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Novel transparent MgGa_(2)O_(4) and Ni^(2+)-doped MgGa_(2)O_(4) ceramics

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Journal of Advanced Ceramics 2022年第3期11卷 470-481页

作者： guangran zhang Adrian GOLDSTEIN Yiquan WU Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNew York 14802USA Israel Ceramic and Silicate Institute HaifaIsrael

In this study we fabricated, for the first time, magnesium gallate (MgGa_(2)O_(4), a partially inverted spinel) transparent ceramics, both undoped and doped with 1 at% Ni. The specimens were derived from in-house prepared powder, with a crystallite size of ∼10 nm (by wet chemistry) and densified by pulsed electric current sintering (PECS;peak temperature 950 ℃ for 90 min). Densification levels of 99.84% and 99.52% of theoretical density were attained for doped and undoped materials, respectively. Doping with Ni was seen to marginally improve the densification level. Quite transparent specimens were produced: the best showing transmission of ∼89% of the theoretical level (thickness t = 0.85 mm). The absorption spectra revealed that the dopant was accumulated as Ni^(2+) in the octahedral sites of the lattice, as occurs in single-crystal specimens. After excitation at 980 nm, the doped disks exhibited a wide fluorescence band centered at 1264 nm.

关键词： magnesium gallate(MgGa_(2)O_(4)) spinel transparent ceramics pulsed electric current sintering(PECS)

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LED显示测力计教具的设计与实现

哈尔滨师范大学自然科学学报 2023年第3期39卷 74-80页

作者：姚远张伟光张光冉张婷李东明王小周哈尔滨师范大学

教具是辅助教育教学的重要工具.在验证力的“平行四边形法则”实验中,由于当前实验器材的局限性导致实验结果的可视性和操作的便捷性都存在一定的问题.针对这些问题,设计了一种基于STC89C51的LED显示测力计作为此实验的教具.该教具由LE... 详细信息

教具是辅助教育教学的重要工具.在验证力的“平行四边形法则”实验中,由于当前实验器材的局限性导致实验结果的可视性和操作的便捷性都存在一定的问题.针对这些问题,设计了一种基于STC89C51的LED显示测力计作为此实验的教具.该教具由LED亮的个数来表示力的大小,采用锁存器74LS373级联的方式连接所需LED,通过改变力来达到控制LED的目的,完成力与灯光的结合.直线型LED渐亮的过程使整个实验更加直观可视化,便于学生观察并体会力的变化过程,实现教具使用的多样化.

关键词：自制教具直线型LED STC89C51 锁存器74LS373

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温度可调半导体制冷实验箱的设计与制作

哈尔滨师范大学自然科学学报 2023年第3期39卷 81-88页

作者：张婷张伟光姚远张光冉李东明王小周哈尔滨师范大学

基于半导体制冷片设计了一种制冷实验箱,温度可调范围为-23~25℃,可将被测试的芯片或小型功能模块放入其中,以测试其低温性能.该实验箱以ATMEGA328P为主控芯片,由温度传感器采集温度信号,通过PWM方式的PID控制算法,调节箱内温度,从而达... 详细信息

基于半导体制冷片设计了一种制冷实验箱,温度可调范围为-23~25℃,可将被测试的芯片或小型功能模块放入其中,以测试其低温性能.该实验箱以ATMEGA328P为主控芯片,由温度传感器采集温度信号,通过PWM方式的PID控制算法,调节箱内温度,从而达到恒温调节的目的;主控芯片处理的数据会传送给LCD1602显示温度.经实验验证,温度可调半导体制冷实验箱满足探究温度性能的恒温要求.

关键词：半导体制冷 ATMEGA328P 温度传感器 PID PWM

Tumor-derived apoptotic extracellular vesicle-mediated intercellular communication promotes metastasis and stemness of lung adenocarcinoma

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Bioactive Materials 2024年第6期36卷 238-255页

作者： Xiaotian He Yiyang Ma Yingsheng Wen Rusi zhang Dechang Zhao Gongming Wang Weidong Wang Zirui Huang guangran Guo Xuewen zhang Huayue Lin Lanjun zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Thoracic Surgery Sun Yat-sen University Cancer CenterSun Yat-sen UniversityGuangzhouChina Department of Breast Surgery Sun Yat-sen University Cancer CenterSun Yat-sen UniversityGuangzhouChina Department of Anesthesiology Sun Yat-sen University Cancer CenterSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina

Apoptosis has long been recognized as a significant mechanism for inhibiting tumor formation,and a plethora of stimuli can induce apoptosis during the progression and treatment of ***,tumor-derived apoptotic extracellular vesicles(apoEVs)are inevitably phagocytosed by live tumor cells,promoting tumor *** the mechanism by which apoEVs regulate tumor cells is imperative for enhancing our knowledge of tumor metastasis and ***,we conducted a series of in vivo and in vitro experiments,and we report that tumor-derived apoEVs promoted lung adenocarcinoma(LUAD)metastasis,self-renewal and ***,we demonstrated that apoEVs facilitated tumor metastasis and stemness by initiating the epithelial-mesenchymal transition program and upregulating the transcription of the stem cell factor *** addition,we found that ALDH1A1,which was transported by apoEVs,activated the NF-κB signaling pathway by increasing aldehyde dehydrogenase enzyme activity in recipient tumor ***,targeting apoEVs-ALDH1A1 significantly abrogated these ***,our findings elucidate a novel mechanism of apoEV-dependent intercellular communication between apoptotic tumor cells and live tumor cells that promotes the formation of cancer stem cell-like populations,and these findings reveal that apoEVs-ALDH1A1 may be a potential therapeutic target and biomarker for LUAD metastasis and recurrence.

关键词： Lung adenocarcinoma Apoptotic extracellular vesicles Stemness Proteomics SOX2

Recent advances in photocatalytic CO_(2) cycloaddition reaction

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Nano Research 2024年第11期17卷 9601-9619页

作者： Xing Chen Ye Liu Guoqiang Wang Yubo Kuang Xiaoqian Xiang guangran Di Xiaojing Yin Lei zhang Kaixin Wang Qianqian Cai Xiaojun Lv New Energy North China Electric Power University Beijing 102206 China

Carbon dioxide (CO_(2)) is a principal greenhouse gas with a substantial impact on global climate change. The photocatalytic reduction of CO_(2) represents an economically viable and environmentally benign approach. This technique involves the catalysis of the reaction between CO_(2) and epoxides under photocatalytic conditions to yield cyclic carbonates. Notably, this process has garnered significant attention due to its high atomic efficiency and alignment with green chemistry principles. Increasingly, photocatalysts are employed to facilitate the synthesis of cyclic carbonates, demonstrating outstanding performance even under natural light. This review evaluates the current state of research on the photocatalytic cycloaddition of CO_(2) with epoxides, analyzes the reaction mechanism and key influencing factors, and provides a comparative summary of the photocatalysts developed in this domain. Additionally, this paper underscores the significance of the reaction devices. The paper explores reaction devices with potential applications for photocatalytic CO_(2) and epoxides and envisions future integrations of CO_(2) photocatalytic cycloaddition reactions with advanced reaction devices for practical applications in this area.

关键词： CO_(2)cycloaddition reaction cycloaddition mechanism green chemistry photocatalytic device

Longitudinal study of a community hospital integrated model for diabetes management in the Beijing Jingsong community

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Family Medicine and Community Health 2014年第1期2卷 20-27页

作者： Jiandong zhang Ning Zhuang Mingxia Yuan Lijuan Gao Chuan Bian Huaining Chen Qing Chi Suqing Hui Guiying Li Yanli Su Hongsong Bao Gang Wan guangran Yang Shenyuan Yuan Jingsong Community Health Service Center Beijing 100021China Medical Record Statistics Room Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Endocrinology Department Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective:To determine the effects of a community hospital integrated model on the longitu-dinal management of diabetic ***:Four hundred forty-one patients with type 2 diabetes residing in Jingsong Commu-nity were randomly assigned to intensive and standard *** parameters were meas-ured in the two groups at baseline and after 36 months of management to compare the rate of goal ***:After comprehensive management,the overall control rate in the intensive group was increased from 2.7%to 9.6%compared with 2.3%-4.5%in the standard ***,the control rates for fasting plasma glucose,glycosylated hemoglobin,and blood pressure in the intensive group were significantly increased from 54.1%,40.0%,and 68.2%to 85.5%,74.6%,and 89.1%,*** control rate for glycosylated hemoglobin in the intensive group was significantly higher than the standard group after 36 months of ***:The community hospital integrated model for longitudinal management effec-tively improved the control rate of glycosylated hemoglobin and the overall control rate in patients with type 2 diabetes.

关键词： Diabetes Community management Overall control

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ZL205A合金壳体铸件低压铸造工艺研究

特种铸造及有色合金 2012年第9期32卷 811-813页

作者：吴士平王晔吴光然张建兵肖文峰哈尔滨工业大学材料科学与工程学院首都航天机械厂

以低压铸造成形ZL205A合金壳体件作为研究对象,采用数值模拟方法,研究了壳体铸件低压铸造过程温度场及缩孔、缩松缺陷随工艺方案的变化规律。结果表明,采用冷铁及冒口,缝隙式浇口由8个增加到10个,补缩距离由200mm减小到157mm,铸件的温... 详细信息

以低压铸造成形ZL205A合金壳体件作为研究对象,采用数值模拟方法,研究了壳体铸件低压铸造过程温度场及缩孔、缩松缺陷随工艺方案的变化规律。结果表明,采用冷铁及冒口,缝隙式浇口由8个增加到10个,补缩距离由200mm减小到157mm,铸件的温度场分布合理,铸件缺陷部位的缩松倾向明显减小,模拟结果与试验结果对比,表明采用冒口结合冷铁的工艺方案合理可行。

关键词： ZL205A合金壳体铸件低压铸造

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普萘洛尔对氧诱导视网膜新生血管的作用

中华儿科杂志 2016年第2期54卷 131-136页

作者：黄雪蓉王亚娟杨光燃杨子馨张景尚首都医科大学附属北京儿童医院新生儿中心 100045 首都医科大学附属北京同仁医院内分泌科 100045 首都医科大学附属北京同仁医院眼科 100045

目的观察普萘洛尔对氧诱导小鼠视网膜新生血管的作用及不同给药途径的差异。方法36只7日龄C57BL／6J小鼠建立氧诱导视网膜病变（OIR）动物模型，区组分层随机方法分为6组（正常对照组、普萘洛尔滴眼液组、普萘洛尔腹腔注射组、滴眼液阴... 详细信息

目的观察普萘洛尔对氧诱导小鼠视网膜新生血管的作用及不同给药途径的差异。方法36只7日龄C57BL／6J小鼠建立氧诱导视网膜病变（OIR）动物模型，区组分层随机方法分为6组（正常对照组、普萘洛尔滴眼液组、普萘洛尔腹腔注射组、滴眼液阴性对照组、腹腔注射阴性对照组、病理模型组），每组6只。正常对照组为713龄小鼠在空气中饲养至17日龄。病理模型组为建立OIR动物模型后不予药物干预。其余4组建立OIR动物模型，分别于12-1713龄予普萘洛尔2mg／（kg·次）、3次／d滴眼或腹腔注射及用相同剂量的柠檬酸缓冲液3次／d滴眼或腹腔注射。所有小鼠均于1713龄处死，每组取3只小鼠（6只眼球）行右旋糖苷一异硫氰酸荧光灌注视网膜铺片、另3只小鼠（6只眼球）制作HE染色眼球石蜡切片了解视网膜新生血管情况。结果视网膜铺片显示，普萘洛尔干预组（滴眼液、腹腔注射组）较病理模型组及阴性对照组（滴眼液组、腹腔注射组）视网膜视盘周围的无血管灌注区少，视网膜新生血管丛少。病理模型组视网膜无血管灌注区及新生血管占总面积的比例平均值明显大于普萘洛尔滴眼液组及普萘洛尔腹腔注射组[（38．9±9．9）％、（5．6±2．3）％比（16．2±10．0）％、（2．2±0．8）％和（25．9±5．0）％、（2．1±2．7）％，F=36．12、14．55，P〈0．001]；其中普萘洛尔滴眼液组视网膜无血管灌注区占总面积的比例平均值大于普萘洛尔腹腔注射组（P〈0．01），两组视网膜新生血管占总面积的比例平均值差异无统计学意义（P〉0．05）。普萘洛尔滴眼液组及普萘洛尔腹腔注射组视网膜突破内界膜的血管内皮细胞核均少于病理模型组、滴眼液阴性对照组及腹腔注射阴性对照组[（14．2±5．1）、（18．0±5．9）1：L（49．1±8．9）、（47．4±8．1）、（49．9±7．1）个／张切片，F=187．60，P均〈0．05]；其中普萘洛尔滴眼液组少于普萘洛尔腹腔注射组（P〈0．05）。结论普萘洛尔的干预可减少氧诱导视网膜新生血管的发生，滴眼液给药方式优于腹腔注射。

关键词：氧诱导视网膜病变普萘洛尔早产儿视网膜病

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传承中医特色针灸镇痛造福人民

医学综述 2020年第20期26卷 3959-3963页

作者：孙远征赵广然张淼黑龙江中医药大学附属第二医院针灸科哈尔滨150001 黑龙江中医药大学研究生院哈尔滨150040

中医药是中华民族几千年传承下来的宝贵财富,在现代疾病治疗中起重要作用。疼痛严重影响人民现代生活,且现代医学治法单一,疗效欠佳,针灸作为中医药中的独特自然疗法,经过近现代特别是建国之后的不断发展,针灸镇痛在临床实践和科学研究... 详细信息

中医药是中华民族几千年传承下来的宝贵财富,在现代疾病治疗中起重要作用。疼痛严重影响人民现代生活,且现代医学治法单一,疗效欠佳,针灸作为中医药中的独特自然疗法,经过近现代特别是建国之后的不断发展,针灸镇痛在临床实践和科学研究中均取得长足发展。新时代下,中医药事业的发展越来越得到党和国家的重视,人民对中医药接受程度不断提高,针灸镇痛将在传承好中医特色的基础上,不断创造出新的治疗方法,造福广大人民。

关键词：疼痛针灸镇痛