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Childhood sleep:physical,cognitive,and behavioral consequences and implications

World Journal of Pediatrics 2024年第2期20卷 122-132页

作者： Jianghong Liu Xiaopeng Ji Susannah Pitt guanghai wang Elizabeth Rovit Terri Lipman Fan Jiang School of Nursing University of Pennsylvania418 Curie Blvd.Room 424Claire M.Fagin HallPhiladelphiaPA 19104USA College of Health Sciences University of DelawareNewarkDE 19716USA Geisinger Commonwealth School of Medicine ScrantonPA 18510USA Pediatric Translational Medicine Institute Department of Developmental and Behavioral PediatricsSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Sleep problems in children have been increasingly recognized as a major public health *** research has extensively studied and presented many risk factors and potential mechanisms for children’s sleep *** this paper,we aimed to identify and summarize the consequences and implications of child sleep *** sources A comprehensive search for relevant English language full-text,peer-reviewed publications was performed focusing on pediatric sleep studies from prenatal to childhood and adolescence in a variety of indexes in PubMed,SCOPUS,and Psych Info published in the past two *** relevant data-based articles and systematic reviews are *** Many adverse consequences are associated with child sleep deficiency and other sleep problems,including physical outcomes(e.g.,obesity),neurocognitive outcomes(e.g.,memory and attention,intelligence,academic performance),and emotional and behavioral outcomes(e.g.,internalizing/externalizing behaviors,behavioral disorders).Current prevention and intervention approaches to address childhood sleep problems include nutrition,exercise,cognitive–behavioral therapy for insomnia,aromatherapy,acupressure,and *** interventions may be particularly important in the context of coronavirus disease *** research and policy strategies can target the risk factors of child sleep as well as the efficacy and accessibility of *** Given the increasing prevalence of child sleep problems,which have been shown to affect children’s physical and neurobehavioral wellbeing,understanding the multi-aspect consequences and intervention programs for childhood sleep is important to inform future research direction as well as a public health practice for sleep screening and intervention,thus improving sleep-related child development and health.

关键词： Behavior Child sleep Consequences Implications Neurocognitive Physical Prevention/intervention

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睡眠呼吸障碍儿童的心理健康状况与定量脑电图频谱功率的关联

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中国儿童保健杂志 2024年第10期32卷 1055-1063页

作者：金玲凛翟丰王广海陈洁上海交通大学医学院附属上海儿童医学中心耳鼻咽喉科上海200127 上海交通大学医学院附属上海儿童医学中心发育行为儿科上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所上海交通大学医学院附属新华医院环境与儿童健康教育部和上海市重点实验室上海脑科学与类脑研究中心

目的本研究旨在分析睡眠呼吸障碍(SDB)儿童心理健康状况与定量脑电图(qEEG)频谱特征之间的联系,以便及时发现并诊治SDB的情绪并发症,从而保障SDB儿童神经心理的健康发育。方法2020年12月-2022年10月期间于上海儿童医学中心对存在SDB症... 详细信息

目的本研究旨在分析睡眠呼吸障碍(SDB)儿童心理健康状况与定量脑电图(qEEG)频谱特征之间的联系,以便及时发现并诊治SDB的情绪并发症,从而保障SDB儿童神经心理的健康发育。方法2020年12月-2022年10月期间于上海儿童医学中心对存在SDB症状的儿童进行整夜多导睡眠监测(PSG),同时收集其睡眠qEEG数据。受试者父母填写儿童抑郁量表(CDI),Spence儿童焦虑量表家长版(SCAS-P)[或学龄前焦虑量表(PAS)],以及阻塞性睡眠呼吸暂停问卷疾病特异性生活质量调查表(OSA-18)。采用独立样本t检验、Wilcoxon秩和检验和χ^(2)检验和Fisher精确检验比较SDB儿童各个组别之间的变量,并构建SDB儿童心理健康的多重线性回归模型。结果本研究共纳入105例3~12岁SDB患儿。学龄期SDB患儿的CDI评分[6.50(3.00,9.00)]高于学龄前期组[3.00(1.00,6.00)],差异有统计学意义(Z=701.00,P=0.010)。相对δ和θ功率与学龄前SDB儿童的社交恐惧症状(β=-1.06,-0.62,P<0.05)和学龄儿童的人际关系问题(β=-3.62,-2.36,P<0.05)得分均呈负相关。结论PSG是诊断SDB的必要检查手段,PSG中的qEEG特征与SDB患儿情绪状况相关,为日后在临床实践中对于SDB患儿心理健康问题的早期发现提供了便捷准确的方法。

关键词：焦虑抑郁脑电图睡眠呼吸障碍社会交往儿童

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等级水准项目分析可视化程序的设计与应用

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测绘与空间地理信息 2024年第S1期47卷 291-293页

