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Material basis and pharmacodynamic mechanism of YangshenDingzhi granules in the intervention of viral pneumonia:Based on serum pharmacochemistry and network pharmacology

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Animal Models and Experimental Medicine 2024年第3期7卷 259-274页

作者： Huirong Xu Meiyue Dong Ruikun Du Chengcheng Zhang Zinuo Chen guangyu Tian Qinghua cui Kejian Li College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinanChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Qingdao Academy of Chinese Medical Sciences Shandong University of Traditional Chinese MedicineQingdaoChina College of Pharmacy Shandong University of Traditional Chinese MedicineJinanChina

Background:YangshenDingzhi granules(YSDZ)are clinically effective in preventing and treating COVID-19.The present study elucidates the underlying mechanism of YSDZ intervention in viral pneumonia by employing serum pharmacochemistry and network pharmacology.Methods:The chemical constituents of YSDZ in the blood were examined using ultraperformance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry(UPLC-Q-Exactive Orbitrap MS).Potential protein targets were obtained from the SwissTargetPrediction database,and the target genes associated with viral pneumonia were identified using GeneCards,DisGeNET,and Online Mendelian Inheritance in Man(OMIM)databases.The intersection of blood component-related targets and disease-related targets was determined using Venny 2.1.Protein-protein interaction networks were constructed using the STRING database.The Metascape database was employed to perform enrichment analyses of Gene Ontology(GO)functions and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathways for the targets,while the Cytoscape 3.9.1 software was utilized to construct drug-component-disease-target-pathway networks.Further,in vitro and in vivo experiments were performed to establish the therapeutic effectiveness of YSDZ against viral pneumonia.Results:Fifteen compounds and 124 targets linked to viral pneumonia were detected in serum.Among these,MAPK1,MAPK3,AKT1,EGFR,and TNF play significant roles.In vitro tests revealed that the medicated serum suppressed the replication of H1N1,RSV,and SARS-CoV-2 replicon.Further,in vivo testing analysis shows that YSDZ decreases the viral load in the lungs of mice infected with RSV and H1N1.Conclusion:The chemical constituents of YSDZ in the blood may elicit therapeutic effects against viral pneumonia by targeting multiple proteins and pathways.

关键词： network pharmacology pharmacodynamical material basis serum pharmacochemistry viral pneumonia YangshenDingzhi granules

Feasibility of housefly larvae-mediated vermicomposting for recycling food waste added digestate as additive

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Journal of Environmental Sciences 2023年第6期128卷 150-160页

作者： guangyu cui Fan Lü Tao Lu Hua Zhang Pinjing He Institute of Waste Treatment and Reclamation Tongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Shanghai Engineering Research Center of Multi-source Solid Wastes Co-processing and Energy Utilization Shanghai 200092China

The development of methods for the efficient treatment and application of food waste digestate is an important research goal.Vermicomposting via housefly larvae is an efficient way to reduce food waste and achieve its valorization,however,studies on the application and performance of digestate in vermicomposting are rarely.The present study aimed to investigate the feasibility of the co-treatment of food waste and digestate as an additive via larvae.Restaurant food waste(RFW)and household food waste(HFW)were selected to assess the effects of waste type on vermicomposting performance and larval quality.Waste reduction rates of 50.9%–57.8%were observed in the vermicomposting of food waste mixed with digestate at a ratio of 25%,which were slightly lower than those for treatments without the addition of digestate(62.8%–65.9%).The addition of digestate increased the germination index,with a maximum value of 82%in the RFW treatments with 25%digestate,and decreased the respiration activity,with a minimum value of 30 mg-O_(2)/g-TS.The larval productivity of 13.9%in the RFW treatment system with a digestate rate of 25%was lower that without digestate(19.5%).Materials balance shows that larval biomass and metabolic equivalent had decreasing trends as the amount of digestate increased and HFW vermicomposting exhibited lower bioconversion efficiency than that of RFW treatment system regardless of the addition of digestate.These results suggest that mixing digestate at a low ratio(25%)during vermicomposting of foodwaste especially RFW could lead to considerable larval biomass and generate relatively stable residues.

