Modules Against Impact Loads

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Automotive Innovation 2020年第3期3卷 260-269页

作者： Zitong Shi guanhua chen Lingxiao Zhu Jie Li Yong Xia State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China State Key Laboratory of Vehicle NVH and Safety Technology Chongqing 401120China

Lithium-ion batteries(LIBs)are widely employed in electric vehicles owing to their high power density,long cycle life,and environmental friendliness.However,LIBs are hazardous in the event of a crash,leading to thermal runaway.In this study,the basic structure of a battery module is analyzed to improve the crashworthiness of LIBs.A simplified finite element model of the battery module structure,which is a battery unit composed of two pouch cells and a cooling fin,is set up and verified by conducting module-level simulations.The simulation results reveal that the cooling fin in the battery module has the potential to absorb energy.Six sandwich configurations are introduced to modify the cooling fin.With a unidirection-ally stiffened double hull USDH structure serving as an example,a parametric analysis is conducted,demonstrating that the sandwich height does not influence the areal density;a small height of 3 mm can make the material work sufficiently while avoiding early buckling of the structure.Further,the crashworthiness of different sandwich configurations with the same areal density and height is compared,leading to three deformation modes.USDH and circular core structures are found to be able to effectively reduce the peak force and improve the energy absorption ability.

关键词： Lithium-ion battery Impact protection Sandwich configuration Cooling fin

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物联网技术支持下的城市热环境时空变化分析

生态学报 2024年第7期44卷 2849-2858页

作者：郭冠华陈丽飞曹峥吴志峰陈颖彪广州大学地理科学与遥感学院广州511006

热环境是城市生态系统最为关键的大气环境要素之一,开展城市热环境研究的前提是在时空维度上获取足量的热环境参数。利用先进的物联网技术构建了在线式热环境监测设备,收集2022年10月16日至24日广州大学校园气温、风速、太阳辐射和地面... 详细信息

热环境是城市生态系统最为关键的大气环境要素之一,开展城市热环境研究的前提是在时空维度上获取足量的热环境参数。利用先进的物联网技术构建了在线式热环境监测设备,收集2022年10月16日至24日广州大学校园气温、风速、太阳辐射和地面温度四种热环境参数,分析小尺度下城市热环境的时空变化特征。研究结果表明:1)不同测点之间的风速特征具有一定的相关性,极个别测点的风速特征与其它测点相关性仅在0.5左右,显示其小气候的独特性;2)不同测点风速和热岛强度变化时空差异明显,即使距离靠近的测点,受邻近建筑和植被特征的影响热环境特征会有所差异,各测点的日间风速大,热岛强度较为明显,夜间风速较小,热岛强度较弱;3)地面温度与气温的相关性达0.8左右,这种相关性在夜间表现更为密切,并且这种关系受风速的影响不大。研究结果反映了城市热环境参数在小尺度上的高度异质性,并揭示了物联网技术在城市热环境监测领域的可行性、便捷性和高效性。

关键词：城市热环境时空变化物联网广州校园

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基于两相交开口谐振环的超材料太赫兹带阻滤波器

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光学学报 2024年第5期44卷 112-119页

作者：袁航付旺廷刘祖耀饶志明骆兴芳朱冠华吴帅克陈威江西师范大学物理与通信电子学院江西南昌330022

提出一种基于两相交开口谐振环(TI-SRR)的超材料太赫兹带阻滤波器,通过改变TI-SRR线宽、环间间隔和半径大小,探究各参数对滤波器透射系数的影响。研究了超材料太赫兹带阻滤波器三个谐振点处的电场和表面电流分布,进而分析了滤波器的工... 详细信息

