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Bladder paraganglioma after kidney transplantation:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9044-9049页

作者： Lin Wang Yan-Ning Zhang guang-yong chen Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Kidney transplantation is associated with an increased risk of tumors in the urinary bladder.Among all the pathological types of tumors in the bladder,paraganglioma,which arises from extra-adrenal paraganglia and consists of chromaffin cells,is rare.Paragangliomas might cause severe clinical symptoms due to catecholamine hypersecretion or mass compression.Bladder paragangliomas are rare,especially those appearing after kidney transplantation.Here,we report a case of bladder paraganglioma developing after kidney transplantation.CASE SUMMARY A 63-year-old woman received a kidney transplant 12 years ago and took oral immunosuppressants(cyclosporine,mizoribine,and methylprednisolone)for regular post-transplant treatment.The patient felt no discomfort and she came to the hospital for a routine checkup.A mass located in the bladder was incidentally discovered by computed tomography,and she underwent surgical treatment.A 2 cm×2 cm invasive mass was found in the trigone of the bladder and the mass was removed.The diagnosis of paraganglioma was confirmed by morphology and immunophenotyping.The patient had a good prognosis and is still alive.CONCLUSION Paraganglioma can grow in the bladder,which might cause no clinical symptoms.The diagnosis mainly depends on morphology and immunophenotyping.Surgical resection is an important treatment option for such patients.

关键词： Paraganglioma Urinary bladder tumor Kidney transplantation Case report

Coexistent Kaposi sarcoma and post-transplant lymphoproliferative disorder in the same lymph nodes after pediatric liver transplantation:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9004-9011页

作者： Shu-Hong Zhang guang-yong chen Zhi-Jun Zhu Lin Wei Ying Liu Jing-Yi Liu Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Liver Transplantation Center National Clinical Research Center for Digestive DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Clinical Center for Pediatric Liver Transplantation Capital Medical UniversityBeijing 100050China Department of Critical Liver Diseases Liver Research CenterBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Kaposi sarcoma and post-transplant lymphoproliferative disorder have been occasionally reported in post-liver transplant patients.However,the simultaneous occurrence of these two diseases in the same lymph nodes is very rare.CASE SUMMARY We report the case of a 19-mo-old boy,who presented with intermittent fever and enlarged cervical lymph nodes after liver transplantation.Six cervical lymph nodes were biopsied,and the histopathological examinations revealed multifocal hyperplasia of spindle cells around small blood vessels,extravasated erythrocytes,and heavy infiltration of plasma cells in the cortex and medulla of the lymph nodes.The immunohistochemical analyses of spindle cells revealed positive expression of CD34,CD31,erythroblast transformation-specific-related gene,friend leukemia integration 1,and human herpesvirus-8.The lymphoproliferative lesions expressed CD38,CD138,and multiple myeloma 1.Epstein-Barr encoded RNA in situ hybridization demonstrated Epstein-Barr virus-positive lymphoid cells.Finally,we diagnosed the coexistence of Kaposi sarcoma and post-transplant lymphoproliferative disorder(plasmacytic hyperplasia)in the same lymph nodes.Treatment strategy included anti-CD20 monoclonal antibody(rituximab)and discontinuation of the immunosuppressant therapies.Lymph node biopsies during follow-up examinations revealed lymphoid hyperplasia.CONCLUSION The rare coexistence of Kaposi sarcoma and post-transplant lymphoproliferative disorder in the same lymph nodes post-liver transplantation possibly associates with immunodeficiency and Epstein-Barr virus and human herpesvirus-8 coinfection.

关键词： Kaposi sarcoma Post-transplant lymphoproliferative disorder Liver transplantation Epstein-Barr virus infections Human herpesvirus-8 Case report

Mediastinum metastasis in a post-surgical pancreatic cancer patient successfully confi rmed with endoscopic ultrasonography

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World Journal of Emergency Medicine 2021年第3期12卷 244-246页

作者： Hong-tao Wei guang-yong chen Peng Li Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Dear editor,Pancreatic carcinoma is highly malignant and is mainly characterized by a low rate of eligibility for curative-intent resection,rapid metastases and/or local relapses even after surgery.[1-3]Imaging examinations like enhanced computed tomography(CT)/magnetic resonance imaging(MRI),and positron emission tomography-computed tomography(PET-CT),play an important role in detecting tumor recurrence or residual after radical resection of pancreatic cancer.However,these detection platforms are increasingly reported to have insufficient sensitivity and specificity.[4,5]Here we report a pancreatic cancer patient who had progressively increased carbohydrate antigen 19-9(CA199)level one year and three months after surgery;however,none of the above imaging methods were able to identify the cause.After our investigations,we discovered mediastinal metastasis using endoscopic ultrasonography(EUS)and confi rmed by EUS-guided fi ne needle aspiration(EUS-FNA).

