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Impact of HIV/HCV Co-Infection on Mortality and Attrition in Antiretroviral Therapy Among People with HIV — Guangxi Zhuang Autonomous Region, China, 2003–2022

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China CDC weekly 2023年第44期5卷 973-977,I0001页

作者： He Jiang Qiuying Zhu Jinghua huang Xiuling Wu Bo Li Xuanhua Liu Qin Meng Shuai Tang guanghua Lan Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory for Major Infectious Diseases Prevention and Control and Biosafety Emergency Response Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina

Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy ... 详细信息

关键词： mortality Therapy Impact

Construction of a High-Quality Organic-Inorganic Hybrid Heterostructure and Its Photo-response Performance

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Chinese Journal of Chemistry 2023年第1期41卷 50-56页

作者： Yadan Zhang guanghua Yu Di Xue Jie Lu Xing Meng Yao Yin Qi Wang Zi Wang Lizhen huang Lifeng Chi Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow University199 Ren'ai RoadSuzhouJiangsu 215123China Gusu Laboratory of Materials 388 Ruoshui RoadSuzhouJiangsu 215123China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

The combination of metal oxide and organic semiconductor for constructing organic-inorganic hybrid heterostructure is promising to offer unique optoelectronic ***,the distinct difference in electron structure and processing technology of the two types of materials makes it usually difficult to fully deliver their complementary ***,we report the construction of a high quality organic/In_(2)O_(3) hybrid heterostructure presenting a good ambipolar transport with average electron mobility>1 cm^(2)V^(-1)·s^(-1) and hole mobility up to 0.4 cm^(2)·V^(-1)·s^(-1),respectively,together with a high-gain *** addition,the incorporation with organic film on top of In_(2)O_(3) remarkably reduces the dark current,enabling the realization of high photoconductivity response with photo-sensitivity of two magnitudes higher than that of pure *** photoconductor and phototransistor of the hybrid structure demonstrate high photoresponsivity>10^(3) AW^(-1) and detectivity up to 10^(14) Jones,demonstrating the promising functionality of such a high quality hybrid heterostructure.

关键词： Sol-gel process Thin films Semiconductors Phthalocyanines Hybrid heterostructure

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临沂烟区漂浮育苗基质筛选研究

中国农学通报 2017年第14期33卷 43-46页

作者：刘恩锋李联玉黄广华周龙刘彦宁李东霞郭强史久长山东临沂烟草有限公司山东临沂273300 浙江中烟工业有限责任公司杭州310000

为实现烟叶生产可持续发展,探索新型烤烟育苗基质,摆脱对草炭土基质的依赖,本研究以草炭土为对照,选用当地较为广泛的小麦秸秆、蘑菇菌下脚料、粗砂为原料,设置对比试验,研究了替代基质对出苗时间、出苗率、成苗率和烟苗成苗素质的影响... 详细信息

为实现烟叶生产可持续发展,探索新型烤烟育苗基质,摆脱对草炭土基质的依赖,本研究以草炭土为对照,选用当地较为广泛的小麦秸秆、蘑菇菌下脚料、粗砂为原料,设置对比试验,研究了替代基质对出苗时间、出苗率、成苗率和烟苗成苗素质的影响。结果表明:小麦秸秆基质的出苗率和部分成苗期农艺形状与CK达到显著差异,成苗率基本一致;蘑菇菌下脚料出苗率与CK一致,但是长势较弱没有成苗;粗砂基质出苗率、成苗率和农艺形状优于或接近CK;3种替代基质成本都低于CK,且粗砂基质成本最低。因此,粗砂基质的替代效果最好,可作为替代草炭土的漂浮育苗基质配方进行适当示范推广。

关键词：烤烟漂浮育苗粗砂

Complete genome sequence of a novel bacteriophage infecting Bradyrhizobium diazoefficiens USDA110

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Science China(Life Sciences) 2018年第1期61卷 118-121页

作者： Junjie Liu Hao Yu Yong huang Zhenhua Yu Guoquan Fan Jian Jin Xiaobing Liu guanghua Wang Key Laboratory of Mollisols Agroecology Northeast Institute of Geography and Agroecology Chinese Academy of Sciences State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Virus-free Seedling Heilongjiang Academy of Agricultural Sciences

Dear Editor,The nitrogen-fixing symbiotic bacteria, rhizobia are the most important beneficial bacteria in soil, as they form nodules with host legume plants to fix nitrogen to maintain soil fertility and facilitate plant growth. Although these bacteria are critically important to agriculture, bacteriophages of rhizobia (rhizobiophages) are commonly present in soils, rhizosphere,and nodules, which have major influences on the composition and population of rhizobia in soils and affect nodulation and nitrogen fixation. Despite the importance of rhizobiophages,only 23 phage full genomes have been sequenced.

