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如何理解中国当下教育实证研究取向

大学教育科学 2020年第5期 4-11页

作者：阎光才华东师范大学高等教育研究所上海200062

我国当下教育实证研究的兴起有其特定的语境,决策部门对证据的关注、大数据及其分析技术的运用和脑科学的初步进展等,是促成其兴起的主要动因。教育实证研究取向多少体现了倡导者的科学主义、技术主义、证据主义和工具主义立场,有利于... 详细信息

我国当下教育实证研究的兴起有其特定的语境,决策部门对证据的关注、大数据及其分析技术的运用和脑科学的初步进展等,是促成其兴起的主要动因。教育实证研究取向多少体现了倡导者的科学主义、技术主义、证据主义和工具主义立场,有利于校正传统研究重思辨与质性的取向。然而,面对当前中国教育中最为棘手的人的精神价值与生命意义失落问题,它不仅难以提供药方,而且还涉及诸多需要反思的伦理议题。教育研究不能沦为唯方法主义,更遑论唯实证取向,而是要体现一种开放和多元、人文诠释与科学解释的统一。

关键词：教育研究实证主义大数据脑科学循证研究伦理关怀

政策情境、组织行动逻辑与个人行为选择——四十年来项目制的政策效应与高校组织变迁

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高等教育研究 2019年第7期40卷 33-45页

作者：阎光才华东师范大学高等教育研究所

40年来我国注重效率的项目制宏观政策取向,具有行政科层与市场竞争双重逻辑嵌套的特征,它推动了高校内部组织结构与制度的快速变迁,使得高校基于指标生产的组织特征愈加凸显,进而影响到微观层面个体的工作动机与行为。当前有必要反思这... 详细信息

40年来我国注重效率的项目制宏观政策取向,具有行政科层与市场竞争双重逻辑嵌套的特征,它推动了高校内部组织结构与制度的快速变迁,使得高校基于指标生产的组织特征愈加凸显,进而影响到微观层面个体的工作动机与行为。当前有必要反思这一政策取向所带来的相关效应,减少政府过多项目发包,还原项目的资源本质并回归学术组织本性。

关键词：项目制高等学校行动逻辑政策效应

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大学与城市、社区间关系的历史与现实

比较教育研究 2006年第6期27卷 24-30页

作者：阎光才教育部人文社会科学重点研究基地北京师范大学比较教育研究中心北京师范大学国际与比较教育研究所北京100875

大学与城市、社区间关系的历史就是一部充满冲突又存在整合的历史,如果没有各种文化或利益的冲突,在城市化的过程中,大学是否能够得益续存恐怕都成为一个问题;然而,如果没有整合,大学也就不可能得到发展的机遇,对城市社区而言也同样如... 详细信息

大学与城市、社区间关系的历史就是一部充满冲突又存在整合的历史,如果没有各种文化或利益的冲突,在城市化的过程中,大学是否能够得益续存恐怕都成为一个问题;然而,如果没有整合,大学也就不可能得到发展的机遇,对城市社区而言也同样如此。本文试图通过对大学与城市、社区间关系历史的梳理和现实的分析,揭示这种互动关系的本质,并针对当下中国的现实提出相关的思考。

关键词：互动大学城市文化冲突利益整合社区互动关系

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教师“身份”的制度与文化根源及当下危机

北京师范大学学报（社会科学版） 2006年第4期 12-17页

作者：阎光才北京师范大学比较教育研究中心北京100875

从历史的角度考察,中国教师的传统身份是制度型构起来的,正是通过制度的型构,才逐渐形成民间尊师重教的习俗和传统。由于教育制度的变迁,目前教师传统身份正遭遇严峻的危机,甚至民间日常生活中的尊师习俗和传统也面临着“去根化”的危险。

关键词：教师身份制度型构文化建构

Relationship between serum C3/C4 ratio and prognosis of immunoglobulin A nephropathy based on propensity score matching

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Chinese Medical Journal 2020年第6期133卷 631-637页

