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SiC_f/TC17复合材料残余应力及界面力学性能研究

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稀有金属 2024年第06期48卷 822-832页

作者：王敏涓杨光戚继球孟庆坤孙光耀黄浩中国航发北京航空材料研究院中国航空发动机集团有限公司先进钛合金重点实验室中国矿业大学材料与物理学院

采用基体涂层法制备出SiC连续纤维增强钛基（SiC_f/Ti）复合材料，通过纤维顶出试验和有限元模拟研究复合材料的热残余应力分布特征与界面力学性能的影响因素。SiC_f/TC17复合材料中SiC纤维呈近似六方排布，均匀分布在钛合金基体中。根... 详细信息

采用基体涂层法制备出SiC连续纤维增强钛基（SiC_f/Ti）复合材料，通过纤维顶出试验和有限元模拟研究复合材料的热残余应力分布特征与界面力学性能的影响因素。SiC_f/TC17复合材料中SiC纤维呈近似六方排布，均匀分布在钛合金基体中。根据单纤维顶出试验的载荷-位移曲线计算出SiC_f/TC17复合材料的平均界面剪切强度和摩擦应力分别为49 MPa和34 MPa。有限元模拟结果表明，随SiC_f/TC17复合材料中热残余应力的增加，顶出试验的摩擦力显著增加，而界面脱粘力先降后升；随摩擦系数的增加，脱粘力和摩擦力都增加；随本征界面剪切强度增加，脱粘力增加而摩擦力不变。结合顶出试验和有限元模拟结果，确定SiC_f/TC17复合材料的界面摩擦系数和本征界面剪切强度分别为0.17和390 MPa。单纤维顶出试验中，SiC_f/TC17复合材料在C涂层和反应层之间脱粘，顶出载荷在界面产生的剪切应力与支撑端的剪切残余应力方向一致，导致界面脱粘首先发生在支撑端，而后脱粘区域沿着纤维/基体界面向加载端扩展，当载荷-位移曲线达到最大值时界面完全脱粘。

关键词： SiC纤维 Ti基复合材料残余应力界面剪切强度有限元

天天胶囊及其原料芦荟在大鼠体内的存在形式研究

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中国中药杂志 2024年第6期49卷 1641-1660页

作者：张静郝北泉李寅庆王光路徐风刘广学尚明英蔡少青北京大学药学院生药学研究室北京100191 河北御芝林药业有限公司河北石家庄050035

为了阐明组方药材芦荟对天天胶囊体内存在形式(原形成分和代谢产物)的贡献,首次对芦荟、天天胶囊及去芦荟天天胶囊在大鼠体内的存在形式进行了研究。大鼠灌胃给药,每天1次,连续灌胃7 d。收集给药7 d的全部尿液和粪便,最后一次灌胃给药... 详细信息

为了阐明组方药材芦荟对天天胶囊体内存在形式(原形成分和代谢产物)的贡献,首次对芦荟、天天胶囊及去芦荟天天胶囊在大鼠体内的存在形式进行了研究。大鼠灌胃给药,每天1次,连续灌胃7 d。收集给药7 d的全部尿液和粪便,最后一次灌胃给药后分别于0.5、1、1.5 h收集血液。采用UHPLC⁃Q⁃TOF⁃MS检测和鉴定生物样品中的存在形式,分别鉴定了芦荟给药组、天天胶囊给药组、去芦荟天天胶囊给药组生物样品中的原形成分34、28、2个及代谢产物64、94、0个。代谢反应类型主要为甲基化、氢化、羟基化、脱羟基、葡萄糖醛酸结合、硫酸结合等。该研究首次阐明了芦荟、天天胶囊、去芦荟天天胶囊在大鼠体内的存在形式和部分代谢途径,为进一步揭示其显效形式奠定基础,并对中药芦荟和天天胶囊的作用机制及质量控制研究具有重要意义。

关键词：天天胶囊芦荟 UHPLC⁃Q⁃TOF⁃MS 体内代谢

Efficacy and safety of Huzhang Granule,a compound Chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

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Journal of Integrative Medicine 2024年第3期22卷 270-278页

作者： hao Wang Si-ting Chen Xiao-jie Ding Le Kuai Liang Hua Xin Li Yi-fei Wang Ming Zhang Bin Li Rui-ping Wang Mi Zhou Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Department of Dermatology the Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000Jiangxi ProvinceChina Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200443China Institute of Dermatology School of MedicineTongji UniversityShanghai 200443China

Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high *** medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse *** Granule(HZG),a compound Chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse ***,the efficacy and safety of HZG in AGA patients remains ***:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA ***,setting,participants and interventions:The current study was conducted as a noninferiority,randomized controlled clinical trial on 180 eligible enrolled *** were randomly assigned into the HZG and etoricoxib *** were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and placebo HZG in the same ratio(1:1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment *** pain level was measured via a visual analogue scale,ranging from 0 mm to 100 *** secondary outcomes comprised joint tenderness and swelling,reduction of inflammatory biomarkers,and the patient’s and investigator’s global evaluations of therapeutic ***:The mean reduction in pain was-51.22 mm(95%confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95%CI,[-54.06,-49.94]mm)for the etoricoxib *** mean difference between the two groups was 0.78 mm(95%CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of *** in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etoricoxib group(4.44%vs 13.33%;P≤0.05).Conclusion:HZG and etoricoxib groups demons

关键词： Acute gouty arthritis Huzhang Granule Randomized controlled trial Blind

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华北平原区村内供水管网水力计算方法探讨

海河水利 2024年第2期 67-70,83页

作者：户广勇梁好沧州水利勘测规划设计院有限公司河北沧州061003 沧州市市政公用事业服务中心河北沧州061003

在村内供水管网工程中,准确的管网水力计算并合理确定管径是保证工程合理性与经济性的重要基础。根据农村供水管网工程的设计经验及相关文献,对适用于华北平原区村内供水管网的水力计算方法进行了总结,并通过工程实例对计算管段设计流... 详细信息

在村内供水管网工程中,准确的管网水力计算并合理确定管径是保证工程合理性与经济性的重要基础。根据农村供水管网工程的设计经验及相关文献,对适用于华北平原区村内供水管网的水力计算方法进行了总结,并通过工程实例对计算管段设计流量和确定管径的方法和步骤进行了说明,提出了相关指导建议,以供类似工程设计参考。

关键词：村内供水管网人均用水当量法设计秒流量计算管径

Exploring the autophagy-related pathogenesis of active ulcerative colitis

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World Journal of Clinical Cases 2024年第9期12卷 1622-1633页

作者： Zhuo-Zhi Gong Teng Li He Yan Min-hao Xu Yue Lian Yi-Xuan Yang Wei Wei Tao Liu Wangjing Hospital China Academy of Chinese Medical SciencesBeijing 100102China College of Traditional Chinese Medicine School of Traditional Chinese MedicineBeijing 100102China guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND The pathogenesis of ulcerative colitis(UC)is complex,and recent therapeutic advances remain unable to fully alleviate the *** To inform the development of novel UC treatments,bioinformatics was used to explore the autophagy-related pathogenesis associated with the active phase of *** The GEO database was searched for UC-related datasets that included healthy controls who met the screening *** analysis was conducted to obtain differentially expressed genes(DEGs).Au-tophagy-related targets were collected and intersected with the DEGs to identiy differentially expressed autophagy-related genes(DEARGs)associated with active *** were then subjected to KEGG,GO,and DisGeNET disease enrichment analyses using R *** analysis of immune infiltrating cells was performed using the CiberSort *** least absolute shrinkage and selection operator algorithm and protein-protein interaction network were used to narrow down the DEARGs,and the top five targets in the Dgree ranking were designated as core *** A total of 4822 DEGs were obtained,of which 58 were classified as ***1,BAG3,HSPA5,CASP1,and CX3CL1 were identified as core *** enrichment analysis revealed that DEARGs were primarily enriched in processes related to autophagy regulation and *** enrichment analysis showed that DEARGs were predominantly associated with NOD-like receptor signaling and other signaling *** enrichment analysis indicated that DEARGs were significantly linked to diseases such as malignant glioma and middle cerebral artery *** infiltration analysis demonstrated a higher presence of immune cells like activated memory CD4 T cells and follicular helper T cells in active UC patients than in healthy *** Autophagy is closely related to the active phase of UC and the potential targets obtained from the analysis in this study may provide new insight into

