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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. n6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RnA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RnA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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Hilger-type impulsive differential inequality and its application to impulsive synchronization of delayed complex networks on time scales

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Science China(Information Sciences) 2018年第7期61卷 244-246页

作者： Zhenkun HUAnG Jinde cao Youssef n.RAFFOUL School of Science Jimei University School of Mathematics Southeast University Department of Mathematics University of Dayton

The synchronization and synchronous control of complex networks[1]have rich dynamics and are lately receiving much needed attention[2–6].Owing to the major role that impulsive control plays[6]in investigating synchronization problems and impulsive synchronization in dynamical networks,researchers have devoted more time researching them[2–6].However,most of the existing literature concerning impulsive effects are confined to continuous or discrete time domains[2,6].

关键词： Hilger-type impulsive differential inequality and its application to impulsive synchronization of delayed complex networks on time scales

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EVOLUTIOn OF THE ELECTROCHEMICAL CHARACTERISTICS DURInG PITTInG CORROSIOn OF PURE ALUMInUM In SODIUM CHLORIDE SOLUTIOn

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Acta Metallurgica Sinica(English Letters) 2005年第4期18卷 525-532页

作者： Z. Zhang C. Cai F.H. cao Z.n. Gao J.Q. Zhang C.n. cao Department of Chemistry Zhejiang University Hangzhou 310027 China Department of Chemistry Ningxia University Yinchuan 750021 China State Key Laboratory for Corrosion and Protection of Metals Institute of Metal Research The Chinese

The corrosion behavior of pure aluminum in neutral 3.0% （mass fraction） sodium chloride （na-Cl） solution has been studied using electrochemical impedance spectroscopy （EIS） measurement in conjunction with the scanning electron microscopy （SEM） technique. EIS information on the evolution of pitting corrosion over a period of 15 days has been obtained and analyzed with equivalent circuit technique. The results shown that, during the ensemble constant immersion time, two time constants involved, the high frequency one originated from the protective layer on the corroding surface while the low frequenO, one from the diffusion process or the corrosion reaction and so on. And there existed a period for oxide film to growth and thickening prior to the of the attacking of chloride ions to the substrate. Meanwhile, good relationship between EIS and the material corrosion type/severity has been obtained, which has been interpreted according to the characteristics of corrosion process such as auto acceleration of pitting corrosion and the protection of local anodic reaction to the area around them.

关键词： pure aluminum pitting corrosion electrochemical impedance spectroscopy pit-rnorphology

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Quantum beetle antennae search: a novel technique for the constrained portfolio optimization problem

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Science China(Information Sciences) 2021年第5期64卷 121-134页

作者： Ameer Tamoor KHAn Xinwei cao Shuai LI Bin HU Vasilios n.KATSIKIS Department of Computing Hong Kong Polytechnic University School of Management Shanghai University School of Information Science and Engineering Lanzhou University Department of Economics Division of Mathematics and Informatics National and Kapodistrian University of Athens

In this paper, we have formulated quantum beetle antennae search(QBAS), a meta-heuristic optimization algorithm, and a variant of beetle antennae search(BAS). We apply it to portfolio selection,a well-known finance problem. Quantum computing is gaining immense popularity among the scientific community as it outsmarts the conventional computing in efficiency and speed. All the traditional computing algorithms are not directly compatible with quantum computers, for that we need to formulate their variants using the principles of quantum mechanics. In the portfolio optimization problem, we need to find the set of optimal stock such that it minimizes the risk factor and maximizes the mean-return of the portfolio. To the best of our knowledge, no quantum meta-heuristic algorithm has been applied to address this problem yet. We apply QBAS on real-world stock market data and compare the results with other meta-heuristic optimization algorithms. The results obtained show that the QBAS outperforms swarm algorithms such as the particle swarm optimization(PSO) and the genetic algorithm(GA).

关键词： quantum computing beetle antennae search portfolio selection optimization finance problem

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BAS-ADAM:An ADAM Based Approach to Improve the Performance of Beetle Antennae Search Optimizer

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 461-471页

作者： Ameer Hamza Khan Xinwei cao Shuai Li Vasilios n.Katsikis Liefa Liao Department of Computing Hong Kong Polytechnic UniversityHong KongChina School of Management Shanghai UniversityShanghai 201900China Department of Electronics and Electrical Engineering Swansea UniversitySwansea SA18ENUK Department of Economics Division of Mathematics and InformaticsNational and Kapodistrian University of AthensAthens 10679Greece School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