作者： yan Zhang Shu-Wei Duan Pu Chen Zhong Yin Yong Wang guang-yan cai Xiang-Mei Chen Department of Nephrology Chinese People's Liberation Army General HospitalChinese People's Liberation Army Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China

Background:Aberrant activation of the complement system plays an important role in the pathogenesis and development of immunoglobulin A nephropathy(IgAN).The relationship between serum complement and the clinical-histopathological features and outcomes of IgAN is *** retrospective study aimed to examine the relationship between the complement 3/4(C3/C4)ratio and the clinicopathologic changes and prognosis of patients with ***:A total of 397 patients with primary IgAN from January 2007 to December 2012 at the Chinese People's Liberation Army General Hospital were included in this *** correlation test and Chi-square test or one-way analysis of variance test were performed to evaluate the relationship between the C3/C4 ratio and other clinical-pathological *** score matching and a multivariate Cox regression model were used to calculate the risk factors of renal ***:The median follow-up period was 75 *** the follow-up period,62 patients(15.6%)developed into the endstage renal disease(ESRD).The C3/C4 ratio at baseline was associated with the level of serum creatinine(SCr),24 h urinary protein excretion(24 h Upre),global glomerular sclerosis,and tubulointerstitial *** level of SCr and 24 h Upre and the degree of chronic kidney injury were statistically different among groups defined by different C3/C4 ratio *** survival rates of patients among groups with different C3/C4 ratio levels were *** propensity score matching,eighty-eight pairs of patients were successfully matched,and the C3/C4 ratio was an influencing factor for the patients5 outcome(hazard ratio 0.587,95%confidence interval 0.329-0.880).Patients with a C3/C4 ratio<3.6 had a poorer outcome compared with the others(P=0.002).Conclusions:IgAN patients with decreased C3/C4 ratio displayed significantly more severe clinical symptoms and chronic renal injury than patients with higher ratios.A low C3/C4 ratio could be a risk

关键词： Complement Serum C3/C4 Immunoglobulin A nephropathy Prognosis

Reveal the lost entanglement for accelerated atoms in the high-dimensional spacetime

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 48-57页

作者： Jiatong yan Baocheng Zhang Qingyu cai School of Mathematics and Physics China University of GeosciencesWuhan 430074China Physics Department Brown UniversityProvidenceRhode Island 02912USA Center for Theoretical Physics Hainan UniversityHaikou 570228China School of Information and Communication Engineering Hainan UniversityHaikou 570228China Peng Huanwu Center for Fundamental Theory Hefei 230026China

When atoms are accelerated in the vacuum,entanglement among atoms will degrade compared with the initial situation before the *** this study,we propose a novel and interesting view that the lost entanglement can be recovered completely when the high-dimensional spacetime is exploited,in the case that the acceleration is not too large,since the entanglement loss rate caused by the large acceleration is faster than the recovery *** also calculate the entanglement change caused by the anti-Unruh effect and found that the lost entanglement could just be recovered part by the anti-Unruh effect,and the anti-Unruh effect could only appear for a finite range of acceleration when the interaction time scale is approximately shorter than the reciprocal of the energy gap in two dimensional *** limit case of zero acceleration is also investigated,which gives an analytical interpretation for the increase or recovery of entanglement.

关键词： entanglement acceleration high-dimensional spacetime

Progress of small ubiquitin-related modifiers in kidney diseases

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Chinese Medical Journal 2019年第4期132卷 466-473页

作者： Ou Li Qian Ma Fei Li guang-yan cai Xiang-Mei Chen Quan Hong Department of Nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing 100853China.

