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Effects of entecavir and lamivudine for hepatitis B decompensated cirrhosis: Meta-analysis

World Journal of Gastroenterology 2013年第39期19卷 6665-6678页

作者： Xiao-guang Ye Qi-min Su Department of Infectious Diseases the SecondAffiliated Hospital of Guangzhou Medical University

AIM:To compare the effects of entecavir(ETV)and lamivudine(LAM)for the treatment of hepatitis B decompensated cirrhosis using a ***:We conducted a literature search for all eligible studies published prior to May 30,2013 using PUBMED,MEDlinE,EMBASE,the China National Knowledge Infrastructure(CNKI),the VIP database,the Wanfang database and the Cochrane Controlled Trial *** controlled trials(RCTs)comparing ETV with LAM for the treatment of hepatitis B decompensated cirrhosis were *** data were analyzed with Review Manager Software *** used RR as an effect measure,and reported its95%*** meta-analysis was performed using either a fixed-effect or random-effect model,based on the absence or presence of significant *** reviewers assessed the risk of bias and extracted data independently and in *** analysis was executed using the main outcome parameters including hepatitis B virus(HBV)DNA undetectability,HBV DNA level,hepatitis B e antigen(HBeAg)seroconversion,alanine aminotransferase(ALT)level,albumin level,total bilirubin(TBIL)level,prothrombin time activity(PTA)level,Child-Turcotte-Pugh(CTP)score,mortality,drugresistance,and adverse ***-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics and the therapeutic effects of the two ***:Thirteen eligible trials(873 patients in total)were included and evaluated for methodological quality and *** these studies,all had baseline comparability,12 of them reported baseline values of the two treatment groups in *** various treatment durations(12,24,36,48 and>48 wk),both ETV and LAM significantly reduced HBV DNA level,however,reductions were greater in the ETV group(MD=-0.66,95%CI:-0.83-0.50,P<0.00001),(MD=-0.93,95%CI:-1.36-0.51,P<0.0001),(MD=-1.4,95%CI:-1.78-1.01,P<0.00001),(MD=-1.18,95%CI:-1.90-0.46,P=0.001),(MD=-0.14,95%CI:-0.17-0.

关键词： Hepatitis B Decompensated cirrhosis Entecavir Lamivudine Randomized controlled trial Metaanalysis.

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A comparison of the CMIP5 models on the historical simulation of the upper ocean heat content in the South China Sea

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Acta Oceanologica Sinica 2014年第11期33卷 75-84页

作者： WANG Gang lin min Key Laboratory of Marine Science and Numerical Modeling (MASNUM) the First Institute of OceanographyState Oceanic Administration Key Laboratory of Data Analysis and Applications the First Institute of OceanographyState Oceanic Administration Department of Mathematics Ocean University of China

Seventeen models participating in the Coupled Model Intercomparison Project phase 5（CMIP5） activity are compared on their historical simulation of the South China Sea（SCS） ocean heat content（OHC） in the upper 300 m. Ishii＇s temperature data, based on the World Ocean Database 2005（WOD05） and World Ocean Atlas 2005（WOA05）, is used to assess the model performance by comparing the spatial patterns of seasonal OHC anomaly（OHCa） climatology, OHC climatology, monthly OHCa climatology, and interannual variability of OHCa. The spatial patterns in Ishii＇s data set show that the seasonal SCS OHCa climatology, both in winter and summer, is strongly affected by the wind stress and the current circulations in the SCS and its neighboring areas. However, the CMIP5 models present rather different spatial patterns and only a few models properly capture the dominant features in Ishii＇s pattern. Among them, GFDL-ESM2 G is of the best performance. The SCS OHC climatology in the upper 300 m varies greatly in different models. Most of them are much greater than those calculated from Ishii＇s data. However, the monthly OHCa climatology in each of the 17 CMIP5 models yields similar variation and magnitude as that in Ishii＇s. As for the interannual variability, the standard deviations of the OHCa time series in most of the models are somewhat larger than those in Ishii＇s. The correlation between the interannual time series of Ishii＇s OHCa and that from each of the 17 models is not satisfactory. Among them, BCC-CSM1.1 has the highest correlation to Ishii＇s, with a coefficient of about 0.6.

关键词： South China Sea ocean heat content Coupled Model Intercomparison Project phase 5

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Isothermal oxidation behavior of a new Re-free nickel-based single-crystal superalloy at 950℃

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Rare Metals 2017年第8期36卷 617-621页

作者： Xue-Feng Zhou guang Chen Ya-Ya Feng Zhi-Xiang Qi min-Zhi Wang Pei Li Jia-lin Cheng Engineering Research Center of Materials Behavior and Design ministry of Education Nanjing University of Science and TechnologyNanjing 210094China School of Chemistry and Materials Engineering Changshu Institute of TechnologyChangshu 215500China School of Materials Science and Engineering Nanjing Instituteof TechnologyNanjing 211167China

The isothermal oxidation behavior of a new Refree nickel-based single-crystal superalloy in air at 950 ℃ for 200 h was studied by scanning electron microscopy（SEM）with energy-dispersive spectroscopy（EDS）and X-ray diffraction（XRD）.The results indicate that oxidation kinetics obeys parabolic law approximately,and the mass gain increases rapidly during initial oxidation stage and then gradually slows *** oxidation scales are composed of three layers：the outer layer mainly consists of NiO with a small amount of CoO;the intermediate layer is mainly composed of Cr_2O_3 with a small amount of spinel compounds such as CrTaO_4,NiCr_2O_4,CoCrAl_2O_4,CoAl_2O_4,and NiAl_2O_4;and the inner layer is composed of Al_2O_*** Al_2O_3 layer suppresses the diffusion of elements between oxygen and alloy elements,slows down the alloy oxidation speed,and also suppresses the growth of the oxide scale and reduces the oxidation rate,which is agreeable with the oxidation kinetics.

关键词： Nickel-based single-crystal superalloy Isothermal oxidation Oxidation kinetic Surfacemorphology

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The uncertainty propagation analysis of the projectile-barrel coupling problem

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Defence Technology（防务技术） 2017年第4期13卷 229-233页

作者： lin-fang Qian guang-song Chen Nanjing University of Science & Technology 200 Xiaolingwei Nanjing Jiangsu 210094 China

Based on the model which couples the projectile and gun barrel during an interior ballistic cycle,the uncertainty propagation analysis of the model is presented caused by the uncertainty of the input *** Bootstrap method is employed to calculate the statistical moments(*** mean,variance,skewness coefficient and kurtosis coefficient)of the parameters of the ***,the maximum entropy method is used to estimate the probability density function(PDF)and the cumulative density function(CDF),the interval of the parameters of the projectile are also ***,the results obtained are compared to the results calculated by Monte Carlo(MC)method to verify the effectiveness of the presented ***,the rule and the uncertainty propagation model of the projectile-barrel coupling system are given with the variation of the uncertainties of the input parameters.

关键词： Uncertainty propagation Projectile-barrel coupling Bootstrap Maximum entropy Interval

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Preparing Nano-ZnS by Solid State Reaction at Room Temperature

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Chinese Chemical Letters 2001年第2期12卷 187-188页

作者： Xiao lin SUN guang Yan HONG Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied ChemistryChangchun 130022

ZnS nanoparticles were prepared by using solid-state reaction method at room temperature in agate mortar for the first time. The average particle size was about 20nm. This reaction is affected by the structure of reac... 详细信息

关键词： Zn nanoparticle solid-state reaction room temperature

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Interplay between diet and genetic susceptibility in obesity and related traits

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Frontiers of Medicine 2018年第6期12卷 601-607页

作者： Tiange Wang min Xu Yufang Bi guang Ning State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of HealthNational Clinical Research Center for Metabolic DiseasesShanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic DiseasesRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.

