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Burns & Trauma 2015年第2期3卷 61-65页

作者： Jie Luo guang-hua guo Department of Burns the First Affiliated Hospital of Nanchang UniversityNanchang 330006 JiangxiChina

"American Burn Association Practice Guidelines for Prevention,Diagnosis,and Treatment of Ventilator-Associated Pneumonia in Burn Patients"was published to provide recommendation for the prevention,diagnosis,and treatment of ventilator-associated pneumonia in burn *** article makes interpretations and conclusions for prevention,diagnosis and treatment from this guideline in the combination of domestic burn patients.

关键词： Ventilator-associated pneumonia Inhalation injury Burn Burn ICU

Alternating spin splitting of electronic and magnon bands in two-dimensional altermagnetic materials

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Chinese Physics B 2024年第9期33卷 194-198页

作者： Qian Wang Da-Wei Wu guang-hua guo Meng-Qiu Long Yun-Peng Wang School of Physics Central South UniversityChangsha 410083China

Unconventional antiferromagnetism dubbed as altermagnetism was first discovered in rutile structured magnets,which is featured by spin splitting even without the spin–orbital coupling *** interesting phenomenon has been discovered in more altermagnetic *** this work,we explore two-dimensional altermagnetic materials by studying two series of two-dimensional magnets,including MF4 with M covering all 3d and 4d transition metal elements,as well as TS2 with T=V,Cr,Mn,*** the magnetic symmetry operation of RuF4 and MnS2,it is verified that breaking the time inversion is a necessary condition for spin *** on symmetry analysis and first-principles calculations,we find that the electronic bands and magnon dispersion experience alternating spin splitting along the same *** work paves the way for exploring altermagnetism in two-dimensional materials.

关键词： two-dimensional altermagnetic materials altermagnetism spin splitting first-principles calculations

In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

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World Journal of Gastroenterology 2008年第8期14卷 1167-1174页

作者： guang-hua guo Su-Zuan Chen Jing Yu Juan Zhang Li-Li Luo Li-hua Xie Zhong-Jing Su Hong-Mei Dong Hong Xu Li-Biao Wu Department of Gastroenterology The First Affiliatecl Hospital of Shantou University Medical College Shantou 515041Guangdong Province China

AIM： To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells （DC） and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 （EC109）. METHODS： The fusion vaccine was produced by fusing traditional polyethyleneglycol （PEG）, inducing cytokine, sorting CD34＋ magnetic microbead marker and magnetic cell system （MACS）. The liver, spleen and lung were pathologically tested after injection of the fusion vaccine. To study the therapeutic and protective effect of the fusion vaccine against tumor EC109, mice were divided immune group and therapeutic group. The immune group was divided into P, E, D and ED subgroups, immunized by phosphate buffered solution （PBS）, inactivated EC109, DC and the fusion vaccine respectively, and attacked by EC109 cells. The tumor size, weight, latent period and mouse survival period were recorded and statistically analyzed. The therapeutic group was divided into four subgroups： P, inactivated EC109, D and ED subgroups, which were attacked by EC109 and then treated with PBS, inactivated EC109, DC, and EC109-DC respectively. Pathology and flow cytometry were also used to study the therapeutic effect of the fusion vaccine against EC109 cells.RESULTS： Flow cytometry showed that the expression of folate receptor （FR）, EC109 （C）, Des （D） in human nasopharyngeal carcinoma cell line （HNE1）（B） was 78.21%, 89.50%, and 0.18%, respectively. The fusion cells （C） were highly expressed. No tumor was found in the spleen, lung and liver after injection of the fusion vaccine. Human IgG was tested in peripheral blood lymphocytes （PBL）. In the immune group, the latent period was longer in EC109-DC subgroup than in other subgroups, while the tumor size and weight were also smaller than those in ED subgroup. In the therapeutic group, the tumor size and weight were smaller in ED subgroup than in P, inactivated EC109 and DC subgroups. CONCLUSION： Fusion cells are highly expressed not only in FR but also in CD8

关键词： Dendritic cells Esophageal carcinoma cells Cell fusion Immune protection Immunotherapy

Electronic-magnonic spin current conversion at the heavy mental/magnetic insulator interface

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Electronic-magnonic spin current conversion at the heavy men...

Effects of bone marrow-derived mesenchymal stemcells engraftment on vascular endothelial cell growthfactor in lung tissue and plasma at early stage of smoke inhalation injury

中国晶体学会第六届学术年会暨会员代表大会（极端条件晶体材料分会）

作者： guang-hua guo School of Physics and Electronics Central South University

Electronic spin current is conversable to magnonic spin current via the creation or annihilation of thermal magnons at the interface of a magnetic insulator and a metal with a strong spin-orbital *** far this phenomen...

