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Differences and dynamics of multidimensional poverty in rural China from multiple perspectives analysis

Journal of Geographical Sciences 2022年第7期32卷 1383-1404页

作者： WANG Bingbing LUO Qing chen guangping ZHANG Zhe JIN Pingbin School of Earth Sciences Zhejiang UniversityHangzhou 310013China Institute for Geography&Spatial Information Zhejiang UniversityHangzhou 310013China College of Resources and Environment Henan University of Economics and LawZhengzhou 450046China Zhejiang Provincial Key Laboratory of Geographic Information Science Hangzhou 310013China

Absolute poverty was completely eliminated in China in ***,poverty measured by income does not fully reflect the actual *** paper analyses multidimensional poverty and its dynamics in rural China from perspectives of region,terrain,and geographical location during 2010–*** use the Chinese Family Panel Survey data,adopt the Alkire-Foster method and improve the multidimensional poverty index(MPI),calculating and comparing multidimensional poverty and its dynamics among 3009 rural *** addition,the contribution of the indicator to multidimensional poverty is *** results indicate that multidimensional poverty has obvious regional differences,topographical differences,and geographical ***,the targeted poverty alleviation policy has a significant impact on multidimensional poverty eradication,and the rate of decline of the MPI during 2016–2018 is significantly greater than that of 2010–*** contributes more than 50%to the *** general,the proportion of households with persistent multidimensional poverty is higher than temporary multidimensional poverty,and temporary multidimensional poverty is higher than no multidimensional *** results obtained from a large scale,long time and multiple perspectives could offer new insights for the government to further consolidate the results of poverty alleviation while offering China’s experience to other developing countries.

关键词： multidimensional poverty dynamics regional differences geographical location differences topographical differences rural China

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Analysis of city centrality based on entropy weight TOPSIS and population mobility:A case study of cities in the Yangtze River Economic Belt

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Journal of Geographical Sciences 2020年第4期30卷 515-534页

作者： LUO Jing chen Siyun SUN Xuan ZHU Yuanyuan ZENG Juxin chen guangping Key Laboratory for Geographical Process Analysis&Simulation of Hubei Province Central China Normal UniversityWuhan 430079China The College of Urban&Environmental Sciences Central China Normal UniversityWuhan 430079China Academy of Wuhan Metropolitan Area Hubei Provincial Development and Reform Commission/Central China Normal UniversityWuhan 430079China Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China School of Earth Sciences Zhejiang UniversityHangzhou 310027China

Based on statistical data and population flow data for 2016,and using entropy weight TOPSIS and the obstacle degree model,the centrality of cities in the Yangtze River Economic Belt(YREB)together with the factors influencing centrality were *** addition,data for the population flow were used to analyze the relationships between cities and to verify *** results showed that:(1)The pattern of centrality conforms closely to the pole-axis theory and the central geography *** axes,corresponding to the Yangtze River and the Shanghai-Kunming railway line,interconnect cities of different *** the whole,the downstream cities have higher centrality,well-defined gradients and better development of city infrastructure compared with cities in the middle and upper reaches.(2)The economic scale and size of the population play a fundamental role in the centrality of cities,and other factors reflect differences due to different city *** most of the coastal cities or the capital cities in the central and western regions,factors that require long-term development such as industrial facilities,consumption,research and education provide the main competitive *** cities that are lagging behind in development,transportation facilities,construction of infrastructure and fixed asset investment have become the main methods to achieve development and enhance competitiveness.(3)The mobility of city populations has a significant correlation with the centrality score,the correlation coefficients for the relationships between population mobility and centrality are all greater than 0.86(P<0.01).The population flow is mainly between high-class cities,or high-class and low-class cities,reflecting the high centrality and huge radiating effects of high-class ***,the cities in the YREB are closely linked to Guangdong and Beijing,reflecting the dominant economic status of Guangdong with its geographical proximity to the YREB and Beijing's e

关键词： city centrality entropy weight TOPSIS population mobility Yangtze River Economic Belt obstacle degree model

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Assessment of the Retail Food Environment Using Integrated GIS and Modified Measures in Wuhan, China

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Journal of Geographic Information System 2023年第5期15卷 421-439页

作者： Yitian Liu guangping chen School of Earth Sciences Zhejiang University Hangzhou China Institute for Geography & Spatial Information Zhejiang University Hangzhou China

