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Anti-inflammatory and DNA Repair Effects of Astragaloside IV on PC12 Cells Damaged by Lipopolysaccharide

Current Medical Science 2024年第4期44卷 854-863页

作者： Hai-long LI Li-hua SHAO Xi CHEN Meng WANG Qi-jie QIN Ya-li YANG guang-run zhang Yang HAI Yi-hong TIAN Department of Geriatrics The Affiliated Hospital of Gansu University of Chinese MedicineLanzhou730000China Key Laboratory for Mining Innovation and Transformation of Traditional Chinese Medicine in Gansu Province and the New Product Creation Engineering Laboratory of Traditional Chinese Medicine in Gansu ProvinceLanzhou730000China Department of Neurology the First People’s Hospital of LanzhouLanzhouGansu730000China School of Public Health Gansu University of Chinese MedicineLanzhou730000China People’s Hospital of Gansu Province Lanzhou730000China Scientific Research and Experimental Center Gansu University of Chinese MedicineLanzhou730000China

Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and bioinformatics *** PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 *** morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival ***12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 *** concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for subsequent *** activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western *** differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,P0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulat

关键词： PC12 cells astragaloside IV inflammation DNA damage

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Static recrystallization behaviors and mechanisms of 7Mo super-austenitic stainless steel with undissolved sigma precipitates during double-stage hot deformation

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Journal of Iron and Steel Research International 2024年第2期31卷 475-487页

作者： Shi-guang Xu Jin-shan He run-ze zhang Fu-cheng zhang Xi-tao Wang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina Shandong Provincial Key Laboratory for High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Science)Jinan250353ShandongChina

Static recrystallization(SRX)behaviors and corresponding recrystallization mechanisms of 7Mo super-austenitic stainless steel were studied under different deformation *** order of influence of deformation parameters on static recrystallization behaviors,from high to low,is followed by temperature,first-stage strain and strain ***,the effect of holding time on static recrystallization behaviors is significantly controlled by *** addition,with the increase in temperature from 1000 to 1200°C,the static recrystallization mechanism evolves from discontinuous static recrystallization and continuous static recrystallization(cSRX)to metadynamic recrystallization and cSRX,and finally to *** cSRX exists at all *** is because high stacking fault energy(56 mJ m−2)promotes the movement of dislocations,making the deformation mechanism of this steel is dominated by planar slip of *** undissolved sigma precipitates promote static recrystallization through particle-stimulated ***,small strain-induced precipitates at grain boundaries hinder the nucleation of conventional SRX and the growth of recrystallized grains,while the hindering effect decreases with the increase in temperature.

关键词： 7Mo super-austenitic stainless steel Double-stage hot deformation Conventional static recrystallization Metadynamic recrystallization Strain-induced precipitation

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Research Progress in the Fabrication of Covalent Organic Framework Membranes for Chemical Separations

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Chinese Journal of Polymer Science 2024年第2期42卷 141-158,I0005页

作者： Cui-Ting Ding Jin-Qiu Yuan Meng-Ying Xie Qing-Yuan Liu Zeng-guang Yao Shi-Yu zhang run-Nan zhang Hong Wu Zhong-Yi Jiang Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Zhejiang Institute of Tianjin University NingboZhejiang315201China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Membrane technology has become one of the most promising separation technologies for its energy saving, high separation efficiency, environmental friendliness, and economic feasibility. Covalent organic frameworks(COFs) with intrinsically high porosity, controllable pore size, uniform pore size distribution and long-range ordered channel structure, have emerged as next-generation materials to fabricate advanced separation membranes. This feature article summarizes some latest studies in the development of pure COF membranes in our lab, including their fabrication and applications in chemical separations. Finally, current challenges facing high-performance COF separation membranes are discussed.

关键词： Covalent organic frameworks Covalent organic framework membranes Water treatment Organic solvent nanofiltration Gas separation

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Intermittent melena and refractory anemia due to jejunal cavernous lymphangioma:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1208-1214页

作者： Kai-Rui Liu Sheng zhang Wei-run Chen You-Xing Huang Xu-guang Li Department of Abdominal Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of guangdong Province and The Ministry of Education of China Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Lymphangiomas in the gastrointestinal tract are extremely rare in *** a benign lesion,small intestine lymphangiomas often remain asymptomatic and pose challenges for definitive ***,lymphangiomas can give rise to complications such as abdominal pain,bleeding,volvulus,and ***,we report a case of jejunal cavernous lymphangioma that presented with intermittent melena and refractory anemia in a male *** SUMMARY A 66-year-old man presented with intermittent melena,fatigue and refractory anemia nine months *** and colonoscopy were performed many times and revealed no apparent *** management,including transfusion,hemostasis,gastric acid secretion inhibition and symptomatic treatment,was performed,but the lesions tended to recur shortly after ***,the patient underwent capsule endoscopy,which revealed a more than 10 cm lesion accompanied by active *** singleballoon enteroscopy and biopsy,a diagnosis of jejunal cavernous lymphangioma was confirmed,and the patient underwent surgical *** complications or recurrences were observed *** Jejunal cavernous lymphangioma should be considered a cause of obscure gastrointestinal *** endoscopy and single-balloon enteroscopy can facilitate *** resection is an effective management method.

