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Analyzing the potential mechanism of Buyang Huanwu decoction for the treatment of salt-sensitive hypertension based on network pharmacology and in vivo experiments

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Traditional Medicine Research 2024年第7期9卷 49-61页

作者： Jian-Bo Wang Yi Qu Ren-Jun Yu Guo-Rui xu Ya-Nan xue Jia-Hao Zhang Yong-Gang Ma Li-De Zhang Traditional Chinese Medicine Innovation Engineering Technology Center Liaoning University of Traditional Chinese MedicineShenyang 110847China. Key Laboratory of Visceral Image Theory and Application of Traditional Chinese Medicine Ministry of EducationShenyang 110847China. Center for Research and Evaluation of Higher Traditional Chinese Medicine Education Liaoning University of Traditional Chinese MedicineShenyang 110847China. Emergency Department Nanjing Lishui District Hospital of Traditional Chinese MedicineJiangsu 211200China. College of Acupuncture and Moxibustion Liaoning University of Traditional Chinese MedicineShenyang 110847China. Department of Rehabilitation the Second Affiliated Hospital of Liaoning University of Chinese MedicineShenyang 110034China. College of Integrated Chinese and Western Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847China.

Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral *** study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension ***:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against *** compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were *** docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network ***,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were ***:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative *** experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell ***:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional Chinese medicine BHD in the treatment of salt-sensitive hypertension.

关键词： BHD salt-sensitive hypertension network pharmacology oxidative stress

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共同富裕:马克思主义共享思想的当代意涵

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中共福建省委党校（福建行政学院）学报 2024年第3期 39-45页

作者：徐龙建中共江苏省委党校(江苏行政学院)科社与政治学教研部

马克思主义共享思想产生于资本主义上升时期,是对资本主义私有制条件下非共享的批判谴责,以及对社会主义制度下共享社会发展成果的集中阐发。共同富裕以马克思主义共享思想为理论根脉,以高质量发展、高效能治理、高品质生活为实践路径,... 详细信息

马克思主义共享思想产生于资本主义上升时期,是对资本主义私有制条件下非共享的批判谴责,以及对社会主义制度下共享社会发展成果的集中阐发。共同富裕以马克思主义共享思想为理论根脉,以高质量发展、高效能治理、高品质生活为实践路径,实现了对马克思主义共享思想的赓续创新和跃迁发展。作为马克思主义共享思想的当代意涵,共同富裕谱写了新时代中国特色社会主义的崭新篇章,深刻把握二者的内在逻辑,对于更好彰显马克思主义理论的真理性,释放马克思主义真理光芒;深刻阐述中国式现代化重要特征,丰富和发展人类文明新形态;推动构建人类命运共同体,为建设更加美好世界贡献中国智慧中国力量具有重要意义。

关键词：马克思主义共享思想共同富裕当代意涵

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论中国共产党独特优势的深厚底蕴

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理论视野 2024年第3期289卷 78-83页

作者：徐龙建江苏省委党校

中国共产党的独特优势是全面的,这些独特优势的全面形成和坚持发挥,有着深厚的理论底蕴、文化底蕴、历史底蕴和价值底蕴,充分体现了百年大党的“魂”“根”“梦”“情”。具体而言,主要表现为以马克思主义铸牢中国共产党立党立国指导思... 详细信息

中国共产党的独特优势是全面的,这些独特优势的全面形成和坚持发挥,有着深厚的理论底蕴、文化底蕴、历史底蕴和价值底蕴,充分体现了百年大党的“魂”“根”“梦”“情”。具体而言,主要表现为以马克思主义铸牢中国共产党立党立国指导思想之魂、以中华优秀传统文化培固中国共产党理论创新之根、以实现中华民族伟大复兴构筑中国共产党繁荣富强之梦、以坚持人民至上根本立场践行中国共产党爱民为民之情。

关键词：中国共产党独特优势深厚底蕴

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《电子档案移交与接收办法》(档发[2012]7号)的内容解读与相关问题探讨

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北京档案 2024年第2期 30-35页

作者：许夏媛深圳信息职业技术学院

《电子档案移交与接收办法》(档发[2012]7号)是国家档案局为规范电子档案移交与接收工作而制定的。该办法具有创新进步、承上启下的特点,本文主要从要点分析、意义总结和问题思考等方面对其进行解读和探讨。

关键词：电子档案移交接收规范解读

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Hyperspectral imaging for one-step growth simulation of Brochothrix thermosphacta in chilled beef during storage

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Food Science and Human Wellness 2024年

作者： Xiaohua Liu Binjing Zhou Jin Song Kang Tu Jing Peng Weijie Lan Jing xu Jie Wu Juqing Wu Leiqing Pan School of Food and Biological Engineering Bengbu University College of Food Science and Technology Nanjing Agricultural University College of Artificial Intelligence Nanjing Agricultural University

In this work， one-step growth models using hyperspectral imaging (HSI) (400–1 000) nm were successfully developed in order to estimate the microbial loads， minimum growth temperature (Tmin) and maximum specific growth rate (μmax) of Brochothrix thermosphacta in chilled beef at isothermal temperatures (4–25) ℃. Three different methods were compared for model development， particularly using (Model I) the predicted microbial loads from partial least squares regression of the whole spectral variables; (Model II) the selected spectral variables related to microbial loads; and (Model III) the first principal scores of HSI spectra by principal component analysis. Consequently， Model I showed the best ability to predict the microbial loads of B. thermosphacta， with the coefficient of determination (Rv2) and root mean square error in internal validation (RMSEV) of 0.921 and 0.498 (lg (CFU/g)). The Tmin(–12.32 ℃) and μmaxcan be well estimated with R2and RMSE of 0.971 and 0.276 (lg (CFU/g))， respectively. The upward trend of μmaxwith temperature was similar to that of the plate count method. HSI technique thus can be used as a simple method for one-step growth simulation of B. thermosphacta in chilled beef during storage.

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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Silencing of early auxin responsive genes MdGH3-2/12 reduces the resistance to Fusarium solani in apple

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Journal of Integrative Agriculture 2024年第9期 3012-3024页

作者： Qianwei Liu Shuo xu Lu Jin Xi Yu Chao Yang Xiaomin Liu Zhijun Zhang Yusong Liu Chao Li Fengwang Ma State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F University

Apple replant disease(ARD) has led to severe yield and quality reduction in the apple industry. Fusarium solani(F. solani) has been identified as one of the main microbial pathogens responsible for ARD. Auxin(indole-3-acetic acid, IAA), an endogenous hormone in plants, is involved in almost all plant growth and development processes and plays a role in plant immunity against pathogens. Gretchen Hagen3(GH3) is one of the early/primary auxin response genes. The aim of this study was to evaluate the function of MdGH3-2 and MdGH3-12 in the defense response of F. solani by treating MdGH3-2/12 RNAi plants with F. solani. The results show that under F. solani infection,RNAi of MdGH3-2/12 inhibited plant biomass accumulation and exacerbated root damage. After inoculation with F. solani, MdGH3-2/12 RNAi inhibited the biosynthesis of acid-amido synthetase. This led to the inhibition of free IAA combining with amino acids, resulting in excessive free IAA accumulation. This excessive free IAA altered plant tissue structure, accelerated fungal hyphal invasion, reduced the activity of antioxidant enzymes(SOD, POD and CAT), increased the reactive oxygen species(ROS) level, and reduced total chlorophyll content and photosynthetic ability, while regulating the expression of PR-related genes including PR1, PR4, PR5 and PR8. It also changed the contents of plant hormones and amino acids, and ultimately reduced the resistance to F. solani. In conclusion, these results demonstrate that MdGH3-2 and MdGH3-12 play an important role in apple tolerance to F. solani and ARD.

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鼻咽清毒颗粒通过调节铜离子转运蛋白CTR1逆转鼻咽癌细胞顺铂耐药的作用效应及机制研究

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现代药物与临床 2024年第8期39卷 1937-1943页

作者：石子叶林娟杨冰徐科一张铁军李鹏徐旭天津中医药大学研究生院广州白云山和记黄埔中药有限公司天津药物研究院天津市中药质量标志物重点实验室天津药物研究院现代制剂与质量控制技术国家地方联合工程实验室

目的观察鼻咽清毒颗粒逆转鼻咽癌细胞顺铂耐药的作用效应，并探讨其作用机制。方法采用MTS法检测系列质量浓度鼻咽清毒颗粒对人鼻咽癌CNE-2、人鼻咽癌顺铂耐药CNE2/DDP细胞增殖的抑制作用；计算鼻咽清毒颗粒对CNE-2、CNE2/DDP细胞的... 详细信息

目的观察鼻咽清毒颗粒逆转鼻咽癌细胞顺铂耐药的作用效应，并探讨其作用机制。方法采用MTS法检测系列质量浓度鼻咽清毒颗粒对人鼻咽癌CNE-2、人鼻咽癌顺铂耐药CNE2/DDP细胞增殖的抑制作用；计算鼻咽清毒颗粒对CNE-2、CNE2/DDP细胞的耐顺铂半数抑制浓度（IC50）的影响；流式细胞技术测定CNE2/DDP的细胞凋亡情况；采用Western blotting法检测CNE2/DDP细胞中铜转运蛋白和抗凋亡蛋白的表达。结果 CNE2/DDP细胞的顺铂耐药指数为RI值为3.03；与顺铂组比较，鼻咽清毒颗粒0.1、1、10 mg/mL组分别与系列质量浓度的顺铂联用，对CNE-2细胞顺铂IC50分别降低12.19%、46.37%、63.81%;CNE2/DDP细胞顺铂IC50分别降低61.75%、70.42%、83.82%。流式细胞技术检测结果表明，与顺铂组比，顺铂+鼻咽清毒颗粒0.1、1、10 mg/mL组CNE2-DDP晚期凋亡或坏死细胞增加（P<0.01）;Western blotting法检测结果表明，与顺铂组比较，顺铂+鼻咽清毒颗粒0.1、1、10 mg/mL组铜特异性转运蛋白（CTR1）蛋白的表达均显著升高，B细胞淋巴瘤2(Bcl-2)、骨髓细胞白血病序列1(Mcl-1)的表达显著降低（P<0.05、0.01）。结论鼻咽清毒颗粒具有增强鼻咽癌细胞顺铂敏感性、逆转CNE2/DDP细胞顺铂耐药作用，其作用机制可能与增加CTR1蛋白表达，降低Bcl-2、Mcl-1蛋白表达有关。

关键词：鼻咽清毒颗粒鼻咽癌顺铂耐药铜特异性转运蛋白 B细胞淋巴瘤2 骨髓细胞白血病序列1

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Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat

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Science China Life Sciences 2024年

作者： xuemei Liu Min Deng Bingxin Shi Kehui Zhu Jinchao Chen Shujuan xu Xiaomin Bie Xiansheng Zhang xuelei Lin Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Science and Technology Austria (ISTA) National Key Laboratory of Wheat Improvement College of Life Sciences Shandong Agricultural University Centre of Excellence for Plant and Microbial Science (CEPAMS) JIC-CAS

Winter plants rely on vernalization, a crucial process for adapting to cold conditions and ensuring successful reproduction. However,understanding the role of histone modifications in guiding the vernalization process in winter wheat remains limited. In this study, we investigated the transcriptome and chromatin dynamics in the shoot apex throughout the life cycle of winter wheat in the field. Two core histone modifications, H3K27me3 and H3K36me3, exhibited opposite patterns on the key vernalization gene VERNALIZATION1(VRN1),correlating with its induction during cold exposure. Moreover, the H3K36me3 level remained high at VRN1 after cold exposure, which may maintain its active state. Mutations in FERTILIZATION-INDEPENDENT ENDOSPERM(TaFIE) and SET DOMAIN GROUP 8/EARLY FLOWERING IN SHORT DAYS(TaSDG8/TaEFS), components of the writer complex for H3K27me3 and H3K36me3, respectively, affected flowering time. Intriguingly, VRN1 lost its high expression after the cold exposure memory in the absence of H3K36me3. During embryo development,VRN1 was silenced with the removal of active histone modifications in both winter and spring wheat, with selective restoration of H3K27me3 in winter wheat. The mutant of Tafie-cr-87, a component of H3K27me3 “writer” complex, did not influence the silence of VRN1during embryo development, but rather attenuated the cold exposure requirement of winter wheat. Integrating gene expression with H3K27me3 and H3K36me3 patterns identified potential regulators of flowering. This study unveils distinct roles of H3K27me3 and H3K36me3 in controlling vernalization response, maintenance, and resetting in winter wheat.

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Role of polyphenols in epilepsy: from the perspective of gut microbiota

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Food Science and Human Wellness 2024年

作者： Xiaoxue xu Jian Shi Yinsi Tang Guiyang Cai Chao Ma Wuyang Wang Rui Feng Tomasz Boczek Zhenwei He Feng Guo Department of Pharmaceutical Toxicology School of Pharmacy China Medical University Shenyang Department of Neurology the First Hospital of China Medical University Department of Pharmacy the Fourth Affiliated Hospital of China Medical University Department of Gastroenterology the Fourth Affiliated Hospital of China Medical University Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University Jiangsu Province Key Laboratory of Anesthesiology xuzhou Medical University Department of Molecular Neurochemistry Medical University of Lodz Department of Neurology the Fourth Affiliated Hospital of China Medical University

Epilepsy is a devastating neurological condition that affects over 70 million people worldwide. Apart from idiopathic epilepsy， numerous diseases have been reported to cause secondary epilepsy. Polyphenols， ubiquitously existing in fruits and vegetables， has become a promising neuroprotective candidate against multiple neurological abnormalities due to its interplay with gut microbiome composed of the bacterial population in gastrointestinal system. This bioactive compound is also being tested for the management of epileptogenesis. However， there is still insufficient evidence from mechanistic studies to demonstrate the causal relationship between anti-epileptic effect of polyphenols and microbial alteration. In this review， we provide the brief overview of epilepsy， polyphenols and gut microbiota. We then analysis the association of polyphenols and gut microbiota particularly in the epilepsy and symptomatic seizures-induced by epilepsy-related disorders. We also discuss the possibility for the combined application with probiotics to improve the bioavailability and bioaccessibility of polyphenols for expanding its anti-epileptic function. We finally summarize the therapeutic potential of anti-seizure polyphenols through affecting gut microbiome， and propose that the anti-epileptic effect of polyphenols may be tightly relevant to intestinal bacterial flora for overcoming epilepsy and its comorbidities simultaneously. Therefore， the dietary polyphenols targeting specific bacteria may achieve the outcome of ‘one stone， two birds’.

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