作者：王广海许言海徐红晶王博自然资源部第二大地测量队黑龙江哈尔滨150025 黑龙江测绘地理信息局后勤管理中心黑龙江哈尔滨150081

国家基本网及区域性精密水准网复测项目中水准观测路线分布广、高差变化大,简单的作业工期计算与实际工作情况偏差较大,造成项目投入与生产实际不符,不是资源浪费就是投入不足延误工期。精确的路线分析、准确的工作计划是项目高效实施... 详细信息

国家基本网及区域性精密水准网复测项目中水准观测路线分布广、高差变化大,简单的作业工期计算与实际工作情况偏差较大,造成项目投入与生产实际不符,不是资源浪费就是投入不足延误工期。精确的路线分析、准确的工作计划是项目高效实施的保证,快速的修改、可视化的计划表格输出更适应现如今的生产需要。本文阐述了采用VBA开发Microsoft Office Excel制作一款等级水准项目分析可视化程序,主要用于等级水准项目的路线分析,生成各种生产计划类图表作为项目执行的数据参考。

关键词：国家基本网区域性精密水准网重站比 VBA

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基于BPNN-PID控制策略的果蔬保鲜环境参数调控优化

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华南农业大学学报 2024年第1期45卷 137-147页

作者：吕恩利蔡晋炜曾志雄蔡威谢伯铭王广海郭嘉明华南农业大学工程学院广东广州510642 岭南现代农业科学与技术广东省实验室茂名分中心广东茂名525000 广东机电职业技术学院广东广州510550

【目的】开发新的控制策略,用于解决传统控制方法果蔬保鲜环境参数因时变性、非线性、滞后性强和惯性大等特点导致的控制精度低、鲁棒性弱等问题。【方法】将传统比例−积分−微分(Proportional-integral-derivative,PID)和BP神经网络(Bac... 详细信息

【目的】开发新的控制策略,用于解决传统控制方法果蔬保鲜环境参数因时变性、非线性、滞后性强和惯性大等特点导致的控制精度低、鲁棒性弱等问题。【方法】将传统比例−积分−微分(Proportional-integral-derivative,PID)和BP神经网络(Back-propagation neural network,BPNN)算法相结合,开发一种基于BPNN-PID的控制策略,通过自主搭建的果蔬保鲜环境调控试验平台和自主设计的控制系统,研究不同控制策略对保鲜环境参数调控效果的影响。【结果】基于BPNN-PID控制策略的果蔬保鲜环境控制系统,环境温度超调量为1.7℃、稳定时间为80 min、稳态误差为±0.2℃,环境相对湿度超调量为2.8%、稳定时间为55 min,相对湿度稳定维持在80%~90%范围内。与传统PID控制策略相比,BPNN-PID控制策略环境温度超调量减小了2.1℃、稳态误差减小了0.3℃、稳定时间缩短了25 min,环境相对湿度超调量减小了2.2%、稳定时间缩短了25 min,环境参数波动幅度均有所降低。【结论】本文开发的果蔬保鲜环境控制系统呈现出良好的动态调整能力,具有较强的鲁棒性,控制性能明显提升,实现了保鲜环境参数的精准控制,满足果蔬保鲜贮藏要求。研究结果为果蔬保鲜环境参数调控提供了参考。

关键词： PID BPNN 控制系统果蔬保鲜环境参数超调量

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磁共振成像在儿童脑智发育研究中的应用及挑战

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教育生物学杂志 2024年第2期12卷 85-91页

作者：桂一丁孙晓宁王广海江帆上海交通大学医学院附属上海儿童医学中心发育行为儿科上海200127 上海交通大学医学院附属新华医院教育部和上海市环境与儿童健康重点实验室上海200092 上海脑科学与类脑研究中心上海201602 上海交通大学心理学院上海200030 上海交通大学医学院附属上海精神卫生中心上海200030

儿童时期是脑智发育的关键阶段,探索这一阶段脑智发育的规律和影响因素具有重要意义。随着技术的发展,磁共振成像已成为儿童脑智研究的首选脑成像方法。该文综述了不同的磁共振成像方法(结构、功能、质子波谱)及相关脑影像指标在揭示儿... 详细信息

儿童时期是脑智发育的关键阶段,探索这一阶段脑智发育的规律和影响因素具有重要意义。随着技术的发展,磁共振成像已成为儿童脑智研究的首选脑成像方法。该文综述了不同的磁共振成像方法(结构、功能、质子波谱)及相关脑影像指标在揭示儿童脑发育规律中的作用,并指出在儿童中开展磁共振成像研究所面临的挑战。

关键词：脑科学磁共振成像脑智发育婴幼儿青少年儿童发展

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One Case of Pulmonary Chondroma, Rare Benign Tumor of the Lung

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The Chinese-German Journal of Clinical Oncology 2006年第4期5卷 301-302页

作者： YANG Kun YANG guanghai LI Jinsong wang Jianjun Department of Thoracic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Pulmonary chondroma is a rare form of benign neoplasms of the lung, of which the cartilage is the only constituent. Most of the patients with lung ehondroma are asymptomatie at the time of diagnosis and the occupying lesion in lung is mostly detected in the routine health examination. Tile image of pulmonary ehondroma is similar to the other benign solitary neoplasms of the lung and the definitive diagnosis can only be established under a microscope after the resection of the tumor. In the present report, a 33-years-old woman with ehondroma in the left lower lung was described.

