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Journal of Energy Chemistry 2024年第4期91卷 194-202页

作者： guangtong hai Xiangdong Xue Zhenyu Wu Canyang Zhang Xin Liu Xiubing Huang Institute of Zhejiang University-Quzhou Zhejiang UniversityQuzhou 324000ZhejiangChina Beijing Key Laboratory of Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and TechnologyBeijing 100083China CentreÉnergie Matériaux et Télécommunications(EMT) Institut national de la recherche scientifique(INRS)Varennes J3X1P7QuébecCanada

Electrocatalytic water splitting is crucial for H2generation via hydrogen evolution reaction(HER)but subject to the sluggish dynamics of oxygen evolution reaction(OER).In this work,single Fe atomdoped MoS_(2)nanosheets(SFe-DMNs)were prepared based on the high-throughput density functional theory(DFT)calculation *** to the synergistic effect between Fe atom and MoS_(2)and optimized intermediate binding energy,the SFe-DMNs could deliver outstanding activity for both HER and *** assembled into a two-electrode electrolytic cell,the SFe-DMNs could achieve the current density of 50 mA cm^(-2)at a low cell voltage of 1.55 V under neutral *** results not only confirmed the effectiveness of high-throughput screening,but also revealed the excellent activity and thus the potential applications in fuel cells of SFe-DMNs.

关键词： High-throughput calculation Overall water splitting Single atom doped catalyst Molybdenum disulfide nanosheet

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电催化还原氮制氨的最新进展

Chinese Journal of Catalysis 2024年第5期60卷 107-127页

作者：海广通富忠恒刘欣黄秀兵浙江大学衢州研究院浙江衢州324000 清华大学化工系膜技术与工程研究中心北京100084 北京科技大学新材料与技术研究所北京材料基因工程高精尖创新中心北京100083 加拿大国立科学研究院能源材料通讯中心瓦雷纳斯加拿大北京科技大学材料科学与工程学院北京材料基因工程高精尖创新中心北京100083

氮还原反应在生态系统、农业系统和工业氮循环中发挥着至关重要的作用.然而,由于氮气在水中的溶解度低,N≡N三键结构稳定,且存在与析氢反应的激烈竞争,因此目前电化学氮还原反应面临着产率缓慢、法拉第效率低等挑战.尽管研究者们通过不... 详细信息

氮还原反应在生态系统、农业系统和工业氮循环中发挥着至关重要的作用.然而,由于氮气在水中的溶解度低,N≡N三键结构稳定,且存在与析氢反应的激烈竞争,因此目前电化学氮还原反应面临着产率缓慢、法拉第效率低等挑战.尽管研究者们通过不懈的努力已经在该领域取得了显著的进展,但距离其实际应用仍有较大差距.因此,如何通过多方面的调控手段,尽早实现人工固氮的工业化生产,成为当前该领域亟待解决的关键问题.本文系统梳理了电催化还原氮制氨的最新进展.首先,对NRR的机理进行了全面介绍.详细介绍了五种备受关注的氮还原机理:解离机理、结合机理、交替机理、酶促机理以及最新发现的马尔斯-范克雷维伦机理.通过对比电催化氮还原与哈珀法催化氮还原的反应机理,阐明了电催化氮还原的优势.然后,总结了该领域最新的研究进展.详细介绍了高性能氮还原催化剂的最新设计开发成果,基于近五年的相关报道,重点介绍了Mo基催化剂、Cu基催化剂、Ru基催化剂、Bi基催化剂和Fe基催化剂的研究进展.此外,对其他过渡金属基催化剂和非金属催化剂也进行了评述和展望,并对不同催化剂的优缺点进行了系统的比较.随后,对新型氮还原反应装置的研究进展进行了综述.讨论了新型反应器对缓解氮分子低溶解度这一问题的关键作用,强调了研发新型氮还原反应装置对提升电催化氮还原性能的重要性.在NRR反应路径的调控和优化方面,本文总结了最新的研究成果,特别是Li介导的氮还原反应的重要意义,证实了反应路径的调控优化是提升氮还原性能的有效手段.更为重要的是,从目前最新的研究成果出发,提出了氮还原性能的提升需要多方面的协同调控,单一的优化手段难以突破现有的瓶颈,这为后续的研究提供了重要参考.在展望部分,强调了氮还原领域目前面临的挑战并讨论了未来的研究方向.综上,本文系统地总结了近年来的研究进展,包括高性能催化剂、新型反应设备以及氮还原反应路径的调控和优化.提升氮还原反应的整体性能需要多方面的协调调控,仅关注催化剂很难取得重大突破.本文旨在为氮还原催化剂和反应器的设计以及反应路径的调控优化提供参考.

