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Seismic behavior of outrigger truss-wall shear connections using multiple steel angles

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Earthquake Engineering and Engineering Vibration 2016年第2期15卷 197-208页

作者： Li Xian Wang Wei Lü Henglin Zhang guangchang State Key Laboratory for Geomechanics & Deep Underground Engineering China University of Mining and Technology Jiangsu Key Laboratory of Environmental Impact and Structural Safety in Civil Engineering School of Mechanics and Civil Engineering China University of Mining and Technology

An experimental investigation on the seismic behavior of a type of outrigger truss-reinforced concrete wall shear connection using multiple steel angles is presented. Six large-scale shear connection models, which involved a portion of reinforced concrete wall and a shear tab welded onto a steel endplate with three steel angles, were constructed and tested under combined actions of cyclic axial load and eccentric shear. The effects of embedment lengths of steel angles, wall boundary elements, types of anchor plates, and thicknesses of endplates were investigated. The test results indicate that properly detailed connections exhibit desirable seismic behavior and fail due to the ductile fracture of steel angles. Wall boundary elements provide beneficial confinement to the concrete surrounding steel angles and thus increase the strength and stiffness of connections. Connections using whole anchor plates are prone to suffer concrete pry-out failure while connections with thin endplates have a relatively low strength and fail due to large inelastic deformations of the endplates. The current design equations proposed by Chinese Standard 04G362 and Code GB50011 significantly underestimate the capacities of the connection models. A revised design method to account for the influence of previously mentioned test parameters was developed.

关键词： anchor truss suffer welded reinforced stiffness tensile desirable properly frames

WiFi6 Dynamic Channel Optimization Method for Fault Tolerance in Power Communication Network

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Computers, Materials & Continua 2023年第6期75卷 5501-5519页

作者： Hong Zhu Lisha Gao Lei Wei guangchang Yang Sujie Shao Nanjing Power Supply Branch State Grid Jiangsu Electric Power Co.Nanjing210000China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China

As the scale of power networks has expanded,the demand for multi-service transmission has gradually *** emergence of WiFi6 has improved the transmission efficiency and resource utilization of wireless ***,it still cannot cope with situations such as wireless access point(AP)*** solve this problem,this paper combines orthogonal fre-quency division multiple access(OFDMA)technology and dynamic channel optimization technology to design a fault-tolerant WiFi6 dynamic resource optimization method for achieving high quality wireless services in a wirelessly covered network even when an AP ***,under the premise of AP layout with strong coverage over the whole area,a faulty AP determination method based on beacon frames(BF)is ***,the maximum signal-to-interference ratio(SINR)is used as the principle to select AP reconnection for the affected ***,this paper designs a dynamic access selection model(DASM)for service frames of power Internet of Things(IoTs)and a schedul-ing access optimization model(SAO-MF)based on multi-frame transmission,which enables access optimization for differentiated *** the above mechanisms,a heuristic resource allocation algorithm is proposed in *** results show that the method can reduce the delay by 15%and improve the throughput by 55%,ensuring high-quality communication in power wireless networks.

关键词： WiFi6 OFDMA fault tolerance dynamic channel optimization cross-slot scheduling access

Failure analysis of 3D woven composites under tension based on realistic model

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Chinese Journal of Aeronautics 2024年第11期37卷 242-253页

作者： Binbin ZHANG guangchang CHEN Bing WANG Jingran GE Mengran LI Zengfei LIU Jun LIANG Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China China Helicopter Research and Development Institute Jingdezhen 333001China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and Structures Beijing 100081China

The failure behavior of the three-dimensional(3D)woven composites under tension are evaluated via experimentation and *** accurately depict the intricate geometry of the woven composites,including the fluctuation of yarn paths,variations in cross-section,and resin distribution,the image-aided digital elements modeling approach is ***,to further assess both the tensile performance and damage response,a realistic voxel model is established with the integration of a well-suited progressive damage *** obtained stress-strain curves align with the experimental results,and damage progression and underlying mechanisms involved are clearly ***,when subjected to warp tension,severe transverse damage and fiber bundle pull-out towards the warp yarns are observed within the curved ***,under weft loading,longitudinal damage is found to occur in the weft yarns,while the warp yarns suffer from transverse damage,leading to the formation of a smooth and brittle ***,the findings of this study hold potential to advance the engineering applications of the3D woven composites.