关键词： Ulcerative colitis Autophagy Bioinformatic Targets Pathogenesis

肠易激综合征及其亚型与胆囊结石的相关性分析

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解放军医学杂志 2024年第2期49卷 159-164页

作者：王广祥董昌昊李超冼锐崔立红南方医科大学第二临床医学院广东广州510280 解放军总医院第一医学中心消化内科北京100853

目的分析肠易激综合征(IBS)及其亚型与胆囊结石的相关性。方法选取2019年1月-2023年3月于解放军总医院第六医学中心消化内科就诊的患者556例,其中IBS组161例,非IBS组395例。对研究对象进行问卷调查、体格检查及血液检查,比较两组性别、... 详细信息

目的分析肠易激综合征(IBS)及其亚型与胆囊结石的相关性。方法选取2019年1月-2023年3月于解放军总医院第六医学中心消化内科就诊的患者556例,其中IBS组161例,非IBS组395例。对研究对象进行问卷调查、体格检查及血液检查,比较两组性别、年龄、身高、体重、血压、血生化指标等资料。采用logistic回归分析IBS与胆囊结石的关系。结果556例患者中胆囊结石90例(16.2%),其中IBS组胆囊结石37例(23.0%),非IBS组胆囊结石53例(13.4%),IBS组胆囊结石患病率高于非IBS组(P0.05)。结论IBS与胆囊结石间存在相关性。与非IBS患者比较,腹泻型IBS患者罹患胆囊结石的风险增加。

关键词：肠易激综合征腹泻型肠易激综合征便秘型肠易激综合征胆囊结石

2014—2022年中药新药审评与医保准入时长分析

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临床药物治疗杂志 2024年第1期22卷 51-55页

作者：刘春光张昊中国人民武装警察部队北京市总队医院药剂科北京100027 北京中医药大学东方学院河北廊坊301739

目的以近十年我国中药新药为研究对象,分析中药新药审批数量和审批时长变化规律,为中药创新发展政策落实情况及相关制度的制定提供参考。方法查阅国家药品监督管理局发布的年度药品审评报告,整理2014—2022年中药新药上市品种;通过药品... 详细信息

目的以近十年我国中药新药为研究对象,分析中药新药审批数量和审批时长变化规律,为中药创新发展政策落实情况及相关制度的制定提供参考。方法查阅国家药品监督管理局发布的年度药品审评报告,整理2014—2022年中药新药上市品种;通过药品审评中心受理品种查询系统和药智网检索各中药新药的受理和审评审批时间。结果2014—2022年,纳入研究的40个中药新药审评审批所需的时长中位数38个月,2019年之后上市的中药新药审评审批时长明显缩短,时长中位数降至11个月。同时,2019年之后,中药新药进医保目录时长明显缩短,时长中位数降至14个月。并且进医保目录的中药新药占审批上市的中药新药的比例明显增加,已经增加至59.09%。结论国务院发布的《关于促进中医药传承创新发展的意见》及相关政策在一定程度提升了中药新药审评审批效率,促进了中药新药的上市和医保使用。

关键词：中药新药审评审批医保准入

土地规模经营潜力对家庭农场加入合作社或农业企业的决策影响机制分析

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农业现代化研究 2024年第4期45卷 626-635页