关键词：氮还原反应电催化催化剂反应设备反应途径

Covalent-organic frameworks with keto-enol tautomerism for efficient photocatalytic oxidative coupling of amines to imines under visible light

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Science China Chemistry 2021年第12期64卷 2169-2179页

作者： Zhenyu Wu Xiubing Huang Xiangjun Li guangtong hai Baozhen Li Ge Wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China

Photocatalytic oxidation of organic molecules into highly value-added products is an innovative and challenging research which has gradually attracted remarkable attention of *** this work,it is demonstrated that the COF-TpPa with keto-enol tautomerism equilibrium structure shows excellent performance(yield>99%after 8 h)in the selective photocatalytic oxidative coupling of amines to imines under visible light *** is revealed that three kinds of reactive oxygen species(superoxide radical,hydroxyl radical and singlet oxygen)participate in this photocatalytic oxidation *** addition,hydrogen protons cleaved from the benzyl are proven to be reduced to hydrogen in the conduction band of COF-TpPa in anaerobic atmosphere,accompanied with the formation of *** direct hydrogen evolution from amine provides an effective way to extract clean energy from organic molecule as well as the production of value-added *** a contrast,COF-LZU1 with similar structure and chemical composition to COF-TpPa but without keto-enol tautomerism exhibits worse optical properties and photocatalytic *** is also demonstrated that keto-enol tautomerism favors the adsorption of benzylamine based on the characterization results and theoretical calculations.

关键词： covalent-organic frameworks photocatalysts aerobic/anaerobic benzylamine oxidation keto-enol tautomerism

Molecular and therapeutic landscape of ferroptosis in skin diseases

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中华医学杂志(英文版) 2024年第15期137卷 2024 Jul 8页

作者： Le Jiayuan Meng Yu Wang Ying Li Daishi Zeng Furong Xiong Yixiao Chen Xiang Deng guangtong Department of Dermatology Xiangya Hospital Central South University Changsha Hunan China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha Hunan China Furong Laboratory Changsha Hunan China Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital Central South University Changsha Hunan China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha Hunan China Department of Oncology Xiangya Hospital Central South University Changsha Hunan China Department of Dermatology Tongji Hospital Huazhong University of Science and Technology Wuhan Hubei China

Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features of iron accumulation, lipid peroxidation, and involvement of various inhibitory antioxidant systems. In recent years, an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders. Therefore, understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies. This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis, embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (SLE), vitiligo, and dermatological ailments precipitated by ultraviolet (UV) exposure, and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.

关键词： Ferroptosis Skin diseases Regulated cell death Homeostasis Melanoma Psoriasis Systemic lupus erythematosus Vitiligo

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1359-1388页

作者： Qian Zhou Yu Meng Daishi Li Lei Yao Jiayuan Le Yihuang Liu Yuming Sun Furong Zeng Xiang Chen guangtong Deng Department of Dermatology Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Furong Laboratory 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya Hospital87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of General Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Plastic and Cosmetic Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Oncology Xiangya HospitalCentral South University87Xiangya RoadChangsha 410008Hunan ProvinceChina

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membranelocalized lipid *** acts as an innate tumor suppressor mechanism and participates in the biological processes of ***,mesenchymal and dedifferentiated cancer cells,which are usually resistant to apoptosis and traditional therapies,are exquisitely vulnerable to ferroptosis,further underscoring its potential as a treatment approach for cancers,especially for refractory ***,the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor *** induction not only inhibits cancer but also promotes cancer development due to its potential negative impact on anticancer ***,a comprehensive understanding of the role of ferroptosis in cancer is crucial for the successful translation of ferroptosis therapy from the laboratory to clinical *** this review,we provide an overview of the recent advancements in understanding ferroptosis in cancer,covering molecular mechanisms,biological functions,regulatory pathways,and interactions with the tumor *** also summarize the potential applications of ferroptosis induction in immunotherapy,radiotherapy,and systemic therapy,as well as ferroptosis inhibition for cancer treatment in various *** finally discuss ferroptosis markers,the current challenges and future directions of ferroptosis in the treatment of cancer.