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World Journal of Emergency Medicine 2010年第3期1卷 224-228页

作者： FengZhu guang-hua guo Wen Chen Nian-yun Wang Department of Critical Care Medicine(ZhuF) DepartmentofBurns(GuoGHChenWWangNY)First Affiliated Hospital of NanchangUniversityNanchang330006China

BACKGROUND： This study was undertaken to determine the effect of mesenchymal stem cells （MSCs） engraftment on vascular endothelial cell growth factor （VEGF） in lung tissue, plasma and extravascular lung water at early stage of smoke inhalation ***： A rabbit smoke inhalation injury model was established using a home-made smoke inhalation injury generator, and rabbits were divided into two groups randomly： a control group （S group, n=32） and a MSCs treatment group （M group, n=32）. 10 ml PBS was injected via the ear marginal vein immediately at injury into the S group. Third generation MSCs with a concentration of 1×107/10 ml PBS were injected via the ear marginal vein immediately at injury into the M group. VEGF in peripheral blood and lung tissue were measured at 0 （baseline）, 2, 4 and 6 hours after injection respectively and analyzed. The right lungs of rabbits were taken to measure lung water mass ***： In the lung tissue, VEGF decreased gradually in the S group （P〈0.05） and signi？ cantly decreased in the M group （P〈0.05）, but it increased more signi？ cantly than the values at the corresponding time points （P〈0.05）. In peripheral blood, VEGF increased gradually in the S group （P〈0.05） and markedly increased in the M group （P〈0.05）, but it decreased more signi？ cantly than the values at corresponding time points （P〈0.05）.CONCLUSION： MSCs engraftment to smoke inhalation injury could increase VEGF in lung tissue, decrease VEGF in plasma and reduce extravascular lung water, indicating its protective effect on smoke inhalation injury.

关键词： Mesenchymal stem cells Smoke inhalation injury Vascular endothelial cell growth factor Extravascular lung water Rabbit

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： Yuwei hua Yizhi Zhang Zhenming guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He hua guo guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

Enhancement of Spatial Learning-Memory in Developing Rats via Mozart Music

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Journal of Electronic Science and Technology of China 2009年第1期7卷 47-50页

作者： Jian-Gao Yao Yang Xia Sheng-Jun Dai guang-Zhan Fang hua guo De-Zhong Yao Key Laboratory for Neurolnformation of Ministry of Education School of Life Science and Technology School of Life Science and Technology University of Electronic Science and Technology of China

This paper studies the effect of musical stimulations on the capability of the spatial learningmemory in developing rats by behavioral and electrophysiological techniques. Rats, which are exposed to Mozart＇s Sonata for Two Pianos in D Major, complete learning tasks of the Moriss water maze with significantly shorter latencies, and the power spectrum of alpha band of electrohippocampogram （EHG） significantly increase, compared with the control rats and rats exposed to the horror music. The results indicate that if given the stimulation of Mozart music in the developmental period of the auditory cortex, the capability of the spatial learning-memory can be significantly changed. The enhancement of alpha band of EHG may be related to the change of this function mainly.

关键词： Electrohippocampogram Morris water maze music power spectrum.

早期肠内谷氨酰胺补给对烫伤大鼠肠黏膜细胞紧密连接的影响

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世界华人消化杂志 2009年第20期17卷 2031-2036页

作者：邓志云郭光华杨毅广东省边防武警总队医院一外科广东省深圳市518029 南昌大学一附院烧伤中心江西省南昌市330006

目的:了解早期肠内谷氨酰胺补给对烫伤后肠黏膜屏障功能的保护作用,并探讨其可能的作用机制.方法:选取健康SD大鼠随机分为标准肠内营养组(EN组)和谷氨酰胺补给组(EN+Gln组),每组32只,制成烫伤动物模型(30%TBSAⅢ度烫伤),伤后早期分别给... 详细信息

目的:了解早期肠内谷氨酰胺补给对烫伤后肠黏膜屏障功能的保护作用,并探讨其可能的作用机制.方法:选取健康SD大鼠随机分为标准肠内营养组(EN组)和谷氨酰胺补给组(EN+Gln组),每组32只,制成烫伤动物模型(30%TBSAⅢ度烫伤),伤后早期分别给予标准肠内营养制剂(能全力)和标准肠内营养制剂+谷氨酰胺,于第1、4、7、10天观察血清D-乳酸,Western blo半定量分析紧密连接结构蛋白Occludin和RTPCR分析ZO-1mRNA表达的变化.结果:烫伤后血清D-乳酸水平升高,EN组在观察时间内血清D-乳酸水平没有恢复至伤前水平,EN+Gln组在伤后4d恢复(4.5±0.8mg/Lvs3.8±0.6mg/L);Western blot半定量分析显示EN+Gln组伤后Occludin表达先下降后上升在4、7d时明显高于EN组(1.18±0.14vs0.79±0.09,1.59±0.16vs1.12±0.13,均P<0.05)烧伤后1d时,2组ZO-1mRNA表达与伤前比较均明显下降(0.71±0.19,0.76±0.17vs1.00,均P<0.05),4d时EN+Gln组与EN组比较差异有显著的统计学意义(1.17±0.16vs0.76±0.15P<0.05),其余时间点各组间差异均无统计学意义.结论:早期肠内谷氨酰胺补给支持能快速逆转烧伤后TJ结构蛋白Occludin、ZO-1表达的下降,从而改善肠黏膜的屏障功能.

关键词：烫伤 D-乳酸紧密连接谷氨酰胺

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi Ran Sun Lianfei Ding Mukun He Jiaming Li hua guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption