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Recent efficacy and long-term survival of Astragalus polysaccharide combined with gemcitabine and S-1 in pancreatic cancer

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World Journal of Clinical Oncology 2024年第11期15卷 1404-1411页

作者： guang-yu li Jing Jiang The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou 310000ZhejiangChina The First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou 310000Zhejiang ProvinceChina Zhejiang Cancer Hospital Hangzhou 310000Zhejiang ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant tumor with a rapid progression rate and a high susceptibility to infiltration and *** polysaccharide(APS),a pure Chinese medicine preparation primarily made from the traditional Chinese herb Astragalus,plays a positive role in the treatment of many malignant *** To explore the recent efficacy of APS combined with gemcitabine plus tegafur gimeracil oteracil potassium capsule(S-1)(GS)regimen in the treatment of pancreatic cancer and assess its effect on the immune function and long-term survival of *** A total of 97 patients who were diagnosed with pancreatic cancer and received GS chemotherapy at The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)from March 2021 to December 2021 were included in the retrospective *** them,41 patients received APS combined with GS chemotherapy,and 56 patients received GS chemotherapy *** recent efficacy,immune function,adverse reactions,and long-term survival were compared among these *** After 4 cycles of treatment,the objective response rate of patients receiving the combined therapy of APS and GS was 51.22%,and the disease control rate(DCR)was 56.10%,higher than those of patients receiving the monotherapy with GS alone(30.36%and 35.71%,respectively).Besides,the percentages of CD3+T cells(50.18%±9.57%)and CD4+T cells(31.52%±5.33%)in the peripheral blood of patients receiving the combined therapy of APS and GS were higher compared with those treated with GS regimen alone[(44.06%±8.55%)and(26.01%±7.83%),respectively].Additionally,the incidences of leukopenia,thrombocytopenia,and fatigue in patients receiving the combined therapy of APS and GS were significantly lower than those in patients receiving the monotherapy of GS alone(17.07%,9.76%,31.71%vs 37.50%,28.57%,60.71%).Moreover,the median survival time of patients receiving the combined therapy of APS

关键词： Pancreatic cancer Astragalus polysaccharide Long-term survival Immune function Traditional Chinese medicine

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Clinical comprehensive treatment protocol for managing diabetic foot ulcers:A retrospective cohort study

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World Journal of Clinical Cases 2024年第17期12卷 2976-2982页

作者： Yan-Bin Wang Yan Lv guang-yu li Ji-Ting Zheng Qing-Xin Jiang Ran Wei Department of Vascular Surgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina First Department of General Surgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of *** current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications.A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with *** hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing,reduced amputation rates,and improved overall patient outcomes compared to standard treatment *** To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment *** This retrospective study included 62 patients with DFUs,enrolled between January 2022 and January 2024,randomly assigned to the experimental(n=32)or control(n=30)*** experimental group received a comprehensive treatment comprising blood circulation improvement,debridement,vacuum sealing drainage,recombinant human epidermal growth factor and anti-inflammatory dressing,and skin *** control group received standard treatment,which included wound cleaning and dressing,antibiotics administration,and surgical debridement or amputation,if *** taken to reduce the white blood cell count,number of dressing changes,wound healing rate and time,and amputation rate were *** The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate,wound healing time,and amputation ***,the comprehensive treatment protocol was safe and well tolerated by the *** Comprehensive treatment for DFUs is more effective than standard treatment,promoting granulation tissue growth,shortening hospitalization time,reducing pain and amputation rate,improving wound healing,and enhancing quality of life.

关键词： Diabetic foot ulcers Comprehensive treatment protocol Clinical study White blood cell count Wound healing Amputation rate

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A 1-Dimensional Nonlinear Filtering Problem

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Acta Mathematica Sinica,English Series 2010年第3期26卷 555-560页

作者： guang yu li Ke WANG Department of Mathematics Oujiang College Wenzhou Univercity Wenzhou 325027 P. R. China Department of Mathematics Harbin Institute of Technology Weihai 264209 P. R. China

We will concentrate on a 1-dimensional nonlinear filtering problem, which allows an explicit solution in terms of a stochastic differential equation for Xt.

关键词： Ito's formula filtering stochastic differential equation

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CaY-zeolite Catalyzed Etherification and Alkylation of Substituted Benzyl Alcohols

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Chinese Chemical Letters 2006年第1期17卷 15-18页

作者： Wei yu Miao WEN guang yu ZHAO li YANG Zhong li liU National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

The reaction of p- and/ α-subtituted benzyl alcohols in CaY-zeolite produced the corresponding dibenzyl ethers and/or benzyl toluenes as the principal products.

关键词： Benzyl alcohols CaY-zeolite etherification alkylation.

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The dynamical architecture and habitable zones of the quintuplet planetary system 55 Cancri

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Research in Astronomy and Astrophysics 2009年第6期9卷 703-711页

作者： Jiang-Hui Ji Hiroshi Kinoshita lin liu guang-yu li Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China National Astronomical Observatory Mitaka Tokyo 181--8588 Japan Department of Astronomy Nanjing University Nanjing 210093 China

We perform numerical simulations to study the secular orbital evolution and dynamical structure of the quintuplet planetary system 55 Cancri with the self-consistent orbital solutions by Fischer and coworkers. In the simulations, we show that this system can be stable for at least 108 yr. In addition, we extensively investigate the planetary configuration of four outer companions with one terrestrial planet in the wide region of 0.790AU 〈 a 〈 5.900AU to examine the existence of potential asteroid structure and Habitable Zones （HZs）. We show that there are unstable regions for orbits about 4：1, 3：1 and 5：2 mean motion resonances （MMRs） of the outermost planet in the system, and several stable orbits can remain at 3：2 and 1：1 MMRs, which resembles the asteroid belt in the solar system. From a dynamical viewpoint, proper HZ candidates for the existence of more potential terrestrial planets reside in the wide area between 1.0 AU and 2.3 AU with relatively low eccentricities.

