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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao hu Si Wang Weiqi Zhang Jing Qu guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-hui Zhang Zhi-Lai Zhan guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

A new variable-mode control strategy for LLC resonant converters operating in a wide input voltage range

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Frontiers of Information Technology & Electronic Engineering 2017年第3期18卷 410-422页

作者： hui-pin LIN Xiao-guang JIN Liang XIE Jin hu Zheng-yu LU College of Electrical Engineering Zhejiang UniversityHangzhou 310027China

This paper proposes a new variable-mode control strategy that is applicable for LLC resonant converters operating in a wide input voltage range. This control strategy incorporates advantages from full-bridge LLC resonant converters, half-bridge LLC resonant converters, variable-frequency control mode, and phase-shift control mode. Under this control strategy, different input voltages determine the different operating modes of the circuit. When the input voltage is very low, it works in a full-bridge circuit and variable frequency mode(FB_VF mode). When the input voltage rises to a certain level, it shifts to a full-bridge circuit and phase-shifting control mode(FB_PS mode). When the input voltage further increases, it shifts into a half-bridge circuit and variable frequency mode(HB_VF mode). Such shifts are enabled by the digital signal processor(DSP), which means that no auxiliary circuit is needed, just a modification of the software. From light load to heavy load, the primary MOSFET for the LLC resonant converter can realize zero-voltage switching(ZVS), and the secondary rectifier diode can realize zero-current switching(ZCS). With an LLC resonant converter prototype with a 300 W rated power and a 450 V output voltage, as well as a resonant converter with 20–120 V input voltage, the experiments verified the proposed control strategy. Experimental results showed that under this control strategy, the maximum converter efficiency reaches 95.7% and the range of the input voltage expands threefold.

关键词： LLC Full bridge Half bridge Variable frequency Phase shift Wide input voltage range

Mechanically Reinforced Chitosan/Cellulose Nanocrystals Composites with Good Transparency and Biocompatibility

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Chinese Journal of Polymer Science 2015年第1期33卷 61-69页

作者： Cheng-zhen Geng Xin hu guang-hui Yang Qin Zhang Feng Chen 傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

Chitosan/cellulose nanocrystals（CS/CNCs） composites were prepared with different contents of CNCs. Due to the homogeneous dispersion of CNCs and the strong interfacial interactions resulting from hydrogen bonding between CS chains and CNCs, the transparency of CS is well retained and the overall mechanical properties of CS are significantly improved. Furthermore, because both CS and CNCs are biocompatible materials, cell proliferation test shows that the obtained composites are noncytotoxic and can potentially meet safety requirements of biomedical applications. These advantages pave the way of potential applications of CS in the field of commercial plastics and encourage the use of CS as environmentfriendly material and biomedical material.

关键词： Chitosan Cellulose nanocrystals Reinforcement Cytotoxicity.

Effects and complications of placement of motility coupling post in porous polyethylene orbital implants

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 464-469页

作者： Hong-guang CUI Rong-rong hu hui-yan LI Wei HAN Department of Ophthalmology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate the effects and complications of primary and secondary placements of motility coupling post （MCP） in the unwrapped porous polyethylene orbital implant （PPOI） following enucleation. Methods： We investigated 198 patients who received PPOI implantation following the standard enucleation procedure in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, from 2002 to 2004. These patients were subgrouped into PPOI-only patients （112 cases, received PPOI following enucleation）, primary MCP patients （46 cases, received primary placement of MCP during PPOI operation）, and secondary MCP patients （40 cases, received secondary placement ofMCP 6 months after the initial surgery）. Effects and complications among these three groups were compared. Results： The PPOI-only patients took shorter treatment course when compared with other two MCP groups （P〈0.001）, without significant difference noted between the two MCP groups. However, the two MCP groups had better prosthetic motility than PPOI-only group （P〈0.001）, without significant difference between the two MCP groups. In the early stage, 2 eyes in the PPOI-only group and l eye in the primary MCP group had PPOI infection. In PPOI-only group, 3 （2.68%） eyes had PPOI exposure, which occurred after fitting the prostheses; 4 eyes （8.70%） in primary MCP group and 1 eye （2.50%） in secondary MCP had PPOI exposure, which occurred before fitting the prostheses. After prosthesis was fit successfully, the excessive discharge and granuloma were 33.9% and 1.79% in PPOI group-only, 53.3% and 8.9% in primary MCP group, and 52.5% and 7.5% in secondary MCP group, respectively. Conclusion： Both primary and secondary placements of MCP into the PPOI following enucleation can help patients to obtain desirable prosthetic motility, but may be associated with more complications. The primary placement of MCP with skilled operation in selected patients is more recommendable than secondary placemen