Objective: Small ubiquitin-related modifiers (SUMOs) are a group of post-translational modification proteins extensively expressed in eukaryotes. Abnormal SUMOylation can lead to the development of various diseases. This article summarizes the progress on research of the role of SUMOs in various types of kidney diseases to further increase the understanding of the regulatory functions of SUMOylation in the pathogenesis of kidney diseases. Data sources: This review was based on articles published in the PubMed databases up to January 2018, using the keywords including "SUMOs," "SUMOylation," and "kidney diseases." Study selection: Original articles and critical reviews about SUMOs and kidney disease were selected for this review. A total of 50 studies were in English. Results: SUMO participates in the activation of NF-κB inflammatory signaling pathway, playing a central regulatory role in the inflammation and progression of DN, and the secretion of various chemokines in AKI. SUMO involves in the regulation of TG2 and Nrf2 antioxidant stress, affecting renal tubular injury in AKI. SUMO affects the MAPK/ERK pathway, regulating intracellular signal transduction, modulating the transcription and expression of effector molecules in DN. SUMO contributes to the TGF-β/Smad pathway, leading to fibrosis of the kidney. The conjugate combination of SUMO and p53 regulates cell proliferation and apoptosis, and participates in the regulation of tumorigenesis. In addition, SUMOylation of MITF modulates renal tumors secondary to melanoma, Similarly, SUMOylation of tumor suppressor gene VHL regulates the occurrence of renal cell carcinoma in VHL syndrome. Conclusions: Tissue injury, inflammatory responses, fibrosis, apoptosis, and tumor proliferation in kidney diseases all involve SUMOs. Further research of the substrate SUMOylation and regulatory mechanisms of SUMO in kidney diseases will improve and develop new treatment measures and strategies targeting kidney diseases.

关键词： Small ubiquitin-related modifiers SUMOylation Kidney diseases

Single-cell RNA sequencing data suggest a role for angiotensin-converting enzyme 2 in kidney impairment in patients infected with 2019-novel coronavirus

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Chinese Medical Journal 2020年第9期133卷 1129-1131页

作者： Yi-Yao Deng Ying Zheng guang-yan cai Xiang-Mei Chen Quan Hong Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing 100039China

The World Health Organization has recently declared the 2019-novel coronavirus(2019-nCoV)a global public health *** et al[1]reported acute kidney injury(AKI)in 7%of the 41 patients infected with 2019-nCoV,this value was even higher(up to 31%)among intensive-care ***,Li et al[2]reported that plasma creatinine levels increased in 11 of 59 patients with 2019-nCoV infection,suggesting that kidney function was probably impaired when the disease *** et al[3]reported that plasma creatinine level increased in 4.3%of severely diseased patients.2019-nCoV is a highly contagious pathogen that predominantly causes pneumonic *** respiratory failure has been associated with the highest mortality,the lung was not the only organ *** et al[4]reported that 2019-nCoV and severe acute respiratory syndrome-associated coronavirus(SARS-CoV)share a common receptor angiotensin-converting enzyme 2(ACE2)that is required to enter target cells,and cellular protease transmembrane protease serine 2(TMPRSS2)can cleave and activate the spike protein of 2019-nCoV for membrane *** investigated whether ACE2 and TMPRSS2 were expressed in kidney cells using precisiontechnology single-cell RNA sequencing.

关键词： ACE2 patients kidney

亚努斯的隐喻——去行政化语境下的学术精英角色与权力内涵分析

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复旦教育论坛 2010年第5期8卷 5-9页

作者：阎光才华东师范大学高等教育研究所上海200062

在当代学术体制运行过程中,学术精英在很大程度上构成了学术权力的行使主体,他不仅承担了学术共同体的守门人角色,而且也在学术与政治(行政)之间发挥了调停功能。但是,作为人神合体的学术精英所具有的两面性表明,没有行政权力的制衡和... 详细信息

在当代学术体制运行过程中,学术精英在很大程度上构成了学术权力的行使主体,他不仅承担了学术共同体的守门人角色,而且也在学术与政治(行政)之间发挥了调停功能。但是,作为人神合体的学术精英所具有的两面性表明,没有行政权力的制衡和公开透明的学术内部和外部监督机制,没有约束的学术权力也同样可能带来学术失序的风险。

关键词：学术精英学术权力行政权力去行政化