检索结果-南通市图书馆

World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai zhang Chuan Lu Sheng Zheng guang Hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and *** repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing *** To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture *** Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their *** vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing *** could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial ***,the effect of hydrogel on fracture healing was confirmed using a mouse fracture *** The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone *** effects were further validated in fracture *** We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

Selective nickel-electrocatalyzed benzylic C-H oxygenation of functionalized alkyl arenes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 396-401页

作者： Shunyao Tang Siyi Wang Dongmei zhang Xinxing zhang guang Yang Yanwei Wang Youai Qiu State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education)Renewable Energy Conversion and Storage Center (RECAST)Frontiers Science Center for New Organic MatterNankai UniversityTianjin 300071China

Herein, a site-selective paired electrochemical C–H oxidation of functionalized alkyl arenes promoted by nickel catalyst is disclosed. A Ni(Ⅱ)-dioxygen species formed in situ efficiently enable the oxidation process under mild conditions with a broad substrate scope with excellent functional group compatibilities,such as free carboxylic acid, aldehyde, halogen(including aryl iodide), amide and amino acid. The use of the nickel catalyst in combination with water provides a safe, green and economical method for oxidation of a range of molecules varying in complexity and drug derivatives, demonstrating its potential application in organic synthesis and the pharmaceutical industry. Reaction outcomes and mechanistic studies revealed the key role of the in situ Ni(Ⅱ)-dioxygen species for the subsequent oxidation of C(sp^(3))–H bonds,and short-lived reactive intermediates(aryl radical cation) was rapidly captured by the combination of a bipolar ultramicroelectrode(BUME) with nano-electrospray ionization mass spectrometry.

关键词： Electrochemical C-H oxidation Functionalized alkyl arenes Paired nickel-electrocatalysis H_(2)O oxidation Ketones

The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 252-271页

作者： Qing Ma guang Chen Ying Li Zhenming Guo Xue zhang NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Child and Adolescent Health School of Public HealthHarbin Medical UniversityHarbinHeilongjiang 150000China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200120China

Malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental *** kinds of MCD are caused by genetic *** is the common cause of intellectual disability and intractable *** rapid advances in imaging and sequencing technologies,the diagnostic rate of MCD has been increasing,and many potential genes causing MCD have been successively ***,the high genetic heterogeneity of MCD makes it challenging to understand the molecular pathogenesis of MCD and to identify effective targeted ***,in this review,we outline important events of cortical *** we illustrate the progress of molecular genetic studies about MCD focusing on the PI3K/PTEN/AKT/mTOR ***,we briefly discuss the diagnostic methods,disease models,and therapeutic strategies for *** information will facilitate further research on *** the role of the PI3K/PTEN/AKT/mTOR pathway in MCD could lead to a novel strategy for treating MCD-related diseases.

关键词： Epilepsy Gene mutation Genetics Malformations of cortical development PI3K/PTEN/AKT/mTOR pathway

Closed-form solution to the dynamic programming for a heavy-duty parallel hybrid vehicle energy management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Control and Decision 2024年第1期11卷 107-116页

作者： tao zhang Zhongjun Yu Huangda Lin National Key Laboratory for Vessel Integrated Power System Technology Naval University of EngineeringWuhanPeople’s Republic of China

Dynamic programming(DP)is frequently used to obtain the optimal solution to the hybrid electric vehicle(HEV)energy *** trade-off between the accuracy and the computational effort is the biggest problem for the DP *** closed-form solution to the DP is proposed to solve this ***,the affine linear model of the engine fuel rate is obtained based on engine test *** piecewise linear approximation of the motor power demand is obtained considering the different energy flows in the charging and discharging stages of the ***,the second-order Taylor expansion for the cost matrix at each time and state grid point is introduced to get the closed-form solution of the optimal torque *** results show that this method can greatly reduce the computing burden by 93%while ensuring near-optimal fuel economy compared with the conventional DP method.

关键词： Dynamic programming energy management closed-form solutions fuel economy hybrid electric vehicles

A review on capacity sizing and operation strategy of grid-connected photovoltaic battery systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy and Built Environment 2024年第4期5卷 500-516页

作者： Yijie zhang tao Ma Hongxing Yang Renewable Energy Research Group(RERG) Department of Building Environment and Energy EngineeringThe Hong Kong Polytechnic UniversityHong KongChina School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghaiChina

Due to the fluctuation and intermittency of distributed PV generation,battery energy storage is required with higher renewable installation towards carbon ***,the photovoltaic battery(PVB)system receives increasing *** study provides a critical review on PVB system design optimization,including system component sizing and strategy improvement studies,from mathematical modeling,evaluation system establish-ment to feasibility and optimization *** PVB simulation software packages are compared and eval-uated,and acknowledged system models are *** evaluation indicators are summarized from various aspects with cases of various evaluation systems combining different indicators or using the Pareto front for multi-criteria system *** PVB system feasibility study is analyzed from system configuration varia-tion,critical technical and economic parameter analyses,rule-based operation strategies to future expectations like large-scale energy storage profitability,grid parity,and energy community trading *** targets,methods,tariffand time resolution influences,and PVB system capacity optimization design recommendations are critically *** research directions for system operation development and future expectations are analyzed from system feasibility,flexibility to *** co-planning of PVB system capacity and operation design optimization makes the problem complicated,leading to relatively short time resolution but more flexi-bility to system operation *** study could provide guidance and references to distributed PVB system future design and optimization studies.