The retail food environment (RFE) has a significant impact on people’s dietary behavior and diet-related outcomes. Although RFE research has received a lot of attention, there are very few studies that shed light on the foodscape and assessment methodologies in the China context. Based on open data obtained from *** and AutoNavi map, we classified all food outlets into six types. Geographic Information Systems (GIS) techniques were employed to create two network buffer areas (1-km and 3-km) and calculate the absolute measures and relative measures (i.e., mRFEI and Rmix). We modified the calculation of relative measures by adding items and assigning weights. The mean mRFEI using the 1-km and 3-km buffer sizes across the communities were 10.45 and 20.12, respectively, while the mean mRmix of the two buffer sizes were 20.97 and 58.04, indicating that residents in Wuhan have better access to fresh and nutritious food within 3-km network buffers. Residents in urban areas are more likely to be exposed to an unhealthy food environment than those in rural areas. Residents in Xinzhou and Qiaokou districts are more likely to be subjected to unfavorable neighborhood RFE. The open data-driven methods for assessing RFE in Wuhan, China may guide community-level food policy interventions and promote active living by shifting built environments to increase residents’ access to healthy food.

关键词： Retail Food Environment (RFE) Diet Quality Geographic Information Systems (GIS) Density Big Data

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Equal compressibility structural phase transition of molybdenum at high pressure

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Chinese Physics B 2022年第11期31卷 412-415页

作者： Lun Xiong Bin Li Fang Miao Qiang Li guangping chen Jinxia Zhu Yingchun Ding Duanwei He School of Intelligent Manufacturing Sichuan University of Arts and ScienceDazhou 635000China DaZhou Industrial Technology Institute of Intelligent Manufacturing Dazhou 635000China College of Optoelectronics Engineering Chengdu University of Information TechnologyChengdu 610225China Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China Key Laboratory of High Energy Density Physics and Technology of Ministry of Education Sichuan UniversityChengdu 610065China

We have studied the high-pressure compression behavior of molybdenum up to 60 GPa by synchrotron radial x-ray diffraction(RXRD)in a diamond anvil cell(DAC).It is found that all diffraction peaks of molybdenum undergo a split at around 27 GPa,and we believe that a phase transition from a body-centered cubic structure to a rhombohedral structure at room pressure has *** slope of pressure–volume curve shows continuity before and after this phase transition,when fitting the pressure–volume curves of the body-centered cubic structure at low pressure and the rhombohedral structure at high pressure.A bulk modulus of 261.3(2.7)GPa and a first-order derivative of the bulk modulus of 4.15(0.14)are obtained by using the nonhydrostatic compression data at the angleψ=54.7°between the diffracting plane normal and stress axis.

关键词： molybdenum high pressure phase transition radial x-ray diffraction diamond anvil cell

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Breast Cancer MCF-7 Cell Spheroid Culture for Drug Discovery and Development

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Journal of Cancer Therapy 2022年第3期13卷 117-130页

作者： guangping chen William Liu Bingfang Yan Department of Physiological Sciences College of Veterinary Medicine Oklahoma State University Stillwater OK USA College of Pharmacy University of Cincinnati Cincinnati OH USA

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found in solid tumors. 3D spheroid culture methods recreate more physiologically relevant microenvironments for cells. Therefore, these models are more appropriate for cancer drug screening. We have recently developed a protocol for MCF-7 cell spheroid culture, and used this method to test the effects of different types of drugs on this estrogen-dependent breast cancer cell spheroid. Our results demonstrated that MCF-7 cells can grow spheroid in medium using a low attachment plate. We managed to grow one spheroid in each well, and the spheroid can grow over a month, the size of the spheroid can grow over a hundred times in volume. Our targeted drug experimental results suggest that estrogen sulfotransferase, steroid sulfatase, and G protein-coupled estrogen receptor may play critical roles in MCF-7 cell spheroid growth, while estrogen receptors α and β may not play an essential role in MCF-7 spheroid growth. Organoids are the miniatures of in vivo tissues and reiterate the in vivo microenvironment of a specific organ, best fit for the in vitro studies of diseases and drug development. Tumoroid, developed from cancer cell lines or patients’ tumor tissue, is the best in vitro model of in vivo tumors. 3D spheroid technology will be the best future method for drug development of cancers and other diseases. Our reported method can be developed clinically to develop personalized drugs when the patient’s tumor tissues are used to develop a spheroid culture for drug screening.

关键词： MCF-7 Cell Spheroid Culture 3D Cell Culture Estrogen-Dependent Breast Cancer Cancer Drug Development Personalized Cancer Drug Development

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Classification of regional agricultural structure:method and its application to China

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Ecological Economy 2008年第4期4卷 410-417页

作者： Mou Ziping Lei Hongmei chen guangping Li Xin Department of Environmental Science and Engineering Suzhou University of Science and Technology Suzhou 215011 P.R. China College of Foreign Languages Suzhou University of Science and Technology Suzhou 215011 P. R. China

Regional agriculture is the basis of regional sustainable development, so sustainable regional agricultural development is essential to the sustainable development of the whole society and becomes the focus of global research. The classification of regional agricultural structure is the basic work of regional agriculture study. This paper constructs index system （27 indices） of regional agricultural structure types with the three big indices： natural resources, developmental level of the agro-economy, and agro-ecological conditions. This paper also endows weight to every sub-classification index by means of AHP and obtains the comprehensive evaluation value of the three types of indices with arithmetic average weight approach. The regional agricultural structure can be classified into eight types in accordance with this evaluation results. The empirical study of China shows that the 31 provinces （municipalities and autonomous regions） are of different agriculture structural types. Finally, countermeasures of sustainsable agricultural development are put forward for the different agriculture structure features.

关键词： Agro-ecology China Classification method, Regional agriculture Structural type

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中国城市创业情感的时空差异及其对企业家精神的影响

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地理研究 2024年第1期43卷 31-50页

作者：陈广平王琛张佳浙江大学地球科学学院杭州310058 多伦多大学地理与规划学院加拿大多伦多M5S1A1 墨尔本大学建筑与规划学院澳大利亚墨尔本3010

创业情感是个体对创业的主观体验和感受,反映了社会对创业者及其创业活动的认可和接受程度。本文基于2014—2018年新浪微博“创业”话题的36.82万条文本数据,运用自然语言分析技术、文本数据分析与相关空间分析方法,在定量测度中国192... 详细信息

创业情感是个体对创业的主观体验和感受,反映了社会对创业者及其创业活动的认可和接受程度。本文基于2014—2018年新浪微博“创业”话题的36.82万条文本数据,运用自然语言分析技术、文本数据分析与相关空间分析方法,在定量测度中国192个城市的创业情感基础上,分析了正、负面两类创业情感的总体特征和时空差异,采用面板固定效应模型探究了创业情感对地区企业家精神的影响。研究发现:①个体创业情感主要受创业社会网络、创业体验、创业动机、创业环境、创业方式等因素的影响,其中“朋友”的词频最高,表明非亲属的熟人关系是影响个体创业情绪的关键要素。语义网络显示具有正面情感的创业者更关注投资机会和注重发挥创业平台的作用,而具有负面情绪的个体可能对房价、租金等与创业成本相关的因素更为敏感。②在城市尺度,正面的创业情感呈现“南高北低”“沿海高内陆低”的空间格局。随着时间推移,中国城市居民创业情感总体上趋于弱化且出现了空间“极化”现象。特别地,珠三角地区的深圳、广州、珠海和长三角地区的杭州、南京、苏州、宁波等城市始终是创业者的“乐园”。③模型结果显示,正面的创业情绪能够提振企业家精神,地区正面创业情感比例越高,越有利于促进地区创业水平的提升。政府的创业干预措施可以正向调节创业情感并有助于提振当地企业家精神,而高房价给创业者带来的负面创业情绪会显著削弱企业家精神。本研究基于大数据分析,定量论证了创业情感和社会态度对企业家精神的影响,可为区域创业政策调整、地区良好创业氛围的营造以及个体创业情绪的调节提供参考。

关键词：创业情感企业家精神新浪微博 BERT模型非正式制度情感分析

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Discovery of novel diarylamides as orally active diuretics targeting urea transporters

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Acta Pharmaceutica Sinica B 2021年第1期11卷 181-202页

作者： Shun Zhang Yan Zhao Shuyuan Wang Min Li Yue Xu Jianhua Ran Xiaoqiang Geng Jinzhao He Jia Meng Guangying Shao Hong Zhou Zemei Ge guangping chen Runtao Li Baoxue Yang Department of Pharmacology School of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences Ministry of EducationBeijing 100191China School of Pharmaceutical Sciences Peking UniversityBeijing 100191China College of Pharmacy Inner Mongolia Medical UniversityHohhot 010110China Department of Anatomy and Neuroscience Center Chongqing Medical UniversityChongqing 400016China Department of Physiology Emory University School of MedicineAtlantaGA 30322USA

Urea transporters(UT)play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing ***,UT inhibitors are promising for development as novel *** the present study,a novel UT inhibitor with a diarylamide scaffold was discovered by high-throughput *** of the inhibitor led to the identifi-cation of a promising preclinical candidate,N-[4-(acetylamino)phenyl]-5-nitrofuran-2-carboxamide(1 H),with excellent in vitro UT inhibitory activity at the submicromolar *** half maximal inhibitory concentrations of 1 H against UT-B in mouse,rat,and human erythrocyte were 1.60,0.64,and0.13 mmol/L,*** investigation suggested that 8 mmol/L 1 H more powerfully inhibited UT-A1 at a rate of 86.8%than UT-B at a rate of 73.9%in MDCK cell *** interestingly,we found for the first time that oral administration of 1 H at a dose of 100 mg/kg showed superior diuretic effect in vivo without causing electrolyte imbalance in ***,1 H did not exhibit apparent toxicity in vivo and in vitro,and possessed favorable pharmacokinetic characteristics.1 H shows promise as a novel diuretic to treat hyponatremia accompanied with volume expansion and may cause few side effects.

