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Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang guang Yang Liping Wang Shijun Shen Jia Zhao Zhiyi lin Jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing Yin Hong Wang Zhiyang Chen Zhenyu Ju Cizhong Jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Medicine of ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong Key Laboratory of Animal Bioengineering and Disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

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Impulse pressuring diffusion bonding of titanium to 304 stainless steel using pure Ni interlayer

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Rare Metals 2016年第4期35卷 331-336页

作者： Fang-Li Wang guang-min Sheng Yong-Qiang Deng College of Materials Science and Engineering Chongqing University

In the present study, impulse pressuring diffu- sion bonding technology （IPDB） was utilized between commercially pure titanium and 304 stainless steel （SS） using pure nickel （Ni） as interlayer metal. The interfacial microstructures of the bonded joints were investigated by scanning electron microscopy （SEM） and energy dispersive spectroscope （EDS） analyses. It is found that with the aid of the Ni interlayer, the interdiffusion and reaction between Ti and SS can be effectively restricted and robust joints can be obtained. Intermetallic compounds （IMCs） including Ti2Ni, TiNi, and TiNi3 are detected at the Ti/Ni interface; however, only Ni-Fe solid solution is found at the Ni/SS interface. The maximum tensile strength of 358 MPa is obtained by IPDB for 90 s and the fracture takes place along the Ti2Ni and TiNi phase upon tensile loading. The existence of cleavage pattern on the fracture surface indi- cates the brittle nature of the joints.

关键词： Impulse pressuring diffusion bonding Titanium Stainless steel Ni interlayer

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Origami-inspired frequency selective surface with large bandwidth modulation range based on electromagnetically induced transparency effect

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Science China(Information Sciences) 2022年第10期65卷 303-304页

作者： Sihong CHEN Taisong PAN Wei WANG Yu GU guang YAO min GAO Zhumei CHEN Yuan lin School of Materials and Energy University of Electronic Science and Technology of China School of Physics University of Electronic Science and Technology of China Qiantang Science and Technology Innovation Center

Dear editor,Frequency selective surfaces(FSSs) have been intensively studied as a powerful tool to modulate the transmission of the electromagnetic(EM) waves, allowing either bandpass or bandstop selection of the EM waves [1]. In this study, we periodically deployed the classical resonators for electromagnetically induced transparency(EIT), cut-wire(CW),

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Complement components of nerve regeneration conditioned fluid influence the microenvironment of nerve regeneration

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Neural Regeneration Research 2016年第4期11卷 682-686页

作者： guang-shuai Li Qing-feng Li ming-min Dong Tao Zan Shuang Ding lin-bo Liu Plastic&Reconstructive Surgery of the First Affiliated Hospital of Zhengzhou University ZhengzhouHenan ProvinceChina Plastic&Reconstructive Surgery of the Ninth People's Hospital Affiliated to Shanghai Jiaotong University ShanghaiChina Otolaryngology-Head&Neck Surgery of the First Affiliated Hospital of Zhengzhou University ZhengzhouHenan ProvinceChina

Nerve regeneration conditioned fluid is secreted by nerve stumps inside a nerve regeneration chamber.A better understanding of the proteinogram of nerve regeneration conditioned fluid can provide evidence for studying the role of the microenvironment in peripheral nerve *** this study,we used cylindrical silicone tubes as the nerve regeneration chamber model for the repair of injured rat sciatic *** tags for relative and absolute quantitation proteomics technology and western blot analysis confirmed that there were more than 10 complement components（complement factor I,C1q-A,C1q-B,C2,C3,C4,C5,C7,C8β and complement factor D） in the nerve regeneration conditioned fluid and each varied at different time *** findings suggest that all these complement components have a functional role in nerve regeneration.

关键词： nerve regeneration peripheral nerve injury nerve regeneration chamber model sciatic nerve nerve regeneration conditioned fluid complement i TRAQ proteomics technology neural regeneration

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Morphology and Mechanical Properties of Vibratory Organs in the Leaf-cutting Ant （Atta cephalotes）

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Journal of Bionic Engineering 2018年第4期15卷 722-730页

作者： guang Yao lin Feng Deyuan Zhang Xinggang Jiang School of Mechanical Engineering and Automation Beihang University Beijing 100191 China Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100083 China

The ultrasonic scalpel has a number of excellent properties; however, its use in in vivo surgery is limited since the scalpel is not flexible enough. Changing the mechanism of ultrasonic vibration can allow the ultrasonic scalpel to bend. This paper reveals the mecha- nism of vibration generation of leaf-cutting ants, which is based on the microstructural and mechanical properties of special organs that produce the vibrations. Mierostructural characteristics of cross-sections of the vibratory organ of Atta cephalotes were observed using scanning electron microscopy. It was found that the scraper perfectly matches the file plate dorsoventrally; however, the file teeth cannot catch the scraper. An exploration of the kinematics of the file-scraper device was subsequently carried out to reveal a face-to-face contact mode, facilitating a gentler engagement process. For the first time, the mechanism of vibration generation of leaf-cutting ants was inves- tigated using a laser micrometer and high-speed camera. Results reveal the file-scraper device significantly amplifies the input frequency by 125 times, and magnification depends mainly on the tooth spacing and speed of engagement. Finally, nanoindentation tests were performed on file and scraper samples. The results show that they have similar mechanical properties, which greatly reduces friction and wear. This paper may provide theoretical guidance for the develooment of bionic vibration generators.