关键词：肺癌良性肿瘤病理机制治疗

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葡萄响应盐胁迫的研究进展

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中外葡萄与葡萄酒 2024年第1期 94-99页

作者：牛帅科董宣赵艳卓陈展宣立锋张志超杨丽丽王广海河北省农林科学院石家庄果树研究所河北石家庄050064 中粮华夏长城葡萄酒有限公司河北秦皇岛066600

在葡萄生产中,盐胁迫是常见的非生物胁迫之一。在发生盐胁迫时,葡萄的产量与品质常常会降低,因此提高葡萄对盐胁迫的耐受性,已成为葡萄栽培中迫在眉睫的问题。本文综述了盐胁迫对葡萄生长发育及生理生化影响的研究进展,探讨了葡萄响应... 详细信息

在葡萄生产中,盐胁迫是常见的非生物胁迫之一。在发生盐胁迫时,葡萄的产量与品质常常会降低,因此提高葡萄对盐胁迫的耐受性,已成为葡萄栽培中迫在眉睫的问题。本文综述了盐胁迫对葡萄生长发育及生理生化影响的研究进展,探讨了葡萄响应盐胁迫的分子机制和缓解盐胁迫的应对措施,并展望了葡萄耐受盐胁迫研究的方向。以期为葡萄耐盐机理的解析及耐盐品种的选育提供理论依据,为缓解葡萄盐害的栽培技术提供新思路。

关键词：葡萄盐胁迫耐盐性

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Decreased eggshell strength caused by impairment of uterine calcium transport coincide with higher bone minerals and quality in aged laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1258-1277页

作者： Yu Fu Jianmin Zhou Martine Schroyen Haijun Zhang Shugeng Wu guanghai Qi Jing wang Key Laboratory of Feed Biotechnology Ministry of Agriculture and Rural AffairsInstitute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Precision Livestock and Nutrition Laboratory Gembloux Agro‑Bio TechTERRA Teaching and Research CentreUniversity of LiegeGembloux B‑5030Belgium

Background Deteriorations in eggshell and bone quality are major challenges in aged laying *** study compared the differences of eggshell quality,bone parameters and their correlations as well as uterine physiologi-cal characteristics and the bone remodeling processes of hens laying eggs of different eggshell breaking strength to explore the mechanism of eggshell and bone quality reduction and their interaction.A total of 24074-week-old Hy-line Brown laying hens were selected and allocated to a high(HBS,44.83±1.31 N)or low(LBS,24.43±0.57 N)eggshell breaking strength *** A decreased thickness,weight and weight ratio of eggshells were observed in the LBS,accompanied with ultrastructural deterioration and total Ca *** quality was negatively correlated with eggshell quality,marked with enhanced structures and increased components in the *** the LBS,the mammillary knobs and effective layer grew *** the initiation stage of eggshell calcification,a total of 130 differentially expressed genes(DEGs,122 upregulated and 8 downregulated)were identified in the uterus of hens in the LBS relative to those in the *** DEGs were relevant to apoptosis due to the cellular Ca *** values of p62 protein level,caspase-8 activity,Bax protein expression and lower values of Bcl protein expression and Bcl/Bax ratio were seen in the *** assay and hematoxylin-eosin staining showed a significant increase in TUNEL-positive cells and tissue damages in the uterus of the *** few DEGs were identified at the growth stage,similar uterine tissue damages were also observed in the *** expressions of runt-related transcription factor 2 and osteocal-cin were upregulated in humeri of the *** diameter and more structural damages of endocortical bones and decreased ash were observed in femurs of the *** The lower eggshell breaking strength may be attributed to a declined Ca transport due to uterine tissue damages,which

关键词： Bone parameter Calcium transport Eggshell quality Laying hen Tissue damage

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Dietary supplementation with calcitriol or quercetin improved eggshell and bone quality by modulating calcium metabolism

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Animal Nutrition 2024年第3期18卷 340-355页

作者： Yu Fu Jianmin Zhou Martine SchroyenJing Lin Haijun Zhang Shugeng Wu guanghai Qi Jing wang Key Laboratory of Feed Biotechnology Laboratory of Quality&Safety Risk Assessment for Animal Products on Feed Hazards(Beijing)Ministry of Agriculture and Rural AffairsInstitute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Precision Livestock and Nutrition Laboratory TERRA Teaching and Research CentreGembloux Agro-Bio TechUniversity of LiègeB-5030 GemblouxBelgium