关键词： Biogas digestate Food waste Housefly larvae Larvae valorization Vermicomposting

Positioning error compensation of an industrial robot using neural networks and experimental study

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Chinese Journal of Aeronautics 2022年第2期35卷 346-360页

作者： Bo LI Wei TIAN Chufan ZHANG Fangfang HUA guangyu cui Yufei LI College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Hebei Hanguang Industry Co. LtdHandan 056017China

Due to the characteristics of high efficiency,wide working range,and high flexibility,industrial robots are being increasingly used in the industries of automotive,machining,electrical and electronic,rubber and plastics,aerospace,food,etc.Whereas the low positioning accuracy,resulted from the serial configuration of industrial robots,has limited their further developments and applications in the field of high requirements for machining accuracy,e.g.,aircraft assembly.In this paper,a neural-network-based approach is proposed to improve the robots’positioning accuracy.Firstly,the neural network,optimized by a genetic particle swarm algorithm,is constructed to model and predict the positioning errors of an industrial robot.Next,the predicted errors are utilized to realize the compensation of the target points at the robot’s workspace.Finally,a series of experiments of the KUKA KR 500–3 industrial robot with no-load and drilling scenarios are implemented to validate the proposed method.The experimental results show that the positioning errors of the robot are reduced from 1.529 mm to 0.344 mm and from 1.879 mm to 0.227 mm for the no-load and drilling conditions,respectively,which means that the position accuracy of the robot is increased by 77.6%and 87.9%for the two experimental conditions,respectively.

关键词： Aircraft assembly Error compensation Industrial robot Neural network Robotic drilling

Co-digestion of food waste and hydrothermal liquid digestate:Promotion effect of self-generated hydrochars

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Environmental Science and Ecotechnology 2023年第3期15卷 77-87页

作者： Mingshuai Shao Chao Zhang Xue Wang Ning Wang Qindong Chen guangyu cui Qiyong Xu Shenzhen Engineering Laboratory for Eco-efficient Recycled Materials School of Environment and EnergyPeking University Shenzhen Graduate SchoolNanshan DistrictShenzhen518055PR China

Hydrothermal treatment(HTT)can efficiently valorize the digestate after anaerobic digestion.However,the disposal of the HTT liquid is challenging.This paper proposes a method to recover energy through the anaerobic co-digestion of food waste and HTT liquid fraction.The effect of HTT liquid recirculation on anaerobic co-digestion performance was investigated.This study focused on the self-generated hydrochars that remained in the HTT supernatant after centrifugation.The effect of the self-generated hydrochars on the methane(CH_(4))yield and microbial communities were discussed.After adding HTT liquids treated at 140 and 180C,the maximum CH4 production increased to 309.36 and 331.61 mL per g COD,respectively.The HTT liquid exhibited a pH buffering effect and kept a favorable pH for the anaerobic co-digestion.In addition,the self-generated hydrochars with higher carbon content and large oxygen-containing functional groups remained in HTT liquid.They increased the electron transferring rate of the anaerobic co-digestion.The increased relative abundance of Methanosarcina,Syntrophomonadaceae,and Synergistota was observed with adding HTT liquid.The results of the principal component analysis indicate that the electron transferring rate constant had positive correlationships with the relative abundance of Methanosarcina,Syntrophomonadaceae,and Synergistota.This study can provide a good reference for the disposal of the HTT liquid and a novel insight regarding the mechanism for the anaerobic co-digestion.

