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Flame-retardant quasi-solid polymer electrolyte enabling sodium metal batteries with highly safe characteristic and superior cycling stability

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Nano Research 2019年第9期12卷 2230-2237页

作者： Jinfeng Yang Min Zhang Zheng Chen Xiaofan Du Suqi huang Ben Tang Tiantian Dong Han Wu Zhe Yu Jianjun Zhang guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Center of Materials Science and Optoelectronics Engirt eering University of Chinese Academy of SciencesBeijing 100049China School of Material Science and Engineering Qingdao UniversityQingdao 266071China

Con ventio nal liquid electrolytes based sodium metal batteries suffer from severe safety hazards owing to electrolyte leakage,in flammability and dendritic sodium deposit!***,we report a flame-retardant quasi-solid polymer electrolyte with poly(methyl vinyl ether-alt-maleic an hydride)(P(MVE-alt-MA))as host,bacterial cellulose(BC)as reinforceme nt,and triethyl phosphate/vinyle ne carb on ate/sodium perchlorate(TEP/VC/NaClO4)as plasticizer for highly safe sodium metal *** as-obtained quasi-solid polymer electrolyte exhibits superior flame retardancy(self-extinguish within 1 s),complete non-leakage property and wide electrochemical windows(4.4 V).More importantly,Na3V2(PO4)3/Na metal batteries using such polymer electrolyte delivers superior I on g-term cycli ng stability(84.4%capacity rete ntion after 1000 cycles)which is significantly better than that(only 2%after 240 cycles)of liquid *** addition,this flame-retardant quasi-solid polymer electrolyte provides favorable cycle performance(80.2%capacity retention after 70 cycles at 50°C and 84.8%capacity retention after 50 cycles at-10°C)for Na3V2(PO4)3/Na metal *** this battery also displayed a normal charge/discharge property even at-15°*** fascinating cycle properties are mainly ascribed to the effective pro怕ctive layers formed on Na3V2(PC>4)3 cathode and sodium metal ano *** thorough in vestigati on elucidates that such flame-retardant quasi-solid polymer electrolyte plays a multif unctional role in the adva need sodium metal batteries:(1)being in volved in the formatio n of a favorable cathode electrolyte in terface(CEI)to inhibit the dissolutio n of van adium and maintai n the structure integrity of the Na3V2(PO4)3;(2)participati ng in building a stable solid electrolyte in terface(SEI)to suppress the growth of Na dendrites;(3)integrating flame-retardanee into polymer sodium batteries to enhance flame-resistanee,eliminate electrolyte leakage,and thus improve safety of

关键词： flame-retarda nt quasi-solid polymer electrolyte highly safe characteristic sodium metal batteries long-term cycling stability

An in-situ generated composite solid-state electrolyte towards high-voltage lithium metal batteries

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Science China Chemistry 2022年第5期65卷 934-942页

作者： Qinglei Wang Tiantian Dong Qian Zhou Zili Cui Xuehui Shangguan Chenglong Lu Zhaolin Lv Kai Chen Lang huang Huanrui Zhang guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266100China School of Materials Science and Engineering Linyi UniversityLinyi 276000China School of Materials Science and Engineering Ocean University of ChinaQingdao 266042China

The solid-state electrolyte(SSE) has promising applications in next-generation lithium(Li) metal batteries(LMBs) because of its significantly enhanced safety and more compatible interface characteristics than flammable traditional liquid ***,only a few attempts have achieved high-performance high-voltage LMBs,which is attributed to the fact that both high ionic conductivity and good compatibility with electrodes can hardly be achieved ***,a composite solid-state electrolyte(CSE) based on star-shaped siloxane-based polymer electrolyte coupled with Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(LLZTO)ceramic fillers is designed and prepared through a facile in-situ polymerization *** obtained CSE exhibits high ionic conductivity(i.e.,1.68 × 10^(-4) S cm^(-1) at a temperature of 60 ℃),superior anodic stability,and high Li-ion transference number(i.e.,0.53) because of the multifunctional synergistic effect of the polymer electrolyte with LLZTO ceramic ***,the as-developed CSE shows excellent compatibility with Li *** a result,the as-developed CSE enables the development of long-life 4.4-V-class solid-state LMBs with a Li CoO_(2) cathode,with 79.7% capacity retention and 99.74% average Coulombic efficiency after 500 cycles at a 0.5 C *** analysis of cycled batteries confirms that such superior battery performance can be mainly ascribed to the formation of a compatible electrode/electrolyte ***,excellent safety features can be observed in LiCoO_(2)/Li pouch *** work provides an important guide for the rational design of SSEs for high-voltage LMBs.