关键词： Photovoltaic battery system Evaluation system System sizing Strategy improvement Multi-objective optimization

Effects of ignition voltage and electrode structure on electric ignition and combustion characteristics of Ammonium Dinitramide(ADN)-based liquid propellants in electric ignition mode in inert gas environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第4期37卷 229-242页

作者： Lei LI Guoxiu LI Hongmeng LI Zhaopu YAO tao zhang Jinze WU Shuo zhang School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Beijing Institute of Control Engineering Beijing 100190China

Hydrazine is toxic and carcinogenic, which greatly increases the difficulty of application and no longer meets the needs of green aerospace. As a green propellant, the Ammonium Dinitramide(ADN)-based liquid propellant has the advantages of higher specific impulse, being non-toxic,pollution-free, and easy storage. However, an ADN-based space engine in orbit has exposed the problems of high-temperature deactivation of catalysts and cold-start failure. An active ignition technology—electric ignition technology was explored in this paper to break through the technical bottleneck of catalyst deactivation and the inability to a cold start. An experimental system of a constant-volume combustor for the ADN-based liquid propellant based on the electric ignition method was established. The electric ignition and combustion characteristics of the ADN-based liquid propellant in a volume combustor with an electric ignition method were studied. The influencing mechanisms of the ignition voltage and the electrode structure on the electric ignition characteristics of the ADN-based liquid propellant were investigated. An elevation of the ignition voltage could facilitate the ignition process of the ADN-based liquid propellant, curtail electric energy input and heating effect, while exerting an adverse impact on the combustion process of the *** increase in the ignition voltage enhanced the ignition process of the propellant while simultaneously suppressing its combustion process when utilizing mesh electrodes. Compared to the strip electrodes, the mesh electrodes increased the contact area between the electrodes and the propellant,increased the electric energy input power in the electric ignition process, and reduced the ignition delay time. The mesh electrodes could promote the combustion process of the propellant to a certain extent.

关键词： ADN-based liquid propellant Resistive ignition Electrical ignition characteristic Combustion Inert gas

Deformation mechanism and limit support pressure of cutting steel plate during connection between pipes in large spacing using pipe curtain structure method

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Underground Space 2024年第5期18卷 83-96页

作者： Xiang Liu Rui zhang Jun Huang guang Zhao Qian Fang Annan Jiang Liaoning Key Laboratory of Marine Environmental Bridge and Tunnel Engineering Dalian Maritime UniversityDalian 116026China JSTI Group Nanjing 210017China Key Laboratory for Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China

The pipe curtain structure method(PSM)is a novel construction method to control ground deformation *** with the traditional pipe-roofing and pipe jacking method,the connection between pipes in large spacings using PSM is widely acknowledged as a unique construction *** study on this connection procedure is needed to resolve similar cases in that the pipes are inevitably constructed on both sides of existing *** the steel plate during the connection procedure is the first step,which is crucial to control the safety and stability of the surrounding environment and existing *** deformation mechanism and limit support pressure of the cutting steel plate during the connection between pipes in large spacings are studied in this paper,relying on the undercrossing Yifeng gate tower project of Jianning West Road River Crossing Channel in Nanjing,China.A modified 3D wedge-prism failure model is proposed using the 3D discrete element *** with Terzaghi loose earth pressure theory and the limit equilibrium theory,the analytical solutions for the limit support pressure of the excavation face of the cutting steel plate are *** modified 3D wedge-prism failure model and corresponding analytical solutions are categorised into two cases:(a)unilateral cutting scheme,and(b)bilateral cutting *** analytical solutions for the two cases are verified from the numerical simulation and in-situ data and compared with the previous *** comparative analysis between the unilateral and bilateral cutting schemes indicates that the bilateral cutting scheme can be adopted as a *** bilateral cutting scheme saves more time and induces less ground deformation than the unilateral one due to the resistance generated from the superimposed *** addition,the parametric sensitivity analysis is carried out using an orthogonal experimental *** main influencing factors arranged from high to low are the pipe sp

关键词： Pipe curtain structure method Wedge-prism failure model Limit support pressure Discrete element method Connection between pipes

Sparse-Grid Implementation of Fixed-Point Fast Sweeping WENO Schemes for Eikonal Equations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2024年第1期6卷 3-29页

作者： Zachary M.Miksis Yong-tao zhang Department of Applied and Computational Mathematics and Statistics University of Notre DameNotre DameIN46556USA

