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基于数据挖掘技术探讨《千金方》治疗胸痹心痛病用药规律

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内蒙古中医药 2024年第7期43卷 153-157页

作者：孙英杰成利王光允罗群日照市中医医院山东日照276800

目的:分析《千金方》中胸痹心痛病用药规律。方法:筛选符合纳入标准的处方建立数据库,对中药频数和性味归经进行统计,运用SPSS 25.0软件对高频中药(频次≥8次)进行系统聚类分析,运用IBM SPSS Modeler 18.0软件Apriori算法进行关联规则... 详细信息

目的:分析《千金方》中胸痹心痛病用药规律。方法:筛选符合纳入标准的处方建立数据库,对中药频数和性味归经进行统计,运用SPSS 25.0软件对高频中药(频次≥8次)进行系统聚类分析,运用IBM SPSS Modeler 18.0软件Apriori算法进行关联规则分析。结果:频数最高的前四味中药分别是肉桂、甘草、干姜、人参;药味主要以辛、甘、苦为主;药性主要集中在温、寒、热;归经主要集中在脾、心、肺、肾经。高频药物系统聚类出6个药物组,关联规则分析得出9个药对关联组和8个角药关联组。结论:《千金方》中治疗胸痹心痛病主要以温阳通脉,散寒止痛,健脾养心,补益气血为主,兼顾化痰、理气、清热等法。

关键词：胸痹心痛病《千金方》数据挖掘用药规律

病例教学在中医儿科学专业生物化学课程中的设计与应用

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广东化工 2024年第3期51卷 186-188,182页

作者：周会汪光云李璐刘岩岩那莎蔡标安徽中医药大学安徽合肥230012

生物化学对于中医药高等院校的师生来说是一门“难教”和“难学”的课程。教学内容和教学方式如何能更好满足人才培养的目标,提高学生学习本课程的兴趣和积极性是迫切需要解决的问题。可选择与学生专业相关的一些病例进行课程导入,引领... 详细信息

生物化学对于中医药高等院校的师生来说是一门“难教”和“难学”的课程。教学内容和教学方式如何能更好满足人才培养的目标,提高学生学习本课程的兴趣和积极性是迫切需要解决的问题。可选择与学生专业相关的一些病例进行课程导入,引领学生主动学习、再由教师总结归纳。本文选择几个儿科疾病,运用于我校中医儿科学专业生物化学课程的教学。将枯燥、抽象的课程知识点与学生将来从事的专业岗位联系起来,以此提高学生学习的积极性,实现生物化学的教学目标和情感价值目标。

关键词：生物化学病例教与学设计中医儿科学

Effects of Tong-Qiao-Huo-Xue-Decoction on the Blood-Brain Barrier permeability and the expressions of related proteins after cerebral ischemia in rats

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Effects of Tong-Qiao-Huo-Xue-Decoction on the Blood-Brain Ba...

中国近海卫星测高数据的重力异常反演——II.沿轨迹垂线偏差反演法

中华中医药学会第十六次医史文献分会学术年会暨新安医学论坛

作者： Yafang Liu Lili Li Ning wang Yan wang guangyun wang Xinxin Piao Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine Anhui Academy of Chinese Medicine College of Pharmacy Anhui University of Chinese Medicine

Ethnopharmacological relevance:Tong-Qiao-Huo-Xue-Decoction(TQHXD) is a classical prescription in traditional Chinese medicine for the treatment of stagnation of blood in the head and face channel,especially cerebral *** previous work showed that TQHXD has beneficial effects on cerebral *** of the study:To evaluate the effects of TQHXD on the Blood-Brain Barrier(BBB) permeability and the expressions of related proteins on the rats with focal cerebral ischemia *** and Methods:Cerebral ischemia injury in rats was induced by middle cerebral artery occlusion(MCAO).Adult male Sprague-Dawley(SD) rats were randomly divided into seven groups:shamgroup;model group;Nimodipine(NMP)-treated group;Nao Mai Tai(NMT)-treated group and TQHXD-treated groups(3,6 and12g/kg body weight);.The recoveries of neurological function in rats were estimated by neurological defect scoring after 24 h modeled,the 7 day and 15 day after *** structures of the brain in rats were observed by hematoxylin and eosin(H & E)*** features of hippocampus neurons and the opening of tight junction(TJ) were observed by Transmission Electron Microscope(TEM).Western blot was performed to detect the expression of ZO-1,Occludin,claudin-5,AQP-4 and MMP-9in BBB after cerebral ischemia ***:TQHXD administration significantly reduced the neurological defect *** examination indicated that dense neuropil and largely surviving neurons were seen in TQHXD-treated *** electron microscope observation revealed that TQHXD could significantly inhibit the damage of hippocampal neurons and reduce the degree of TJ’ s *** decreased protein expression levels of claudin-5,occludin,ZO-1 and the increased protein expression levels of AQP-4 and MMP-9 in cerebral ischemia tissue were significantly prevented by treatment with TQHXD after ischemia in ***:These results demonstrated that TQHXD may act as

