检索结果-南通市图书馆

Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration

在线全文

学校读者我要写书评

暂无评论

Research 2022年第4期2022卷 757-779页

作者： guangbo xia Beibei Song Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China Nationai Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123China

Electrical stimulation has demonstrated great effectiveness in the modulation of cell fate in vitro and regeneration therapy in ***,the employment of electrical signal comes with the electrodes,battery,and connectors in an invasive *** tedious procedure and possible infection hinder the translation of electrical stimulation technologies in regenerative *** electromechanical coupling and flexibility,piezoelectric polymers can overcome these limitations as they can serve as a self-powered stimulator via scavenging mechanical force from the organism and external stimuli *** electrical cue mediated by electrospun piezoelectric polymeric nanofibers constitutes a promising paradigm allowing the generation of localized electrical stimulation both in a noninvasive manner and at cell ***,numerous studies based on electrospun piezoelectric nanofibers have been carried out in electrically regenerative *** this review,brief introduction of piezoelectric polymer and electrospinning technology is elucidated ***,we highlight the activating strategies(e.g.,cell traction,physiological activity,and ultrasound)of piezoelectric stimulation and the interaction of piezoelectric cue with nonelectrically/electrically excitable cells in regeneration ***,quantitative comparison of the electrical stimulation effects using various activating strategies on specific cell behavior and various cell types is ***,this review explores the present challenges in electrospun nanofiber-based piezoelectric stimulation for regeneration therapy and summarizes the methodologies which may be contributed to future efforts in this field for the reality of this technology in the clinical *** the end,a summary of this review and future perspectives toward electrospun nanofiber-based piezoelectric stimulation in tissue regenerationare elucidated.

关键词： piezoelectric fibers electrical

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

智能可穿戴纺织品用电活性纤维材料

纺织学报 2021年第9期42卷 1-9页

作者：方剑任松张传雄陈钱夏广波葛灿苏州大学纺织与服装工程学院江苏苏州215021 苏州大学现代丝绸国家工程实验室江苏苏州215123 纺织工业科学技术发展中心北京100020

为促进智能纤维材料和智能可穿戴纺织品的发展,对智能可穿戴纺织品用电活性纤维材料进行了全面的陈述。总结了近几年纤维基和织物基智能可穿戴纺织品的发展现状;介绍了电活性纤维材料的定义、常用制备方式、发展过程以及最新研究进展,... 详细信息

为促进智能纤维材料和智能可穿戴纺织品的发展,对智能可穿戴纺织品用电活性纤维材料进行了全面的陈述。总结了近几年纤维基和织物基智能可穿戴纺织品的发展现状;介绍了电活性纤维材料的定义、常用制备方式、发展过程以及最新研究进展,并对其应用领域进行系统分类与性能探讨,包括应变传感、电致变色、智能调温、能量收集与存储等领域;讨论了目前电活性纤维材料用于智能可穿戴纺织品的发展潜力和面临的问题;最后指出其未来发展方向,以期为电活性纤维材料在智能可穿戴纺织品中的广泛应用提供理论和技术参考。

关键词：智能可穿戴纺织品电活性纤维材料传感器电致变色智能调温能量收集与存储

在线全文

学校读者我要写书评

暂无评论

柔性及纺织基钙钛矿太阳能电池的研究进展

材料导报 2020年第7期34卷 53-60页

作者：董丽卡丁明乐庄志山夏广波邓倩囡邱琳琳杜平凡浙江理工大学材料与纺织学院杭州310016

传统的能源器件大多为平面刚性结构,虽然坚固耐用,但对于实现器件的可穿戴来说,较难满足微型化、轻量化、柔性化、集成化的要求,这正是目前的应用瓶颈。纺织材料作为天然的穿戴材料,具有无可比拟的柔性和穿戴舒适性,且能适应人体曲面,因... 详细信息

传统的能源器件大多为平面刚性结构,虽然坚固耐用,但对于实现器件的可穿戴来说,较难满足微型化、轻量化、柔性化、集成化的要求,这正是目前的应用瓶颈。纺织材料作为天然的穿戴材料,具有无可比拟的柔性和穿戴舒适性,且能适应人体曲面,因此,基于纺织材料构建能源器件是可穿戴技术发展的重要方向。本文介绍了钙钛矿太阳能电池的器件结构和工作原理,从电子传输层材料、空穴传输层材料、基底材料这三方面介绍了柔性钙钛矿太阳能电池的研究进展,并对纺织基柔性钙钛矿太阳能电池的最新研究进展进行了评述,最后对包括纺织基在内的柔性钙钛矿太阳能电池的未来发展进行了展望。