关键词： Urea transporter inhibitor Diuretic Structure optimization Oral administration

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社会资本是否促进污染型企业退出?——来自中国城市的微观数据

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地理研究 2022年第1期41卷 34-45页

作者：翁鸿妹陈广平王琛浙江大学地球科学学院杭州310027 浙江大学地理与空间信息研究所杭州310027

污染型企业的区位选择、转移及其驱动机制研究是环境经济地理研究的热点话题。现有文献从正式制度的角度深入探讨了地方政府的环境规制对污染型企业进入退出、空间分布和产业转移的影响,相对忽视了地方社会资本如公众环保意识、企业环... 详细信息

污染型企业的区位选择、转移及其驱动机制研究是环境经济地理研究的热点话题。现有文献从正式制度的角度深入探讨了地方政府的环境规制对污染型企业进入退出、空间分布和产业转移的影响,相对忽视了地方社会资本如公众环保意识、企业环境责任等非正式制度因素对污染型企业区位选择的作用机制。本文基于2011年中国工业企业数据、中国综合社会调查(CGSS)以及城市统计年鉴等数据资料,从社会规范、社会网络和社会信任三方面构建中国城市尺度社会资本,利用二元logit回归模型探讨了社会资本与环境规制对中国污染型企业退出的影响。研究发现:(1)环境规制对污染型企业退出的促进作用存在门槛效应。(2)公众环保意识、企业环境责任作为社会规范因素,对污染型企业生存构成了外部非正式环境压力;但社会信任和社会网络并没有直接促进污染型企业退出。(3)社会资本在强环境规制地区中的交互作用显著,能够形成正式制度与非正式制度的良好互动。本研究从社会资本这一非正式制度的视角理解污染型企业退出的影响机制,不仅是对正式制度层面环境规制研究的补充,同时也对污染型企业的区位选择和地方政府环境治理政策的制定具有借鉴意义。

关键词：污染型企业企业退出社会资本非正式制度环境规制

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Red blood cell distribution width improves the prediction of 28-daymortality for patients with sepsis-induced acute kidney injury:A retrospective analysis from MIMIC-IV database usingpropensity score matching

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Journal of Intensive Medicine 2023年第3期3卷 275-282页

作者： Honghao Lai Guosheng Wu Yu Zhong guangping chen Wei Zhang Shengjun Shi Zhaofan Xia Department of Burns Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280GuangdongChina Department of Burns Changhai HospitalNaval Medical UniversityShanghai 200433China Research Institute Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510060China Department of Burns Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Background:The predictive value of red blood cell distribution width(RDW)for mortality in patients withsepsis-induced acute kidney injury(SI-AKI)remains *** present study aimed to investigate the potentialassociation between RDW at admission and outcomes in patients with ***:The Medical Information Mart for Intensive Care(MIMIC)-IV(version 2.0)database,released in Juneof 2022,provides medical data of SI-AKI patients to conduct our related *** on propensity scorematching(PSM)method,the main risk factors associated with mortality in SI-AKI were evaluated using Coxproportional hazards regression analysis to construct a predictive *** concordance index(C-index)and decision curve analysis were used to validate the predictive ability and clinical utility of this *** SI-AKI were classified into the high-and low-RDW groups according to the best cut-off value obtained bycalculating the maximum value of the Youden ***:A total of 7574 patients with SI-AKI were identified according to the filter *** withthe low-RDW group,the high-RDW group had higher 28-day(9.49%vs.31.40%,respectively,P<0.001)and7-day(3.96%vs.13.93%,respectively,P<0.001)mortality *** in the high-RDW group were moreprone to AKI progression than those in the low-RDW group(20.80%vs.13.60%,respectively,P<0.001).Basedon matched patients,we developed a nomogram model that included age,white blood cells,RDW,combinedhypertension and presence of a malignant tumor,treatment with vasopressor,dialysis,and invasive ventilation,sequential organ failure assessment,and AKI *** C-index for predicting the probability of 28-day survivalwas *** curve analysis revealed that the model with RDW offered greater net benefit than that ***:The present findings demonstrated the importance of RDW,which improved the predictive ability ofthe nomogram model for the probability of survival in patients with SI-AKI.

关键词： Red blood cell distribution width Sepsis-induced acute kidney injury Medical Information Mart for Intensive Care IV (MIMIC-IV) Propensity score matching Mortality

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