提出一种基于两相交开口谐振环(TI-SRR)的超材料太赫兹带阻滤波器,通过改变TI-SRR线宽、环间间隔和半径大小,探究各参数对滤波器透射系数的影响。研究了超材料太赫兹带阻滤波器三个谐振点处的电场和表面电流分布,进而分析了滤波器的工作机理。为了验证理论模型的计算结果,采用微纳光刻技术制备滤波器的实物样品,使用太赫兹时域光谱系统进行测试。结果表明,该滤波器有3个谐振点,谐振频率分别为0.431、0.476、0.934 THz,对应的透射系数(S21)分别为-42.518、-40.331、-14.132 dB,-10 dB阻带带宽分别为0.220 THz和0.026 THz。实测曲线整体趋势与仿真曲线保持一致,阻带特性相较良好,测试结果与仿真结果较为符合。该滤波器在新型通信设备和精密仪器领域有较高的应用价值。

关键词：超材料太赫兹带阻滤波器微纳光刻太赫兹时域光谱

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非酒精性脂肪肝发病的影响因素及预防调摄

实用中医内科杂志 2024年第6期38卷 96-100页

作者：陈朦朦吕冠华辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属第二医院辽宁沈阳110034

非酒精性脂肪肝(NAFLD)是国际常见的慢性肝病之一,且近年来发病率持续上升,其发病机制复杂,目前尚没有完全清楚。NAFLD与不良的膳食结构、缺乏运动、代谢综合征(肥胖、2型糖尿病、高血压病、高血脂等)的危险因素有关,通过实施生活预防调... 详细信息

非酒精性脂肪肝(NAFLD)是国际常见的慢性肝病之一,且近年来发病率持续上升,其发病机制复杂,目前尚没有完全清楚。NAFLD与不良的膳食结构、缺乏运动、代谢综合征(肥胖、2型糖尿病、高血压病、高血脂等)的危险因素有关,通过实施生活预防调摄,包括饮食干预、运动干预及健康教育,不仅可降低NAFLD的发病率,还可提高NAFLD的逆转率,有效促进病情康复。

关键词：非酒精性脂肪肝影响因素预防调摄

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Propagation analysis and prediction of the COVID-19

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Infectious Disease Modelling 2020年第1期5卷 282-292页

作者： Lixiang Li Zihang Yang Zhongkai Dang Cui Meng Jingze Huang Haotian Meng Deyu Wang guanhua chen Jiaxuan Zhang Haipeng Peng Yiming Shao Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China State Key Laboratory of Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

Based on the official data modeling,this paper studies the transmission process of the Corona Virus Disease 2019(COVID-19).The error between the model and the official data curve is quite small.At the same time,it realized forward prediction and backward inference of the epidemic situation,and the relevant analysis help relevant countries to make decisions.

关键词： COVID-19 Short-term forecast Epidemic control

基于细胞代谢组学的柴胡皂苷b2对皮质酮诱导PC12细胞损伤的保护作用研究

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中国药理学与毒理学杂志 2024年第1期38卷 11-21页

作者：李萌施浩陈佳俊吕家乐秦雪梅杜冠华周玉枝山西大学中医药现代研究中心山西太原030006 山西大学化学生物学与分子工程教育部重点实验室山西太原030006 山西大学地产中药功效物质研究与利用山西省重点实验室山西太原030006 中国医学科学院药物研究所北京100050

