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Thiolated arsenicals in arsenic metabolism: Occurrence,formation, and biological implications

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Journal of Environmental Sciences 2016年第11期28卷 59-73页

作者： Yuzhen Sun Guangliang liu Yong Cai Institute of Environment and Health Jianghan University Department of Chemistry and Biochemistry&Southeast Environmental Research Center Florida International University

Arsenic（As） is a notoriously toxic pollutant of health concern worldwide with potential risk of cancer induction, but meanwhile it is used as medicines for the treatment of different conditions including hematological cancers. Arsenic can undergo extensive metabolism in biological systems, and both toxicological and therapeutic effects of arsenic compounds are closely related to their metabolism. Recent studies have identified methylated thioarsenicals as a new class of arsenic metabolites in biological systems after exposure of inorganic and organic arsenicals, including arsenite, dimethylarsinic acid（DMAV）, dimethylarsinous glutathione（DMAIIIGS）, and arsenosugars. The increasing detection of thiolated arsenicals,including monomethylmonothioarsonic acid（MMMTAV）, dimethylmonothioarsinic acid（DMMTAV） and its glutathione conjugate（DMMTAVGS）, and dimethyldithioarsinic acid（DMDTAV） suggests that thioarsenicals may be important metabolites and play important roles in arsenic toxicity and therapeutic effects. Here we summarized the reported occurrence of thioarsenicals in biological systems, the possible formation pathways of thioarsenicals, and their toxicity, and discussed the biological implications of thioarsenicals on arsenic metabolism, toxicity, and therapeutic effects.

关键词： Arsenic Thioarsenicals Occurrence Formation pathways Toxicity

Porcine Bocavirus: A 10-Year History since Its Discovery

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Virologica Sinica 2021年第6期36卷 1261-1272页

作者： Manita Aryal Guangliang liu State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730046China

Porcine bocavirus(PBoV)is a single-stranded DNA virus,belongs to the genus Bocaparvovirus of family Parvoviridae.It was discovered along with porcine circovirus 2(PCV 2)and torque tenovirus(TTV)in the lymph nodes of pigs suffering from postweaning multisystemic wasting syndrome(PMWS)in Sweden in 2009.PBoV has been reported throughout the world,mostly in weaning piglets,and has a broad range of tissue tropism.Since PBoV is prevalent in healthy as well as clinically infected pigs and is mostly associated with coinfection with other viruses,the pathogenic nature of PBoV is still unclear.Currently,there are no cell lines available for the study of PBoV,and animal model experiments have not been described.This review summarizes the current state of knowledge about PBoV,including the epidemiology,evolution analysis,detection methods,pathogenesis and public health concerns.

关键词： Porcine bocavirus(PBoV) Emerging pathogen Epidemiology Evolution Detection Pathogenesis Coinfection Public health concerns

Refining mercury emission estimations to the atmosphere from iron and steel production

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Journal of Environmental Sciences 2016年第5期28卷 1-3页

作者： Yongmin Wang Guangliang liu Dingyong Wang Yong Cai College of Resource and Environment Southwest University Institute of Environment and Health Jianghan University Department of Chemistry and Biochemistry Southeast Environmental Research Center Florida International University

Due to its long-range transport in the atmosphere,mercury is a pollutant of global concern with health risks to humans and ecosystems worldwide（Li et al.,2012;Lindqvist et al.,1991;liu et al.,2012a;Tang et al.,2016;Wang et al.,2015;Shao et al.,2016）.Atmospheric mercury,mainly from emission from various natural and anthropogenic sources and re-emission of previously released mercury built up in surface soils and oceans,

关键词： Mercury Emission Iron and steel production Anthropogenic sources

Synthesis of Flowerlike MoS_(2)/CoNi Composites for Enhancing Electromagnetic Wave Absorption

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Acta Metallurgica Sinica(English Letters) 2022年第6期35卷 890-900页

作者： Fei Hu Jingxiong Dai Qi liu Zhiquan Zhang guangliang Xu State Key Laboratory of Environment-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China School of Materials Science and Engineering Southwest University of Science and TechnologyMianyang 621010China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Mianyang 621010China

The hierarchical MoS_(2)/CoNi composites were successfully synthesized by a two-step hydrothermal method.The large surface area of the MoS_(2) enhances the dispersivity of the CoNi nanoparticles and the formation of abundant MoS_(2)/CoNi interfaces,which make an important contribution to the dielectric loss,and the introduction of the CoNi improves impedance matching and introduces magnetic loss,which can improve the absorption performance to electromagnetic waves.Through the calculation of the electromagnetic parameters,the minimum reflection loss(RL)value of the MoS_(2)/CoNi composites achieves-41.44 dB at 13.53 GHz under a thickness of 2.0 mm and the corresponding effective absorption bandwidth(RL below-10 dB)is 5.6 GHz.The MoS_(2)/CoNi composite has the potential to be applied to microwave absorption due to its strong absorption and wide bandwidth.

