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Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study： Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography

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Chinese Medical Journal 2015年第13期128卷 1765-1771页

作者： hua-guang zheng Rong Zhang Xin Li Fang-Fei Li Ya-Chen Wang Xue-Mei Wang Ling-Long Lu Tao Feng Clinical Trial and Clinical Research Center Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China China National Clinical Research Center for Neurological Diseases Beijing 100050 China Department of Neurology Zhang Jiagang City Hospital of Chinese Traditional Medicine Zhangjiagang Jiangsu 215600 China Center of Neurodegenerative Disease Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neurology The First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116021 China Parkinson's Disease Center Beijing Institute for Brain Disorders Capital Medical University Beijing 100069 China

Background： The relationship between monosymptomatic resting tremor （mRT） and Parkinson＇s disease （PD） Iemains controversial. In this study, we aimed to assess tile function ofpresynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography （DAT-PET） and to evaluate the utility of clinical features or electrophysioIogical studies in differential diagnosis. Methods： Thirty-three consecutive patients with toRT were enrolled prospectively. The Unified Parkinson＇s Disease Rating Scale and electromyography were tested before DAT-PET. Striatal asymmetry index （SAI） was calculated, and a normal DATPET was defined as a SAI of 〈15%. Scans without evidence of dopaminergic deficits （SWEDDs） were diagnosed in patients with a subsequent normal DAT-PET and structural magnetic resonance imaging. Results： Twenty-eight toRT patients with a significant reduction in uptake of DAT binding in the striatum were diagnosed with PD, while the remained 5 with a normal DAT-PET scan were SWEDDs. As for UPRDS, the dressing and hygiene score, walking m motor experiences of daily living （Part I1） and motor examination （Part Ill ） were significant different between two groups （P 〈 0.05 and P 〈 0.01, respectively）. Bilateral tremor was more frequent in the SWEDDs group （P 〈 0.05）. The frequency of resting tremor and the amplitude ofpostural tremor tend to be higher in the SWEDDs group （P = 0.08 and P= 0.05, respectively）. Conclusions： mRT is heterogeneous in presynaptic nigrostriatal dopaminergic degeneration, which can be determined by DAT-PET brain imaging. Clinical and electrophysiological features may provide clues to distinguish PD from SWEDDs.

关键词： Dopamine Transporter Positron Emission Tomography Heterogeneity Monosymptomatic Resting Tremor Parkinson's Disease: Scans Without Evidence of Dopaminergic Deficit

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing Xuyun hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

阴极电场增强活性炭纤维-臭氧体系去除水中硝基苯

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环境科学 2017年第1期38卷 212-219页

作者：赵纯张帅周宇李琨周炜黎鹏宇杨广孙志华郑怀礼重庆大学三峡库区生态环境教育部重点实验室重庆400045 重庆大学低碳绿色建筑国际联合研究中心重庆400045 石河子大学水利建筑工程学院石河子832003 中国城市规划设计研究院西部分院重庆400021

通过对电流强度、反应液初始pH值、电解质种类及浓度等因素分析,探究了电增强活性炭纤维-臭氧体系对水中硝基苯的去除效果和机制.结果表明,与活性炭纤维-臭氧体系比较,电增强活性炭纤维-臭氧体系对硝基苯的去除效率显著提升.电增强活性... 详细信息

通过对电流强度、反应液初始pH值、电解质种类及浓度等因素分析,探究了电增强活性炭纤维-臭氧体系对水中硝基苯的去除效果和机制.结果表明,与活性炭纤维-臭氧体系比较,电增强活性炭纤维-臭氧体系对硝基苯的去除效率显著提升.电增强活性炭纤维-臭氧体系中电流强度对体系影响不显著,臭氧浓度对水中硝基苯的去除效率有一定影响,反应初始液的pH值对活性炭纤维催化臭氧体系的影响较大.水中无机盐如硫酸钠、硝酸钠及氯化钠的存在会抑制活性炭纤维催化臭氧.此外,单独臭氧对活性炭纤维有破坏作用,降低了活性炭纤维对反应的促进效果,外加阴极电场时,不仅活性炭纤维对有机物的去除效果显著提升,而且保证了活性炭纤维结构不被臭氧所破坏.

关键词：臭氧活性炭纤维电化学硝基苯高级氧化

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu Wen-Jia Chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

脑脊液培养阳性肺炎克雷伯菌和鲍曼不动杆菌的分布与耐药性分析

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中国卫生检验杂志 2016年第23期26卷 3481-3483页

作者：常欣魁郑光辉郑华光刘文松司学众首都医科大学天坛医院北京100000

目的分析2011年-2015年神经外科术后脑脊液培养阳性患者革兰阴性菌中肺炎克雷伯菌和鲍曼不动杆菌的分布和耐药性的变化情况。方法收集2011年-2015年首都医科大学附属北京天坛医院神经外科术后脑脊液培养阳性患者的革兰阴性菌种类分布及... 详细信息