Fixed-point fast sweeping methods are a class of explicit iterative methods developed in the literature to efficiently solve steady-state solutions of hyperbolic partial differential equations(PDEs).As other types of fast sweeping schemes,fixed-point fast sweeping methods use the Gauss-Seidel iterations and alternating sweeping strategy to cover characteristics of hyperbolic PDEs in a certain direction simultaneously in each sweeping *** resulting iterative schemes have a fast convergence rate to steady-state ***,an advantage of fixed-point fast sweeping methods over other types of fast sweeping methods is that they are explicit and do not involve the inverse operation of any nonlinear local ***,they are robust and flexible,and have been combined with high-order accurate weighted essentially non-oscillatory(WENO)schemes to solve various hyperbolic PDEs in the *** multidimensional nonlinear problems,high-order fixed-point fast sweeping WENO methods still require quite a large amount of computational *** this technical note,we apply sparse-grid techniques,an effective approximation tool for multidimensional problems,to fixed-point fast sweeping WENO methods for reducing their computational ***,we focus on fixed-point fast sweeping WENO schemes with third-order accuracy(zhang et al.2006[41]),for solving Eikonal equations,an important class of static Hamilton-Jacobi(H-J)*** experiments on solving multidimensional Eikonal equations and a more general static H-J equation are performed to show that the sparse-grid computations of the fixed-point fast sweeping WENO schemes achieve large savings of CPU times on refined meshes,and at the same time maintain comparable accuracy and resolution with those on corresponding regular single grids.

关键词： Fixed-point fast sweeping methods Weighted essentially non-oscillatory(WENO)schemes Sparse grids Static Hamilton-Jacobi(H-J)equations Eikonal equations

Astronomical forcing and sedimentary noise modeling of lake-level changes in the Middle Eocene Chezhen Sag,Bohai Bay Basin,eastern China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2024年第2期18卷 446-459页

作者： Xuwei LUAN Jinliang zhang Na LI tao CHEN Long SUN Xuecai zhang Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Management Center of Oil and Gas Exploration Sinopec Shengli OilfieldDongying 257000China

The accurate determination of geological age is a key to understanding the history and process of paleolake evolution and oil and gas exploration in continental lake ***,improving the accuracy of geological age has always been a difficult scientific problem.A 609-m-thick,continuous lacustrine mudstone and sandstone succession in Chezhen Sag(eastern China)provides an ideal middle Eocene sedimentary record for establishing a high-resolution stratigraphic chronology *** on spectrum analysis and sliding window spectrum analysis of the natural gamma(GR)logging data of well Che 271(C271)in Chezhen Sag,the periods of 405 kyr and 40.1 kyr were filtered by a Gaussian bandpass filter,and a“floating”astrochronological time scale(ATS)was *** total number of 405 kyr eccentricity cycles were 13.6 and 40.1 kyr obliquity cycles were 138 which recorded from the upper member 4(Es4U)to the member 3(Es3)of the Eocene Shahejie Formation,and the depositional duration was 5.53 *** Coefficient(COCO)analysis and evolutionary Correlation Coefficient(eCoCo)analysis found that the optimal sedimentary rate of different *** noise simulation revealed the history of paleolake water changes in the Middle Eocene in the Chezhen Sag,according to which four sequences are *** study shows that the lake level change of Chezhen Sag in the middle Eocene shows prominent 1.2 Myr cycles and an antiphase well-coupled relationship with obliquity ***,we propose a model to explain the relationship between the orbital cycle and lake level change in the continental lake *** the obliquity of the earth increases,the middle and high latitudes of the earth will be closer to the sun,the direct sunlight will be higher,and the meridional sunshine will increase,thus accelerating the evaporation process of lake basin *** the seasonal changes are obvious(maximum period of 1.2 Myr ultra-long obliquity),this effect is more signific

关键词： Chezhen Sag cyclostratigraphy astrochronological time scale sedimentary noise

Upregulation of circ0000381 atienuates microglial/macrophage pyroptosis after spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1360-1366页

作者： Yan zhang Wenkai zhang tao Liu Ziqian Ma Wenxiu zhang Yun Guan Xueming Chen Central Laboratory Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedics Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Emergency Medicine Aerospace Center HospitalBeijingChina Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neurological Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Neuroinflammation exacerbates secondary damage after spinal cord injury,while microglia/macrophage pyroptosis is important to *** RNAs(circRNAs)play a role in the central nervous ***,the functional role and mechanism of circRNAs in regulating microglia/macrophage pyroptosis after spinal cord injury are still poorly *** the present study,we detected microglia/macrophage pyroptosis in a female rat model of spinal cord injury,along with upregulated levels of circ0000381 in the spinal *** further experimental results suggest that circ0000381 may function as a sponge to sequester endogenous microRNA423-3p(miR-423-3p),which can increase the expression of NOD-like receptor 3(NLRP3),a pyroptosis ***,upregulation of circ0000381 may be a compensatory change after spinal cord injury to attenuate microglia/macrophage ***,knockdown of circ0000381 expression exacerbated microglia/macrophage ***,our findings provide novel evidence for the upregulation of circ0000381,which may serve as a neuroprotective mechanism to attenuate microglia/macrophage pyroptosis after spinal cord ***,circ0000381 may be a novel therapeutic target for the treatment of spinal cord injury.

关键词： circ0000381 inflammasome macrophage microglia miR-423-3p neuroinflammation neuroprotection NLRP3 pyroptosis RNA-Seq spinal cord injury