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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi song Ruixin li Xiaolei Chu qi li Ruihua li qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

The calculation of coronal magnetic field and density of nonthermal electrons in the 2003 October 27 microwave burst

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Research in Astronomy and Astrophysics 2013年第2期13卷 215-225页

作者： guang-li Huang Jian-ping li qi-Wu song Purple Mountain Observatory Chinese Academy of Sciences key Laboratory of Dark Matter and Space Astronomy Chinese Academy of Sciences key Laboratory of Solar Activities Chinese Academy of Sciences

Based on Dulk and Marsh＇s approximate theory about nonthermal gyrosyn- chrotron radiation, one simple impulsive microwave burst with a loop-like structure is selected for radio diagnostics of the coronal magnetic field and column density of non- thermal electrons, which are calculated from the brightness temperature, polarization degree, and spectral index, as well as the turnover frequency, observed by using the Nobeyama Radioheliograph and the Nobeyama Radio Polarimeters, respectively. Very strong variations （up to one or two orders of magnitude） of the calculated transverse and longitudinal magnetic fields with respect to the line-of-sight, as well as the cal- culated electron column density, appear in the looptop and footpoint sources during the burst. The absolute magnitude and varied range of the transverse magnetic field are evidently larger than those of the longitudinal magnetic field. The time evolution of the transverse magnetic field is always anti-correlated with that of the longitudi- nal magnetic field, but positively correlated with that of the electron column density. These results strongly support the idea that quantifying the energy released in a flare depends on a reconstruction of the coronal magnetic field, especially for the trans- verse magnetic field, and they are basically consistent with the recent theoretical and observational studies on the photospheric magnetic field in solar flares.

关键词： Sun flares -- Sun magnetic fields -- Sun radio radiation

Global trends and hotspots of type 2 diabetes in children and adolescents:A bibliometric study and visualization analysis

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World Journal of Diabetes 2025年第1期16卷 140-168页

作者： Fang-Shuo Zhang Hai-Jing li Xue Yu Yi-ping song Yan-Feng Ren Xuan-Zhu qian Jia-li liu Wen-Xun li Yi-Ran Huang Kuo Gao School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus(T2DM)among children and adolescents *** to rapid disease progression,severe long-term cardiorenal complications,a lack of effective treatment strategies,and substantial socioeconomic burdens,it has become an urgent public health issue that requires management and *** T2DM differs from adult *** a significant increase in our understanding of youth-onset T2DM over the past two decades,the related review and evidence-based content remain *** To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research *** This study utilized the terms“children”,“adolescents”,and“type 2 diabetes”,retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection(SCI,SSCI,ESCI).Utilizing CiteSpace and VoSviewer software,we analyze and visually represent the annual output of literature,countries involved,and participating *** allows us to predict trends in this research *** analysis encompasses co-cited authors,journal overlays,citation overlays,time-zone views,keyword analysis,and reference analysis,*** A total of 9210 articles were included,and the annual publication volume in this field showed a steady growth *** United States had the highest number of publications and the highest *** United States also had the most research institutions and the strongest research *** global hot journals were primarily diabetes professional journals but also included journals related to nutrition,endocrinology,and *** analysis showed that research related to endothelial dysfunction,exposure risk,cardiac metabolic risk,changes in gut microbiota,the impact on comorbidities and outcomes,etc.,were emerging *** have maintained their popularity in this field,sugges

关键词： Child Adolescent Type 2 diabetes mellitus Bibliometrics Knowledge mapping Visualization CiteSpace VOSviewer

Synthesis of Hydroxystilbene Derivatives and their Antioxidant Activity by DPPH Method

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Chemical Research in Chinese Universities 2006年第6期22卷 742-746页

作者： li Yue-qing song qi-ling CHEN ping-ping ZHAO Wei-jie WANG Shi-sheng State key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China

Five hydroxystilbene derivatives were synthesized and their structures were determined using high-resolution mass spectrometry, ^1H NMB, and IR. In this study, the antioxidant activities of eight hydroxystilbenes （five synthesized hydroxystilbene derivatives and three other compounds） were evaluated with the free radiced scavenging model 1,1-diphenyl-2-picrylhydraxyl. It was observed that there exists a very significant linear rehtionship between the reciprocal of the EC50 value of each of the compounds and the maximum wavelength of the ultraviolet absorption peaks, It is believed that this result will be helpful for the further synthesis of such antioxidants.