关键词： composite solid-state electrolyte in-situ lithium metal batteries high-voltage

基于ANSYS的剖分式机械密封热力耦合分析

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机械工程师 2024年第6期 106-109页

作者：黄朝林曾光磊朱权廖国平奚文杰帅梦潇自贡蜜蜂牌机械密封有限责任公司四川自贡643002 西华大学机械工程学院成都610039

为了研究摩擦热、介质压力对剖分式机械密封变形的影响,对剖分式机械密封进行热力耦合数值分析。结果表明:在温度场中密封环外径侧温度较低,剖分动环端面最高温度出现在与剖分静环相接触的密封端面处,剖分静环端面最高温度出现在密封端... 详细信息

为了研究摩擦热、介质压力对剖分式机械密封变形的影响,对剖分式机械密封进行热力耦合数值分析。结果表明:在温度场中密封环外径侧温度较低,剖分动环端面最高温度出现在与剖分静环相接触的密封端面处,剖分静环端面最高温度出现在密封端面内径处;在热、力耦合作用下密封端面由外径向内径的变形形成收敛状间隙;随着介质压力增大,密封环的轴向变形增大,密封环分型面的径向变形减小;介质压力的变化导致密封环端面间产生的摩擦热不同,从而引起密封环变形的差异。

关键词：剖分式机械密封热力耦合分型面

Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP

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Science Bulletin 2018年第17期63卷 1101-1107页

作者： Guang Yang Tianyu Zhu Zongyang Lu guanglei Li Hao Zhang Songjie Feng Yajing Liu Jianan Li Yu Zhang Jia Chen Xuejiang Guo Xingxu huang School of Life Science and Technology Shanghai Tech University Shanghai 201210 China State Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing 211166 China

Although CRISPR/Cas9 has been widely used to generate knockout mice, two major limitations remain:the founders usually carry a mixture of genotypes, and mosaicism harboring multiple ***, it takes a long time to get homozygous mutants. Recently developed base editing(BE) system,which introduces C-to-T conversion without double strand DNA cleavage, has been used to introduce artificial stop codons(i-STOP) to prematurely terminate translation, providing a cleaner strategy for genome engineering. Using this strategy, we generated CD160 KO and VISTA/CD160 double KO mice by microinjection of a single sg RNA targeting CD160 and a mixture of sg RNAs targeting VISTA and CD160,respectively. The BE system induced STOP efficiently in mouse embryos and consequently in founder mice without detectable off-target. Most interestingly, the majority of the mutants harbor same genetic modifications, indicating we generated isogenic single and multiplex gene mutant mice by BE-induced STOP. We also obtained homozygous mutant mouse in F1 mice, demonstrating the accelerated strategy in generating animal models.

关键词： Base editing i-STOP isogenic Knockout VISTA CDI60

Rational construction and triethylamine sensing performance of foam shapedα-MoO_(3)@SnS_(2) nanosheets

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Chinese Chemical Letters 2022年第1期33卷 567-572页

作者： Xianhui Dong Qing Han Yaru Kang Haidong Li Xinyu huang Zhengtao Fang Huimin Yuan Ahmed A.Elzatahry Zongtao Chi guanglei Wu Wanfeng Xie School of Material Science&Engineering Institute of Materials for Energy and EnvironmentState Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071China School of Electronics and Information Qingdao UniversityQingdao 266071China College of Physics and Electronic Engineering Qilu Normal UniversityJi'nan 250200China Materials Science and Technology Program College of Arts and SciencesQatar UniversityPO Box 2713DohaQatar

Owing to their high surface area,stable structure and easy fabrication,composite nanomaterials with encapsulation structures have attracted considerable research interest as sensing materials to detect volatile organic ***,a hydrothermal route is designed to prepare foam shapedα-MoO_(3)@SnS_(2)nanosheets that exhibit excellent sensing performance for triethylamine(TEA).The developed sensor,based onα-MoO_(3)@SnS_(2)nanosheets,displays a high response of 114.9 for 100 ppm TEA at a low working temperature of 175℃with sensitivity higher than many other reported *** addition,the device shows a wide concentration detection range(from 500 ppb to 500 ppm),good stability after exposure to air for 80 days,and excellent *** superior sensing characteristics of the developed sensor are attributed to the high crystallinity ofα-MoO_(3)/SnS_(2),excessive and accessible active sites provided by the good permeability of porous SnS_(2)shells,and the excellent conductivity of the encapsulation heterojunction ***,the foam shapedα-MoO_(3)@SnS_(2)nanosheets presented herein have promising practical applications in TEA gas sensing devices.

关键词： MoO_(3) SnS_(2) Encapsulation heterojunction Triethylamine Sensing performance

Highly efficient and precise base editing in discarded human tripronuclear embryos

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Protein & Cell 2017年第10期8卷 776-779页

作者： guanglei Li Yajing Liu Yanting Zeng Jianan Li Lijie Wang Guang Yang Dunjin Chen Xiaoyun Shang Jia Chen Xingxu huang Jianqiao Liu Department of Reproductive Medicine Third Affiliated Hospital ( Guangzhou Medical University Guangzhou 510150 China School of Life Science and Technology ShanghaiTech University Shanghai 201210 China Institute of Immunology PLA Third Military Medical University Chongqing 400038 China Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes Key Laboratory for Major Obstetric Diseases of Guangdong Province Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China

CRISPR/Cas9 is a powerful tool for genome editing （Komor et al., 2017）. Recently, it has been employed in several attempts to edit the human embryos （Liang et al., 2015; Kang et al., 2016; Tang et al., 2017）.

