检索结果-南通市图书馆

Journal of Integrative Plant Biology 2008年第2期50卷 157-167页

作者： Zhong-Lian Yu Jin-guang Zhang xue-chen Wang Jia chen State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100094 China

Tobacco BY-2 suspension cells were used to study the chemical damage and its associated mechanisms caused by Cu^2＋. Treatment with 100 μmol/L Cu^2＋ generated a large amount of HzOz and thiobarbituric acid-reactive substances （TBARS） in cells. Using phospholipase D （PLD） specific inhibitor （1-butanol） or phosphatidic acid （PA）, we demonstrated that PLD plays an important role in the generation of H2O2 and TBARS. Semi-quantitative reverse-transcriptase polymerase chain reaction and enzyme activity assays with wild type and nicotinamide adenine dinucleotide phosphate （NADPH） oxidaseoverexpressing BY-2 cells revealed that PLD and PA are the key factors leading to NADPH oxidase activation, which is responsible for H2O2 and TBARS production induced by Cu^2＋. Moreover, the content of ascorbic acid （AsA）, an effective antioxidant, was sharply reduced in BY-2 cells exposed to excessive Cu^2＋. Furthermore, a significant downregulation of the enzymes of AsA biosynthesis and the antioxidant system was found. This evidence suggests that excessive Cu^2＋-elevated reactive oxygen species （ROS） production is caused by upregulated PLD that elevates the activity of NADPH oxidase and its collapsed antioxidant systems that scavenges ROS.

关键词： ascorbic acid Cu^2+ nicotinamide adenine dinucleotide phosphate oxidase phospholipase D reactive oxygen species.

A thioxanthone-based photocaged superbase for highly effective free radical photopolymerization

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2014年第11期25卷 1445-1448页

作者： Ming-Hui He Rui-Xin Xu guang-xue chen Zhao-Hua Zeng Jian-Wen Yang State Key Laboratory of Pulp & Paper Engineering South China University of Technology School of Media and Communication Shenzhen Polytechnic Institute of Polymer Science DSAPM Lab School of Chemistry and Chemical Engineering Sun Yat-Sen University

Thioxanthone-based N-phthalimidoamino acid ammonium salt（thioxanthen-DBU） as a photocaged base was synthesized and characterized. The photochemical properties and initiation mechanism were analyzed. It was found that the compound absorbs over the UV and visible region with relatively high absorption coefficients. Furthermore, the covalent binding of N-phthalimidoamino acid and type II chromophores（thioxanthone, TX） remarkably improved the photoreactivity. Specifically, in combination with a benzoyl peroxide initiator, thioxanthen-DBU was able to initiate the amine-mediated redox photopolymerization of trimethylol propane triacrylate（TMPTA）, and an excellent photopolymerization profile was obtained.

关键词： Photocaged superbase Redox initiation Photopolymerization

Benzoylformamides as new photocaged bases for photo-latent anion polymerization

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2015年第1期26卷 21-25页

作者： Ming-Hui He Mei-Lin Su Zhao-Hui Yu guang-xue chen Zhao-Hua Zeng Jian-Wen Yang State Key Laboratory of Pulp & Paper Engineering South China University of Technology Institute of Polymer Science DSAPM LabSchool of Chemistry and Chemical EngineeringSun Yat-Sen University

Benzoylfonnamide（BFA） derivatives are proposed as new photocagcd bases with good solubility in epoxy *** their structures were confirmed by ~1H NMR,^（13）C NMR,and elemental ***,we detail their thermal stability,solubility behavior,and photolysis ***,the model photo-latent anion polymerization（AP） of epoxide system in the presence of BFA-dBA（N,N-dibenzyl-2-oxo-2-phenylacetamide） as a photocaged base has been investigated,and excellent photopolymerization profile is obtained.

关键词： Anion polymerization Photocaged superbase Photopolymerization

Dynamic and quasi-static compressive performance of integral-forming aluminum foam sandwich

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2023年第2期30卷 392-403页

作者： Tao Xu Zi-chen Zhang Jian Ding Nan-nan Liu Zeng Wang Xing-chuan Xia Ying Tang xue-guang chen Kai-hong Song Ri Li Yong-chang Liu School of Material Science and Engineering Hebei University of TechnologyTianjin300130China State Key Laboratory of Hydraulic Engineering Simulation and Safety School of Materials Science&EngineeringTianjin UniversityTianjin300354China