关键词： MI

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γ-聚谷氨酸对烤烟生长及产质量的影响

浙江农业科学 2023年第12期64卷 2879-2882页

作者：王晓郑宏斌黄广华史久长王卫民高加明舒照鹤向修志上官力郭祥高林浙江中烟工业有限责任公司浙江杭州310008 中国烟草总公司湖北省公司湖北武汉430030 湖北省烟草公司恩施州公司湖北恩施445000 中国农业科学院烟草研究所山东青岛266101

为了明确高分子生物活性物质γ-聚谷氨酸在烤烟上的使用效果,以云烟87为材料,采用田间小区试验,分析了不同的γ-聚谷氨酸使用方式对烤烟农艺性状、经济性状、外观质量、化学成分以及感官质量的影响。结果表明,γ-聚谷氨酸促进了田间烟... 详细信息

为了明确高分子生物活性物质γ-聚谷氨酸在烤烟上的使用效果,以云烟87为材料,采用田间小区试验,分析了不同的γ-聚谷氨酸使用方式对烤烟农艺性状、经济性状、外观质量、化学成分以及感官质量的影响。结果表明,γ-聚谷氨酸促进了田间烟株生长发育,各部位烟叶叶长均优于对照,γ-聚谷氨酸配合追肥的使用方式在提高烟叶产量、产值以及等级结构比例方面具有较大作用。使用γ-聚谷氨酸后烟叶成熟度水平改善,增加了烟叶油分,烟叶组织结构相对疏松,烟碱含量有下降趋势,整体提升了烤后烟叶总糖和还原糖含量,感官评吸质量在香气质感及口腔圆润感方面得到改善,综合而言,γ-聚谷氨酸增效减量化施肥以及叶面喷施技术,在烤烟生产中具有较好的应用前景。

关键词：聚谷氨酸烤烟生长发育品质

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A polygalacturonase gene OsPG1 modulates water homeostasis in rice

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The Crop Journal 2024年第1期12卷 79-91页

作者： Qinwen Zou Ranran Tu Jiajun Wu Tingting huang Zhihao Sun Zheyan Ruan Hongyu Cao Shihui Yang Xihong Shen guanghua He Hong Wang Rice Research Institute Key Laboratory of Application and Safety Control of Genetically Modified CropsAcademy of Agricultural SciencesSouthwest UniversityChongqing 400715China State Key Laboratory of Rice Biology and Breeding Key Laboratory for Zhejiang Super Rice ResearchChina National Center for Rice ImprovementChina National Rice Research InstituteHangzhou 311401ZhejiangChina

A dynamic plant architecture is the basis of plant adaptation to changing *** many genes regulating leaf rolling have been identified,genes directly associated with water homeostasis are largely ***,we isolated a rice mutant,dynamic leaf rolling 1(dlr1),characterized by‘leaf unfolding in the morning-leaf rolling at noon-leaf unfolding in the evening’during a sunny *** content was decreased in rolled leaves and water sprayed on leaves caused reopening,indicating that in vivo water deficiency induced the leaf ***-based cloning and expression tests demonstrated that an A1400G single base mutation in Oryza sativa Polygalacturonase 1(OsPG1)/PHOTO-SENSITIVE LEAF ROLLING 1(PSL1)was responsible for the dynamic leaf rolling phenotype in the dlr1 ***1 encodes a polygalacturonase,one of the main enzymes that degrade demethylesterified homogalacturonans in plant cell ***1 was constitutively expressed in various tissues and was enriched in *** of the OsPG1 gene exhibited defects in stomatal closure and decreased stomatal density,leading to reduced transpiration and excessive water loss under specific conditions,but had normal root *** analysis revealed that mutation of OsPG1 led to reduced pectinase activity in the leaves and increased demethylesterified homogalacturonans in guard *** findings reveal a mechanism by which OsPG1 modulates water homeostasis to control dynamic leaf rolling,providing insights for plants to adapt to environmental variation.