In this paper,we propose enhancements to Beetle Antennae search(BAS)algorithm,called BAS-ADAIVL to smoothen the convergence behavior and avoid trapping in localminima for a highly noin-convex objective *** achieve this by adaptively adjusting the step-size in each iteration using the adaptive moment estimation(ADAM)update *** proposed algorithm also increases the convergence rate in a narrow valley.A key feature of the ADAM update rule is the ability to adjust the step-size for each dimension separately instead of using the same *** ADAM is traditionally used with gradient-based optimization algorithms,therefore we first propose a gradient estimation model without the need to differentiate the objective ***,it demonstrates excellent performance and fast convergence rate in searching for the optimum of noin-convex *** efficiency of the proposed algorithm was tested on three different benchmark problems,including the training of a high-dimensional neural *** performance is compared with particle swarm optimizer(PSO)and the original BAS algorithm.

关键词： Adaptive moment estimation(ADAM) Beetle antennae search(BAM) gradient estimation metaheuristic optimization nature-inspired algorithms neural network

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Comparing hydrogen embrittlement behaviors of two press hardening steels:2 GPa vs.1.5 GPa grade

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Journal of Materials Science & Technology 2022年第29期124卷 109-115页

作者： Z.H.cao B.n.Zhang M.X.Huang Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongChina

*** The pursuit of advanced high-strength steels(AHSS)has been rising for the automobile industry to build lightweight and fuelefficient vehicles without compromising crashworthiness[1,2].The group of press hardening steels(PHS)is an excellent candidate that comprises high strength,high toughness,and good formability,which are optimal to build intrusion resistant components such as(ⅰ)A/B-pillar reinforcements,(ⅱ)bumper and door beams.

关键词： strength toughness steels

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Eye and Vision 2019年第1期6卷 322-330页

作者： Ke cao Srujana Sahebjada Andrea J.Richardson Paul n.Baird Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalMelbourneAustralia. Department of Surgery OphthalmologyThe University of Melbourne32 Gisborne StreetEast MelbourneVIC 3000Australia

Background:Keratoconus(KC)is a common corneal condition with an unknown gender *** numerous studies have investigated the genetic component of KC,no specific genes have yet been attributed to the *** recently reported posterior segment changes occurring in the eyes of KC ***,it is not clear whether these changes are part of KC pathogenesis or reflect changes in anatomical features of the eye manifested by changes at the *** retinal changes represent the main characteristics observed in agerelated macular degeneration(AMD)and that pleiotropy has been demonstrated between different eye diseases,we wished to assess if known AMD associated genes were also associated with ***:A total of 248 KC subjects and 366 non-KC(control)subjects were recruited from public and private clinics in Melbourne for this *** single nucleotide polymorphisms(SnPs)previously associated with AMD,including rs10490924(ARMS2/HTRA1),rs10737680(CFH),rs13278062(TnFRSF10A),rs1864163(CETP),rs2230199(C3),rs3130783(IER3/DDR1),rs334353(TGFBR1),rs3812111(COL10A1),rs429608(C2/CFB),rs4420638(APOE),rs4698775(CFI),rs5749482(TIMP3),rs6795735(ADAMTS9),rs8017304(RAD51B),rs8135665(SLC16A8),rs920915(LIPC),rs943080(VEGFA),rs9542236(B3GALTL)and rs13081855(COL8A1/FILIP1L),were genotyped in this *** regression was applied to evaluate the association between these SnPs and KC on both genders together,as well as each gender *** regression was also applied to assess the association between SnPs and corneal *** correction was applied to adjust for multiple ***:Genotyping data were available for 18 *** SnP,rs6795735(ADAMTS9)was significantly associated with KC(p=3.5×10−4)when both genders were assessed,whereas rs5749482(TIMP3)was only associated in males(p=7.7×10−4)following Bonferroni multiple ***,when the covariates of age and gender were included,the associations became non-sign

关键词： Keratoconus Gender Genetic Age-related macular degeneration

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SAMPLED-DATA STATE ESTIMATIOn FOR nEURAL nETWORKS WITH ADDITIVE TIME–VARYInG DELAYS

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Acta Mathematica Scientia 2019年第1期39卷 195-213页

作者： M.SYED ALI n.GUnASEKARAn Jinde cao Department of Mathematics Thiruvalluvar University Research Center for Wind Energy Systems Kunsan National University School of Mathematics Southeast University

