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Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

Frontiers of Medicine 2007年第4期1卷 413-417页

作者： zhou guangde ZHAO Jingmin DING Xiaohui PAN Deng SUN Yanling YANG Jianfa ZHAO Yulai Department of Pathology The 302nd Hospital of PLABeijing 100039China

To summarize the pathological features of non-alcoholic liver disease(NAFLD)in China based on a histo-logical scoring system for NAFLD designed by the Pathology Committee of NASH Clinical Research Network(NASH-CRN),the specimens of liver needle biopsies from 130 patients with NAFLD were histopathologically analyzed by haematoxylin eosin,reticular fiber and Masson trichrome *** staining was used to exclude non-NAFLD cases combined with clinical *** steatosis,lobular inflammation,hepatocytic ballooning and fibrosis were presented widespread in NAFLD liver ***,macrovesicular steatosis predominantly located in acinar zone 3 was the main histologic feature of NAFLD and lobular inflammation was usually presented *** ballooning was observed in 94.6%of all 130 *** perisinusoidal fibrosis and periportal fibrosis were often observed in stage 1 *** to the stati-stic analysis,hepatic steatosis was positively correlated with lobular inflammation,hepatocytic ballooning and fibrosis(r=0.587,0.488,0.374,respectively,all P value<0.01).The number of microgranulomas,lipogranulomas and apo-ptotic bodies increased following severity of steatosis,lobular inflammation and ***,the number of mega-mitochondria and glycogen nuclei was paralleveled to the degree of hepatocytic ballooning(P value all<0.01).We suggest that the role of portal inflammation should be empha-sized besides hepatic steatosis,lobular inflammation,hepa-tocyte ballooning and fibrosis in diagnosis and evaluation of *** needs to be further verified whether microgranu-lomas,lipogranulomas and apoptosis bodies could be used as histopathological markers of development of *** number of megamitochondria is more frequently be found in NAFLD,while in alcoholic liver diseases was Mallory bodies.

关键词： pathology nonalcoholic fatty liver diseases NASH-CRN scoring system

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Significant histologic changes are not rare in indeterminate CHB with HBeAg negative and persistently normal ALT levels

Significant histologic changes are not rare in indeterminate...

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第12届全国疑难及重症肝病大会

作者： Deliang Huang guangde zhou Jun Chen Department of Liver Diseases The Third People’s Hospital of Shenzhen

Background & Objectives: The degree of liver injury in indeterminate CHB patients with HBeAg-negative and persistently normal alanine aminotransferase(ALT) levels(PNALT) is yet unclear, we aimed to assess liver histological changes in those by liver biopsy and to explore the ***: 711 of HBeAg negative CHB patients with PNALT who underwent liver biopsy from January 2017 to June 2022 were included in this retrospective study. The relationship between histological changes and predictors was assessed by smooth curve fitting and multivariate logistic regression analyses models. Patient with PNALT was defined by having at least two or more normal ALT values and no elevated ALT at any time points in the previous 1 year before liver biopsy, and the normal upper limits(ULN) of ALT was 40 U/L for both male and female(conventional ALT criteria). Serum HBeAg negative and persistently normal ALT levels(conventional ALT criteria, ALT < 40 U/L) CHB patients, with HBV DNA <2000 IU/ml was defined as immune inactive phase;and with HBV DNA ≥ 2000 IU/ml was defined as indeterminate phase. Two additional modified ALT criteria(ULNs were 25 U/L for female and 35 U/L for male, and 19 U/L for female and 30 U/L for male, respectively) recommended by AASLD guidelines were also further analyzed in this study. The Scheuer scoring system was used to evaluate the liver tissue necroinflammation and fibrosis. The grading of necroinflammation ranged from G0 to G4, and fibrosis graded from S0 to S4. Significant necroinflammation, significant fibrosis, significant histological changes were defined by ≥ G2, ≥ S2, and ≥ G2 and/or ≥ S2, ***: Among all patients, the proportions of significant necroinflammation, significant fibrosis, and significant liver histological changes were 17.72%, 42.90%, and 47.82%, respectively. And the proportions of significant necroinflammation, fibrosis, and histological changes in indeterminate phase were significantly higher than in inactive

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Step layered combination of non-invasive fibrosis model increases diagnostic accuracy of advanced fibrosis in nonalcoholic steatohepatitis

Step layered combination of non-invasive fibrosis model incr...