关键词：能源器件钙钛矿太阳能电池柔性纺织基可穿戴应用

在线全文

学校读者我要写书评

暂无评论

柔性钙钛矿太阳能电池研究进展

材料导报 2018年第A2期32卷 5-8页

作者：庄志山邱琳琳陈悦褚朱丹丁明乐夏广波杜平凡浙江理工大学材料与纺织学院杭州310016

近年来,柔性钙钛矿太阳能电池由于具有质量轻、成本低、形状可塑、适用性广等优点,成为了太阳能电池领域炙手可热的研究课题。目前,该类柔性电池的最高光电转换效率已超过16%。本文针对柔性钙钛矿太阳能电池的结构及其柔性衬底,介绍了... 详细信息

近年来,柔性钙钛矿太阳能电池由于具有质量轻、成本低、形状可塑、适用性广等优点,成为了太阳能电池领域炙手可热的研究课题。目前,该类柔性电池的最高光电转换效率已超过16%。本文针对柔性钙钛矿太阳能电池的结构及其柔性衬底,介绍了其主要的研究方向和目前的研究进展,并探讨了柔性钙钛矿太阳能领域面临的主要问题与挑战,最后展望了柔性钙钛矿太阳能电池的发展。

关键词：钙钛矿太阳能电池柔性衬底器件结构研究进展

在线全文

学校读者我要写书评

暂无评论

纤维及织物基柔性可穿戴器件研究进展

材料导报 2020年第S1期34卷 490-497页

作者：马香钰夏广波邱琳琳董丽卡丁明乐杜平凡浙江理工大学纺织科学与工程学院杭州310018

近年来,随着智能技术的迅速发展,可穿戴器件逐渐成为研究热点。在实际应用中,柔性的可穿戴器件具有更广阔的应用前景,尤其是以纤维和织物为基底制作的柔性器件为解决穿着舒适性、耐水洗性不佳及三维形变时与人体贴合性差等问题提供了基... 详细信息

近年来,随着智能技术的迅速发展,可穿戴器件逐渐成为研究热点。在实际应用中,柔性的可穿戴器件具有更广阔的应用前景,尤其是以纤维和织物为基底制作的柔性器件为解决穿着舒适性、耐水洗性不佳及三维形变时与人体贴合性差等问题提供了基础,同时符合绿色环保的理念,具有现实的研究意义。本文介绍了几种典型的柔性可穿戴器件,并简要回顾了可穿戴设备的柔性化进程;概述了以纤维、织物为基底的柔性可穿戴器件的制备方法;对纤维/织物基器件进行了分类并综述了在柔性传感器、柔性能源器件、柔性电极等领域的最新应用,指出随着材料科学、纺织技术和微电子技术的融合发展,通过系统设计和一体成型构建纺织结构柔性器件是穿戴式产品进一步发展的客观需求和必然趋势。

关键词：柔性可穿戴器件纤维及织物基底传感器能源器件电极

Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2019年第2期9卷 258-278页

作者： xia Lv Yangliu xia Moshe Finel Jingjing Wu guangbo Ge Ling Yang Institute of Interdisciplinary Medicine Shanghai University of Traditional Chinese Medicine Key Laboratory of Biotechnology and Bioresources Utilization Ministry of Education College of Life ScienceDalian Minzu University Dalian Institute of Chemical Physics Chinese Academy of Sciences Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki

Uridine-diphosphate glucuronosyltransferase 1 A1(UGT1 A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1 A1 may trigger adverse drug/herb–drug interactions, or result in metabolic disorders of endobiotic metabolism. Therefore, both the US Food and Drug Administration(FDA)and the European Medicines Agency(EMA) have recommended assaying the inhibitory potential of drugs under development on the human UGT1 A1 prior to approval. This review focuses on the significance,progress and challenges in discovery and characterization of UGT1 A1 inhibitors. Recent advances in the development of UGT1 A1 probes and their application for screening UGT1 A1 inhibitors are summarized and discussed in this review for the first time. Furthermore, a long list of UGT1 A1 inhibitors, including information on their inhibition potency, inhibition mode, and affinity, has been prepared and analyzed. Challenges and future directions in this field are highlighted in the final section. The information and knowledge that are presented in this review provide guidance for rational use of drugs/herbs in order to avoid the occurrence of adverse effects via UGT1 A1 inhibition, as well as presenting methods for rapid screening and characterization of UGT1 A1 inhibitors and for facilitating investigations on UGT1 A1–ligand interactions.