关键词： Photosynthesis Stomata Transpiration Leaf rolling

Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI huang CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG huang YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG guanghua CHEN WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

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水温对黄鳝消化酶活性的影响

水产养殖 2022年第11期43卷 32-36页

作者：安雨琪张文平周秋白胡重华周磊涛黄广华梁立文张亚洲江西农业大学动物科学技术学院江西农业大学特种水产研究所江西南昌330045

为了解不同养殖水温对黄鳝消化酶活性的影响,开展了6,16,26,28,32℃的水温条件下黄鳝养殖试验,并测定其消化酶活性。结果显示,黄鳝淀粉酶活性除肝胰脏在28℃时显著高于其他温度组外,胃、前肠、后肠均在26℃时显著高于其他温度组;胃蛋白... 详细信息

为了解不同养殖水温对黄鳝消化酶活性的影响,开展了6,16,26,28,32℃的水温条件下黄鳝养殖试验,并测定其消化酶活性。结果显示,黄鳝淀粉酶活性除肝胰脏在28℃时显著高于其他温度组外,胃、前肠、后肠均在26℃时显著高于其他温度组;胃蛋白酶和胰蛋白酶活性各组织均在26℃组显著高于其他温度组;脂肪酶活性在26℃最高,胃、前肠26℃时显著高于其他温度组,后肠显著高于16、28、32℃组,肝胰脏不同温度间无显著差异。不同组织消化酶活性,总体上前肠显著高于其他组织。指出,黄鳝主要消化活动在前肠,适宜生长的水温为26~28℃,在该水温下黄鳝消化酶活力较高,消化能力较好,26℃是最适合黄鳝摄食生长的水温,水温高于32℃时,应考虑减少黄鳝饲料的投喂。

关键词：黄鳝水温消化酶消化道肝胰腺

2010-2017年灵山县手足口病流行病学特征分析及2018年疫情预测

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广西医科大学学报 2020年第3期37卷 520-525页

作者：蒋家晓陈富玲 THI MAI NGUYEN 周子寒赖银娟黄光华叶力梁浩梁冰玉广西医科大学公共卫生学院广西艾滋病防治研究重点实验室广西医科大学生命科学研究院南宁530021 广西灵山县疾病预防控制中心灵山530000 广西医科大学第一附属医院南宁530021

目的:探讨灵山县手足口病(HFMD)流行病学特征,并预测灵山县2018年HFMD发病趋势,为开展HFMD防治工作提供科学依据。方法:收集2010-2017年灵山县HFMD报告资料,建立时间序列模型即自回归移动平均模型(ARIMA),预测灵山县2018年HFMD发病趋势... 详细信息

目的:探讨灵山县手足口病(HFMD)流行病学特征,并预测灵山县2018年HFMD发病趋势,为开展HFMD防治工作提供科学依据。方法:收集2010-2017年灵山县HFMD报告资料,建立时间序列模型即自回归移动平均模型(ARIMA),预测灵山县2018年HFMD发病趋势。结果:2010-2017年HFMD年平均发病率为115.80/10万。灵山县灵城镇发病例数高于其他乡镇。发病性别比为1.74∶1,男性发病高于女性(χ^2=534.34 P<0.05)。HFMD主要以散居儿童为主,1岁年龄组所占比例最高。每年5~6月和9~10月为病例报告高峰期。肠道病毒71型(EV71)为HFMD确诊病例中最常见的病原体。应用ARIMA(0,0,2)(0,1,1)12预测出2018年1~12月HFMD发病例数,其中9月达到589例,合计为4117例。结论:灵山县HFMD发病集中在散居儿童,在5~6月和9~10月呈双峰分布,EV17为主要病原体。预测结果表明,2018年该地区HFMD疫情将有可能依旧严峻。提示在两个发病高峰期应监测重点人群,加强防控力度。

关键词：手足口病疾病流行 ARIMA预测