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Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

World Journal of Gastroenterology 2024年第21期30卷 2763-2776页

作者： Li He Wan-Sheng Ji Hai-Long Jin Wen-Jing Lu Yuan-Yuan Zhang hua-guang wang Yu-Yu Liu Shuang Qiu Meng Xu Zi-Peng Lei Qian Zheng Xiao-Li Yang Qing Zhang Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Clinical Research Center The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Physiatry Department Naval Aviation UniversityYantai 100071Shandong ProvinceChina

BACKGROUND At present,liver transplantation(LT)is one of the best treatments for hepatocellular carcinoma(HCC).Accurately predicting the survival status after LT can significantly improve the survival rate after LT,and ensure the best way to make rational use of liver *** To develop a model for predicting prognosis after LT in patients with *** Clinical data and follow-up information of 160 patients with HCC who underwent LT were collected and *** expression levels of alphafetoprotein(AFP),des-gamma-carboxy prothrombin,Golgi protein 73,cytokeratin-18 epitopes M30 and M65 were measured using a fully automated chemiluminescence *** best cutoff value of biomarkers was determined using the Youden *** regression analysis was used to identify the independent risk factors.A forest model was constructed using the random forest *** evaluated the accuracy of the nomogram using the area under the curve,using the calibration curve to assess consistency.A decision curve analysis(DCA)was used to evaluate the clinical utility of the *** The total tumor diameter(TTD),vascular invasion(VI),AFP,and cytokeratin-18 epitopes M30(CK18-M30)were identified as important risk factors for outcome after *** nomogram had a higher predictive accuracy than the Milan,University of California,San Francisco,and Hangzhou *** calibration curve analyses indicated a good *** survival and recurrence-free survival(RFS)of high-risk groups were significantly lower than those of low-and middle-risk groups(P<0.001).The DCA shows that the model has better clinical *** The study developed a predictive nomogram based on TTD,VI,AFP,and CK18-M30 that could accurately predict overall survival and RFS after *** can screen for patients with better postoperative prognosis,and improve longterm survival for LT patients.

关键词： Hepatocellular carcinoma Liver transplantation Liver cancer Nomogram Prognosis

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Development of new ductile iron with super-high thermal conductivity and elongation

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Journal of Iron and Steel Research International 2022年第3期29卷 462-473页

作者： guang-hua wang Yan-xiang Li School of Materials Science and Engineering Tsinghua UniversityBeijing100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing100084China

The effects of Si content,graphite volume fraction and pearlite volume fraction on the thermal conductivity of ductile iron were studied based on theoretical model *** results showed that the thermal conductivity of ductile iron was more sensitive to Si content compared with the volume fractions of pearlite and *** key method to design and develop high thermal conductivity ductile iron was to control the Si *** 0.9-2.2 wt.%Si content,experimental results showed that with the increase in Si content,the thermal conductivity of ductile iron decreased dramatically,and the yield strength and tensile strength of ductile iron almost linearly increased,but the elongation remained almost *** dependence of thermal conductivity of ductile iron on temperature changed from monotonic decreasing to increasing first and then ***,we broke the common composition range of ductile iron and designed a new high C(≥3.9 wt.%)and low Si(1.0-1.4 wt.%)ductile iron with super-high thermal conductivity and *** thermal conductivity exceeded 40 W/(m K)within 27-300℃,and maintained at 35-40 W/(m K)at 500℃.The elongation was over 25%,and the tensile strength was more than 300 MPa.

关键词： Thermal conductivity Ductile iron Elongation Tensile strength Silicon alloying

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Thermal conductivity of cast iron-A review

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China Foundry 2020年第2期17卷 85-95页

作者： guang-hua wang Yan-xiang Li School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

This paper gives a brief introduction to the four research methods for the study on thermal conductivity of cast irons,including experimental measurement,statistical analysis,effective medium theory and numerical *** studies on the thermal conductivity of various cast irons are reviewed through the influence of alloying elements,structural constituents,and *** addition of alloying elements is the main reason that restricts the thermal conductivity of cast irons,especially spheroidal graphite cast *** connectivity of graphite has a significant effect on the thermal conductivity of flake and compacted graphite cast irons,semiquantitative and quantitative analysis of this factor is a key and difficult point in the study of thermal conductivity of cast *** thermal conductivities of different types of cast irons show varying degrees of dependence on *** phenomenon is the combination of graphite and matrix,rather than just depending on graphite *** study of the relationship between individual phase and temperature is the focus of future *** summaries and discussions may provide reference and guidance for the future research and development of high thermal conductivity cast irons.

