检索结果-南通市图书馆

Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

在线全文

学校读者我要写书评

暂无评论

Eye and Vision 2024年第3期10卷 1-12页

作者： Meifang Yan Junjian li li Yan xue li Jie-guang Chen School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityState Key Laboratory of OptometryOphthalmology and Vision Scienceand Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology270 Xueyuan RoadWenzhouZhejiang325027People’s Republic of China Joint Shantou International Eye Center(JSIEC)of Shantou University and the Chinese University of Hong Kong ShantouGuangdong515000People’s Republic of China

Background The exudative form of age-related macular degeneration(AMD)is characterized by abnormal blood vessel growth,which is stimulated by vascular endothelial growth factor(VEGF)released from retinal pigment epithelium(RPE).The angiogenic behaviors of vascular endothelial cells in vitro depend on forkhead box protein P1(Foxp1),a transcription repressor widely expressed in human and murine tissues during *** this study,we aimed to determine whether loss of Foxp1 affects laser-induced choroidal neovascularization(CNV)in *** Eye-selective deletion of Foxp1 was obtained by crossing Foxp1flox/flox with Six3-Cre *** photocoagulation was delivered to six-to eight-week-old mice to induce *** expression of Foxp1 and Cre was determined by immunofluorescence in cryostat sections of the *** fluorescein angiography(FFA),optical coherence tomography(OCT),and B4 isolectin staining were applied to analyze the leakage,bulge height,and area of CNV lesions,***-choroid tissues were isolated for the determination of VEGF and pigment epithelium derived factor(PEDF)by Western *** Foxp1 was expressed in retinal ganglion cells,RPE,and the choroidal endothelial *** photocoagulation increased the number of Foxp1+-endothelial cells and induced ***3-Cre reduced Foxp1 expression in RPE but not the endothelium,leading to a lower level of VEGF in the ***1 knockout inhibited pathological angiogenesis and vascular leakage of the laser-induced CNV *** Foxp1 regulates the expression of VEGF in the RPE,and inhibition of Foxp1 could potentially be a novel strategy for the prevention and therapy of neovascularization related to AMD.

关键词： Foxp1 Choroidal neovascularization Angiogenesis Laser photocoagulation Age-related macular degeneration

Plastic surgery for giant metastatic endometrioid adenocarcinoma in the abdominal wall:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第19期10卷 6702-6709页

作者： Jing-Yuan Wang Zhi-Qi Wang Si-Chen liang guang-xue li Jing-li Shi Jian-liu Wang Department of Obstetrics and Gynecology Peking University People's HospitalBeijing 100044China Department of Plastic Surgery Peking University People’s HospitalBeijing 100044China Department of Pathology Peking University People’s HospitalBeijing 100044China

BACKGROUND Endometrial cancer(EC)is a common gynecological malignancy,but metastasis to the abdominal wall is extremely ***,an appropriate treatment approach for large metastatic lesions with infection remains a great *** SUMMARY We report the case of a 65-year-old woman who developed abdominal metastasis of endometrioid adenocarcinoma,as defined by International Obstetrics and Gynecology stage II,in which the lesion was complicated by infection.A right hemicolectomy was performed for colon metastasis in relation to her initial gynecological cancer 3 years *** admitted to our department,a complete resection of the giant abdominal wall lesion was performed,and a Bard composite mesh was used to reconstruct the abdominal wall.A local flap was used to close the resultant large defect in the external covering of the *** patient underwent chemotherapy following cytoreductive *** revealed metastasis of EC,and molecular subtyping showed copy number high of TP53 mutation,implying a poor *** When EC patients develop giant abdominal wall metastasis,a plastic surgeon should be included before contemplating resection of tumors.