关键词： Tong-Qiao-Huo-Xue-Decoction Blood-Brain Barrier Tight junction Tight junction proteins

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高技术通讯 2000年第1期10卷 46-49,42页

作者：王海瑛王广运中国科学院测量与地球物理研究所动力大地测量学开放实验室武汉 430077

给出了一套基于直角坐标系下的垂线偏差求解重力异常公式 ,并将之发展成为一套新的沿轨迹重力异常求解公式。据此 ,利用Geosat/GM、ERS 1/ 35d及Topex/Posei don 3种测高数据 ,反演了南中国海域 ( 0°～ 2 5°N ,10 5°～ 12 2°E)的 2... 详细信息

给出了一套基于直角坐标系下的垂线偏差求解重力异常公式 ,并将之发展成为一套新的沿轨迹重力异常求解公式。据此 ,利用Geosat/GM、ERS 1/ 35d及Topex/Posei don 3种测高数据 ,反演了南中国海域 ( 0°～ 2 5°N ,10 5°～ 12 2°E)的 2’× 2’重力异常———IGG S。通过与实际船测资料和国际同行提供的重力模型相比 ,IGG S总体精度达到 10× 10 - 5m/s2 。

关键词：卫星测高数据沿轨迹重力异常反演南中国海域

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论大庆油田振兴发展战略

大庆石油地质与开发 2019年第5期38卷 1-7页

作者：孙龙德王广昀大庆油田有限责任公司

资源采掘型企业,资源枯竭是必然面对的问题。大庆油田贯彻党的十九大精神,学习习近平新时代中国特色社会主义思想,落实习近平治国理政新理念,结合油田产量步入衰减期实际,提出了以“当好标杆旗帜,建设百年油田”为总体目标的振兴发展战... 详细信息

资源采掘型企业,资源枯竭是必然面对的问题。大庆油田贯彻党的十九大精神,学习习近平新时代中国特色社会主义思想,落实习近平治国理政新理念,结合油田产量步入衰减期实际,提出了以“当好标杆旗帜,建设百年油田”为总体目标的振兴发展战略。本文用历史唯物主义与辩证唯物主义观点,从振兴发展的必然选择、核心内涵、基础条件、总体目标、有效途径以及保障措施等方面,讨论了大庆油田振兴发展战略的客观性、科学性和可行性。

关键词：标杆旗帜百年油田振兴发展使命责任大庆油田

Large-scale spatial data visualization method based on augmented reality

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 132-147页

作者： Xiaoning QIAO Wenming XIE Xiaodong PENG guangyun LI Dalin LI Yingyi GUO Jingyi REN Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Ordnance Science and Research Academy of China Beijing 100089China

Background A task assigned to space exploration satellites involves detecting the physical environment within a certain ***,space detection data are complex and *** data are not conducive for researchers'visual perceptions of the evolution and interaction of events in the space *** A time-series dynamic data sampling method for large-scale space was proposed for sample detection data in space and time,and the corresponding relationships between data location features and other attribute features were established.A tone-mapping method based on statistical histogram equalization was proposed and applied to the final attribute feature *** visualization process is optimized for rendering by merging materials,reducing the number of patches,and performing other *** The results of sampling,feature extraction,and uniform visualization of the detection data of complex types,long duration spans,and uneven spatial distributions were *** real-time visualization of large-scale spatial structures using augmented reality devices,particularly low-performance devices,was also *** The proposed visualization system can reconstruct the three-dimensional structure of a large-scale space,express the structure and changes in the spatial environment using augmented reality,and assist in intuitively discovering spatial environmental events and evolutionary rules.

关键词： Large-scale spatial data analysis Visual analysis technology Augmented reality 3D reconstruction Space environment

Sweroside ameliorates α-naphthylisothiocyanate induced cholestatic liver injury through bile acid regulation and further pro-inflammatory responses mediation

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Sweroside ameliorates α-naphthylisothiocyanate induced chol...

Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation

中国药学会第十三届青年药学科研成果交流会

作者： Qiaoling Yang Fan Yang Junting Gong Xiaowen Tang guangyun wang Zhengtao wang Li Yang The Ministry of Education(MOE)Key Laboratory for Standardization of Chinese Medicines and the State Administration of Traditional Chinese Medicine(SATCM)Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese Medicine Center for Chinese Medical Therapy and Systems Biology Shanghai University of Traditional Chinese Medicine

Aim:Sweroside,an iridoid glycoside,exerts diverse biological *** study aimed to investigate how sweroside attenuates the a-naphthylisothiocyanate（ANIT）-induced cholestatic liver injury in ***:C57BL mice were treated with sweroside（120 mg/kg,ig） or INT-747（12 mg/kg,ig） for five consecutive days（once daily）,*** the 3rd day,4h after sweroside or INT-747 treatment,mice were orally administered a single dose of ANIT in olive oil（75 mg/kg,ig）.Serum biochemical markers,histological change,and hepatic bile acids were *** pro-inflammatory mediators and bile acid metabolism-related genes were also *** addition,to explore the role of bile acids in the progress of ANIT-induced liver injury,primary hepatocytes were treated with bile acid milieu,which were composed of the most elevated hepatic individual bile acids after ANIT exposure in vivo ***:Sweroside effectively ameliorated ANIT-induced cholestatic liver injury in mice,as evidenced by reduction of serum biochemical markers and attenuation of pathological ***,sweroside dramatically decreased the elevation of hepatic individual bile acids caused by ANIT treatment,such as the P-MCA,CA,and TCA *** underlying insights were possibly related to the regulation of mRNA expression of bile acid synthesis,bile acid transports,and pro-inflammatory *** addition,overload hepatic bile acids after ANIT exposure may act as an inducer of pro-inflammatory ***:Sweroside effectively attenuated the ANIT-induced cholestatic liver injury in mice by regulating bile acids and restoring their normal levels,as well as repressing pro-inflammatory responses.

关键词： sweroside ANIT cholestasis inflammation bile acids

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Curcumin protects ANIT-induced cholestasis through signaling...

中国药学会第十三届青年药学科研成果交流会

作者： Fan Yang Xiaowen Tang Lili Ding Yue zhou Qiaoling Yang Junting Gong guangyun wang Zhengtao wang Li Yang The MOE Key Laboratory for Standardization of Chinese Medicines and the SHTCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese Medicine Center for Chinese Medical Therapy and Systems Biology Shanghai University of Traditional Chinese Medicine

Cholestasis is a clinically significant symptom and widely associated with liver diseases,however,there are very few effective therapies for *** tablet(DNT,a Chinese patent medicine preparation) has been clinically used to treat human liver and gallbladder diseases for more than 20 years in ***,which ingredients of DNT contributed to this beneficial effect and their mechanistic underpinnings have been largely *** the present study,we discovered that DNT not only demonstrated greater benefits for cholecystitis patients after cholecystectomy surgery in clinic but also showed protective effect against alpha-naphthylisothiocyanate(ANIT)-induced cholestasis model in ***,one major compound derived from DNT,exerted the protective effect against cholestasis through farnesoid X receptor(FXR),which has been focused as potential therapeutic targets for treating *** underlying mechanism of curcumin against cholestasis was restoring bile acid homeostasis and antagonizing inflammatory responses in a FXR-dependent manner and in turn contributed to overall cholestasis ***,curcumin can be served as a potential treatment option for liver injury with cholestasis.

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古龙页岩油战略意义及攻关方向

大庆石油地质与开发 2020年第3期39卷 8-19页

作者：王广昀王凤兰蒙启安谷社峰大庆油田有限责任公司黑龙江大庆163002 大庆油田有限责任公司勘探开发研究院黑龙江大庆163712 黑龙江省致密油和泥岩油成藏研究重点实验室黑龙江大庆163712

页岩油气革命改变着世界能源格局,成为全球石油行业的研究热点。通过对松辽盆地青山口组与国内外含页岩油层系地质特征对比可知,古龙页岩油与国内外海相或咸化湖盆沉积为主的页岩油在岩石组构、物性、含油性、流动性方面有很大差别:古... 详细信息

页岩油气革命改变着世界能源格局,成为全球石油行业的研究热点。通过对松辽盆地青山口组与国内外含页岩油层系地质特征对比可知,古龙页岩油与国内外海相或咸化湖盆沉积为主的页岩油在岩石组构、物性、含油性、流动性方面有很大差别:古龙页岩有机质丰度高,含油性好;矿物纹层和页理非常发育,储集空间类型多样,储集性较好;热演化程度较高,气油比较高,地层超压,油质轻且黏度小,易于流动;黏土矿物含量高、碳酸盐含量低,但黏土矿物以伊利石为主,储层水敏低,仍然表现出较强的可压性。古龙页岩油地质条件优越、资源量巨大,具有广阔的勘探开发前景。向古龙页岩油进军,是大庆油田面向未来作出的战略抉择,对保障国家能源战略安全、推进中国石油建设综合性国际能源公司和促进区域经济社会发展具有战略意义。古龙页岩油的规模效益开发,必须突出科技创新的引领作用和管理创新的保障作用。

关键词：古龙页岩页岩油甜点青山口组基本特征战略意义攻关方向