关键词： cast iron thermal conductivity gray cast iron nodular castiron compacted graphite cast iron

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Calculating the effective thermal conductivity of gray cast iron by using an interconnected graphite model

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China Foundry 2020年第3期17卷 183-189页

作者： guang-hua wang Yan-xiang Li School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

A new theoretical model of gray cast iron taking into account a locally interconnected structure of flake graphite was designed,and the corresponding effective thermal conductivity was calculated using the thermal resistance network *** calculated results are obviously higher than that of the effective medium approximation assuming that graphite is distributed in *** is suggested that the interconnected structure significantly enhances the overall thermal ***,it is shown that high anisotropy of graphite thermal conductivity,high volume fraction of graphite,and small aspect ratio of flake graphite will cause the connectivity effects of graphite to more obviously improve the overall thermal *** graphite volume fraction,lower aspect ratio and higher matrix thermal conductivity are beneficial to obtain a high thermal conductivity gray cast *** work can provide guidance and reference for the development of high thermal conductivity gray cast iron and the design of high thermal conductivity composites with similar locally interconnected structures.

关键词： gray cast iron effective thermal conductivity flake graphite interconnected graphite structure

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Effect of the westward-propagating zonal wind anomaly on the initial development of quasi-biweekly oscillation over the South China Sea during early summer

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Atmospheric and Oceanic Science Letters 2017年第1期10卷 89-95页

作者： CHEN guang-hua wang Xu Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of Science

The characteristics of quasi-biweekly oscillation（QBWO） over the South China Sea during early summer are *** results demonstrate that QBWO convection and the meridional wind anomaly exhibit local variation,while the zonal wind anomaly displays zonal ***,emergence of the zonal wind anomaly precedes the enhancement of QBWO convection,suggesting the zonally propagating zonal wind anomaly may play a key role in initiating the development of QBWO *** of the convergence of moisture flux and divergence tendency indicate that QBWO convection is primarily modulated by eddy *** the contributing factors in the divergence tendency,the β effect associated with the zonally-propagating zonal wind anomaly makes an appropriate phase difference with the eddy divergence,which can contribute to the convergence tendency in the initial stage of *** a result,QBWO convection and the meridional wind anomaly are enhanced,thus facilitating the initial development of QBWO convection over the SCS during early summer.

关键词： Westward-propagating zonal wind quasi-biweekly oscillation South China Sea early summer

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Existing form of Mo(Ⅵ)in acidic sulfate solution

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Rare Metals 2017年第7期36卷 612-616页

作者： Ming-Yu wang Chang-Jun Jiang Xue-Wen wang Peng-Fei Xian hua-guang wang Yang Yang School of Metallurgy and Environment Central South UniversityChangsha 410083China

The existing form of molybdenum in acidic sulfate solution was studied by means of ion exchange, infrared （IR） spectra and X-ray photoelectron spectroscopy （XPS）. The results indicate that the anionic molybdenum species are predominant in acidic sulfate solution, and Mo（VI） can combine with sulfate radical to form heteropoly acid anions [Mo205（804）2]2- and [MoO2（HSO4）4]2-. With the decrease in solution pH from 1.92 to 0.06, the existing form of Mo（VI） changes from MovO21（OH）3^3- to [Mo205（S04）2]2- and then becomes [MoOz（HSO4）4]2-, which results in the decrease in the resin adsorption capacity for molybdenum.

关键词： Molybdenum Acidic sulfate solution Ionexchange

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Occurrence of HTO and NE-OBT in soil in the vicinity of the Qinshan Nuclear Power Plant

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Nuclear Science and Techniques 2016年第4期27卷 1-6页

作者： lin du qin zhang zheng-hai xia yu-hua ma ling wang lai-lai qin ke deng sheng-wei wu guang-hua wang wei liu Shanghai Institute of Applied Physics Chinese Academy of Science Shanghai 201800 China University of Chinese Academy of Science Beijing 100049China CNNC Nuclear Power Operations Management Co. Ltd Haiyan 314300 China Shanghai Tech University Shanghai 201210 China

In this study, concentrations of tritiated water(HTO) and non-exchangeable organically bound tritium(NE-OBT) and the NE-OBT/HTO ratios were determined in soil around Qinshan Nuclear Power Plant(NPP), Zhejiang, China, and their vertical profile and spatial distribution were investigated. Results showed variations in both the HTO and NE-OBT concentrations in the vertical profile. The HTO concentrations generally decreased firstly and then increased with the increasing depths, but the trend was not significant. The NE-OBT concentrations in the surface soils(0–5 cm) were considerably lower than those in the deep soils(5–25 cm) at all the sites. The NE-OBT/HTO ratios also show a variable vertical profile, initially increasing and then decreasing with increasing soil *** the HTO and NE-OBT concentrations decreased with the increasing distance to the HWRs in deep soil layers(5–25 cm), revealing that the released tritium from the NPP affected the spatial distribution.