关键词： Abdominal metastasis Infection Endometrial cancer Reconstruction Mesh Case report

The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 252-271页

作者： Qing Ma guang Chen Ying li Zhenming Guo xue Zhang NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Child and Adolescent Health School of Public HealthHarbin Medical UniversityHarbinHeilongjiang 150000China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200120China

Malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental *** kinds of MCD are caused by genetic *** is the common cause of intellectual disability and intractable *** rapid advances in imaging and sequencing technologies,the diagnostic rate of MCD has been increasing,and many potential genes causing MCD have been successively ***,the high genetic heterogeneity of MCD makes it challenging to understand the molecular pathogenesis of MCD and to identify effective targeted ***,in this review,we outline important events of cortical *** we illustrate the progress of molecular genetic studies about MCD focusing on the PI3K/PTEN/AKT/mTOR ***,we briefly discuss the diagnostic methods,disease models,and therapeutic strategies for *** information will facilitate further research on *** the role of the PI3K/PTEN/AKT/mTOR pathway in MCD could lead to a novel strategy for treating MCD-related diseases.

关键词： Epilepsy Gene mutation Genetics Malformations of cortical development PI3K/PTEN/AKT/mTOR pathway

Research on shell-side heat and mass transfer with multi-component in LNG spiral-wound heat exchanger under sloshing conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1333-1345页

作者： xue-Ping Du guang-Lei Yu Ya-Cheng Xu Zhi-Jie Chen Nai-liang li Huan-guang Wang School of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou221116JiangsuChina Key Laboratory of Thermo-Fluid Science and Engineering MOEXi'an Jiaotong UniversityXi'an710049ShaanxiChina Xi'an Aerospace Propulsion Test Technology Institute Xi'an710100ShaanxiChina

The spiral-wound heat exchanger(SWHE) is the primary low-temperature heat exchanger for large-scale LNG plants due to its high-pressure resistance, compact structure, and high heat exchange efficiency. This paper studied the shell-side heat and mass transfer characteristics of vapor-liquid two-phase mixed refrigerants in an SWHE by combining a multi-component model in FLUENT software with a customized multicomponent mass transfer model. Besides, the mathematical model under the sloshing condition was obtained through mathematical derivation, and the corresponding UDF code was loaded into FLUENT as the momentum source term. The results under the sloshing conditions were compared with the relevant parameters under the steady-state condition. The shell-side heat and mass transfer characteristics of the SWHE were investigated by adjusting the component ratio and other working conditions. It was found that the sloshing conditions enhance the heat transfer performance and sometimes have insignificant effects. The sloshing condition is beneficial to reduce the flow resistance. The comprehensive performance of multi-component refrigerants has been improved and the improvement is more significant under sloshing conditions, considering both the heat transfer and pressure *** results will provide theoretical support for the research and design of multi-component heat and mass transfer enhancement of LNG SWHE under ocean sloshing conditions.

关键词： Spiral-wound heat exchanger Sloshing conditions Two-phase flow Multi-component Heat and mass transfer

Thorium isotopes ((228)Th,(230)Th,(232)Th) and applications in reconstructing the Yangtze and Yellow River floods

在线全文

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2013年第4期28卷 588-595页

作者： Wei-feng YANG Min CHEN Xin-xing ZHANG Zhi-gang GUO guang-xue li Qiang MA Jun-hong YANG Yi-pu Huang State Key Laboratory of Marine Environmental Science Xiamen University Department of Environmental Science and Engineering Fudan University College of Marine Geo-Science Ocean University of China

In the past decades,the Hoods of the Yangtze and Yellow River introduced unexpected changes of the ecological community and sedimentary dynamics in the Fast China Sea(KCS).To reconstruct the flood events in the ECS,228Th,230Th and232Th have been examined in a sediment *** specific activities of three thorium isotopes have good positive relations with line fractions(lized activities of228Th,230Th and232Th showed significant *** between the higher Th activities and historical Hoods of the Yangtze and Yellow River demonstrated that size-normalized Th recorded the two rivers’ flood *** activity ratios of thorium isotopes,i.e.230Th/232Th and228Th/232Th,also showed similar patterns to the historical river *** three periods(1740s,[840—1860s and1930- 1960s),characterized by frequent Hoods,the thorium activity ratios were fairly low and close to the Yangtze and Yellow River estuary sediments,coinciding with the less oceanic228Th and230Th contributions during the flooding ***,these results support the size-normalized Th activity and thorium ratios as proxies of the river floods in coastal seas.