作者：张展殷冠羿魏玮孙庆芝李广昊朱胜浩山东师范大学地理与环境学院山东济南250000

各类新型农业经营主体的协同发展被视为实现农业规模经营的有效途径,家庭农场融入合作社和农业企业的耦合发展机制备受关注。本研究采用Tobit回归模型和调节效应模型,探讨土地规模经营潜力对家庭农场加入合作社或农业企业的影响机理,并... 详细信息

各类新型农业经营主体的协同发展被视为实现农业规模经营的有效途径,家庭农场融入合作社和农业企业的耦合发展机制备受关注。本研究采用Tobit回归模型和调节效应模型,探讨土地规模经营潜力对家庭农场加入合作社或农业企业的影响机理,并阐述土地整理在此过程中的调节作用。研究结果显示:1)家庭农场土地经营面积的现状、过去增加趋势及未来增加意愿,均对其加入合作社或农业企业的意愿起正向促进作用。2)土地经营面积对家庭农场加入合作社或农业企业的影响呈倒“U”型曲线规律,当家庭农场的土地规模达到阈值时,其加入合作社或农业企业的概率最高。3)在土地规模经营潜力对家庭农场加入合作社或企业的促进机制中,土地整理具有显著的调节作用。4)第一产业占比越高、机械化水平越高以及农场发展势头越好的地区,其土地规模经营潜力对家庭农场加入合作社或农业企业的正向促进作用越显著。因此,应以土地整理和规模经营为引领,推动家庭农场、合作社和企业的一体化发展,以促进农业产业结构升级和生产效率提升。

关键词：土地规模经营潜力土地整理家庭农场合作社农业企业

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Development and Application of Detection Methods for Capture and Transcription Elongation Rate of Bacterial Nascent RNA

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生物化学与生物物理进展 2024年第9期51卷 2249-2260页

作者： LI Yuan-Yuan WANG Yu-Ting WU Zi-Chun LI hao-Xuan FEI Ming-Yue SUN Dong-Chang GUALERZI O.Claudio FABBRETTI Attilio GIULIODORI Anna Maria MA Hong-Xia HE Cheng-guang Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development College of Life SciencesJilin Agricultural UniversityChangchun 130118China School of Biosciences and Veterinary Medicine University of CamerinoCamerino(MC)62032Italy College of Biotechnology and Bioengineering Zhejiang University of TechnologyHangzhou 310014China

Objective Detection and quantification of RNA synthesis in cells is a widely used technique for monitoring cell viability,health,and metabolic *** exposure to environmental stimuli,both the internal reference gene and target gene would be *** a result,it is imperative to consider the accurate capture of nascent RNA and the detection of transcriptional levels of RNA following environmental *** study aims to create a Click Chemistry method that utilizes its property to capture nascent RNA from total RNA that was stimulated by the *** The new RNA was labeled with 5-ethyluridine(5-EU)instead of uracil,and the azido-biotin medium ligand was connected to the magnetic sphere using a combination of“Click Chemistry”and magnetic bead *** the new RNA was captured and the transcription rate of 16S rRNA was detected by fluorescence molecular beacon(M.B.)and quantitative reverse transcription PCR(qRT-PCR).Results The bacterial nascent RNA captured by“Click Chemistry”screening can be used as a reverse transcription template to form *** with the fluorescent molecular beacon M.B.1,the synthesis rate of rRNA at 37℃is 1.2 times higher than that at 15℃.The 16S rRNA gene and cspI gene can be detected by fluorescent quantitative PCR,it was found that the measured relative gene expression changes were significantly enhanced at 25℃and 16℃when analyzed with nascent RNA rather than total RNA,enabling accurate detection of RNA transcription *** Compared to other article reported experimental methods that utilize screening magnetic columns,the technical scheme employed in this study is more suitable for bacteria,and the operation steps are simple and easy to implement,making it an effective RNA capture method for researchers.

关键词： nascent RNA selection Click Chemistry fluorescence molecular beacon