关键词：土壤水秦山核电站空间分布土层深度秦山核电厂 HTO 水浓度氚浓度

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Application of response surface methodology for optimization of Orange Ⅱ removal by heterogeneous Fenton-like process using Fe_3O_4nanoparticles

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Chinese Chemical Letters 2014年第11期25卷 1455-1460页

作者： Kun Chen guang-hua wang Wen-Bing Li Dong Wan Qin Hu Lu-Lu Lu College of Chemical Engineering and Technology Wuhan University of Science and Technology

In this study, Fe3O4nanoparticles（Fe3O4NPs） were successfully prepared via oxidation–precipitation method and characterized by scanning electron microscopy（SEM）, X-ray diffraction（XRD） and Fourier transform infrared spectroscopy（FT-IR）. The characterization results indicated that Fe3O4 NPs with regular crystal structure and a narrow of diameters had been synthesized successfully and had high purity. A series of experiments were carried out to investigate the degradation of Orange II by the obtained heterogeneous Fe3O4 catalysts in the presence of H2O2. The response surface methodology（RSM） based on Box–Behnken design（BBD） was employed to design and optimize individual and interactive effects of the four main independent parameters（catalyst loading, initial p H, reaction temperature and H2O2concentration） on decolorization efficiency of Orange II. A significant quadratic model（p-value 〈0.0001, R2= 0.9369） was derived using analysis of variance（ANOVA）. Optimum conditions were catalyst loading of 1.5 g/L, initial p H of 2.7, reaction temperature of 42 8C and H2O2 concentration of 22 mmol/L, respectively. The predicted decolorization rate under the optimum conditions as determined by the proposed model was 99.55%. Confirmatory tests were carried out and the decolorization rate of 99.49% was observed under the optimum conditions, which agreed well with the model prediction.

关键词： Fe3O4 nanoparticles Heterogeneous Fenton-like Orange II Response surface methodology

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Fuzzy Adaptive Control of Stochastic Nonlinear Systems with Unknown Virtual Control Gain Function

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自动化学报 2006年第2期32卷 170-178页

作者： wang Ying-Chun ZHANG hua-guang wang Yi-Zhong Institute of Electrical Automation Northeastern University Shenyang 110004

The problem of track control is studied for a class of strict-feedback stochastic nonlinear systems in which unknown virtual control gain function is the main feature. First, the so-called stochastic LaSalle theory is extended to some extent, and accordingly, the results of global ultimate boundedness for stochastic nonlinear systems are developed. Next, a new design scheme of fuzzy adaptive control is proposed. The advantage of it is that it does not require priori knowledge of virtual control gain function sign, which is usually demanded in many designs. At the same time, the track performance of closed-loop systems is improved by adaptive modifying the estimated error upper bound. By theoretical analysis, the signals of closed-loop systems are globally ultimately bounded in probability and the track error converges to a small residual set around the origin in 4th-power expectation.

关键词：随机非线性系统模糊自适应控制虚拟控制增益函数

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Effect of Al on microstructure and mechanical properties of cast CrCoNi medium-entropy alloy

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China Foundry 2018年第4期15卷 253-262页

作者： Qiang Hu Fu-chu Liu Qian-lu Fan Hui Du Gang Liu guang-hua wang Zi-tian Fan and ＊Xin-wang Liu State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Department of Mechanical Engineering Wuhan University of Science and TechnologyWuhan 430081China School of Materials Science and Engineering Xi'an University of technologyXi’an 710048China

Cast CrCoNiAIx （x=0-1.2） medium-entropy alloys （MEAs） were produced by arc melting and flip cast to investigate the alloying effect of AI addition on the microstructure, phase constituent and mechanical properties. The crystal structure changes from an initial face-centered cubic （FCC） to duplex FCC and body-centered cubic （BCC） and finally a single BCC with increasing AI content. In the duplex region, FCC and BCC phases form under a eutectic reaction in the interdendrite region. In the single BCC region, the dendrites transform to ordered B2 and disordered A2 BCC phases resulting from spinodal decomposition. Corresponding to their phase constituents, yield strength increases accompanied with an elongation reduction with increasing AI addition. A very interesting phenomenon of very weak ordered FCC （001） spots appearing in AI-0.4 alloy was observed, indicating a local ordering of FCC phase. The changes of fracture surfaces after the tensile deformation are also corresponding to the variations in mechanical properties.

关键词： medium-entropy alloy microstructure mechanical properties Al addition

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