关键词： Thorium Yellow River Yangtze River Flood East China Sea

High critical current density in li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 692-701页

作者： Ying-Tong Lv Teng-Fei Zhang Zhao-Tong Hu guang-lin Xia Ze-Ya Huang Zhen-Hua liu li-Hua Que Cai-Ting Yuan Fang-Qin Guo Takayuki Ichikawa xue-Bin Yu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China Centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials Science Fudan UniversityShanghai200433China Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and ***,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical ***,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable li/LLZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) Critical current density Solid-state electrolytes(SSEs) lithium-sulfur batteries

A machine learning framework for remaining useful lifetime prediction of li-ion batteries using diverse neural networks

在线全文

学校读者我要写书评

暂无评论

Energy and AI 2024年第1期15卷 102-135页

作者： Junghwan Lee Huanli Sun Yongshan liu xue li First Automobile Works Group Corporation Research and Development Center No.1 Xinhongqi StreetChangchun130013JilinChina

Accurate prediction of the remaining useful life(RUL)of lithium-ion batteries(liBs)is pivotal for enhancing their operational efficiency and safety in diverse *** operational advantages,precise RUL predictions can also expedite advancements in cell design and fast-charging methodologies,thereby reducing cycle testing *** artificial neural networks(ANNs)showing promise in this domain,determining the best-fit architecture across varied datasets and optimization approaches remains *** study introduces a machine learning framework for systematically evaluating multiple ANN *** only 30%of a training dataset derived from 124 liBs subjected to various charging regimes,an extensive evaluation is conducted across 7 ANN *** architecture is optimized in terms of hyperparameters using this framework,a process that spans 145 days on an NVIDIA GeForce RTX 4090 *** optimizing each model to its best configuration,a fair and standardized basis for comparing their RUL predictions is *** research also examines the impact of different cycling windows on predictive *** a stratified partitioning technique underscores the significance of consistent dataset representation across ***,using only the features derived from individual charge–discharge cycles,our top-performing model,based on data from just 40 cycles,achieves a mean absolute percentage error of 10.7%.

关键词： Remaining useful life Artificial neural networks li-ion batteries Deep neural networks Machine learning Hyperparameter optimization

Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance li-ion battery anodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 599-611页

作者： xue-Ru Zhang Qiong Wu Yong Zhang Xi-Fei li Ting Xie Yu-Cheng Wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox ***,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical *** overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization *** a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon *** integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer *** MnCo_(2)O_(4)@C/Cu possesses slightly longer li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in li-ion *** rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase *** a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials lithium-ion batteries

Investigation and measurement of old building response to the overlapped shield tunnel of multiple schemes in the sandy cobble stratum

在线全文

学校读者我要写书评

暂无评论

Underground Space 2024年第2期15卷 260-274页

作者： xue li Aopeng Geng School of Geoscience and Technology Southwest Petroleum UniversityChengduSichuan 610500China China Railway Construction Bridge Engineering Bureau Group Co. Ltd.Tianjin 300300China

Ground movements due to tunneling are becoming increasingly critical as buildings are located around construction *** study proposes a new combined reinforcement method using a foundation grouting oblique pipe *** former improves the bearing capacity of the subsoil,and the latter blocks the transmission of soil deformation,which weakens the influence of construction during overlapped tunnel *** on this new method,a case study of the shield tunneling response to an old building in line 6 of China’s Chengdu Metro is ***,three-dimensional numerical models without reinforcement,traditional foundation grouting reinforcement,and the new combined reinforcement schemes were *** numerical simulation performance was verified using a set of field instrumentation data,which demonstrated that the old building response to the overlapped tunnels was under control,and the maximum deformation,angular distortion,and principal tensile strain of the building were 5.25 mm,5.1010–6 rad/m,and 0.0081%,*** with the traditional reinforcement scheme,the deformation,angular distortion,and principal tensile strain in the combined reinforcement scheme were reduced by 54.78%,71.02%,and 70.22%,*** results have important implications for the design and construction of shield tunnels and their response to old buildings.

关键词： Overlapped tunnels Reinforcement schemes Under-crossing Old building Numerical simulation