关键词： Mechanical properties Failure analysis Woven composites Realistic model Digital element methodology

How functional foods play critical roles in human health

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Food Science and Human Wellness 2012年第1期1卷 26-60页

作者： guangchang Pang Junbo Xie Qingsen Chen Zhihe Hu Tianjin Key Laboratory of Food Biotechnology Tianjin 300134China Biotechnology&Food Science College Tianjin University of CommerceTianjin 300134China

How do functional foods affect human health?To answer this question it is important to understand what happens when food is digested and taken up by the gastrointestinal(GI)*** gut is a selective nutrient absorption system and the most important signal transduction and information exchange system within the *** acts as a signal transducer,a neuroendocrine sensor,and an immunological recognition and presentation *** is also a complex information exchange system comprising a number of signaling networks involving GI cells and cells immobilized in organs or transported in *** bioactivity of functional foods in vivo may be due to their effects on such networks,but this raises the question of what signaling pathways are used by non-nutrients that cannot be absorbed by the *** purpose of this review is to describe intestinal nutrient transportation,identify a number of widely expressed receptors and signal transduction pathways,and outline our current understanding of the mechanisms involved in health and *** the end of the review,a method for developing a cell communication network is *** network is convenient for investigating the effects of oral administration of experimental medicines,drugs,or functional foods on cytokines of *** cytokines and chemokines are transported via the circulatory system,a simple 2–3 mL blood sample from a volunteer is a rich source of *** method may become the gold standard for evaluating the effects of functional foods or medicines in vivo.©2012 Production and hosting by Elsevier *** behalf of Beijing Academy of Food Sciences.

关键词： Functional foods Signal pathway Gut Cytokine Receptor Cell communication network

Remodeling of the ryanodine receptor isoform 1 channel regulates the sweet and umami taste perception of Rattus norvegicus

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Fundamental Research 2023年第3期3卷 459-468页

作者： Wenli Wang Dingqiang Lu Qiuda Xu Yulian Jin guangchang Pang Yuan Liu Department of Food Science&Technology School of Agriculture&BiologyShanghai Jiao Tong UniversityShanghai 200240China College of Biotechnology&Food Science Tianjin University of CommerceTianjin 300134China

Sweet and umami tastes are elicited by sweet and umami receptors on the tongue and palate epithelium,***,the molecular machinery allowing the taste reaction remains incompletely *** a phosphoproteomic approach,we identified the key proteins that trigger taste mechanisms based on phosphorylation *** receptor isoform 1(RYR1)was further verified by sensory and behavioral *** propose a model of RYR1-mediated sweet/umami signaling in which the RYR1 channel,which mediates Ca^(2+)release from the endoplasmic reticulum,is closed by dephosphorylation in bud tissue after sweet/umami *** alteration in Ca^(2+)content in the cytosol induces transient membrane depolarization and generates a cell current for taste signal *** demonstrate that RYR1 is a new channel involved in the regulation of sweet/umami signal transduction and propose a“metabolic clock”notion based on sweet/umami *** study provides a valuable foundation for a system-level understanding of the taste perception mechanism.

关键词： Umami Sweet Phosphoproteomic Ryanodine receptor isoform 1 Metabolic clock

Effects of casein glycomacropeptide on the early development of primary colorectal cancer in rats

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Food Science and Human Wellness 2013年第3期2卷 113-118页

作者： Qingsen Chen Yun Liang Chenchen Zhu Yali Yan guangchang Pang Tianjin Key Laboratory of Food Biotechnology College of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China

In this paper,we utilized dimethylhydrazine(DMH)-induced colorectal cancer(CC)model rats to explore the effects of casein glycomacropeptide(CGMP)on colorectal *** with CC were orally administrated with 10,50,or 100 mg/kg bw d CGMP,or the same volume of phosphatebuffered saline for 15 *** total numbers of aberrant crypt foci(ACF)and crypts per focus in colon were scored using a light microscope at low magnification after the colon was stained with methylene blue *** methylation level of DNA extracted from colon was detected using methylation-specific *** expression of p16 and mucin 2(MUC2)proteins were measured by *** results showed that although ACF were found in rats treated with CGMP,their number was significantly decreased compared to that of model *** addition,methylation and expression levels of p16 and MUC2 were also inhibited by CGMP,which were more obvious in rats treated with 50 mg/kg bw d *** conclusion,CGMP has potential application as nutritional therapy for preventing colorectal cancer.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Casein glycomacropeptide Colorectal cancer DNA methylation p16 Mucin 2

Comment on Lieberman’s Book Review

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Journal of Mathematical Research with Applications 1993年第4期 529-531页

作者： Dong guangchang(Zhejiang University,Hangzhou,China)

*** published his book review in the1993 January issue of *** AMS on my monograph“Nonlinear Partial Differential Equations of Second Order”(***,Vol.95 AMS).I would like to express my point of view onthe aspects of scholarship,content of my monograph,style,reference literature,and thecontent of the book ***,this would clarify matters and ensure a correctunderstanding of the facts.