This study was aimed to investigate the effects of dietary calcitriol or quercetin supplementation on eggshell and bone quality of laying *** trial 1,72 Hy-Line Brown layers(80-week-old)with weak-shelled strength(25 to 30 N)were assigned into 4 dietary treatments with 6 replicates of 3 birds and fed a basal diet(4%calcium level)or basal diets supplemented with 0.5%calcium,5μg/kg calcitriol or 500 mg/kg quercetin for 4 *** trial 2,360 Hy-Line Brown layers(60-week-old)were divided into 3 groups with 8 replicates of 15 birds:control group(basal diet),calcitriol group(basal diet+5μg/kg calcitriol),and quercetin group(basal diet+500 mg/kg quercetin).This trial lasted for 12 *** results showed that dietary calcitriol or quercetin improved eggshell quality in both trials(P<0.05).In trial 2,compared with the control group,both calcitriol and quercetin supplementations improved femoral bone quality,calcium retention of hens and calcium content in uterine fluid at 18.5 h post-oviposition(PO)(P<0.05),along with enhancing uterine *** to the control group,supplemental calcitriol or quercetin up-regulated the relative mRNA expression levels of uterine transient receptor potential cation channel,subfamily V,member 6(TRPV6)at 8.5 h PO and plasma membrane calcium-ATPase(PMCA),vitamin D receptor(VDR),estrogen receptor alpha(ERα)at 18.5 h PO(P<0.05),but down-regulated the uterine caspase 3(CASP3)relative mRNA expression level at 8.5 h PO(P<0.05).Meanwhile,the femoral relative mRNA expression levels of tartrate-resistant acid phosphatase(TRAP)(up-regulated at 8.5 and 18.5 h PO)and alkaline phosphatase(ALP)(up-regulated at 8.5 h PO but down-regulated at 18.5 h PO)were also affected by calcitriol or quercetin supplementation(P<0.05).Compared to the calcitriol,quercetin increased hen-day egg production and femoral medullary bone volume/bone tissue volume but reduced femoral stiffness(P<0.05),which were accompanied by increased relative mRNA expression levels

关键词： Uterine calcium transport Bone remodeling Eggshell quality Bone quality Calcitriol Quercetin

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Fermented soybean meal improved laying performance and egg quality of laying hens by modulating cecal microbiota,nutrient digestibility,intestinal health,antioxidant and immunological functions

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Animal Nutrition 2024年第3期18卷 309-321页

作者： Uchechukwu Edna Obianwuna Lingling Huang Haijun Zhang Jing wang guanghai Qi Kai Qiu Shugeng Wu National Engineering Research Center of Biological Feed Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Wilmar(Shanghai)Biotechnology Research&Development Center Co. Ltd.Shanghai 200137China

Antinutritional factors in feedstuffs may limit their utilization in livestock production,but fermentation process can be used to improve feed quality;however,studies on fermented soybeans for laying hens remain *** investigated the effect of fermented soybean meal(FSBM)at various inclusion levels as a partial replacement for soybean meal(SBM)on egg production,egg quality,amino acid digestibility,gut morphology and microbiota,antioxidant capacity and immune response of young laying hens.A total of 360 Hy-line Brown laying hens aged 18 weeks were selected and divided into 5 groups of 6 replicates each and 12 birds per *** control group received a basal diet while the trial group received the basal diet with FSBM included at 2.5%,5.0%,7.5%and 10.0%,respectively,for 12 *** findings revealed that the nutritional value of FSBM was higher compared to that of SBM in terms of reduced content of trypsin inhibitors and increased contents of crude protein,amino acids and *** enhanced egg production(P<0.05),feed-to-egg ratio(P<0.05),and albumen quality(albumen height and Haugh unit)(P<0.05).Furthermore,FSBM improved apparent fecal amino acid digestibility(P<0.05),gut morphology(increased villus height,villus width,villus height-to-crypt depth ratio and decreased crypt depth)(P<0.05),antioxidant capacity(reduced malondialdehyde and increased catalase,total superoxide dismutase,glutathione peroxidase and total antioxidant capacity)(P<0.05)and immune function(increased concentrations of IgG,IgA,and IgM;increased levels of transforming growth factor beta and Toll-like receptor 2;and reduced levels of interleukin 1βand tumor necrosis factor alpha)(P<0.05).Further analysis showed that FSBM altered the composition of the gut microbiota favoring beneficial *** findings suggest that probiotic fermentation improved the nutritional value of *** inclusion of FSBM in the diets of laying hens at 2.5%or 5.0%improved amino acid digestibility,gut

关键词： Fermented soybean meal Laying hen Egg production Egg quality Immune response

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