关键词： metastasis ultrasonography needle

Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit

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World Journal of Clinical Cases 2020年第2期8卷 264-275页

作者： Zhi Zheng Rui Xu Jie Yin Jun Cai guang-yong chen Jun Zhang Zhong-Tao Zhang Department of General Surgery Beijing Friendship Hospital Capital Medical University

BACKGROUND Peutz-Jeghers syndrome(PJS) is an autosomal dominant inherited disease easily causing secondary malignant changes without effective treatments.AIM To assess the clinical characteristics, diagnosis, and treatment of malignant changes secondary to PJS.METHODS The clinical data of five patients with malignant changes secondary to PJS diagnosed and treated at Beijing Friendship Hospital from June 2014 to January 2017 were retrospectively analyzed;the follow-up ended in May 2018.RESULTS There were three male and two female patients with an average age of 43.6 years.Intestinal obstruction, intussusception, and abdominal pain were the first symptoms. Computed tomography and gastrointestinal imaging combined with endoscopy helped evaluate the depth of tumor infiltration and determine the need for radical resection. Three patients underwent surgery. Postoperative pathology confirmed adenocarcinoma, genetic test indicated STK11 mutation,and the patients received chemotherapy, including one who succumbed to tumor progression 6 months post-surgery. Other two patients underwent endoscopic resection, and postoperative pathology confirmed high grade intraepithelial neoplasia. The surviving patients had no recurrence by May 2018.CONCLUSION Endoscopy combined with computed tomography and gastrointestinal imaging is of great significance in the diagnosis and treatment of PJS, and pathological examination and gene detection are the gold standards for detecting malignant changes secondary to PJS. Some malignant polyps can be removed under endoscopy, and surgery is feasible when malignant polyps cannot be remove dunder an endoscope. For patients unable to achieve R0 resection, clinical symptoms should be relieved, and postoperative adjuvant chemotherapy could improve long-term prognosis. Meanwhile, close and regular surveillance should be conducted to prevent severe complications.

关键词： Peutz-Jeghers syndrome Malignant Diagnosis Surgery Treatment

Current indications for endoscopic submucosal dissection of early gastric cancer

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 560-573页

作者： Zhi Zheng Jie Yin Xiao-Ye Liu Xiao-Sheng Yan Rui Xu Meng-Yi Li Jun Cai guang-yong chen Jun Zhang Zhong-Tao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

The development of endoscopic treatment technology has further promoted the minimally invasive treatment of early gastric cancer(EGC).Endoscopic treatment has achieved better therapeutic effects in terms of safety and prognosis and is the preferred treatment method for patients who meet the indications for endoscopic treatment.However,the consequent problem is that some patients receiving endoscopic treatment may undergo non-curative resection,and the principle of follow-up management for non-curative resection patients deserves further attention.In addition,there are still debates on how to improve the accuracy of clinical staging,select a reasonable treatment method for patients who meet the expanded indications for endoscopic treatment,manage patients with positive endoscopic surgical margins,conduct research on function-preserving surgery,and manage the treatment of EGC under the current situation in China.Consequently,we aim to review current indications for endoscopic submucosal dissection of EGC in order to better inform treatment options.

关键词： Early gastric cancer Endoscopic submucosal dissection indications Noncurative resection Salvage surgery Function-preserving surgery

Extreme value theory applied to the auroral electrojet indices

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Earth and Planetary Physics 2024年第2期8卷 375-381页

作者： Si chen Hong Yuan yong Wei guang Yang FengZheng Yu Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The study of extreme weather and space events has gained paramount importance in modern society owing to rapid advances in high technology.Understanding and describing exceptional occurrences plays a crucial role in making decisive assessments of their potential impact on technical,economic,and social aspects in various fields.This research focuses on analyzing the hourly values of the auroral electrojet(AE)geomagnetic index from 1957 to 2019 by using the peak over threshold method in extreme value theory.By fitting the generalized Pareto distribution to extreme AE values,shape parameter indices were derived,revealing negative values that establish an upper bound for this time series.Consequently,it became evident that the AE values had reached a plateau,suggesting that extreme events exceeding the established upper limit are rare.As a result,although the need for diligent precautions to mitigate the consequences of such extreme events persists,surpassing the upper limit of AE values becomes increasingly challenging.It is also possible to observe an aurora in the middle-and low-latitude regions during the maximum period of the AE index.

