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Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer:an interim analysis of a phase Ⅲ randomized clinical trial

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Cancer Communications 2024年第10期44卷 1214-1227页

作者： Yan Zheng guanghui liang Dongfeng Yuan Xianben Liu Yufeng Ba Zimin Qin Sining Shen Zhenxuan Li Haibo Sun Baoxing Liu Quanli Gao Peng Li Zongfei Wang Shilei Liu Jianping Zhu Haoran Wang Haibo Ma Zhenzhen Liu Fei Zhao Jun Zhang He Zhang Daoyuan Wu Jinrong Qu Jie Ma Peng Zhang Wenjie Ma Ming Yan Yongkui Yu Qing Li Jiangong Zhang Wenqun Xing Department of Thoracic Surgery The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Immunotherapy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Endoscopy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Pathology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Radiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Biobank The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Strategic Development The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Statistics LinkDoc Technology Co.LtdBeijingP.R.China Department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouP.R.China

Background:In the era of immunotherapy,neoadjuvant immunochemotherapy(NAIC)for the treatment of locally advanced esophageal squamous cell carcinoma(ESCC)is used clinically but lacks of high-level clinical *** study aimed to compare the safety and long-term efficacy of NAIC followed byminimally invasive esophagectomy(MIE)with those of neoadjuvant chemotherapy(NAC)followed by ***:A prospective,single-center,open-label,randomized phase Ⅲ clinical trial was conducted at Henan Cancer Hospital,Zhengzhou,*** were randomly assigned to receive either neoadjuvant toripalimab(240mg)plus paclitaxel(175 mg/m^(2))+cisplatin(75 mg/m^(2))(toripalimab group)or paclitaxel+cisplatin alone(chemotherapy group)every 3 weeks for 2 *** surgery,the toripalimab group received toripalimab(240 mg every 3 weeks for up to 6 months).The primary endpoint was event-free survival(EFS).The pathological complete response(pCR)and overall survival(OS)were key secondary *** events(AEs)and quality of life were also ***:Between May 15,2020 and August 13,2021,252 ESCC patients ranging fromT1N1-3M0 to T2-3N0-3M0were enrolled for interim analysis,with 127 in the toripalimab group and 125 in the chemotherapy *** 1-year EFS rate was 77.9%in the toripalimab group compared to 64.3%in the chemotherapy group(hazard ratio[HR]=0.62;95%confidence interval[CI]=0.39 to 1.00;P=0.05).The 1-year OS rates were 94.1%and 83.0%in the toripalimab and chemotherapy groups,respectively(HR=0.48;95%CI=0.24 to 0.97;P=0.037).The patients in the toripalimab group had a higher pCR rate(18.6%vs.4.6%;P=0.001).The rates of postoperative Clavien-Dindo grade Ⅲb or higher morbidity were 9.8%in the toripalimab group and 6.8%in the chemotherapy group,with no significant difference observed(P=0.460).The rates of grade 3 or 4 treatment-related AEs did not differ between the two groups(12.5%versus 12.4%).Conclusions:The interim results of this ongoing trial showed that in resec

关键词： esophageal squamous cell carcinoma minimally invasive esophagectomy neoadjuvant chemotherapy neoadjuvant immunochemotherapy survival

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Poisson disk sampling through disk packing

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Computational Visual Media 2015年第1期1卷 17-26页

作者： guanghui liang Lin Lu Zhonggui Chen Chenglei Yang School of Computer Science and Technology Shandong University Department of Computer Science Xiamen University

Poisson disk sampling is an important problem in computer graphics and has a wide variety of applications in imaging, geometry, rendering, etc. In this paper, we propose a novel Poisson disk sampling algorithm based on disk packing. The key idea uses the observation that a relatively dense disk packing layout naturally satisfies the Poisson disk distribution property that each point is no closer to the others than a specified minimum distance, i.e., the Poisson disk radius. We use this property to propose a relaxation algorithm that achieves a good balance between the random and uniform properties needed for Poisson disk distributions. Our algorithm is easily adapted to image stippling by extending identical disk packing to unequal disks. Experimental results demonstrate the efficacy of our approaches.