关键词： MoS_(2)/CoNi composite Microwave absorption Interfacial polarization Impedance matching

A network-based virtual slack bus model for energy conversion units in dynamic energy flow analysis

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Science China(Technological Sciences) 2023年第1期66卷 243-254页

作者： HUANG YuJia SUN QiuYe WANG Rui liu guangliang School of Information Science and Engineering Northeastern UniversityShenyang 110819China

Integrated energy system(IES) is a viable route to “carbon peak and carbon neutral”. As the basis and cornerstone of economic operation and security of IES, energy flow calculation(EFC) has been widely studied. Traditional EFC focuses on the single or distributed slack bus models, which results in the lack of unlimited power to maintain system operation, especially for electric power grid working in islanded or coupled mode. To deal with this problem, this paper proposes a network-based virtual-slack bus(VSB) model in EFC. Firstly, considering the anticipated growth of energy conversion units(ECUs) with power adjustment capacity, the generators and ECUs are together modeled as a virtual slack bus model to reduce the concentrated power burden of IES. Based on this model, a power sensitivity method is designed to achieve the power sharing among the ECUs, where the power can be allocated adaptively based on the network conditions. Moreover, the method is helpful to maintain the voltage and pressure profile of IES. With these changes, a dynamic energy flow analysis including virtual slack bus types is extended for IES.It can realize the assessment of the system state. Finally, simulation studies illustrate the beneficial roles of the VSB model.

关键词： integrated energy system energy flow analysis power sensitivity method virtual slack bus

Wnt3a-induced ST2 decellularized matrix ornamented PCL scaffold for bone tissue engineering

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BIOCELL 2022年第9期46卷 2089-2099页

作者： XIAOFANG WANG XIAOLIN TU YUFEI MA JIE CHEN YANG SONG Guangliang liu Laboratory of Skeletal Development and Regeneration The Institute of Life ScienceChongqing Medical UniversityChongqing400016China Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisIN46202USA Bioengineering Collage Chongqing UniversityChongqing400044China

The limited bioactivity of scaffold materials is an important factor that restricts the development of bone tissue engineering.Wnt3a activates the classicWnt/β-catenin signaling pathway which effects bone growth and development by the accumulation ofβ-catenin in the nucleus.In this study,we fabricated 3D printed PCL scaffold with Wnt3a-induced murine bone marrow-derived stromal cell line ST2 decellularized matrix(Wnt3a-ST2-dCM-PCL)and ST2 decellularized matrix(ST2-dCM-PCL)by freeze-thaw cycle and DNase decellularization treatment which efficiently decellularized>90%DNA while preserved most protein.Compared to ST2-dCM-PCL,Wnt3a-ST2-dCM-PCL significantly enhanced newly-seeded ST2 proliferation,osteogenic differentiation and upregulated osteogenic marker genes alkaline phosphatase(Alp),Runx2,type I collagen(Col 1)and osteocalcin(Ocn)mRNA expression.After 14 days of osteogenic induction,Wnt3a-ST2-dCM-PCL promoted ST2 mineralization.These results demonstrated that Wnt3a-induced ST2 decellularized matrix improve scaffold materials’osteoinductivity and osteoconductivity.

关键词： Wnt3a Decellularized matrix Bone marrow stromal cells Osteogenic differentiation Bone tissue engineering

Dissolved metal ion removal by online hollow fiber ultrafiltration for enhanced size characterization of metal-containing nanoparticles with single-particle ICP-MS

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Journal of Environmental Sciences 2023年第4期126卷 494-505页

作者： Haowen Jiang YingWang Zhiqiang Tan Ligang Hu Jianbo Shi Guangliang liu Yongguang Yin Yong Cai Guibin Jiang Laboratory of Environmental Nanotechnology and Health Effect Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry and Biochemistry Florida International UniversityMiami 33199USA School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

Single particle-inductively coupled plasma mass spectrometry (SP-ICP-MS) is a powerful tool for size-characterization of metal-containing nanoparticles (MCNs) at environmentally relevant concentrations,however,coexisting dissolved metal ions greatly interfere with the accuracy of particle size analysis.The purpose of this study is to develop an online technique that couples hollow fiber ultrafiltration (HFUF) with SP-ICP-MS to improve the accuracy and size detection limit of MCNs by removing metal ions from suspensions of MCNs.Through systematic optimization of conditions including the type and concentration of surfactant and complexing agent,carrier pH,and ion cleaning time,HFUF completely removes metal ions but retains the MCNs in suspension.The optimal conditions include using a mixture of 0.05 vol.%FL-70 and 0.5 mmol/L Na2S2O_(3)(pH=8.0) as the carrier and 4 min as the ion cleaning time.At these conditions,HFUF-SP-ICP-MS accurately determines the sizes of MCNs,and the results agree with the size distribution determined by transmission electron microscopy,even when metal ions also are present in the sample.In addition,reducing the ionic background through HFUF also lowers the particle size detection limit with SP-ICP-MS (e.g.,from 28.3 to 14.2 nm for gold nanoparticles).This size-based ion-removal principle provided by HFUF is suitable for both cations (e.g.,Ag+) and anions (e.g.,AuCl_(4)^(-)) and thus has good versatility compared to ion exchange purification and promising prospects for the removal of salts and macromolecules before single particle analysis.

