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Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study

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中华医学杂志（英文版） 2023年第19期136卷 2324-2329页

作者： Yan Geng Yong Fan Yu Wang Xuerong Deng Lanlan Ji Xiaohui Zhang Zhibo Song Hong Huang Yanni Gui Haoze Zhang Xiaoying Sun guangtao li Juan Zhao Zhuoli Zhang China 100034

Background: Vaccination has been shown effective in controlling the global coronavirus disease 2019 (COVID-19) pandemic and reducing severe cases. This study was to assess the flare and change in disease activity after COVID-19 vaccination in patients with stable rheumatoid arthritis (RA). Methods: A prospective cohort of RA patients in remission or with low disease activity was divided into a vaccination group and a non-vaccination group based on their COVID-19 vaccination status. Each of them was examined every 3 to 6 months. In the vaccination group, disease activity was compared before and after vaccination. The rates of flare defined as disease activity scores based on 28-joint count (DAS28) >3.2 with ΔDAS28 ≥0.6 were compared between vaccination and non-vaccination groups. Results: A total of 202 eligible RA patients were enrolled. Of these, 98 patients received no vaccine shot (non-vaccination group), and 104 patients received two doses of vaccine (vaccination group). The median time interval from pre-vaccination visit to the first immunization and from the second dose of vaccine to post-vaccination visit was 67 days and 83 days, respectively. The disease activity scores at pre-vaccination and post-vaccination visits in the vaccination group patients were similar. At enrollment, gender, RA disease course, seropositivity, and disease activity were comparable across the two groups. Flare was observed in five (4.8%) of the vaccination group patients and nine (9.2%) of the non-vaccination group patients at post-vaccination assessment ( P = 0.221). In terms of safety, 29 (27.9%) patients experienced adverse events (AEs) after vaccination. No serious AEs occurred. Conclusions: COVID-19 vaccinations had no significant effect on disease activity or risk of flare in RA patients in remission or with low disease activity. Patients with stable RA should be encouraged to receive the COVID-19 vaccination.

关键词： COVID-19 vaccination Rheumatoid arthritis Disease activity Flare Adverse events

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Gram-scale fabrication of patchy nanoparticles with tunable spatial topology and chemical functionality

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Nano Research 2021年第8期14卷 2666-2672页

作者： Jiecheng Cui Yi li Huili Yuan Ning Gao Kai Feng Wenyun li Kang Zhou Xianpeng Yin guangtao li College of Chemistry and life Science Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal University688 Yingbin RoadJinhua 321004China Department of Chemistry Tsinghua UniversityBeijing 100084China

Patchy particles,defined as particles with one or more well-defined patches,have attracted much attention due to their anisotropic and.directional interactions.The anisotropic nature of the patchy particle surface enables a certain degree of control over the assembly,process.Enormous efforts have been carried out to design and explore the properties of patchy particles and their collective behaviour.However,the techniques to fabricate patchy particles are still limited in terms of tunability and scalability.In this work,an effective method of fabricating patchy particles with tunable spatial topology and chemical composition of patches is presented.The number,distribution and size of the patches can be tailored by adjusting the packing of the colloidal particles and the processing condition.The active secondary reaction on the polydopamine(PDA)-coated surface and silica surface could functionalize the obtained patchy particles with desired properties to meet different requirements.As a proof of principle,the PDA-coated patches were modified with thiol-based dye via the Michael reaction and the silica surfaces were functionalized with amine-terminated alkoxysilanes via the silane coupling reaction have been demonstrated.Furthermore,the unique properties of PDA,such as reductive ability,powerful'adhesive capability and carbonizable feature,have also been proven to fabricate metallic nanoparticle-decorated patchy particles and anisotropic carbon nanocapsules.The well-defined patchy particles are templated from colloidal crystal and their gram-scale fabrication is easily achieved.These results indicate that our strategy will help access the transformative potential of patchy particles in the rational design and large-scale production of functional materials.