关键词： Porous polyethylene orbital implant (PPOI) Motility coupling post (MCP)

A process model for BOF process based on bath mixing degree

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International Journal of Minerals,Metallurgy and Materials 2010年第6期17卷 715-722页

作者： guang-hui Li Bao Wang Qing Liu Xin-zhong Tian Rong Zhu Li-ning hu Guo-guang Cheng School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Research and Development Center Xingtai Steel Co. Ltd. Xingtai 054027 China

The process model for BOF process can be applied to predict the liquid steel composition and bath temperature during the whole steelmaking process. On the basis of the traditional three-stage decarburization theory, the concept of mixing degree was put forward, which was used to indicate the effect of oxygen jet on decarburization. Furthermore, a more practical process model for BOF steelmaking was developed by analyzing the effect of silicon, manganese, oxygen injection rate, oxygen lance height, and bath temperature on decarburization. Process verification and end-point verification for the process model have been carried out, and the verification results show that the predic- tion accuracy of carbon content reaches 82.6% （the range of carbon content at the end-point is less than 0. 1wt%） and 85.7% （the range of carbon content at end-point is 0. 1wt% -0.7wt%） when the absolute error is less than 0.02wt% and 0.05wt%, respectively.

关键词： steelmaking basic oxygen furnace (BOF) decarburization modelling prediction

The Berry-Esseen bound for identically distributed random variables by Stein method

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Applied Mathematics(A Journal of Chinese Universities) 2012年第4期27卷 455-461页

作者： CAI guang-hui Department of Mathematics Zhejiang Gongshang UniversityHangzhou 310018China

In this paper, we obtain the Berry-Esseen bound for identically distributed random variables by Stein method. The results obtained generalize the results of Shao and Su （2006） and Stein （1986）.

关键词： Berry-Esseen bound Stein method exchangeable pair.

A semi-implicit three-dimensional numerical model for non-hydrostatic pressure free-surface flows on an unstructured,sigma grid

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International Journal of Sediment Research 2013年第1期28卷 77-89页

作者： De-chao hu De-yu ZHONG guang-qian WANG Yong-hui Zhu Senior Engineer Yangtze River Scientific Research InstituteWuhan 430010China Senior Engineer Yangtze River Scientific Research Institute State Key Laboratory of Hydroscience and Engineering Tsinghua University Associate Professor State Key Laboratory of Hydroscience and EngineeringTsinghua University

A semi-implicit 3-D numerical formulation for solving non-hydrostatic pressure free-surface flows on an unstructured,sigma grid is ***-splitting and 9 semi-implicit methods are inherited and reformed from Casulli’s z-coordinate *** non-orthogonal sigma-coordinate transformation leads to additional terms. The resulting linear system for the non-hydrostatic correction is diagonally dominant but unsymmetric,and it is solved by the BiCGstab *** contrast with z-coordinate non-hydrostatic models,the new model fits vertical boundaries much better,which is important for the long-time simulation of sediment transport and riverbed deformation.A lock-exchange density flow is computed to determine whether the new scheme is able to simulate non-hydrostatic free-surface *** new model is further verified using the field data of a natural river bend of the lower Yangtze *** agreement between simulations and earlier research results,field data is obtained, indicating that the new model is applicable to hydraulic projects in real rivers.

关键词： Three-dimensional Non-hydrostatic pressure Semi-implicit Sigma-coordinate Unstructured grid

Constitutive modeling of a directionally solidified nickel-based superalloy DZ125 subjected to thermal mechanical creep fatigue loadings

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Rare Metals 2019年第10期38卷 922-936页

作者： Xiao-An hu Xiao-guang Yang Duo-Qi Shi hui-Chen Yu Ting-Ting Ren School of Energy and Power Engineering Beihang UniversityBeijing 100191China Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100095China Air Force Armament Department China Aviation MuseumBeijing 102211China

A transversely isotropic continuum elasto-viscoplasticity model,which was developed from Chaboche’s unified constitutive model,was formulated to capture the thermal mechanical creep fatigue deformation behavior of a directionally solidified nickel-based superalloy.A fourthorder tensor was introduced to model material *** order to model the tertiary creep behavior,the Kachanov damage evolution equation was coupled into the stress *** on the test results of uniaxial tensile,fatigue,and creep loadings at isothermal temperature conditions,the material parameters are *** mechanical fatigue(TMF) and creep-fatigue interaction test results were used to verify the robustness of the ***,strain-temperature-dependent stress-strain responses under TMF loadings were analyzed using the present *** strain-controlled conditions,both of the stress ranges and mean stresses are strongly influenced by the strain-temperature phases,a key parameter for TMF tests.

关键词： Constitutive Thermal mechanical fatigue Creep Viscoplastic Superalloy