关键词： celestial mechanics -- methods n-body simulations -- planetary systems -- stars individual (55 Cancri)

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Characteristics of Antisense Non-coding RNA in the INK4 Locus and Its Roles in Disease

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Chinese Medical Sciences Journal 2013年第2期28卷 122-123页

作者： Jin-hua He yu-guang li Department of Laboratory Panyu Central Hospital

Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.

关键词： long non-coding RNAs antisense non-coding RNA in the INK4 locus expression

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Function of microRNA-346 and its Roles in Human Diseases

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Chinese Medical Sciences Journal 2012年第2期27卷 127-128页

作者： Jin-hua He yu-guang li Department of Laboratory Panyu Center HospitalGuangzhou 511400China

MICRORNAs (miRNAs) are short (20-22 nucleotldes),non-coding RNA molecules involved in the regulation of mRNAs by pairing with their 3'-untranslated region (3'-UTR) and affecting their stability or directing their silencing or degradation.1 miRNAs are likely to play roles in most cellular processes,including proliferation,development,differentiation,and apoptosis.2 People have made progress in the research of miRNA field,but the study about microRNA-346 (miR-346) is very *** study used biological software to analyze the biological characters of miR-346,and further reviewed the function of miR-346 and its roles in human diseases.

关键词：人类疾病 miRNA 生物学特性非编码RNA 细胞凋亡微RNA mRNA 非翻译区

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Entrapment of the temporal horn secondary to postoperative gamma-knife radiosurgery in intraventricular meningioma: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2894-2898页

作者： Jia liu Sheng-Rong Long guang-yu li Department of Neurosurgery the First Hospital of China Medical University

BACKGROUND Entrapment of the temporal horn (ETH) is a rare pathologic condition. It is a kind of focal hydrocephalus caused by obstruction of flow pathway of cerebrospinal fluid. It is caused by various conditions, but ETH secondary to postoperative gamma-knife radiosurgery (GKS) is extremely rare. CASE SUMMARY A 52-year old previously healthy woman underwent resection of a large intraventricular meningioma. A small fragment of residual tumor with no obvious enlargement of the temporal horn was observed 3 mo after surgery, and she was referred for GKS. Two months after GKS, she complained of headache and progressive paralysis of the left limb. Magnetic resonance imaging revealed enlargement of the temporal horn. There was a second procedure to resect the residual tumor 8 mo after GKS. After the second procedure, she recovered smoothly. As of the date of this writing, she has remained in good condition. CONCLUSION This case reminds us that ETH should be considered in the treatment of intraventricular meningiomas, especially before GKS.

关键词： Entrapment of the temporal horn Gamma-knife radiosurgery Intraventricular meningioma Case report

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Combustion characteristics of tannery sludge and volatilization of heavy metals in combustion

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 530-537页

作者： Xu-guang JIANG Chun-yu li Zhen-wei FEI Yong CHI Jian-hua YAN State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

Incineration is considered one of the most readily available techniques for sewage sludge disposal, including tannery sludge, which often contains significant amounts of volatile heavy metals. The combustion characteristics and kinetic analysis of tannery sludge were investigated using thermogravimetric analysis (TGA) at a heating rate of 30 °C/min in 50–950 °C. In addition to confirming that tannery sludge has a high content of volatile material and ash, it was further discovered that almost all the zinc (Zn) in tannery sludge is volatilized at 900 °C. The degree of volatilization for heavy metals at 900 °C followed the order of Zn>Cd>Cu>Mn>Pb>Cr. Moreover, the volatilization of these heavy metals increased with temperature. It is thus concluded that, to avoid heavy metal volatization during incineration disposal, 800 °C is a reasonable incineration temperature.

关键词： Tannery sludge Combustion Heavy metal volatilization Thermogravimetric analysis (TGA) Combustion kinetics

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Research into hydro-liquefaction of bamboo based on GPC

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Forestry Studies in China 2010年第2期12卷 95-100页

作者： yu guang li Zhen-qiu li Jing-hua College of Chemical Engineering Qingdao University of Science ＆ Technology Qingdao 266042 P. R. China

We investigated hydrogenated catalytic liquefaction of bamboo. By comparing the effect of three kinds of conditions on liquefaction, i.e. liquefaction under vapor pressure, liquefaction under high hydrogen pressure and liquefaction under high hydrogen pressure with alkaline as a catalyst, we obtained the conditions for optimum results. The reaction temperature was 170~C, the initial hydrogen pressure 4.0 MPa, the reaction time 80 min, with sodium hydroxide as the catalyst, with a weight amounting to 8.05% of that of dried bamboo. Under these optimum conditions, the yield of the liquid was 58.55% and the conversion ratio of polysacchatides 70.62%.

关键词： liquefaction aromatic compounds polysaccharide

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