关键词： cancer mechanisms treatment

Demonstration of 10 Gbps satellite-to-ground laser communications in engineering

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The Innovation 2024年第1期5卷 7-8页

作者： Yalin Li Hongqun Zhang Peng Huang guangtong Wan Yu Li Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China

In June 2023,researchers at the Aerospace Information Research Institute(AIR)of the Chinese Academy of Sciences undertook a series of experiments on satellite-to-ground laser communication using the Jilin-1 MF02A04(JLMF)satellite and independently developed a 500 mm optical communication ground station(AIROSG),achieving a successful throughput of 10 gigabits per second(Gbps)in the satellite-to-ground optical *** obtained satellite payload data demonstrated good performance and satisfied the requirements of high-standard scientific applications.

关键词： Gbps laser communication

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基于多指标动态优先级的无人机协同路径规划

航空学报 2024年第4期45卷 256-269页

作者：王祝张梦通张振鹏徐广通华北电力大学(保定)自动化系保定071003 浙江大学湖州研究院湖州313002

针对复杂城市环境下多无人机(UAVS)协同巡检、配送等任务,提出一种基于多指标动态优先级的协同路径规划方法,以节省运行成本和增加任务效率。综合考虑碰撞风险、总路程、等待时间等指标构建动态优先级模型,并在优先级单边避碰机制下,定... 详细信息

针对复杂城市环境下多无人机(UAVS)协同巡检、配送等任务,提出一种基于多指标动态优先级的协同路径规划方法,以节省运行成本和增加任务效率。综合考虑碰撞风险、总路程、等待时间等指标构建动态优先级模型,并在优先级单边避碰机制下,定制组合规避策略以处理局部冲突,更好地权衡协同规划效率和路径质量。针对无人机个体路径规划,在Lazy Theta*算法基础上引入拥堵权值地图,引导无人机避开拥堵区域,降低冲突发生可能性。对比仿真试验表明:提出的个体规划算法可以减少拥堵区域和降低拥堵持续时间,提出的多指标动态优先级协同规划算法相比于飞行时间驱动的动态优先级,能够提高规划效率和结果最优性。

关键词：多无人机系统协同路径规划多指标动态优先级 Lazy Theta*算法拥堵权值地图组合规避策略

尼莫地平序贯疗法联合乌拉地尔治疗高血压性脑出血的疗效及安全性

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临床合理用药杂志 2024年第24期17卷 1-4页

作者：黄广通广东省高州市人民医院 525200

目的观察尼莫地平序贯疗法联合乌拉地尔治疗高血压性脑出血的疗效及安全性。方法选取2021年4月—2022年12月高州市人民医院收治的68例高血压性脑出血患者,以随机数字表法将患者分为序贯疗法组34例和常规组34例。患者入院后均接受常规治... 详细信息

目的观察尼莫地平序贯疗法联合乌拉地尔治疗高血压性脑出血的疗效及安全性。方法选取2021年4月—2022年12月高州市人民医院收治的68例高血压性脑出血患者,以随机数字表法将患者分为序贯疗法组34例和常规组34例。患者入院后均接受常规治疗,常规组患者采用盐酸乌拉地尔注射液治疗,序贯疗法组患者在常规组基础上采用尼莫地平序贯治疗。2组患者均持续治疗4周。比较2组患者临床疗效,治疗前后实验室指标[血清C反应蛋白(CRP)、白介素-6(IL-6)、血肌酐(SCr)及血钙]、美国国立卫生研究院卒中量表(NIHSS)评分、脑血肿体积及不良反应。结果序贯疗法组总有效率为94.12%,高于常规组的70.59%(χ^(2)=6.476,P=0.011)。治疗4周后,2组血清CRP、IL-6、SCr水平较治疗前降低,血钙浓度较治疗前升高,且序贯疗法组降低/升高幅度大于常规组(P<0.01);2组NIHSS评分较治疗前降低,脑血肿体积较治疗前缩小,且序贯疗法组低/小于常规组(P<0.01)。序贯疗法组在治疗过程中不良反应总发生率与常规组比较差异无统计学意义(11.76%vs.17.65%,χ^(2)=0.469,P=0.493)。结论在高血压性脑出血患者治疗中,采用尼莫地平序贯疗法联合乌拉地尔治疗能够提升疗效,纠正SCr和血钙浓度,改善神经功能,减小脑血肿体积,减轻肾损伤,且联合用药安全性较高。