关键词： Anaerobic co-digestate Electron transfer Food waste Hydrothermal treatment Microbial community Self-generated hydrochars

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弱刚性构件双机器人协同加工振动抑制方法

振动．测试与诊断 2024年第1期44卷 147-152,203页

作者：崔光裕李波乐毅田威廖文和李明伟南京航空航天大学机电学院南京210016 上海宇航系统工程研究所上海201109 北京卫星制造厂有限公司北京100094

针对弱刚性航天器舱体壁板多任务并行加工的振动抑制需求,研究了弱刚性构件在切削激励作用下的振动产生、传播与耦合机理,提出了基于双加工激励相位差控制的弱刚性构件双机器人协同加工振动抑制方法,并以薄壁舱体壁板为对象进行了仿真... 详细信息

针对弱刚性航天器舱体壁板多任务并行加工的振动抑制需求,研究了弱刚性构件在切削激励作用下的振动产生、传播与耦合机理,提出了基于双加工激励相位差控制的弱刚性构件双机器人协同加工振动抑制方法,并以薄壁舱体壁板为对象进行了仿真与试验研究。结果表明,该方法能够有效实现振动抑制,验证了其正确性与有效性,为多机器人协同原位加工的复杂振动抑制难题提供了一种新思路。

关键词：振动抑制双机器人相位差弱刚性构件协同加工

Facial expression recognition based on improved ResNet

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中国邮电高校学报：英文版 2023年第1期30卷 28-38页

作者： Wang Xianlun Wang guangyu cui Yuxia College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061China

Facial expression recognition(FER)is a vital application of image processing technology.In this paper,a FER model based on the residual network is proposed.The proposed model introduces the idea of the DenseNet,in which the outputs of the residual blocks are not simply added but are linked to the channel dimension.In addition,transfer learning is used to reduce training costs and accelerate training speed.The accuracy and robustness of the proposed FER model were tested by K-fold cross-validation.Experimental results show that the proposed method has competitive performances on FER2013,FER plus(FERPlus),and the real-world affective faces database(RAF-DB).

关键词： facial expression recognition convolutional neural networks ResNet transfer learning K-fold cross-validation

从汗出发热探讨白虎汤、白虎加人参汤、竹叶石膏汤及四逆加人参汤方证

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河南中医 2024年第7期44卷 993-999页

作者：崔光宇陈代奕郭迪长春中医药大学吉林长春130117

白虎汤证、白虎加人参汤证、竹叶石膏汤证、四逆加人参汤证均有汗出发热的表现,四种方证的病机根本区别为有无里热、津液与阳气的盛衰。白虎汤证的病机为里热亢盛、津气略损,机体多无休克表现;白虎加人参汤证的病机为热盛津亏、津亏为重... 详细信息

白虎汤证、白虎加人参汤证、竹叶石膏汤证、四逆加人参汤证均有汗出发热的表现,四种方证的病机根本区别为有无里热、津液与阳气的盛衰。白虎汤证的病机为里热亢盛、津气略损,机体多无休克表现;白虎加人参汤证的病机为热盛津亏、津亏为重,机体多有低血容量休克前兆的表现;竹叶石膏汤证的病机为余热未清、气津两伤,机体多处于疾病将愈的状态;四逆加人参汤证的病机为气随血脱、阴阳两虚,机体多已经进入休克状态。四个方剂的用药区别为清热、补益与回阳的侧重比例不同。白虎汤全方以寒凉药物为主导,共奏清解里热之功;白虎加人参汤清热与补益兼顾;竹叶石膏汤则以补气益津为主,清解里热为辅;四逆加人参汤以回阳固脱为主,补气益津为辅。四个方剂在临床运用时,既要审视病机的不同,也要注重病情的动态变化。

关键词：汗出发热白虎汤白虎加人参汤竹叶石膏汤四逆加人参汤《伤寒论》张仲景

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含油污泥热化学清洗剂复配研究

当代化工 2024年第3期53卷 516-520页

作者：任杰许光宇崔凯郭坤西安交通大学化学工程与技术学院陕西西安710049

采用热化学清洗法处理含油污泥,对不同类型的化学清洗药剂进行单剂筛选和复配优化,考察了不同热化学清洗药剂配方对含油污泥的除油效果,并对热化学清洗的主要工艺条件进行了研究和优化。结果表明:在单独使用的清洗剂中,硅酸钠表现出了... 详细信息