目的研究柴胡皂苷b2(SSb2)对皮质酮(CORT)诱导PC12细胞损伤的保护作用及其机制。方法①将细胞分为细胞对照组(RPMI-1640培养基培养24 h),CORT(100~800μmol·L^(-1)孵育24 h)组和SSb2(1.5625,3.125,6.25,12.5,25,50和100μmol·L^(-1)孵育24 h)组,MTT法检测细胞存活率。②将细胞分为细胞对照组(RPMI-1640培养基培养24 h),模型组(CORT 400μmol·L^(-1)孵育24 h)和模型+SSb2组(SSb21.5625,3.125,6.25,12.5和25μmol·L^(-1)预处理3 h,去上清,然后加入CORT 400μmol·L^(-1)及对应浓度SSb2共孵育24 h)。MTT法检测细胞存活率,微板法检测PC12细胞乳酸脱氢酶(LDH)释放率。③将细胞分为细胞对照组、模型组和模型+SSb212.5μmol·L^(-1)组,采用AnnexinV-FITC/PI流式细胞术检测细胞凋亡;基于超高效液相色谱-四级杆-飞行时间质谱(UPLC-Q-TOF-MS)的代谢组学技术检测PC12细胞代谢轮廓变化;比色法检测谷氨酸含量和谷氨酰胺酶活性。结果①与细胞对照组相比,当CORT浓度为400μmol·L^(-1)时,细胞存活率降低至(55±6)%(P50μmol·L^(-1)时,对PC12细胞有显著的细胞毒性(P<0.01)。②与细胞对照组相比,模型组细胞存活率显著降低(P<0.01),LDH释放率显著升高(P<0.01);与模型组相比,模型+SSb2各浓度组细胞存活率显著升高(P<0.05,P<0.01),LDH释放率显著降低(P<0.01)。③与细胞对照组相比,模型组细胞凋亡率显著升高(P<0.01);与模型组相比,模型+SSb2组细胞凋亡率显著降低(P<0.05)。代谢组学结果表明,SSb2能显著回调谷氨酸、肌酸、N-乙酰天冬氨酸、L-酪氨酸、柠檬酸、L-异亮氨酸、乳酸、谷氨酰胺和胆碱9个差异代谢物。对SSb2调控的关键代谢物进一步富集分析表明,SSb2主要影响5条代谢通路,即D-谷氨酰胺和D-谷氨酸代谢,苯丙氨酸、酪氨酸和色氨酸的生物合成,丙氨酸、天冬氨酸和谷氨酸代谢,酪氨酸代谢和精氨酸生物合成。与细胞对照组相比,模型组谷氨酸含量和谷氨酰胺酶活性显著降低(P<0.01);与模型组相比,模型+SSb2组细胞谷氨酸含量(P<0.01)和谷氨酰胺酶活性显著升高(P<0.05)。结论SSb2对CORT诱导的PC12细胞损伤具有神经保护作用,其机制与抑制细胞凋亡和调节代谢紊乱有关。

关键词：柴胡皂苷b2 皮质酮 PC12细胞代谢组学

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Study on Coupling Coordination between Sci-Tech Innovation and High-Quality Economic Development in the Guangdong-Hong Kong- Macao Greater Bay Area

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2022年第4期17卷 615-642页

作者： chen Zhangxi ZHUANSUN guanhua College of Economics Jinan UniversityGuangzhou 510632China Economic Development Research Center on Guangdong-Hong Kong-Macao Greater Bay Area Jinan UniversityGuangzhou 510632China Center on Economic Social and Regional CooperationMacao Research InstituteJinan UniversityGuangzhou 510632China

Sci-tech innovation is an important measure for the Guangdong-Hong Kong-Macao Greater Bay Area to achieve high-quality economic development.Theoretically,there is a coupling coordination relationship between sci-tech innovation and high-quality economic development,and coordinating the relationship between the two is beneficial to building the Guangdong-Hong Kong-Macao Greater Bay Area into an international innovation and technology hub and promoting high-quality economic development.At present,the Guangdong-Hong Kong-Macao Greater Bay Area has seen a year-on-year increase in both the level of sci-tech innovation and the level of high-quality economic development,with a sound development trend.Its coupling coordination degree between sci-tech innovation and high-quality economic development has steadily improved from a slightly uncoordinated stage to a primarily coordinated stage,but the overall degree of coordination is still not high,with some gaps from realizing the excellently coordinated stage.From the perspective of spatial distribution,the internal development of the Guangdong-Hong Kong-Macao Greater Bay Area is unbalanced,with obvious differences in development level and coupling coordination degree among cities.The convergence analysis shows that the differences in the coupling coordination degree among the cities in the Guangdong-Hong Kong-Macao Greater Bay Area have stabilized after narrowing during the study period.However,the difference among the cities with higher coupling coordination degrees tends to widen in recent years.Therefore,necessary measures should be taken to promote the coordination between sci-tech innovation and high-quality economic development in the Guangdong-Hong Kong-Macao Greater Bay Area.

关键词： sci-tech innovation high-quality economic development coupling coordination Guangdong-Hong Kong-Macao Greater Bay Area