关键词： diet genetic susceptibility obesity interaction

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Expression of regulating apoptosis gene and apoptosis index in primary liver cancer

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World Journal of Gastroenterology 2000年第5期6卷 721-724页

作者： Hong Yu Xu You lin Yang Xi Li Guan guang Song Ai min Jiang Li Jun Shi Department of Digestion The First Hospital of Harbin Medical UniversityHarbin 150001China Department of Pathology The First Hospital of Harbin Medical UniversityHarbin 150001China

INTRODUCTIONProgramed cell death plays an important role in thegenesis of *** cancer genes canregulate ***,several proteins thatare structurally related to Bcl-2,an inhibitor ofapoptosis,have been ***,novel strategies... 详细信息

关键词： liver neoplasms apoptosis immunohistochemistry oncogenes tumor markers biological in situ hybridization

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Effect of non-spherical atmospheric charged particles and atmospheric visibility on performance of satellite-ground quantum link and parameters simulation

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The Journal of China Universities of Posts and Telecommunications 2017年第6期24卷 39-48页

作者： Shi Li Nie min Yang guang Pei Changxing School of Communication and Information Engineering Xi'an University of Posts and Telecommunication School of Electronics and Information Northwestern Polytechnical University State Key Laboratory of Integrated Service Networks Xidian University

In order to study the relationship between the non-spherical atmospheric charged particles and satellite-ground quantum links attenuation. The relationship among the particle concentration, equivalent radius, charge density of the charged particle, the attenuation coefficient and entanglement of the satellite-ground quantum link can be established first according to the extinction cross section and spectral distribution function of the non-spherical atmospheric charged particles. The quantitative relationship between atmospheric visibility and communication fidelity of satellite-ground quantum link were analyzed then. Simulation results show that the ellipsoid, Chebyshev atmospheric charged particle influences on attenuation of the satellite-ground quantum link increase progressively. When the equivalent particle radius is 0.2 gm and the particle concentration is 50 μg/m^3, the attenuation coefficient and entanglement of the satellite-ground quantum link is 9.21 dB/km, 11.46 dB/km and 0.453, 0.421 respectively; When the atmospheric visibility reduces from 8 km to 2 kin, the communication fidelity of satellite-ground quantum link decreases from 0.52 to 0.08. It is shown that the non-spherical atmospheric charged particles and atmospheric visibility influence greatly on the performance of the satellite-ground quantum link communication system. Therefore, it is necessary to adjust the parameters of the quantum-satellite communication system according to the visibility values of the atmosphere and the shapes of the charged particles in the atmosphere to improve reliability of the satellite-ground quantum link.

关键词： satellite-ground quantum link non-spherical atmospheric charged particles atmospheric visibility degree of quantum entanglement

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Relaxation of Evolutionary Dynamics on the Bethe Lattice

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Chinese Physics Letters 2012年第3期29卷 259-262页

作者： TIAN Liang lin min College of Science Nanjing University of Aeronautics and AstronauticsNanjing 210016 School of Economics and Management Tsinghua UniversityBeijing 100084

Realistic evolutionary systems are generally structured and are in infinite *** study the relaxation behavior of evolutionary dynamics on a Bethe lattice,which concerns the invasion of mutants into a population of wild-type *** the boundary effect plays a significant role in a finite system,with proper approximation we propose an effective method to characterize the evolutionary *** relaxation behavior of the invasion process is analytically investigated,which is confirmed by extensive *** work is the first systematical investigation on evolutionary dynamics in an infinitely dimensional lattice.

关键词： dynamics Bethe relaxation

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Simple preparation and catalytic properties of ZnO for ozonation degradation of phenol in water

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Chinese Chemical Letters 2011年第2期22卷 209-212页

作者： Yu ming Dong guang Li Wang Ping Ping Jiang Ai min Zhang lin Yue Xiao ming Zhang School of Chemical and Material Engineering Jiangnan University Wuxi 214122 China School of Chemistry and Chemical Engineering Key Laboratory of Mesoscopic Chemistry Nanjing University Nanjing 210093 China School of Food Science and Technology Jiangnan University Wuxi 214122 China Received 28 June 2010

ZnO particles about 200 nm were prepared through a facile hydrothermal *** with single ozonation,the degradation efficiency of phenol increased about 23.7%and the degradation efficiency of intermediates improved about four times in the presence of ZnO at 298 *** addition,the catalyst had good stability in the ozonation *** influence of temperature was investigated and it was found that the better catalysis efficiency could be obtained at lower temperature.

关键词： Organic pollutants Water treatment Ozone Catalysis

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