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Nano Research 2023年第12期16卷 13042-13055页

作者： Fenfen Li Ying Zhao guangjun nie School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 101408China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China GBA National Institute for Nanotechnology Innovation Guangzhou 510530China

Liver fibrosis and hepatic carcinoma(HCC)pose a huge challenge worldwide due to the lack of effective treatment options for end-stage liver *** to their functions and roles,hepatic myofibroblasts mainly include nontumoral fibroblasts(mainly activated hepatic stellate cells(HSCs)),which are involved in the wound-healing process of liver fibrosis,and cancer-associated fibroblasts(CAFs)in hepatic *** play a significant role in regulating extracellular matrix(ECM)deposition in progressive liver *** can be derived from activated HSCs and differentiate into ECM-producing ***,growing evidence shows that CAFs are the primary regulators of the HCC microenvironment,releasing growth factors and cytokines and suppressing the antitumor immune *** therapeutic strategies show reduced drug resistance and side ***-based combined strategies aim to improve the delivery efficiency of various therapeutic agents with reduced toxicity via multiple *** this review,we will discuss recent developments in combinational strategies based on nanotechnology that regulate myofibroblasts and the diseased microenvironment for liver fibrosis and HCC *** will also identify the major challenges that the field is facing and offer some insights for future drug discovery.

关键词： fibroblasts liver fibrosis hepatic carcinoma nanotechnology

Tumor-discriminating Nanoceria Antioxidant Enables Protection Against Acute Kidney Injury Without Compromising Chemotherapeutic Effects

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Chemical Research in Chinese Universities 2021年第3期37卷 621-622页

作者： WANG Jing nie guangjun ZHAO Yuliang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety National Center for Nanoscience and TechnologyBeijing100190P.R.China

Acute kidney injury is one of the most troublesome and lethal adverse effects in patients receiving *** approaches that mitigate the toxicity of chemotherapeutic agents,however,also consequently compromise their tumor... 详细信息

关键词： Acute Antioxidant Kidney

Precise design of nanomedicines: perspectives for cancer treatment

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National Science Review 2019年第6期6卷 1107-1110页

作者： Jing Wang Yiye Li guangjun nie Yuliang Zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology University of Chinese Academy of Sciences

Nanomedicine is a field in which nanomaterials and nanotechnology are applied to improve or create medications. Combining knowledge in various disciplines including nanoscience, biological science, advanced materials and pharmacy, the current interests in nanomedicine mainly focus on exploiting nanomaterials for drug delivery in order

关键词： Precise design of nanomedicines perspectives for cancer treatment

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

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Frontiers of Medicine 2018年第6期12卷 667-677页

作者： Yinlong Zhang Guangna Liu Jingyan Wei guangjun nie College of Pharmaceutical Science Jilin UniversityChangchun 130021China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries. Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines. For example, platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis. In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment. This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation.

关键词： EPR effect cancer therapy platelet-mimicking delivery systems tumor-associated platelets

Antineoplastic activities of Gd@C_(82)(OH)_(22) nanoparticles: tumor microenvironment regulation

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Science China(Life Sciences) 2012年第10期55卷 884-890页

作者： LI YiYe TIAN YanHuan nie guangjun CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China College of Pharmaceutwal Sczence Jilin UniversityChangchun 130021China

Malignant tumors are complex organs consisting of tumor cells and their microenvironment. Increasing evidence has shown that the tumor microenvironment is critical to the initiation and progression of tumors. Rational design of tumor therapies via targeting the tumor microenvironment to inhibit tumor growth is thus becoming a consensus strategy. Gd@C 82 (OH) 22 nanoparticles, as novel endohedral hydroxylated metallofullerenes, have been demonstrated to be a potent antitumor nanomedicine via targeting multiple factors in the tumor microenvironment. Gd@C 82 (OH) 22 nanoparticles possess excellent biocompatibility and remarkable antineoplastic activity, as a result not of direct tumor cytotoxicity but of their diverse biological effects, including antioxidation, immune activation, angiogenesis inhibition, imprisoning cancer cells, and reversal of drug-resistance. In this article, we summarize the unique nanoscale physiochemical properties and the antineoplastic activities of Gd@C 82 (OH) 22 nanoparticles, and focus on the mechanisms underlying their regulation of the tumor microenvironment.

关键词： Gd @ C82(0H)22 antineoplastic nanoparticles tumor microenvironment

A special issue for the 20^(th) anniversary of National Center for Nanoscience and Technology

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Nano Research 2023年第12期16卷 12881-12882页

作者： Qing Dai guangjun nie Zhiyong Tang Yuliang Zhao CAS Key Laboratory of Nanophotonic Materials and Devices National Center for Nanoscience and TechnologyBeijing 100190China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Centre for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

National Center for Nanoscience and Technology(NCNST),China,established in December 2003,is co-founded by the Chinese Academy of Sciences(CAS)and the Ministry of Education as an institution dedicated to fundamental and applied researches in the field of nanoscience and technology,especially those with important potential *** is operated under the supervision of the Governing Board and aims to become a world-class research center,as well as public technological platform and young talents training center in the field,and to act as an important bridge for international academic exchange and *** NCNST currently has three CAS Key Laboratories:the CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,the CAS Key Laboratory for Standardization and Measurement for Nanotechnology and the CAS Key Laboratory for Nanosystem and Hierarchical *** 2020,the CAS Key Laboratory of Nanophotonic Materials and Devices started ***,there are Division of Nanotechnology Development,Nanofabrication Laboratory,Intelligent Nanosensing Laboratory and Theoretical Laboratory.