关键词： Polyhydroxystilbene Antioxidant activity 1,1-Diphenyl-2-picrylhydrazyl (DPPH)

Angular disturbance prediction for countermeasure launcher in active protection system of moving armored vehicle based on an ensemble learning method

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Defence Technology（防务技术） 2023年第3期21卷 207-218页

作者： Chun-ming li guang-hui Wang Hai-ping song Xu-feng Huang qi Zhou China North Vehicle Research Institute Beijing100072China School of Aerospace Engineering Huazhong Univerisity of Science and TechnologyWuhan430074China

The active protection system(APS),usually installed on the turret of armored vehicles,can significantly improve the vehicles’survivability on the battlefield by launching countermeasure munitions to actively intercept incoming ***,uncertainty over the launch angle of the countermeasure is increased due to angular disturbances when the off-road armored vehicle is moving over rough ***,accurate and comprehensive angular disturbance prediction is essential to the real-time monitoring of the countermeasure launch *** this paper,a deep ensemble learning(DEL)-based approach is proposed to predict the angular disturbances of the countermeasure launcher in the APS based on previous time-series *** view of the intricate temporal attribute of angular disturbance prediction,the sampling information of historical time series measured by an inertial navigation device is adopted as the input of the developed DEL ***,the recursive multi-step(RMS)prediction strategy and multi-output(MO)prediction strategy are combined with the DEL model to perform the final angular disturbance prediction for the countermeasure launcher in the APS of a moving armored *** proposed DEL model is validated by using the different datasets from real *** results reveal that this approach can be used to accurately predict angular disturbances,with the maximum absolute error of each DOF less than 0.1°.

关键词： prediction disturbance moving

Profile and Flatness Control Technology With a Long Shifting Stroke on Wide Non-Oriented Electrical Steel Sheets

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Journal of Iron and Steel Research International 2012年第1期19卷 31-35页

作者： YANG guang-hui CAO Jian-guo ZHANG jie song ping YAN Tan-li RAO ke-feng School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Hot Rolling Plant Wuhan Iron and Steel(Group)CorporationWuhan 430083HubeiChina

In order to solve the difficult profile and flatness control problem of wide non-oriented electrical steel sheets, the factors such as the relationship between strip crown control and strip width, the relationship between the maximum wearing value of work roll and the number of a rolling campaign and the wear contour change of work roll were analyzed on the basis of industrial test. Through analyzing the rolling process characteristics of non-oriented e- lectrical steel sheets, the ASR （asymmetry self-compensating work rolls） shape control technology and its roll shift- ing strategy of the wider non-oriented electrical steel sheets was proposed and developed. When the technology was applied, the number of the wide non-oriented electrical steel （2.3 mm× 1 280 mm） in one rolling campaign rose from 40 coils of the trial production to 70 coils of the industrial production, the ratio of the measured strip crown less than 45 um was increased from 50.0% to 94.9%, and the ratio of the measured strip crown more than 60 um was decreased from 20.0% to 0.7%.

关键词： silicon steel shape control hot rolling roll contour

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na li Yue-Yue Ren Ying Tang qi Yang Tian-Tian Meng song li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

Recent Advances in Carbon-Based Adsorbents for Adsorptive Separation of light Hydrocarbons

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Research 2022年第4期2022卷 261-281页

作者： Yong-Sheng Wang Xue-jie Zhang Ya-qi Ba Tian-Yi li guang-ping Hao An-Hui Lu State key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China

light hydrocarbons(LHs)separation is an important process in petrochemical *** current separation technology predominantly relies on cryogenic distillation,which results in considerable energy *** separation using porous solids has received widespread attention due to its lower energy footprint and higher ***,tremendous efforts have been devoted to the design and synthesis of high-performance porous *** them,porous carbons display exceptional stability,tunable pore structure,and surface chemistry and thus represent a class of novel adsorbents upon achieving the matched pore structures for LHs *** this review,the modulation strategies toward advanced carbonbased adsorbents for LHs separation are firstly ***,the relationships between separation performances and key structural parameters of carbon adsorbents are discussed by exemplifying specific separation *** research findings on the control of the pore structures as well as the quantification of the adsorption sites are ***,the challenges of carbonaceous adsorbents facing for LHs separation are given,which would motivate us to rationally design more efficient absorbents and separation processes in future.

关键词： separation adsorbent porous

General Lyapunov Stability and Its Application to Time-Varying Convex Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2316-2326页

作者： Zhibao song ping li the College of Mathematics and Systems Science Shandong University of Science and Technology

In this article, a general Lyapunov stability theory of nonlinear systems is put forward and it contains asymptotic/finite-time/fast finite-time/fixed-time stability. Especially, a more accurate estimate of the settling-time function is exhibited for fixedtime stability, and it is still extraneous to the initial *** can be applied to obtain less conservative convergence time of the practical systems without the information of the initial conditions. As an application, the given fixed-time stability theorem is used to resolve time-varying(TV) convex optimization *** the Newton's method, two classes of new dynamical systems are constructed to guarantee that the solution of the dynamic system can track to the optimal trajectory of the unconstrained and equality constrained TV convex optimization problems in fixed time, respectively. Without the exact knowledge of the time derivative of the cost function gradient, a fixed-time dynamical non-smooth system is established to overcome the issue of robust TV convex optimization. Two examples are provided to illustrate the effectiveness of the proposed TV convex optimization algorithms. Subsequently, the fixed-time stability theory is extended to the theories of predefined-time/practical predefined-time stability whose bound of convergence time can be arbitrarily given in advance, without tuning the system parameters. Under which, TV convex optimization problem is solved. The previous two examples are used to demonstrate the validity of the predefined-time TV convex optimization algorithms.

关键词： Fixed-time stability nonlinear system predefined-time stability time-varying(TV)convex optimization

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