关键词： patchy particle dopamine scalability remarkable tunability

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红山茶花、叶提取液在化妆品中的抗老功效研究

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中国野生植物资源 2024年第2期43卷 26-32页

作者：胡昕李广涛高宏旗上海林清轩生物科技有限公司上海201400

目的:通过体外测试探究红山茶花、叶提取液在化妆品中抗老(抗皱、抗氧化、抗糖化)的能力。方法:通过实时荧光定量PCR和EliSA试剂盒测试红山茶花、叶提取液在斑马鱼和成纤维细胞中的抗皱能力,使用流式细胞术和MTT比色法测试其在角质形成... 详细信息

目的:通过体外测试探究红山茶花、叶提取液在化妆品中抗老(抗皱、抗氧化、抗糖化)的能力。方法:通过实时荧光定量PCR和EliSA试剂盒测试红山茶花、叶提取液在斑马鱼和成纤维细胞中的抗皱能力,使用流式细胞术和MTT比色法测试其在角质形成细胞的抗氧化能力,使用免疫组织化学测试其在离体皮肤中的糖基化终末产物含量评价抗糖化能力。结果:(1)红山茶花、叶提取液具有促进Ⅰ型胶原蛋白及抑制基质金属蛋白酶MMP-1和MMP-3的能力,可达到抗皱的效果;(2)可抑制活性氧和提升超氧化物歧化酶的含量,具有抗氧化的能力;(3)可抑制表皮层和真皮层中糖基化终末产物的表达,具有抗糖化的效果。结论:红山茶花、叶提取液可从抗皱、抗氧化和抗糖化方面达到抗老的效果。

关键词：红山茶花、叶提取液抗皱抗氧化抗糖化

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Ultrasensitive detection of aliphatic nitro-organics based on“turn-on”fluorescent sensor array

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Science China Chemistry 2016年第1期59卷 89-94页

作者： Chen Wang Heng Zhang li Tian Wei Zhu Yue Lan Jian li Hui Wang Guanxin Zhang Deqing Zhang Shiling Yuan guangtao li Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China Department of Chemical Engineering Shandong UniversityJinan 250100China

The broad class of explosives includes nitro aromatics as well as challenging aliphatic nitro-organics whose detection is important from counter-terrorism and national security perspectives.Here we report a turn-on fluorescent sensor array based on aggregation-induced emission(AIE)fluorophores as receptors.To achieve a good sensing system with fast response,good sensitivity and low detection limit,three receptors with abundant chemical diversities for target analytes were synthesized.The turn-on response of the individual receptor showed highly variable and cross-reactive analyte-dependent changes in fluorescence.The excellent ability to identify a variety of explosives,especially the challenging aliphatic nitro-organics(2,3-dimethyl-2,3-dinitrobutane(DMNB),1,3,5-trinitro-1,3,5-triazinane(RDX),cyclotetramethylene tetranitramine(HMX)and entaerythritol tetranitrate(PETN)),was demonstrated in qualitative and quantitative analyses with 100%accuracy.The fluorescence signal amplification in the presence of explosives allows for application of these receptors in a sensor microarray suitable for high-throughput screening.These results suggested that the cross-reactive sensor array based on AIE fluorophores could find a wide range of applications for sensing various analytes or complex mixtures.

关键词：传感器阵列超灵敏检测硝基芳烃有机物脂肪族荧光导通传感器芯片

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Block copolymer assisted topochemical polymerization:A facile and efficient route to robust polymeric nanoporous membranes decorated with versatile amino acids

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Chinese Chemical Letters 2020年第3期31卷 885-889页

作者： Yun liang Wanyue Ouyang Peng Wang Wanlin Zhang Shiqiang Wang li Tian Yong Ju guangtao li Key Lab of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China

Based on block copolymer assisted topochemical polymerization,a new strategy for facilely producing robust nanoporous membranes with controlled incorporation of functional groups onto nanopores is developed.As exemplified by preparing nanoporous polypyrrole decorated with amino acids,this strategy exhibits a high degree of freedom for tailoring the surface functionality in the created pores.

关键词： Block copolymer Supramolecular ensemble Topochemical polymerization Nanoporous membranes Pore functionalization

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A multiple coupling approach to produce high-performance SERS substrates

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Chinese Chemical Letters 2019年第1期30卷 179-182页

作者： Xianpeng Yin Hao Dong Shiqiang Wang Yun liang Ning Gao Wanlin Zhang li Tian Fuwei Sun guangtao li Department of Chemistry Key Lab of Organic Optoelectronics and Molecular Engineering Tsinghua University

Creating hotspots with significantly enhanced electromagnetic(EF) field, efficiently placing target molecules in hotspot region, and achieving uniform and reproducible Raman signals are three critical issues for developing high-performance SERS substrates. In this work, large area gold nanoparticle cluster pillar array with a gold mirror at bottom was facilely fabricated by combined use of nanosphere lithography and self-assembly approach. It is both theoretically and experimentally found that through multiple coupling interactions, the electromagnetic fields at interparticle gaps within the gold clusters were significantly enhanced in our three-dimentional(3D) pillar array substrates, which can result in one order of magnitude stronger as compared with random gold clusters on a two-dimentional planar case.Due to the periodic stucture, our substrates also possess the capbility of producing highly uniform and reproducible SERS signals. Attractively, in our case, a photoresponsive polymer was used for the formation of pillar array structure. Its unique photoinduced deformation makes it possible to reversibly open and close the gaps of the closely packed Au NP array, thus enabling efficient placement or entrapment of probe molecules into hotspot sites between adjacent nanoparticles.

关键词： Hotspots Electromagnetic Nanoparticles Cluster array SERS

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Direct identification of HMX via guest-induced fluorescence turn-on of molecular cage

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Chinese Chemical Letters 2021年第12期32卷 4006-4010页

作者： Chen Wang Jin Shang li Tian Hongwei Zhao Peng Wang Kai Feng Guokang He Jefferson Zhe liu Wei Zhu guangtao li Department of Chemistry Tsinghua UniversityBeijing 100084China School of Energy and Environment City University of Hong KongHong KongChina Department of Mechanical Engineering The University of MelbourneParkvilleVIC 3010Australia School of Biology and Biological Engineering South China University of TechnologyGuangzhou 510006China Institute of chemistry Hebrew University of JerusalemJerusalem 91904Israel

Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX) is one of the most widely used powerful explosives. The direct and selective detection of HMX, without the requirement of specialized equipment, remains a great challenge due to its extremely low volatility, unfavorable reduction potential and lack of aromatic rings. Here, we report the first chemical probe of direct identification of HMX at ppb sensitivity based on a designed metal-organic cage(MOC). The cage features two unsaturated dicopper units and four electron donating amino groups inside the cavity, providing multiple binding sites to selectively enhance host-guest events. It was found that compared to other explosive molecules the capture of HMX inside the cavity would strongly modulate the emissive behavior of the host cage, resulting in highly induced fluorescence “turn-on”(160 folds). Based on the density functional theory(DFT) simulation, the mutual fit of both size and binding sites between host and guest leads to the synergistic effects that perturb the ligand-to-metal charge-transfer(LMCT) process, which is probably the origin of such selective HMX-induced turn-on behavior.