关键词： field exchange collaboration

Analytical methods for nano-bio interface interactions

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Science China Chemistry 2016年第11期59卷 1467-1478页

作者： Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu guangjun nie CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology

Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

关键词： engineered nanomaterial nano-bio interface nano-bio interaction analytical methods protein corona synchrotron radiation

The accurate localization of fluorescent nanoparticle Au-Ft in nu/nu mice kidney

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 83-90页

作者： Hui Yang Cuji Sun Jun Jia guangjun nie Zhenyu Wu Department of Immunology Guang'anmen HospitalP.R.China Academy of Chinese Medical Sciences Beijing 100053P.R.China CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety Nationai Center for Nanoscience and Technology Beijing 100190 P.R.China Chilong Healthcare Intermational Limited Beijing 1000%0 P.R.China

Au-Ft,as a green synthesized nanoparticle,is composed of a ferritin nanocage enclosing a pair of Au nanoclusters *** previous study has demonstrated that Au-Ft can be an excellentfluorescent probe for whole body imaging of mice with kidney specific ***,the accuratelocalization of Au-Ft in kidney is still *** the current study,we detected and assessed the cellular and subcellular localization of Au-Ft in renal cortex and medulla of nu/nu mice after tailvein injection by using Nuance optical system(CRi,Woburn,USA)and inForm intelligent image analysis soft ware based on single cell *** obtained the fluorescence intensity and cellular location of kidney-targeting Au-Ft probe in particular cell of renal glomerulus or renaltubules,which provided valuable proofs to clarify the mechanism of Au-Ft selective enrichment in kidney and the associated metabolic processes.

关键词： Au-Ft nanoparticle kidney targeting cellular localization renal cortex and medlla multispectral imaging

Intelligent nanomaterials for cancer therapy:recent progresses and future possibilities

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Medical Review 2023年第4期3卷 321-342页

作者： Jing Wang Yuliang Zhao guangjun nie CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China GBA Research Innovation Institute for Nanotechnology Guangzhou 510700Guangdong ProvinceChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy *** by the recent progresses of nanobiotechnology,a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated na-ture of *** rationally designed multifunctionality and programmable assembly of functional subunits,the in vivo behaviors of intelligent nanosystems have become increasingly tunable,making them more efficient in performing sophisticated actions in physiological and path-ological *** recent years,intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery,biological barrier circumvention,multi-responsive tumor sensing and drug release,as well as convergence with precise medication approaches such as personalized tumor *** the other hand,the increasing system complexity of anti-cancer nanomedicines also pose signiﬁcant challenges in charac-terization,monitoring and clinical use,requesting a more comprehensive and dynamic understanding of nano-bio *** review aims to brieﬂy summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery,tumor immunotherapy and temporospatially speciﬁc tumor imaging,as well as impor-tant advances of our knowledge on their interaction with biological *** the perspective of clinical translation,we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nano-materials,highlighting the critical importance clinically-oriented system design.

关键词： intelligent nanomedicine anti-cancer nano-materials tumor microenvironment tumor vaccines immunotherapy personalized medication

Self-assembly of DNA molecules at bio-interfaces and their emerging applications for biomedicines

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Nano Research 2023年第12期16卷 13014-13028页

作者： Jing Li Jingping Wang Ling Chen Yuhang Dong Haonan Chen guangjun nie Feng Li College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China

Interfacial assembly has been intensively investigated in fabricating biomaterials and nanodevices for various ***,due to the precise sequence programmability,unique molecular recognition ability,and good biocompatibility,deoxyribonucleic acid(DNA)has been explored as superior building blocks to assemble at bio-interface for manipulating biological *** the best of our knowledge,the advances in this area have not been systematically *** provide an overview of the area,in this review,the recently developed DNA assembly strategies on bio-interfaces were well summarized,and their representative works are exampled to illustrate how to rationally and elaborately design DNA molecules to realize functional integration and emerging of novel biological functionalities with high controllability and ***,the biomedical applications of DNA assembly at bio-interface are categorially *** fascinating and unique advantages of DNA assembly systems are fully discussed in the exemplified applications to show the distinguished perspective of DNA in the future *** the end of this review,the current limitations and challenges in applications and potential improvement strategies for DNA assembly at bio-interface are fully *** future development direction is *** envision that this review will help scientists in the interdisciplinary fields gain a more comprehensive understanding of the DNA assembly at bio-interface,and therefore jointly promote the advances in this field.

关键词： deoxyribonucleic acid nanotechnology self-assembly interfacial assembly biomedicine