关键词： GENOME NUCLEASES CLEAVAGE ZYGOTES

A polymer electrolyte with a thermally induced interfacial ion-blocking function enables safety-enhanced lithium metal batteries

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eScience 2022年第2期2卷 201-208页

作者： Huanrui Zhang Lang huang Hantao Xu Xiaohu Zhang Zhou Chen Chenhui Gao Chenglong Lu Zhi Liu Meifang Jiang guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesNo.189 Songling RoadQingdao266101China College of Chemistry and Chemical Engineering Yantai UniversityYantai264005China School of Future Technology University of Chinese Academy of SciencesChina

Lithium metal batteries(LMBs)have recently been revitalized as one of the most promising electrochemical energy storage systems,owing to the ultrahigh specific capacity(3860 mAh g^(-1))and ultralow potential(-3.04 V *** hydrogen electrode)of lithium metal ***,safety hazards originating from lithium dendrite growth and pulverization during cycling and thermal stimulation present significant challenges to the practical application of *** address this issue,we have developed an in situ polymer electrolyte with thermally induced interfacial ion-blocking *** demonstrate that the repolymerization and deposition of residual vinylene carbonate in the as-prepared electrolyte under thermal abuse predominantly results in thermally induced ion blocking at the solid electrolyte interface,thus achieving superior LMB *** developed polymer electrolyte also yields superior cyclability in *** design philosophy provides a good paradigm for improving the safety of LMBs.

关键词： Lithium metal battery Polymer electrolyte Interfacial ion-blocking ability Battery safety

Gene editing and its applications in biomedicine

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Science China(Life Sciences) 2022年第4期65卷 660-700页

作者： guanglei Li Xiangyang Li Songkuan Zhuang Liren Wang Yifan Zhu Yangcan Chen Wen Sun Zeguang Wu Zhuo Zhou Jia Chen Xingxu huang Jin Wang Dali Li Wei Li Haoyi Wang Wensheng Wei School of Life Science and Technology ShanghaiTech UniversityShanghai201210China Department of Clinical Laboratory Shenzhen Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen518035China Shanghai Frontiers Science Research Base of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai200241China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Institute for Stem Cell and Regenerative Medicine Chinese Academy of SciencesBeijing100101China Biomedical Pioneering Innovation Center Beijing Advanced Innovation Center for GenomicsPeking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing100871China Gene Editing Center School of Life Science and TechnologyShanghaiTech UniversityShanghai201210China Bejing Institute for Stem Cell and Regenerative Medicine Beijing100101China HIT Center for Life Sciences Harbin Institute of TechnologyHarbin150001China

The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats(CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormous opportunities to advance biomedical research and promote human health. The application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability. Here, we provide a general summary of emerging biomedical applications of genome editing, including open challenges. We also summarize the tools of genome editing and the insights derived from their applications, hoping to accelerate new discoveries and therapies in biomedicine.

关键词： gene editing CRISPR high-throughput functional genomics diagnostics animal model therapeutics

Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos

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Journal of Genetics and Genomics 2022年第10期49卷 982-985页

作者： Yubing Liu Xinmei Lu Min Ye Ling Wang Rongxin Tang Zhiyong Yang Bongkoch Turathum Chenchen Liu Yujing Xue Menghua Wu Yannan Yang Ermeng Gao Di Zhang Feng Yang Keh-Kooi Kee Xingxu huang guanglei Li Ri-Cheng Chian Center for Reproductive Medicine Tenth People's Hospital of Tongji University301 Middle Yanchang RoadShanghai 200072China Center for Reproductive Medicine Zhongshan HospitalFudan University180 Fenglin RoadShanghai 200032China Center for Stem Cell Biology and Regenerative Medicine Department of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China Department of Basic Medical Science Faculty of Medicine Vajira HospitalNavamindradhiraj UniversityBangkok 10300Thailand School of Life Science and Technology Shanghai Tech University100 Haike RoadPudong New AreaShanghai 201210China

The Dux gene plays an important role in mouse embryo development(De Iaco et al.,2017;Hendrickson et al.,2017;Whiddon et al.,2017).It participates in the maternal-to-zygotic transition(MTZ),which mainly includes maternal transcript degradation and zygotic genome activation(ZGA)and is the key process for embryonic *** 11-100 copies of the DUX4 gene form a tandem cluster in the human genome(Snider et al.,2009,2010).

关键词： development maternal