采用热化学清洗法处理含油污泥,对不同类型的化学清洗药剂进行单剂筛选和复配优化,考察了不同热化学清洗药剂配方对含油污泥的除油效果,并对热化学清洗的主要工艺条件进行了研究和优化。结果表明:在单独使用的清洗剂中,硅酸钠表现出了最佳的除油效果,清洗后油泥的残油率为16%;复配清洗药剂中阴离子型-碱性无机盐-碱的清洗药剂组合的清洗效果最好,即十二烷基苯磺酸钠(LAS)+Na_(2)SiO_(3)+KOH,清洗后油泥的残油率仅为4.55%,表明不同类型清洗药剂的复配可以显著提升热化学清洗效果。考察了各操作条件对含油污泥热化学清洗除油效果的影响,最优的清洗条件为热洗温度75℃、液固比5∶1、热洗时间90 min、搅拌速率400 r·min^(-1)。

关键词：含油污泥热化学清洗清洗剂配方清洗条件

亚洲型股骨近端抗旋髓内钉治疗亚洲人群转子间骨折髓内钉突出程度的比较

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中国组织工程研究 2024年第12期28卷 1901-1906页

作者：王安全陈昊华兴一卢晓林周剑崔益亮李光宇尹宗生安徽医科大学第一附属医院骨科安徽省合肥市230022

背景:因亚洲型股骨近端抗旋髓内钉(PFNA-Ⅱ)设计与亚洲人群的不匹配,治疗股骨转子间骨折时可能会出现股骨转子近端的髓内钉突出,突出长度对手术疗效的影响需要进一步探讨。目的:定量测量PFNA-Ⅱ内固定后髓内钉股骨转子近端突出长度,分... 详细信息

背景:因亚洲型股骨近端抗旋髓内钉(PFNA-Ⅱ)设计与亚洲人群的不匹配,治疗股骨转子间骨折时可能会出现股骨转子近端的髓内钉突出,突出长度对手术疗效的影响需要进一步探讨。目的:定量测量PFNA-Ⅱ内固定后髓内钉股骨转子近端突出长度,分析突出长度对PFNA-Ⅱ治疗股骨转子间骨折的疗效是否存在影响。方法:选择68例因股骨转子间骨折在安徽医科大学第一附属医院行PFNA-Ⅱ内固定治疗的患者,于术后6个月内在髋关节X射线前后位片上定量测量股骨大转子近端髓内钉外突值,按照是否存在股骨大转子近端髓内钉突出分为突出组与非突出组。采集患者的性别、身高、骨折类型、使用的髓内钉长度、直径、螺旋刀片在股骨颈的位置及大转子近端髓内钉突出长度等数据,术后6个月时采用髋关节Harris评分及疼痛目测类比评分判断术后疗效,观察PFNA-Ⅱ大转子近端突出对手术疗效是否存在影响。结果与结论:①突出组及非突出组患者性别特征存在明显差异(P=0.001);②按AO/OTA分类,两组患者的骨折类型无明显差异(P=0.289);③两组患者使用的髓内钉直径、长度特征均无明显差异(P=0.067,P=1.000);④患者身高与使用的髓内钉长度无明显相关性(P=0.510),但与突出长度有明显相关性(P=0.034);螺旋刀片位置与突出长度无明显相关性(P=0.968);⑤术后6个月时两组患者髋关节Harris评分差异无显著性意义(P=0.373),但突出组疼痛目测类比评分明显高于非突出组,差异有显著性意义(P=0.000);⑥结果提示PFNA-Ⅱ在治疗亚洲人股骨转子间骨折时,大转子近端经常发生髓内钉突出;当髓内钉伸入大转子近端软组织时,患者主诉大转子近端疼痛,目测类比评分明显高于非突出组;为了更好地适应亚洲人群骨骼特点,建议对PFNA-Ⅱ进行改良,进一步缩短近端钉端,以获得更好的股骨转子间骨折固定效果。

关键词：股骨转子间骨折 PFNA-Ⅱ 髓内钉突出内固定疼痛