关键词： auroral electrojet indices extreme value theory extreme events

Construction of Naphthalenediimide Lanthanide(Ⅲ)-MOFs and Composites Incorporated Electron-Rich Pyrene Derivative as Multifunctional Fluorescence Sensing for Nitro Aromatic Compounds and Aldehydes

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Chinese Journal of Chemistry 2024年第3期42卷 283-293页

作者： Rong Huo Ting Zhang guang Zeng chen Wang yong Heng Xing Feng Ying Bai College of Chemistry and Chemical Engineering Liaoning Normal UniversityDalianLiaoning116029 China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

The development of host-guest MOF luminescent composites has attracted considerable attention. However,it is still a challenge to reasonably design large scale conjugated polycarboxylic acids metal-organic framework (MOF) and modulate donor-acceptor interaction. Herein,a series of isostructural 3D porous lanthanide MOF [Ln_(2)(BINDI)0.5(NO_(3))(DMA)(H_(2)O)]∙DMA∙2.5H_(2)O (Ln = La (1),Ce (2),Pr (3) and Nd (4);H_(4)BINDI (N,N’-bis(5-isophthalic acid)-1,4,5,8-naphthalenediimide) were synthesized. Considering the electron-deficient performances of Ln-BINDI MOFs,D-A type composites Ln-MOFs (1—4@H_(4)TBAPy) were prepared via the incorporation of electron-rich H_(4)TBAPy (1,3,6,8-tetrakis(p-benzoic acid) pyrene),which more improved the luminescence performance of complexes 1—4 and can be used as fluorescence sensors for the detection of nitro compounds and aldehydes. High sensitivity of 1@H_(4)TBAPy towards pNBA,pNA PNP,DNP,and TNP could be achieved through hydrogen bond interactions between MOF and analytes,as well as the π-π interaction between H_(4)TBAPy and the naphthalene ring of BINDI,thus the fluorescence quenching efficiency of 1@H_(4)TBAPy was better than that of the complex 1. In addition,it is found that 1@H_(4)TBAPy has high selectivity and sensitivity to aromatic aldehyde SA,5-Mesal and HMBA. Such strategy to enhance the emission of NDI based Ln-BINDI MOFs,will open up an avenue to obtain more fluorescent MOFs for sensing.

关键词： Ln-MOF Pyrene molecule NACs Aldehydes Fluorescence sensing Carboxylate ligands Charge transfer Donor-acceptor systems

B cell development and antibody responses in human immune system mice:current status and future perspective

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Science China(Life Sciences) 2024年第4期67卷 645-652页

作者： Tao Zhang Wentao Liu yong-guang Yang Key Laboratory of Organ Regeneration&Transplantation of the Ministry of Education The First Hospital of Jilin UniversityChangchun 130061China National-Local Joint Engineering Laboratory of Animal Models for Human Diseases Jilin UniversityChangchun 130061China International Center of Future Science Jilin UniversityChangchun 130061China

Humanized immune system(HIS)mice have been developed and used as a small surrogate model to study human immune function under normal or disease conditions.Although variations are found between models,most HIS mice show robust human T cell responses.However,there has been unsuccessful in constructing HIS mice that produce high-affinity human antibodies,primarily due to defects in terminal B cell differentiation,antibody affinity maturation,and development of primary follicles and germinal centers.In this review,we elaborate on the current knowledge about and previous attempts to improve human B cell development in HIS mice,and propose a potential strategy for constructing HIS mice with improved humoral immunity by transplantation of human follicular dendritic cells(FDCs)to facilitate the development of secondary follicles.

关键词： humanized immune system mouse humoral immunity germinal center B cell follicular dendritic cell

Current status and challenges of pig-to-human organ xenotransplantation

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Science China(Life Sciences) 2024年第4期67卷 829-831页

作者： Minghui Fang yong-guang Yang Zheng Hu Key Laboratory of Organ Regeneration&Transplantation of Ministry of Education and National-Local Joint Engineering Laboratory of Animal Models for Human DiseasesThe First Hospital of Jilin UniversityChangchun 130061China

Organ shortage is a global issue.Data collected by the Global Observatory on Donation and Transplantation reveals that over 150,000 solid organ transplants are conducted globally each year,a 52%increase from 2010(http... 详细信息

关键词： globally global shortage