关键词： leaf-cutting ant vibration mechanism file-scraper device nano-indentation

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Effect of Scale Formation on Copper Enrichment Behavior in Continuously Cast Slab

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Journal of Iron and Steel Research International 2016年第8期23卷 739-744页

作者： Nan WANG Jin XU Shan YU guang-zong ZHANG guang-hao CHEN min CHEN School of Metallurgy Northeastern University School of Computer Science and Engineering Northeastern University

Copper enrichment behavior in continuously cast slab induced by scale formation during continuous cooling was experimentally investigated,and the effects of initial slab surface temperature and oxygen potential in atmosphere were *** results showed that a loose scale adhered to the substrate was formed in H2O-N2 atmosphere at higher slab surface temperature compared to a gap formed between the scale and the steel substrate after continuous cooling in H2O-O2-N2 *** the condition of continuous cooling in H2O-N2 atmosphere,the copper enrichment occurred both within the loose scale and at the scale/steel interface with simultaneous Ni enrichment near the interface at higher slab surface *** combined effects of the loose scale and nickel enrichment were thought to promote the back-migration of Cu-rich phase from the interface and occlusion within the scale *** in H2O-O2-N2 atmosphere,the Cu enrichment was found on the steel side and the formed gap prevented the migration of Cu to the scale.

关键词： loose migration enrichment Enrichment nickel simultaneous crystalline continuously subsequent removed

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Impact of Temperature on Influenza A Status during Global Warming Hiatus

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Biomedical and Environmental Sciences 2019年第7期32卷 554-557页

作者： YAN Shao min WU guang State Key Laboratory of Non-Food Biomass and Enzyme Technology National Engineering Research Center for Non-Food Biorefinery Guangxi Key Laboratory of Bio-refinery Guangxi Academy of Sciences

Temperature is a crucial factor that affects in flue nza tran smissi on. Therefore, several studies have correlated various aspects of in flue nza with temperature from the global warming period during which temperature exhibits a clear trend. The global warming hiatus has been existing since the year 1998. This provides an opportunity to investigate the effect of temperature on the transmission of influenza from the viewpoint that temperature is trendless.

关键词： Influenza A Global Warming Hiatus

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Microwave-activated Coupling Reaction on Polyethylene Glycol

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Chinese Chemical Letters 2002年第1期13卷 1-2页

作者： min XIA Yan guang WANG Department of Chemistry Zhejiang UniversityHangzhou 310027

The two-step Sonogashira coupling reaction took place rapidly under microwave activation conditions. PEG bound substrates acted as PTC and polymer support as well. Its yields are 80~90% and the products are in high pu... 详细信息

关键词： Microwave-activated coupling and cleavage PEG liquid-phase.

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Viscosity prediction on iron-bearing slags during pyrometallurgical recycling: structure-based modeling of CaO-‘FeO’-MgO-Al_(2)O_(3)-SiO_(2) system and its subsystems

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Journal of Iron and Steel Research International 2021年第6期28卷 679-692页

作者： guang-zong Zhang Nan Wang min Chen Yan-qing Cheng School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Institute for Frontier Technologies of Low-Carbon Steelmaking Shenyang 110819LiaoningChina Liaoning Province Engineering Research Center for Technologies of Low-Carbon Steelmaking Shenyang 110819LiaoningChina

A structure-based modeling of the CaO-‘FeO’-MgO-Al_(2)O_(3)-SiO_(2) system and its subsystems was investigated based on iron extraction nickel slagaluminum *** optimization in the present model indicated that the coefficient of free O^(2-)in FeO,a_(O_(FeO)^(2-)),on the lengths of network linkage had the largest value and O_(FeO)^(2-)(free O^(2)-in FeO)had the largest *** coefficients of bridging oxygen(a_(Si-O-Al) and a_(Al-O-Al))were lower than those of nonbridging oxygen and free oxygen(O^(2-)).Viscosity prediction for the CaO-‘FeO’-(8 wt.%)MgO-Al_(2)O_(3)-SiO_(2) system was conducted at a fixed slag basicity,which indicated that the predicted viscosity changed monotonously with the FeO ***,the non-monotonous evolution with Al2O3 content reflected the amphoteric behavior of *** addition,the performances of the present model in predicting viscosity binary(‘FeO’-SiO_(2))to quinary(CaO-‘FeO’-MgO-Al_(2)O_(3)-SiO_(2))system were analyzed and a comparison with the established models was made.

关键词： Nickel slag Viscosity model Slag structure Iron-bearing slag CaO-FeO-MgO-Al_(2)O_(3)-SiO_(2)system

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RNA Methylation m6A:A New Code and Drug Target?

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Chinese Journal of Chemistry 2020年第4期38卷 420-421页

作者： Gan-Qiang Lai lin-lin Zhou Cai-guang Yang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicoChinese Academy of SciencesShanghai 201203China University of the Chinese Academy of Sciences Beijing 100049China

The m^6A-RNA modification is a dynamic and reversible process,which has emerged as a new RNA code for the regulation of gene *** functional network of methyltransferases(writers),demethylases(erasers),and binding proteins(readers)modulate the level of m^6A *** of RNA methylation has been associated with various fundamental biological processes and human ***,we briefly introduce an understanding-enabled manipulation on m^6A RNA modification with an emphasis on the use of small-molecule intervention.

关键词： expression. manipulation modification

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