关键词： Intermittent melena Refractory anemia Capsule endoscopy Single-balloon enteroscopy Jejunal cavernous lymphangioma Enterectomy Case report

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Spin asymmetry and dipole moments inτ-pair production with ultraperipheral heavy ion collisions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 15-21页

作者： Dingyu Shao Bin Yan Shu-run Yuan Cheng zhang Department of Physics Center for Field Theory and Particle PhysicsFudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China(NSFC)and Fudan UniversityShanghai 200438China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics Peking UniversityBeijing 100871China

The anomalous magnetic(MDM)and electric(EDM)dipole moments of theτlepton serve as crucial indicators of new physics beyond the standard *** azimuthal angular asymmetry as a novel tool in ultraperipheral collisions(UPCs),we attain unparalleled precision in the study of these key *** by the highly linear polarization of coherent photons,this method uniquely enables both the MDM and EDM to contribute to the cos 2φangular distribution in similar ***,our approach substantially narrows the parameter space,excluding more than half of it compared to expected UPC-based measurements reliant solely on the total *** method not only provides improved constraints but also minimizes the need for additional theoretical assumptions,and offers a novel avenue to probe the EDM effects.

关键词： ultraperipheral collisions magnetic and electric dipole moments spin asymmetry

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Conduction-convection coupled heat transfer around a hollow cylinder under different buoyancy forces

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Chinese Journal of Aeronautics 2024年第4期37卷 216-228页

作者： Wanyu zhang Jingyi WU guang YANG Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China

In order to clarify the effect of a buoyancy force on conduction–convection coupled heat transfer in a hollow cylinder, the flow and thermal characteristics were analyzed using an RNG k-ε turbulence model. The Reynolds number was fixed at 1.014 × 10^(6), and the Rayleigh number varied from 1.122 × 10^(10)to 1.088 × 10^(11). Results have shown that, when considering the effect of an opposed buoyancy force, increasing the Rayleigh number has a positive impact on the rate of change and uniformity of the cylinder temperature. The temperature distributions along the axial and circumferential directions are similar for different Rayleigh numbers, but extreme values *** the axial direction, the maximum temperature is obtained at the interface between the variable-diameter part and the constant-diameter part. The maximum dimensionless temperature value decreases to 0.12 when the Rayleigh number increases to 1.088 × 10^(11). Along the circumferential direction, the temperature distribution is affected by the buoyancy force, which results in the temperature of the upper part being higher than that of the lower part. After nondimensionalization of the temperature and time, a correlation was proposed to illustrate the transient heat transfer process quantitatively. The standard deviation of the maximum relative temperature, representing the temperature uniformity, was also calculated. It was found that the difference in the direction of the buoyancy force made a huge difference. Compared with the opposed buoyancy force, the maximum dimensionless temperature is almost two times higher with an assisted buoyancy force. Similarly, the heat transfer coefficient with an assisted buoyancy force is half of that with an opposed buoyancy force. Overall, an assisted buoyancy force plays a negative role in terms of thermal characteristics. The flow field around the hollow cylinder was also illustrated to reveal the mechanism of the buoyancy force on magnitude and direction aspects

关键词： Buoyancy Conduction-convection heat transfer Transient analysis Hollow cylinder Non-dimensionalization

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Essential Players in Cooperative Games with Graph Communication Structure

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Journal of the Operations Research Society of China 2024年第1期12卷 93-108页

作者： guang zhang Jing-Yi Ge Business School University of Shanghai for Science and TechnologyShanghai200093China

A class of cooperative games with graph communication structure is studied in this paper by considering some important players,namely essential *** the assumption that only connected coalitions containing essential players are able to cooperate and obtain their worths,the class of graph games with essential players is proposed as well as an allocation *** proposed value follows the spirit of the Myerson value defined by applying the Shapley value on a modified *** properties,feasible component efficiency,the inessential component property,and fairness,are provided to fully characterize this value,where feasible component efficiency and fairness follows the same ideas of component efficiency and fairness for classical graph games,and the inessential component property says that the total payoffs of the players in a non-feasible component is ***,some computational aspects of the proposed value and comparisons with disjunctive permission value for games with permission structure are also studied,respectively.

关键词： Cooperative game Graph structure Essential player Myerson value Computation Permission structure

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Evaluation of microRNA expression profiles in human sperm frozen using permeable cryoprotectant-free droplet vitrification and conventional methods

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Asian Journal of Andrology 2024年第4期26卷 366-376页

作者： Li-Xin zhang Jing Mao Yan-Dong Zhou guang-Yao Mao run-Fa Guo Hong-Shan Ge Xia Chen Department of Histology and Embryology Medical SchoolNantong UniversityNantong 226001China Department of Reproductive Medicine The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityTaizhou 225300China.