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第十五届中国体视学与图像分析学术会议

作者： Mei Yang Lina Jiang guangde zhou Jingmin Zhao Department of Pathology and Hepatology Beijing 302 Hospital

Background:Non-alcoholic Fatty Liver Disease(NAFLD) has become one of the most important public health issues *** fibrosis is the main predictor of NAFLD progression and present varying degrees in *** examination is the Golden Standard of fibrosis diagnosis in NAFLD,however,it is invasive and not easily accepted by all ***-invasive diagnosis has become the inevitable trade of NAFLD diagnosis and *** we aim to evaluate several non-invasive fibrosis diagnostic models in an independent cohort of patients with biopsy-proven ***:320 consecutive patients with biopsy-proven NAFLD were enrolled(169 male,151 female,mean age 29.3 ±11.2 yrs).All subjects were given physical examination as well as physiological and biochemical *** grading and staging of NAFLD fibrosis were scored and stage 3,4 were assessed as advanced ***,BARD,FiB-4,FibroMeter NAFLD,Forns’ Index,Hui model,NIKEI,S Index and NAFLD fibrosis score(NFSA) were calculated for NAFLD *** receiver operating characteristic(ROC) curve analysis was performed for each fibrosis model in diagnosing advanced ***:A total of 125 NAFLD patients(39%) had advanced fibrosis by pathological examination.32%of the NAFLD patients were accompanied with type 2 diabetes and *** area under the ROC curve(AUROC) of APRI was 0.706,FibroMeter NAFLD 0.691,NIKEI 0.674,S Index 0.649,BARD 0.625,FiB-4 0.577,Hui model 0.569,NFSA 0.527 and Forns’ Index was *** high AUROC models were selected for the combined diagnosis of NAFLD *** step layered combination of fibrosis models in diagnosing advanced fibrosis was *** with APRI,FibroMeter NAFLD and NIKEI for diagnosing advanced fibrosis,specificity,sensitivity,negative predictive value(NPV) and positive predictive value(PPV) were up to 91.37%,63.88%,88.63%,and 72.94%,***:The combination of APRI,FibroMeter NAFLD and NIKEI fibrosis scor

关键词： NASH advanced fibrosis Non-invasive fibrosis diagnostic model

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CCL25-mediated steatosis promotes macrophages activation in nonalchoholic fatty liver disease

CCL25-mediated steatosis promotes macrophages activation in ...

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第十五届中国体视学与图像分析学术会议

作者： Lina Jiang Mei Yang guangde zhou Jingmin Zhao Department of Pathology and Hepatology Beijing 302 Hospital

Background:Nonalchoholic fatty liver disease(NAFLD) is one of the widespread diseases *** contains a variety of clinical characteristic features including steatosis and fibrosis during its *** is widely known that immune cells contribute to the pathogenesis of *** are small chemotactic cytokines,most of which are secreted by immune *** interaction between chemokines and their corresponding receptors play a significant role in microenvironment change in *** better understand the mechanism and dysfunction of the progression from steatosis to fibrosis in NAFLD,we detected chemokines production and macrophage function in NAFLD clinical samples and cell ***:154 NAFLD patient were enrolled into the group of chemokines *** chemokines were also detected in a macrophages-hepatocytes co-culture *** functions and molecules alteration of relevant signaling pathway were tested in co-culture model as chemokines over expression and ***:In the detection of chemokines,a significant elevation of C-C chemokine ligand 25(CGL25) was identified in NAFLD patient samples in contrast to healthy samples(P <0.05).GCL25 was even higher in samples of stage above F3(P < 0.01).Over expression of CCL25 induced severe steatosis and promoted macrophages *** dose CCL25 also increased the proliferation of macrophages in the cell co-culture ***:The potential mechanism of chemokines variation and macrophages activation related to steatosis and fibrosis in NAFLD patient serum and cell model may be a key role in the pathogenesis of NAFLD especially the progression from steatosis to fibrosis.

关键词： CCL25 NAFLD Steatosis Macrophages

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Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis

Combined serum biomarkers in non-invasive diagnosis of non-a...

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中华医学会第十三次全国感染病学术会议

作者： Jingmin Zhao Mei Yang Xiaodong Guo Chaonan Guo guangde zhou Shuhong Liu Wenshu Li Department of Pathology and Hepatology Beijing 302 Hospital Department of Clinical Trial Beijing 302 Hospital

Background&Aims Non-alcoholic Fatty Liver Diseases(NAFLD),especially its critical stage of nonalcoholic steatohepatitis(NASH),has become one of the most important public health issues *** liver biopsy remains the Golden Standard"for diagnosing NASH,noninvasive diagnostic methods are eagerly needed to reduce the need for invasive biopsy and risk to *** study aims at testing the accuracy of cytokeratin-18(CK-18)fragment,fibroblast growth factor 21(FGF21),interleukin 1 receptor antagonist(IL-

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Up-regulation of interleukin-22 mediates hepatitis C virus-associated liver fibrosis by activating hepatic stellate cells

Up-regulation of interleukin-22 mediates hepatitis C virus-a...