关键词： disk packing image stippling Poisson disk sampling power diagram

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基于熵权法联合灰色关联度分析法的三七药材质量评价

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中国药业 2024年第6期33卷 82-87页

作者：李秋叶李国祥韦继雯张容溶梁光会云南省文山壮族苗族自治州食品药品检验研究院云南文山663099

目的评价不同产地三七药材的质量。方法选取云南省5个州/市的44批三七药材为样品,按2020年版《中国药典(四部)》通则项下方法测定水分、总灰分、酸不溶性灰分、醇溶性浸出物含量,采用高效液相色谱法测定三七皂苷R1、人参皂苷Rg_(1)、人... 详细信息

目的评价不同产地三七药材的质量。方法选取云南省5个州/市的44批三七药材为样品,按2020年版《中国药典(四部)》通则项下方法测定水分、总灰分、酸不溶性灰分、醇溶性浸出物含量,采用高效液相色谱法测定三七皂苷R1、人参皂苷Rg_(1)、人参皂苷Rb1含量,并计算此3种皂苷(合称总皂苷)含量。采用熵权法计算各指标权重,采用灰色关联度分析法评价药材样品质量。结果44批药材样品中上述8个指标的含量依次为5.13%~8.84%、2.11%~4.96%、0.10%~1.89%、20.18%~28.69%、0.80%~1.58%、2.82%~5.20%、2.79%~5.00%、6.54%~11.44%。醇溶性浸出物、三七皂苷R1、人参皂苷Rb1、人参皂苷Rg_(1)及总皂苷的权重较大。44批药材样品的相对关联度为0.1637~0.7739。等级为Ⅰ级至Ⅴ级的药材样品分别有11批、14批、8批、8批、3批;红河哈尼族彝族自治州样品5种等级均有,文山壮族苗族自治州、昆明市和曲靖市样品均无Ⅴ级,楚雄彝族自治州样品无Ⅰ级。结论所建立的质量评价方法能客观地评价不同产地三七药材的质量,为其质量研究提供了参考。

关键词：三七熵权法灰色关联度法质量评价

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Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 268-276页

作者： ZHENG Xueying GUO liang LAI Siyi LI Fengyue liang Mingli LIU Wanting MENG Chun LIU guanghui Department of Bioengineering College of Biological Science and BiotechnologyFuzhou UniversityFuzhou 350104China Eye Institute of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou 350004China Department of Ophthalmology Affiliated People's Hospital(Fujian Provincial People's Hospital)Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To investigate the effects of emodin on alkali burn-induced corneal inflammation and ***:The ability of emodin to target vascular endothelial growth factor receptor 2(VEGFR2)was predicted by molecular *** effects of emodin on the invasion,migration,and proliferation of human umbilical vein endothelial cells(HUVEC)were determined by cell counting kit-8,Transwell,and tube formation *** of apoptosis was performed by flow ***31 levels were examined by *** abundance and phosphorylation state of VEGFR2,protein kinase B(Akt),signal transducer and activator of transcription 3(STAT3),and P38 were examined by immunoblot *** alkali burn was performed on 40 *** were divided randomly into two groups,and the alkali-burned eyes were then treated with drops of either 10μM emodin or phosphate buffered saline(PBS)four times a *** microscopy was used to evaluate inflammation and corneal neovascularization(CNV)in all eyes on Days 0,7,10,and *** mice were killed humanely 14 d after the alkali burn,and their corneas were removed and preserved at-80℃ until histological study or protein ***:Molecular docking confirmed that emodin was able to target *** findings revealed that emodin decreased the invasion,migration,angiogenesis,and proliferation of HUVEC in a dose-dependent *** mice,emodin suppressed corneal inflammatory cell infiltration and inhibited the development of corneal neovascularization induced by alkali *** to those of the PBS-treated group,lower VEGFR2 expression and CD31 levels were found in the emodintreated *** dramatically decreased the expression of VEGFR2,p-VEGFR2,p-Akt,p-STAT3,and p-P38 in VEGF-treated ***:This study provides a new avenue for evaluating the molecular mechanisms underlying corneal inflammation and *** might be a promising new therapeutic option for corneal alkal

关键词： alkali burn emodin corneal inflammation corneal neovascularisation vascular endothelial growth factor receptor-2 signal transduction

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Constructed Mott-Schottky Heterostructure Catalyst to Trigger Interface Disturbance and Manipulate Redox Kinetics in Li-O_(2) Battery

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Nano-Micro Letters 2024年第12期16卷 42-58页

作者： Yongji Xia Le Wang Guiyang Gao Tianle Mao Zhenjia Wang Xuefeng Jin Zheyu Hong Jiajia Han Dong-liang Peng guanghui Yue State Key Lab of Physical Chemistry of Solid Surface Fujian Key Laboratory of Surface and Interface Engineering for High Performance MaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China

Lithium-oxygen batteries(LOBs)with high energy density are a promising advanced energy storage ***,the slow cathodic redox kinetics during cycling causes the discharge products to fail to decompose in time,resulting in large polarization and battery failure in a short ***,a self-supporting interconnected nanosheet array network NiCo_(2)O_(4)/MnO_(2)with a Mott-Schottky heterostructure on titanium paper(TP-NCO/MO)is ingeniously designed as an efficient cathode catalyst material for *** heterostructure can accelerate electron transfer and influence the charge transfer process during adsorption of intermediate by triggering the interface disturbance at the heterogeneous interface,thus accelerating oxygen reduction and oxygen evolution kinetics and regulating product decomposition,which is expected to solve the above *** meticulously designed unique structural advantages enable the TP-NCO/MO cathode catalyst to exhibit an astounding ultra-long cycle life of 800 cycles and an extraordinarily low overpotential of 0.73 *** study utilizes a simple method to cleverly regulate the morphology of the discharge products by constructing a Mott-Schottky heterostructure,providing important reference for the design of efficient catalysts aimed at optimizing the adsorption of reaction intermediates.

关键词： Mott-Schottky heterostructure Lithium-oxygen batteries Electrocatalysts Electrodeposition

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基于代码进化的恶意代码沙箱规避检测技术研究

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电子与信息学报 2019年第2期41卷 341-347页

作者：梁光辉庞建民单征解放军信息工程大学郑州450001 数学工程与先进计算国家重点实验室郑州450001

为了对抗恶意代码的沙箱规避行为,提高恶意代码的分析效率,该文提出基于代码进化的恶意代码沙箱规避检测技术。提取恶意代码的静态语义信息和动态运行时信息,利用沙箱规避行为在代码进化过程中所产生的动静态语义上的差异,设计了基于相... 详细信息

为了对抗恶意代码的沙箱规避行为,提高恶意代码的分析效率,该文提出基于代码进化的恶意代码沙箱规避检测技术。提取恶意代码的静态语义信息和动态运行时信息,利用沙箱规避行为在代码进化过程中所产生的动静态语义上的差异,设计了基于相似度差异的判定算法。在7个实际恶意家族中共检测出240个具有沙箱规避行为的恶意样本,相比于JOE分析系统,准确率提高了12.5%,同时将误报率降低到1%,其验证了该文方法的正确性和有效性。

关键词：恶意代码沙箱规避静态相似度

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Solid Solution Sm_(1+x)Ba_(2-x)Cu_3O_y and Effect of Quench Temperature on SmBa_2Cu_3O_y

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Journal of Materials Science & Technology 1994年第4期10卷 269-272页

作者： Xianran XING Zhiyu QIAO Wenxia YUAN and Shoukun WEI (University of Science and Technology Beijing, Beijing, 100083, China)(To whom correspondence should be addressed)Xiaolong CHEN, guanghui RAO and Jingkui liang (Institute of Physics, Chinese Academy o Univ of Science and Technology Beijing China

By X-ray powder diffraction technique and oxygen content analysis, a solid solution Sm1+xBa2-xCu3Oy has been determined in the range 0≤x≤0.4. When x<0.25. the Sm1+xBa2-xCu3Oy presents orthorhombic symmetry, and the orthorhombic-tetragonaJ transition ocCurs at x = 0.25. With the increase of x, TC decreases and finally breaks. The correlation between ox ygen content and phase structure at different quench temperatures related to Sm Ba2Cu3Oy has been investigated as well

关键词： x)Ba x)Cu3Oy and Effect of Quench Temperature on SmBa2Cu3Oy Cu Solid Solution Sm

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低频重复经颅磁刺激治疗青少年抑郁症的疗效分析

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大医生 2022年第7期7卷 12-16页

作者：梁炯航梁光辉东莞市第七人民医院精神科广东东莞523230 东莞市第七人民医院医技科广东东莞523230

目的探讨低频重复经颅磁刺激(rTMS)治疗青少年抑郁症的效果,分析其对患者工作记忆和学习能力的影响。方法选取2018年1月至2020年12月东莞市第七人民医院收治的90例青少年抑郁症患者作为研究对象,按照随机数字表法分为观察组和对照组,每... 详细信息