For sperm cryopreservation,the conventional method,which requires glycerol,has been used for a long *** addition,the permeable cryoprotectant-free vitrification method has been continuously *** the differences of cryopreservation effects between the two methods have being studied,differences in microRNA(miRNA)profiles between them remain *** this study,we investigated the differences in miRNA expression profiles among conventional freezing sperm,droplet vitrification freezing sperm and fresh human *** also analyzed the differences between these methods in terms of differentially expressed miRNAs(DEmiRs)related to early embryonic development and paternal *** results showed no significant differences between the cryopreservation methods in terms of sperm motility ratio,plasma membrane integrity,DNA integrity,mitochondrial membrane potential,acrosome integrity,and ultrastructural ***,sperm miRNA-sequencing showed differences between the two methods in terms of the numbers of DEmiRs(28 and 19 with vitrification using a nonpermeable cryoprotectant and the conventional method,respectively)in postthaw and fresh sperm *** related to early embryonic development and paternal epigenetics mainly included common DEmiRs between the *** results showed that the differences between conventional freezing and droplet vitrification were minimal in terms of miRNA expression related to embryonic development and *** in sperm miRNA expression due to freezing are not always detrimental to embryonic *** study compared differences in miRNA expression profiles before and after cryopreservation between cryopreservation by conventional and vitrification *** offers a new perspective to evaluate various methods of sperm cryopreservation.

关键词： cryopreservation cryoprotectant-free vitrification early embryonic development paternal epigenetic inheritance sperm miRNAs sucrose

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Design and test of a double compression seeder for pre-sowing and seed furrow of wheat in wide-seedling belts

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 136-145页

作者： Xun He run zhang Jingfeng zhang Yinghao Zhu Wanzhang Wang Hongmei zhang College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China

To solve the problem of poor sowing quality due to loose soil in wheat seedbed after land preparation in the Huang-Huaihai region of China,a double compression seeder for pre-sowing and seed furrow of wheat in wide-seedling belts was *** machine sowing operation was divided into two processes:pre-sowing compression and seed ditch compression,pre-sowing compression was carried out homogenization of the pre-sowing seed bed that the tractor wheel has crushed,and the seed ditch compression compresses the seeds and soil in the seed ditch,so that the seeds were embedded in the seed ditch *** analyzing the kinematics of the pre-planting compression device and the spiral blade in the process of soil levelling and compression,the structure of the equal-difference variable-diameter equal-pitch spiral conveying winch was designed,and the key parameters of the drum spiral blade were determined,and then the height of the spiral blades,the rutting distance and the speed of the compression roller were taken as the test factors,and the soil flatness was used as the index to carry out the discrete element simulation *** simulation results show that when the spiral blade was 4.85 cm,the rut distance was 37.4 cm,and the rotation speed was 327.16 r/min,the optimal land flatness was ***,field experiments were carried out on the seeder,and the results showed that:the soil bulk density after operation was 22.7%greater than that before sowing(p<0.01),and the soil flatness was 1.9 cm,which was consistent with the simulated *** use of pre-sowing compression and seed furrow compression methods improved the soil environment of the seed bed,increased the uniformity of the seeding depth,and promoted the root growth of *** study provides equipment support and technical reference for agricultural production in wheat-corn rotation areas in the Huang-Huaihai region of China.

关键词： wheat seeding quality pre-sowing compression seed furrow compression field experiment

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Novel self-assembled porous yolk-shell NiO nanospheres with excellent electrochromic performance for smart windows

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Particuology 2024年第1期84卷 72-80页

作者： Baoshun Wang Ya Huang Siming Zhao run Li Di Gao Hairong Jiang Rufan zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing100084China

With the rapid development of optoelectronics,electrochromic(EC)materials(ECMs)with the advan-tages of low power consumption,easy viewing,high contrast ratio,etc have attached more and more attention from the fields of smart windows,electronic billboards,emerging wearable and portable electronics,and other next-generation *** oxide(NiO)is a promising candidate for high-performance ECMs because of its neutral-colored states and low ***,NiO-based ECMs still face the problem of slow switching speed due to their low electrical conductivity and small lattice ***-organic frameworks(MOFs)are promising candidates to fabricate hollow and porous transition metal oxides(TMOs)with high ion transport efficiency,excellent specific capacitance,and electrochemical *** this work,porous yolk-shell NiO nanospheres(PYS-NiO NSs)were syn-thesized via a solvothermal and subsequent calcination process of Ni-MOF,which exhibited outstanding EC *** the large specific surface areas and hollow porous nanostructures were conducive to ionic transport,PYS-NiO NSs exhibited a fast coloring/bleaching speed(3.6/3.9 s per one coloring/bleaching cycle)and excellent cycling stability(82%of capacity retention after 3000 cycles).These superior EC properties indicated that the PYS-NiO NSs was a promising candidate for high-performance EC *** work provides a new and feasible strategy for the efficient preparation of TMOs ECMs with good EC performance,especially fast switching speed.

关键词： Electrochromic Nickel oxide Metal-organic frameworks Hollow structure Smart windows

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