关键词： s Book Review Comment on Lieberman Book

Energy intake,metabolic homeostasis,and human health

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Food Science and Human Wellness 2014年第3期3卷 89-103页

作者： guangchang Pang Junbo Xie Qingsen Chen Zhihe Hu Tianjin Key Laboratory of Food Biotechnology College of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China

The energy substances(mainly carbohydrates and fats)are the basis and guarantee of life activity,especially the oxidative phosphorylation for energy ***,excessive absorption and accumulation of these substances can lead to metabolic diseases such as obesity,hyperlipidemia,diabetes,and cancers.A large amount of studies demonstrate that G protein-coupled receptors(GPCRs)play a key role in identification and absorption of energy substances,and the signaling network of nerves,immune,and endocrine regulates their storage and *** gastrointestinal mucus layer not only identifies these substances through identification in diet components but also transfers immune,metabolic,and endocrine signals of hormones,cytokines,and chemokines by promoting interactions between receptors and *** signaling molecules are transferred to corresponding organs,tissues,and cells by the circulatory system,and cell activity is regulated by amplifying of cell signals that constitute the wireless communication network among cells in the ***,accumulation,and utilization of energy substances in the body obey the law of energy *** is stored in the form of fat,and meets the demand of body via two coupled mechanisms:catabolism and oxidative *** normal physiological conditions,fat consumption involves ketone body metabolism through the circulatory system and glucose consumption requires blood lactic acid *** of excessive energy leads to the abnormal activation of mammalian target of rapamycin(mTOR),thus promoting the excretion of glucose or glycogen in the form of blood glucose and urine ***,the body cancels the intercellular contact inhibition and promotes cell proliferation to induce carcinogenesis,which can induce the consumption of large amounts of *** communication is performed by signaling molecules via sensing,absorption,accumulation,and utilization of energy substances

关键词： Energy substance Metabolism balance Metabolic syndrome Wireless intercellular communication network Metabolic network Human health

A Clinical and Histopathological Analysis of 45 Cases of Cutaneous Neurilemmoma (Schwannomas)

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Journal of Biosciences and Medicines 2024年第11期12卷 384-396页

作者： Shimin He guangchang Shan Department of Dermatology The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen China Department of Pathology The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen China

Background: Neurilemmoma (Schwannomas) are the most common peripheral nerve tumors and usually do not undergo malignant transformation, except in some atypical cases. Additionally, the imaging appearance of schwannomas resembles that of neurofibromas, making it difficult to distinguish between the two. Therefore, the clinical diagnosis and treatment of schwannomas may face certain challenges. The management and prognosis of neurilemmomas differ from their malignant counterparts, making correct diagnosis important. Objective: This study evaluates the clinical and histopathological characteristics of 45 cases of neurilemmoma. Methods: This retrospective study involves 45 cases diagnosed with cutaneous neurilemmoma at the Seventh Affiliated Hospital of Sun Yat-sen University between April 2020 and September 2024. All cases were retrieved from medical records. Results: The age range of the 45 patients was 23 to 73 years, with a male to female ratio of 1.6:1. Over half the cases occurred in individuals aged 30 to 59, with most lesions found in the extremities, predominantly in the lower limbs. Disease duration varied from 7 days to 20 years. All tumors were solitary, with diameters ranging from 0.8 cm to 8 cm. Most tumors (33/45, 73.33%) were asymptomatic, though some patients experienced symptoms like pain and numbness. Mass was the most common clinical diagnosis (33/45, 73.33%). Five patients had suspected neurilemmomas prior to surgery. Immunohistochemical staining revealed all positive results for S-100 and SOX-10 markers, while EMA staining showed a negative rate of 93.33%. Most Ki-67 values (19/23, 82.6%) were less than or equal to 5%. Conclusion: The diversity of clinical features, pathological manifestations, and immunohistochemical results of schwannoma poses a challenge to accurate diagnosis. A comprehensive understanding of its clinical and pathological characteristics is essential for accurate diagnosis, and when combined with immunohistochemical analysis, it

关键词： Neurilemmoma Schwannomas Cutaneous Neurilemmoma Clinical Feature Histopathological Characteristics