关键词： Chemical sensing Explosive detection HMX Molecular cage Host-guest chemistry Fluorescence turn-on

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Cloning and identification of a novel human glioma differentiation related gene GDR1

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Chinese Science Bulletin 2000年第11期45卷 995-999页

作者： guangtao li Hulin Jin Songnian Hu Jian Jin Chun Tu Jiangang Yuan Boqin Qiang Peking Union Med Coll Sch Basic MedNatl Ctr Human Genome Res Chinese Acad Med Sci Inst Basic Med SciNatl Lab Med Mol Biol Beijing 100005 Peoples R China

In order to identify the genes associated with glioblastoma differentiation, some ESTs, expressed differentially in the control cell and the differentiated human glioblastoma cell line BT-325 induced by the all-trans retinoid acid, have been isolated by the method of DDRT-PCR. Of the 46 ESTs sequenced, 19 are from new genes. A full-length 1 535-bp cDNA, termed gene GDR1, has been isolated from the human cDNA library using the probe designed according to one of the novel ESTs, HGBB098. The open reading frame of GDR1 gene encodes a putative protein containing 334 amino acid residues. Blast against the current GenBank DMA and protein sequence database did not reveal significant homology with any known proteins. RT-PCR shows that GDR1 mRNA level increased in the differentiated BT-325 cells after being treated with RA. The different expression patterns of GDR1 mRNA in human tissues have been detected through the multiple tissue Northern blot hybridization.

关键词： human glioma GDR1 RT-PCR.

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Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma

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Cancer Biology & Medicine 2019年第1期16卷 89-99页

作者： Lu Chen Xiangdong Tian Wenchen Gong Bo Sun guangtao li Dongming liu Piao Guo Yuchao He Ziye Chen Yuren Xia Tianqiang Song Hua Guo Department of Tumor Cell Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer

Objective: The aim of the present study was to analyze the prognostic factors in patients with hepatoblastoma(HB) in our single center and to evaluate periostin(POSTN) expression in HB and its association with clinicopathological variables. In addition, the underlying mechanism of how POSTN promotes HB progression was discussed.Methods: POSTN expression was investigated in HB tumors by immunohistochemistry(IHC), immunofluorescence(IF) and Western blot(WB). The association among POSTN expression, clinicopathological features and overall survival(OS) was also evaluated. The migration and adhesion ability of HB cells were measured using chemotaxis and cell-matrix adhesion assays,respectively. Epithelial-mesenchymal transition(EMT)-associated markers and activation of the ERK pathway were detected by WB.Results: HB patients had poor prognosis which displayed lymph node metastasis, vascular invasion, POSTN and vimentin expression. POSTN expression was also associated with lymph node metastasis. Furthermore, overexpressed POSTN promoted migration and the adhesive ability of HB cells in vitro. In addition, we demonstrated that POSTN activated the MAPK/ERK pathway, upregulated the expression of Snail and decreased the expression of OVOL2. Finally, POSTN promoted the expression of EMT-associated markers.Conclusions: POSTN might modulate EMT via the ERK signaling pathway, thereby promoting cellular migration and invasion.Our study also suggests that POSTN may serve as a therapeutic biomarker in HB patients.

关键词： Periostin hepatoblastoma EMT MAPK/ERK

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Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds:A large-scale,retrospective study

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Cancer Biology & Medicine 2021年第1期18卷 256-270页

作者： Dongming liu Yi Luo Lu Chen liwei Chen Duo Zuo Yueguo li Xiaofang Zhang Jing Wu Qing Xi guangtao li lisha Qi Xiaofen Yue Xiehua Zhang Zhuoyu Sun Ning Zhang Tianqiang Song Wei Lu Hua Guo Department of Hepatobiliary Liver Cancer Research Center for Prevention and TherapyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Tumor Cell Biology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Clinical Laboratory Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Medical Laboratory Tianjin Medical University General HospitalTianjin 300052China Clinical Laboratory Tianjin Third Central HospitalTianjin 300170China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Tianjin Research Institute of liver Diseases Tianjin Second People’s HospitalTianjin 300192China Department of Infectious Diseases The First Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotou 014010China Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjin 300070China The Center for Translational Cancer Research Peking University First HospitalBeijing 100034China

Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using EliSAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called"NBNC-HCC")and patients positive for the above indices(called"HBV-HCC and HCV-HCC")were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients.

关键词： Hepatocellular carcinoma serum biomarker AFP AFU

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