关键词： UGT1A1 inhibitors Drug/herbdrug interactions Probe substrates High-throughput screening

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2017年第6期7卷 657-664页

作者： Xuewei Cheng xia Lv Hengyan Qu Dandan Li Mengmeng Hu Wenzhi Guo guangbo Ge Ruihua Dong Clinical Pharmacology Laboratory Military Academy of Medical Science Hospital Dalian Institute of Chemical Physics Chinese Academy of Sciences College of Life Science Dalian Nationalities University Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Institute of Interdisciplinary Medicine Shanghai University of Traditional Medicine

UDP-glucuronosyltransferase 1A1(UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions(DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitory effects of icotinib and erlotinib against UGT1A1, as well as to evaluate their potential DDI risks via UGT1A1 inhibition. The results demonstrated that both icotinib and erlotinib are UGT1A1 inhibitors, but the inhibitory effect of icotinib on UGT1A1 is weaker than that of erlotinib. The IC_(50) values of icotinib and erlotinib against UGT1A1-mediated NCHN-O-glucuronidation in human liver microsomes(HLMs) were 5.15 and 0.68 μmol/L, respectively. Inhibition kinetic analyses demonstrated that both icotinib and erlotinib were non-competitive inhibitors against UGT1A1-mediated glucuronidation of NCHN in HLMs, with the Kivalues of 8.55 and 1.23 μmol/L, respectively. Furthermore, their potential DDI risks via UGT1A1 inhibition were quantitatively predicted by the ratio of the areas under the concentration–time curve(AUC) of NCHN. These findings are helpful for the medicinal chemists todesign and develop next generation tyrosine kinase inhibitors with improved safety, as well as to guide reasonable applications of icotinib and erlotinib in clinic, especially for avoiding their potential DDI risks via UGT1A1 inhibition.

关键词： Icotinib Erlotinib UGT1A1 Inhibitory effects Drug–drug interactions(DDIs)

B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第16期136卷 1977-1989页

作者： Lu xia Yuqi Chen Juntao Li Jiayu Wang Kanger Shen Anjing Zhao Haiyan Jin guangbo Zhang Qinhua Xi Suhua xia Tongguo Shi Rui Li Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Jiangsu Key Laboratory of Clinical Immunology Soochow UniversitySuzhouJiangsu 215000China Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Department of Oncology The First Affiliated Hospital of Naval Military Medical UniversityShanghai 200433China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China

Background:Cancer stem-like cells(CSCs)are a small subset of cells in tumors that exhibit self-renewal and differentiation *** play a vital role in tumor formation,progression,relapse,and therapeutic resistance.B7-H3,an immunoregulatory protein,has many protumor ***,little is known about the mechanism underlying the role of B7-H3 in regulating gastric cancer(GC)*** study aimed to explore the impacts of B7-H3 on GC stemness and its underlying ***:GC stemness influenced by B7-H3 was detected both in vitro and in *** expression of stemness-related markers was examined by reverse transcription quantitative polymerase chain reaction,Western blotting,and flow *** formation assay was used to detect the sphere-forming *** underlying regulatory mechanism of B7-H3 on the stemness of GC was investigated by mass spectrometry and subsequent validation *** signaling pathway(Protein kinase B[Akt]/Nuclear factor erythroid 2-related factor 2[Nrf2]pathway)of B7-H3 on the regulation of glutathione(GSH)metabolism was examined by Western blotting ***-color immunohistochemistry(mIHC)was used to detect the expression of B7-H3,cluster of differentiation 44(CD44),and Nrf2 on human GC ***’s t-test was used to compare the difference between two *** correlation analysis was used to analyze the relationship between two *** Kaplan-Meier method was used for survival ***:B7-H3 knockdown suppressed the stemness of GC cells both in vitro and in *** spectrometric analysis showed the downregulation of GSH metabolism in short hairpin B7-H3 GC cells,which was further confirmed by the experimental ***,stemness characteristics in B7-H3 overexpressing cells were suppressed after the inhibition of GSH ***,Western blotting suggested that B7-H3-induced activation of GSH metabolism occurred through the AKT/Nrf2 pathway,and inhibition

关键词： B7-H3 Cancer stem-like cells Glutathione Protein kinase B Nuclear factor erythroid 2-related factor 2 Gastric cancer

在线全文

学校读者我要写书评

暂无评论

中日中小企业所得税优惠政策比较研究

税务研究 2023年第12期 87-94页

作者：高广波夏智灵北华航天工业学院经济管理学院国家税务总局社会保险费司

我国和日本对中小企业“费用”“资产”等的税收优惠,在设计思路和政策目标方面较为相似。本文对中日两国中小企业所得税在税率优惠、收入减计、费用扣除、固定资产折旧、坏账准备及亏损弥补等方面的异同点进行比较,同时总结了日本中小... 详细信息

我国和日本对中小企业“费用”“资产”等的税收优惠,在设计思路和政策目标方面较为相似。本文对中日两国中小企业所得税在税率优惠、收入减计、费用扣除、固定资产折旧、坏账准备及亏损弥补等方面的异同点进行比较,同时总结了日本中小企业所得税优惠政策在系统性、导向性、适配性、可行性等方面的特点及对我国的启示,旨在为我国中小企业税收制度的改进与完善提供参考。

关键词：中小企业企业所得税税收优惠