关键词：高血压性脑出血尼莫地平乌拉地尔血肌酐血钙安全性

羧基双齿结构连接二氧化钛与NH2-MIL-101(Fe):一种共轭效应引发的高效可见光光催化平台

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Science Bulletin 2020年第8期65卷 658-669,M0004页

作者：马雨威卢云峰海广通董文钧李荣洁刘景海王戈 Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095USA Inner Mongolia Key Laboratory of Carbon Nanomaterials Nano Innovation Institute(NII)College of Chemistry and Chemical EngineeringInner Mongolia University for NationalitiesTongliao 028000China

经过数十年的深入研究,半导体光催化技术已经发展成为一种处理废水的高效技术.TiO2由于其低成本、无毒、可循环性和高稳定性成为光催化降解污染物的最有前途的半导体光催化材料之一.金属有机骨架具有较大的比表面积,可调节的孔径,较多... 详细信息

经过数十年的深入研究,半导体光催化技术已经发展成为一种处理废水的高效技术.TiO2由于其低成本、无毒、可循环性和高稳定性成为光催化降解污染物的最有前途的半导体光催化材料之一.金属有机骨架具有较大的比表面积,可调节的孔径,较多的活性位点和稳定化学性质.将铁基金属有机骨架材料通过羧基双齿结构锚定在TiO2表面是一种增强异质结结构稳定的方法.此外,靠近锚定部分的羧基双齿结构具有较强的吸电子效应,会从Fe-MOFs中拉出电子密度并注入TiO2中.羧基双齿螯合结构可以连接供体和受体,使分子内的电荷从供体向TiO2的迁移能力增强并产生共轭效应.本文使用羧基双齿结构可控的将NH2-MIL-101(Fe)锚定到TiO2空心纳米球表面,TiO2和NH2-MIL-101(Fe)之间的共轭效应有效地提升了光生电子从NH2-MIL-101(Fe)向TiO2的转移能力.同时,引入的带尾结构缩短了复合物的带隙并提升了复合物(TiO2@NH2-MIL-101(Fe))的光催化性能.

关键词： Photocatalysis Conjugation effect Electron transfer capability Bandgap Metal-organic frameworks

基于构效关系研究的石油炼制与化工催化剂表征技术进展

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石油学报（石油加工） 2024年第4期40卷 841-861页

作者：徐广通刘超文邱丽美中石化石油化工科学研究院有限公司石油化工分子转化与反应工程全国重点实验室北京100083

新型催化剂的研发模式正从过去以实验设计、试错为主向理论设计指导转变,基于催化剂组成结构信息与反应性能建立的构效关系是催化剂设计的重要基础。多种超高分辨电子显微技术、表面分析技术、核磁共振技术、光谱表征技术、基于同步辐... 详细信息

新型催化剂的研发模式正从过去以实验设计、试错为主向理论设计指导转变,基于催化剂组成结构信息与反应性能建立的构效关系是催化剂设计的重要基础。多种超高分辨电子显微技术、表面分析技术、核磁共振技术、光谱表征技术、基于同步辐射光源的高分辨谱学等技术为研究催化剂活性中心本质提供了重要手段。概述了近20年来催化剂表征技术的发展概况及构效关系的研究方法,重点介绍了原子尺度与原位表征技术的进展,以及表征技术在分子筛、加氢催化剂、重整和丙烷脱氢催化剂、脱硫吸附剂等典型催化剂研究中的应用情况,以期为研究人员更好地研究催化剂构效关系提供导引和启发。

关键词：催化剂原位表征构效关系石油炼制与化工