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中华医学会第十三次全国感染病学术会议

作者： Jingmin Zhao Liyuan Wu guangde zhou Shuhong Liu Xiaodong Guo Chaonan Guo Wenshu Li Department of Pathology and Hepatology Beijing 302 Hospital Department of Clinical Trail Beijing 302 Hospital

Objective Interleukin-22(IL-22)is upregulated in liver tissues of patients with hepatitis C virus(HCV)and demonstrates anti-fibrotic functions in mouse ***,the role of IL-22 in HCV-associated liver fibrosis is poorly *** study aimed to investigate the role of IL-22 in HCV-associated liver fibrosis and the possible *** and Methods The levels of IL-22 in plasma and frequencies of peripheral

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生态多功能树脂型胶粉与干混砂浆研究

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中国建材科技 2007年第5期16卷 18-21页

作者：周广德北京环益美高分子聚合物研究所北京101113

生态多功能树脂型可分散胶粉,作为新型聚合物,不仅有非常稳定的技术性能,而且与水泥砂浆等材料有极佳的和易性,较强的保水能力,在外墙抗裂腻子粉、干混砂浆、颗粒类保温浆料等产品中的应用,比建筑乳液、可再分散乳胶粉及羟丙基甲基纤维... 详细信息

生态多功能树脂型可分散胶粉,作为新型聚合物,不仅有非常稳定的技术性能,而且与水泥砂浆等材料有极佳的和易性,较强的保水能力,在外墙抗裂腻子粉、干混砂浆、颗粒类保温浆料等产品中的应用,比建筑乳液、可再分散乳胶粉及羟丙基甲基纤维素醚(HPMC)更经济实用。本文就干混砂浆的特性和该胶粉的性能进行探讨。

关键词：干混砂浆可分散胶粉胶粉技术

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浅谈建筑节能技术发展方向

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中国建材科技 2010年第2期19卷 21-23页

作者：周广德北京环益美高分子聚合物研究所北京101113

建筑节能是一个复杂的系统工程,墙体保温系统只是其中的一个很小的子系统。建筑节能事业未来的发展方向,应该是资源能源的高效利用和最大限度地利用自然能源,如风能、太阳能、光能、水气能等。建筑节能将更多地考虑环保和安全健康问题,... 详细信息

建筑节能是一个复杂的系统工程,墙体保温系统只是其中的一个很小的子系统。建筑节能事业未来的发展方向,应该是资源能源的高效利用和最大限度地利用自然能源,如风能、太阳能、光能、水气能等。建筑节能将更多地考虑环保和安全健康问题,逐步迈向建筑、建筑材料、人与健康、自然环境、社会经济和谐发展的道路。

关键词：建筑节能节能减排建筑节能技术

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水泥胶粉与聚苯颗粒保温浆料的应用研究

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中国建材科技 2006年第2期15卷 44-45页

作者：周广德北京环益美高分子聚合物研究所北京101113

人口、资源和环境已成为当今世界3大难以解决的问题,其中又特别是资源、能源已成为世界各国最为重视的问题。我国人口众多,能源紧张,开发能源和节能技术,确保国民经济的可持续发展,已被列为重要国策之一。建筑节能,不仅可以降低能源消... 详细信息

人口、资源和环境已成为当今世界3大难以解决的问题,其中又特别是资源、能源已成为世界各国最为重视的问题。我国人口众多,能源紧张,开发能源和节能技术,确保国民经济的可持续发展,已被列为重要国策之一。建筑节能,不仅可以降低能源消耗、减少环境污染、还能提高建筑的整体质量和装修技术水平。本文就水泥胶粉与聚苯颗粒保温浆料的技术原理及其应用方面进行研究,以供聚苯颗粒保温浆料生产企业、工程技术人员、施工人员参考。

关键词：聚苯颗粒保温浆料水泥胶粉

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多聚胶粉与生态粉末涂料的研究与应用

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中国建材科技 2009年第3期18卷 4-7页

作者：周广德北京环益美高分聚合物研究所北京101113

生态建材是为人类健康与生态环境服务的,特别是生态功能性建材产品,在理论与实践中,还存在一些问题,主要问题是生态功能性材料的有效发挥是需要环境与条件相互作用的,因此,在材料、技术、工艺上的研究与应用方面,还应不断探索。

关键词：生态建材硅藻泥负离子涂料

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