In this paper, we consider the problem of delay-dependent stability for state estimation of neural networks with two additive time–varying delay components via sampleddata control. By constructing a suitable Lyapunov–Krasovskii functional with triple and four integral terms and by using Jensen's inequality, a new delay-dependent stability criterion is derived in terms of linear matrix inequalities(LMIs) to ensure the asymptotic stability of the equilibrium point of the considered neural networks. Instead of the continuous measurement,the sampled measurement is used to estimate the neuron states, and a sampled-data estimator is constructed. Due to the delay-dependent method, a significant source of conservativeness that could be further reduced lies in the calculation of the time-derivative of the Lyapunov functional. The relationship between the time-varying delay and its upper bound is taken into account when estimating the upper bound of the derivative of Lyapunov functional. As a result, some less conservative stability criteria are established for systems with two successive delay components. Finally, numerical example is given to show the superiority of proposed method.

关键词： Lyapunov method linear matrix inequality state estimation sample-data control time-varying delays

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深板层角膜移植与穿透性角膜移植治疗基质角膜营养不良预后的比较

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中国组织工程研究 2025年第8期29卷 1626-1633页

作者：静如意陈颖欣曹蕾北部战区总医院辽宁省沈阳市110000

背景:基质角膜营养不良的传统手术治疗方式为穿透性角膜移植,近年来越来越多的医生开始考虑使用深板层角膜移植治疗基质角膜营养不良。目前国内对比穿透性角膜移植和深板层角膜移植治疗基质角膜营养不良的研究少有报道。目的:比较深板... 详细信息

背景:基质角膜营养不良的传统手术治疗方式为穿透性角膜移植,近年来越来越多的医生开始考虑使用深板层角膜移植治疗基质角膜营养不良。目前国内对比穿透性角膜移植和深板层角膜移植治疗基质角膜营养不良的研究少有报道。目的:比较深板层角膜移植和穿透性角膜移植治疗基质角膜营养不良的疗效。方法:选择2000年1月至2018年1月北部战区总医院收治的基质角膜营养不良患者57例(57眼),男18例,女39例,平均年龄(52.9±20.0)岁,按照手术治疗方式分为深板层角膜移植组(n=21)、穿性角膜移植组(n=36),术后随访观察最佳矫正视力、角膜内皮细胞密度、角膜植片透明度、术中及术后并发症、原病复发情况。结果与结论:①两组患者术后1,3,6,12个月的视力均高于术前(P0.05);随着术后时间的延长,两组患者角膜内皮细胞密度逐渐降低,穿透性角膜移植组患者术后6,12个月的角膜内皮细胞密度年丢失率均高于深板层角膜移植组(P0.05);②深板层角膜移植组有6例出现并发症,穿透性角膜移植组有14例出现并发症,57例患者术后12个月内均无复发,两组患者术后5年的复发率比较差异无显著性意义(P>0.05),穿透性角膜移植组和深板层角膜移植组术后5年的移植物存活率分别为83%和86%,组间比较差异无显著性意义(P>0.05);③结果表明,基质角膜营养不良的治疗可考虑使用深板层角膜移植替代一部分穿透性角膜移植。

关键词：穿透性角膜移植深板层角膜移植基质角膜营养不良最佳矫正视力角膜植片透明度角膜内皮细胞密度并发症复发

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Photo-and electro-production of narrow exotic states:From light quarks to charm and up to bottom

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Frontiers of physics 2023年第4期18卷 71-94页

作者： Xu cao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049China Research Center for Hadron and CSR Physics Lanzhou University and Institute of Modern Physics of CASLanzhou 730000China

Accessing a full image of the inner content of hadrons represents a central endeavour of modern particle physics,with the main scientific motivation to investigate the strong interaction binding the visible *** the one hand,the structure of known exotic candidates is a fundamental open issue addressed widely by *** the other hand,looking for new states of exotic nature is a central component for theoretical and experimental efforts from electron-positron machine and electron accelerator with fixed target to heavy ion and electron-ion *** this article we present a succinct short overview of the attempt to search for exotic narrow n∗and Z states containing light quarks only or also charm,and its connotation for bottom regions(the latter two are also known as Pc(Zc)and Pb(Zb)states,respectively in the literature).We address the effort of searching for exotic narrow n∗and Z states in light quark *** focus on recent progress in searching for signal of Pc and Zc states photoproduction and its implication into the Pb and Zb photoproduction and their decay *** also discuss future perspectives for the field in electron-ion colliders,a good place to disentangle the nature of some of these states and investigate some other enlightening topics including QCD trace anomaly and quarkonium-nucleon scattering length.

关键词： exotic states photo-and electro-production electron-ion colliders hadron

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