目的分析2011年-2015年神经外科术后脑脊液培养阳性患者革兰阴性菌中肺炎克雷伯菌和鲍曼不动杆菌的分布和耐药性的变化情况。方法收集2011年-2015年首都医科大学附属北京天坛医院神经外科术后脑脊液培养阳性患者的革兰阴性菌种类分布及其药敏试验结果。结果脑脊液培养阳性分离株共2 033株,其中革兰阴性菌524株,占25.9%。肺炎克雷伯菌和鲍曼不动杆菌共有180株,其中鲍曼不动杆菌64株,肺炎克雷伯菌116株。而脑脊液培养分离得到的鲍曼不动杆菌和肺炎克雷伯菌对部分抗生素的敏感率总体呈下降趋势。结论由于多重耐药鲍曼不动杆菌与肺炎克雷伯菌的出现以及过度使用抗感染药物,使得神经外科术后颅内感染的细菌耐药情况越来越严重,必须严密监测细菌耐药和控制预防用药疗程和抗感染药物的滥用。

关键词：神经外科脑脊液肺炎克雷伯菌鲍曼不动杆菌敏感率

Application-adaptive resource scheduling in a computational grid

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1634-1641页

作者： LUAN Cui-ju SONG guang-hua zheng Yao School of Computer Science and Center for Engineering and Scientific Computation Zhejiang University Hangzhou 310027 China College of lnformatton Engmeermg Shanghai Maritime University Shanghai 200135 China

Selecting appropriate resources for running a job efficiently is one of the common objectives in a computational grid. Resource scheduling should consider the specific characteristics of the application, and decide the metrics to be used accordingly. This paper presents a distributed resource scheduling framework mainly consisting of a job scheduler and a local scheduler. In order to meet the requirements of different applications, we adopt HGSA, a Heuristic-based Greedy Scheduling Algorithm, to schedule jobs in the grid, where the heuristic knowledge is the metric weights of the computing resources and the metric workload impact factors. The metric weight is used to control the effect of the metric on the application. For different applications, only metric weights and the metric workload impact factors need to be changed, while the scheduling algorithm remains the same. Experimental results are presented to demonstrate the adaptability of the HGSA.

关键词： Grid Resource scheduling Heuristic knowledge Greedy scheduling algorithm

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基于语料库的朝鲜语命名实体结构特征研究

外语学刊 2025年第1期 9-18页

作者：黄政豪金光洙延边大学工学院延吉133002 延边大学外国语学院延吉133002

本文统计Klue⁃ner和Kochet⁃ner两个命名实体语料库中的新闻、评论和文化遗产文本数据包含的不同类别朝鲜语命名实体。根据统计结果分析朝鲜语命名实体的音节长度特征分布和格词尾结合率。分析结果表明,音节长度和格词尾的使用在命名实... 详细信息

本文统计Klue⁃ner和Kochet⁃ner两个命名实体语料库中的新闻、评论和文化遗产文本数据包含的不同类别朝鲜语命名实体。根据统计结果分析朝鲜语命名实体的音节长度特征分布和格词尾结合率。分析结果表明,音节长度和格词尾的使用在命名实体分类中具有一定的规律可循。本文的研究成果可用于命名实体分类工作,同时也可以为朝鲜语命名实体语料库构建提供分布结构建议。

关键词：朝鲜语格词尾命名实体识别特征提取名词分类

A flexible architecture for job management in a grid environment

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 95-105页

作者： LUAN Cui-ju SONG guang-hua zheng Yao ZHANG Ji-fa College of Information Engineering Shanghai Maritime University Shanghai 200135 China School of Computer Science and Center for Engineering and Scientific Computation Zhejiang University Hangzhou 310027 China

Job management is a key issue in computational grids, and normally involves job definition, scheduling, executing and monitoring. However, job management in the existing grid middleware needs to be improved in terms of efficiency and flexibility. This paper addresses a flexible architecture for job management with detailed design and implementation. Frameworks for job scheduling and monitoring, as two important aspects, are also presented. The proposed job management has the advantages of reusability of job definition, flexible and automatic file operation, visual steering of file transfer and job execution, and adaptive application job scheduler. A job management wizard is designed to implement each step. Therefore, what the grid user needs to do is only to define the job by constructing necessary information at runtime. In addition, the job space is adopted to ensure the security of the job management. Experimental results showed that this approach is user-friendly and system efficient.

关键词： Grid Job management Job definition reuse Steering of job transfer Job space

Chinese sunspot drawings and their digitization–(Ⅲ)quasi-biennial oscillation of the hand-drawn sunspot records

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Research in Astronomy and Astrophysics 2020年第11期20卷 354-360页

作者： Miao Wan Shu-guang Zeng Sheng zheng Gang-hua Lin College of Science China Three Gorges UniversityYichang 443002China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

Quasi-biennial Oscillations(QBOs)of the Sun have a significant meaning as a benchmark of solar cycle,not only for understanding the dynamo action but also in terms of space weather *** this paper,the hand-drawn sunspot images recorded from the Purple Mountain Observatory are used to investigate the solar QBOs and the Gnevyshev gap of the sunspot relative numbers(Rs)and group sunspot numbers(Rg)during the period 1954–*** main results are as follows:(1)both the Rs and Rg exhibit similar periods including the 22-year magnetic cycle,the 11-year Schwabe cycle,and the QBOs modes;(2)the reconstructed QBOs of both data sets exhibit coherent behavior and tend to have a high amplitude during the maximum phase of each solar cycle;(3)the Gnevyshev gap is produced by the superposition of the QBOs and the 11-year Schwabe cycle,and the Rs is better to study the variation of the Gnevyshev gap rather than the Rg.

关键词： Sun activity Sun sunspot Sun quasi-biennial oscillation