目的探讨低频重复经颅磁刺激(rTMS)治疗青少年抑郁症的效果,分析其对患者工作记忆和学习能力的影响。方法选取2018年1月至2020年12月东莞市第七人民医院收治的90例青少年抑郁症患者作为研究对象,按照随机数字表法分为观察组和对照组,每组45例。两组患者均给予常规药物治疗并进行认知行为干预。观察组患者在此基础上加用低频rTMS治疗。比较两组患者治疗效果,分别在治疗前后采用执行功能行为评定量表(BRIEF-A)和威斯康星卡片分类测试(WCST)评分评估两组患者工作记忆和学习能力。结果观察组患者治疗总有效率和整体疗效均优于对照组(P<0.05)。治疗后观察组患者行为管理指数、元认知指数及BRIEF-A总评分均显著低于治疗前和对照组(P<0.05)。治疗后观察组患者WCST中正确反应数和完成分类数评分均显著高于治疗前和对照组(P<0.05)。结论低频rTMS用于青少年抑郁症患者疗效显著,有助于改善患者工作记忆和学习能力。

关键词：低频重复经颅磁刺激青少年抑郁症工作记忆学习能力

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跨欧亚大陆交流的响应——新石器至青铜时代中国北方农业区、牧业区和农牧交错带生业模式演变过程及影响因素

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Journal of Geographical Sciences 2024年第4期34卷 681-698页

作者：董广辉梁欢芦永秀王佳 Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Zhaotong University Zhaotong 657000YunnanChina

Significant spatiotemporal variation in human livelihood patterns and its relationship to trans-Eurasian exchange and climate change in north China during the late Neolithic and Bronze Age, has been intensively studied in recent years, but the comprehensive influence of natural and social factors on this variation is not well understood. Therefore, we analyze archaeobotanical, zooarchaeological and carbon isotopic data from late Neolithic and Bronze Age sites in agricultural, pastoral, and agro-pastoral regions of north China. Our results demonstrate human subsistence strategies transformed at different speeds in these three geographic areas after wheat, barley, and sheep, goats, and cattle were introduced into north China. Introduced crops and livestock dominated human livelihoods in pastoral regions and became important subsistence in areas above ~1500 m a.s.l. in agro-pastoral regions after ~3600 BP. In agricultural regions, indigenous millet crops were the most important subsistence throughout 6000– 2200 BP, but wheat use increased significantly around 2700 BP. Our study suggests that the introduction of new crops and herbivorous livestock related to the prehistoric trans-Eurasian exchange, and their adaptive advantage in high-cold environments might have rapidly facilitated human adaptability and social development in pastoral regions and northwest margin of agro-pastoral regions during the Bronze Age.

关键词： subsistence strategy 6th–3rd Millennium BP north China human-land relation long-distance exchange

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胸腺瘤合并重症肌无力患者预后的临床研究

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中国肺癌杂志 2018年第1期21卷 1-7页

作者：袁东风谷志涛梁光辉方文涛李印郑州大学附属肿瘤医院胸外科郑州450008 上海交通大学附属上海胸科医院上海200030

背景与目的胸腺瘤常伴发重症肌无力(myasthenia gravis,MG),但是这些患者行胸腺切除的预后与MG的关系尚不明确。本研究旨在探讨影响胸腺瘤合并MG患者预后的因素。方法回顾性分析中国胸腺瘤协作组(Chinese Alliance for Research of Thym... 详细信息

背景与目的胸腺瘤常伴发重症肌无力(myasthenia gravis,MG),但是这些患者行胸腺切除的预后与MG的关系尚不明确。本研究旨在探讨影响胸腺瘤合并MG患者预后的因素。方法回顾性分析中国胸腺瘤协作组(Chinese Alliance for Research of Thymoma,ChART)数据库1992年-2012年875例随访20年资料完整的胸腺瘤病例,分析世界卫生组织(World Health Organization,WHO)组织学分型、Masaoka分期、术后辅助治疗与MG及预后的关系。结果胸腺瘤WHO组织学分型与MG有相关性,差异有统计学意义(χ~2=24.908,PB3型(65/239,27.20%)>B1型(27/132,20.45%)>AB型(43/267,16.10%)>A型(6/59,10.17%),Masaoka分期与MG无相关性(χ~2=1.365,P=0.714)。生存分析表明WHO分型、Masaoka分期与预后有关(P<0.05),而是否合并MG(χ~2=0.113,P=0.736)、是否行胸腺扩大切除(χ~2=1.548,P=0.213)、术后辅助放疗(χ~2=0.380,P=0.538)与预后无相关,术后辅助化疗与差的预后相关(χ~2=14.417,P<0.001)。是否行胸腺扩大切除与MG的疗效有相关性(χ~2=24.695,P<0.001)。结论胸腺瘤患者是否合并MG和是否行胸腺扩大切除与预后无相关性,胸腺扩大切除可改善MG患者的疗效。

关键词：胸腺瘤重症肌无力胸腺扩大切除预后

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