关键词： Hollow fiber ultrafiltration(HFUF) Single particle-inductively coupled plasma mass spectrometry (SP-ICP-MS) Removal of ions Particle size characterization

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

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Bioactive Materials 2023年第3期21卷 110-128页

作者： Xiaofang Wang Yufei Ma Jie Chen Yujiao liu Guangliang liu Pengtao Wang Bo Wang Makoto M.Taketo Teresita Bellido Xiaolin Tu Laboratory of Skeletal Development and Regeneration Institute of Life SciencesChongqing Medical UniversityChongqing400016China Department of Pharmacology Graduate School of MedicineKyoto UniversityKyoto606-8501Japan Department of Physiology and Cell Biology University of Arkansas for Medical SciencesLittle RockAR72223USA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisIN46202USA

Cell source is the key to decellularized matrix(DM)strategy.This study compared 3 cell types,osteocytes with/without dominant active Wnt/β-catenin signaling(daCO and WTO)and bone marrow stromal cells(BMSCs)for their DMs in bone repair.Decellularization removes all organelles and>95%DNA,and retained>74%collagen and>71%GAG,maintains the integrity of cell basement membrane with dense boundaries showing oval and honeycomb structure in osteocytic DM and smooth but irregular shape in the BMSC-DM.DM produced higher cell survival rate(90%)and higher proliferative activity.In vitro,daCO-DM induces more and longer stress fibers in BMSCs,conducive to cell adhesion,spreading,and osteogenic differentiation.8-wk after implantation of the critical-sized parietal bone defect model,daCO-DM formed tight structures,composed of a large number of densely-arranged type-I collagen under polarized light microscope,which is similar to and integrated with host bone.BV/TV(>54%)was 1.5,2.9,and 3.5 times of WTO-DM,BMSC-DM,and none-DM groups,and N.Ob/T.Ar(3.2×10^(2)/mm^(2))was 1.7,2.9,and 3.3 times.At 4-wk,daCO-DM induced osteoclastogenesis,2.3 times higher than WTO-DM;but BMSC-DM or none-DM didn't.daCO-DM increased the expression of RANKL and MCSF,Vegfa and Angpt1,and Ngf in BMSCs,which contributes to osteoclastogenesis,angiogenesis,and neurogenesis,respectively.daCO-DM promoted H-type vessel formation and nerve markersβ3-tubulin and NeuN expression.Conclusion:daCO-DM produces metabolic and neurovascularized organoid bone to accelerate the repair of bone defects.These features are expected to achieve the effect of autologous bone transplantation,suitable for transformation application.

关键词： Decellularized matrix Osteocyte Wnt signaling 3D printing Regenerative repair Metabolic and neurovascular organoid bone

Simulation of urban expansion based on cellular automata and maximum entropy model

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Science China Earth Sciences 2020年第5期63卷 701-712页

作者： Yihan ZHANG Xiaoping liu guangliang CHEN Guohua HU School of Geography and Tourism Guangdong University of Finance and EconomicsGuangzhou 510230China Guangdong Key Laboratory for Urbanization and Geo-simulation School of Geography and PlanningSun Yat-sen UniversityGuangzhou 510275China School of Geographic Sciences East China Normal UniversityShanghai 200241China

Urban expansion is a hot topic in land use/land cover change(LUCC)researches.In this paper,maximum entropy model and cellular automata(CA)model are coupled into a new CA model(Maxent-CA)for urban expansion.This model can help to obtain transition rules from single-period dataset.Moreover,it can be constructed and calibrated easily with several steps.Firstly,Maxent-CA model was built by using remote sensing data of China in 2000(basic data)and spatial variables(such as population density and Euclidean distance to cities).Secondly,the proposed model was calibrated by analyzing training samples,neighborhood structure and spatial scale.Finally,this model was verified by comparing logistic regression CA model and their simulation results.Experiments showed that suitable sampling ratio(sampling ratio equals the proportion of urban land in the whole region)and von Neumann neighborhood structure will help to yield better results.Spatial structure of simulation results becomes simple as spatial resolution decreases.Besides,simulation accuracy is significantly affected by spatial resolution.Compared to simulation results of logistic regression CA model,Maxent-CA model can avoid clusters phenomenon and obtain better results matching actual situation.It is found that the proposed model performs well in simulating urban expansion of China.It will be helpful for simulating even larger study area in the background of global environment changes.

关键词： Land use/land cover change(LUCC) Cellular automata(CA) Urban expansion Maximum entropy model