Strain rate sensitivity and deformation mechanism of integral-forming aluminum foam sandwich(IFAFS)under quasi-static and dynamic compression were *** Hopkinson pressure bar experiments with high-speed video cameras were conducted to analyze strain rate dependency and actual deformation mechanism of IFAFS.X-ray microtomography technique(Micro-CT)based on 3D finite element(FE)was used to study stress and plastic strain contours of IFAFS sample and to predict stress distribution and deformation history under both dynamic and quasi-static ***-inertia effect of typical cell structures was quantitatively analyzed by FE *** results showed that IFAFS is sensitive to strain rate where the deformation mode under dynamic loading is different from that observed under quasi-static *** strain rate increasing,good metallurgical bonding of face sheet and foam core layer contributed to improving the elastic modulus and peak stress of ***,finite element model confirmed that micro-inertia effect of IFAFS can be ignored during dynamic loading.

关键词： Aluminum foam sandwich Integral-forming Strain-rate effect Mechanical performance Finite element simulation

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

DCN基因转染对大鼠肾系膜细胞生长及表型改变的影响

在线全文

学校读者我要写书评

暂无评论

复旦学报（医学版） 2003年第5期30卷 414-417页

作者：王慧君张志刚刘学光陈广平陈琦郭慕依复旦大学上海医学院病理学系上海200032

目的　通过观察转染DCN基因的大鼠系膜细胞 (MsC)生长及其一些表型的改变 ,为其用作细胞载体回输入大鼠肾病模型体内进行基因治疗奠定实验基础。方法　采用MTT比色法和流式细胞仪技术 ,检测该MsC株生长情况 ;Northernblot和Westernblot... 详细信息

目的　通过观察转染DCN基因的大鼠系膜细胞 (MsC)生长及其一些表型的改变 ,为其用作细胞载体回输入大鼠肾病模型体内进行基因治疗奠定实验基础。方法　采用MTT比色法和流式细胞仪技术 ,检测该MsC株生长情况 ;Northernblot和Westernblot法检测其TGF β1mRNA、ColⅣmRNA和TGF β1蛋白表达水平 ;半定量RT PCR法检测其TIMP 2mRNA表达的改变。结果　与未转染MsC相比 ,转染DCN基因的MsC株的生长受到明显抑制 (5d时P <0 .0 5 ,6d时P <0 .0 1) ;G0 /G1期比例增加 ,S期比例降低 ,提示其生长缓慢 ;TGF β1和ColⅣmRNA表达明显降低 ,TGF β1蛋白分泌减少 ;TIMP 2mRNA表达明显下调。结论　转染DCN基因的MsC可被用作载体开展对大鼠系膜增生性肾炎的实验治疗。

关键词： DCN基因转染大鼠肾系膜细胞基因治疗基因表型 MTT比色法流式细胞仪技术系膜增生性肾炎

在线全文

学校读者我要写书评

暂无评论

多级电磁发射装置设计

自动化技术与应用 2020年第7期39卷 130-132,174页

作者：薛广辰陕西国防工业职业技术学院陕西西安710300

针对电磁发射装置出口速度不足的问题,采用多级加速系统对铁质子弹进行加速,研究并分析了磁阻型电磁发射机理,设计了多级加速电磁发射控制电路。通过测量发射装置的出口速度,验证了所设计的多级电磁发射装置工作稳定可靠,能够实现大幅... 详细信息

针对电磁发射装置出口速度不足的问题,采用多级加速系统对铁质子弹进行加速,研究并分析了磁阻型电磁发射机理,设计了多级加速电磁发射控制电路。通过测量发射装置的出口速度,验证了所设计的多级电磁发射装置工作稳定可靠,能够实现大幅提高铁质子弹的出口速度。

关键词：电磁发射磁阻型电磁发射技术多级加速

肾小球上皮细胞分泌肾上腺髓质素抑制系膜细胞增殖

在线全文

学校读者我要写书评

暂无评论

复旦学报（医学版） 2001年第5期28卷 375-377页

作者：刘学光陈广平张志刚郭慕依复旦大学基础医学院病理学教研室上海200032 美国北海岸LIJ健康机构放射肿瘤学部纽约11030

目的　探讨肾上腺髓质素 (AM)及其受体CRLR在培养的大鼠肾小球上皮细胞 (GEC)和系膜细胞(MsC)的表达 ,以及AM对MsC生长的影响。方法　采用RT PCR法分别制备AM及CRLR探针 ,Northernblot法检测其在GEC和MsC的表达 ,[3H]胸腺嘧啶掺入法测定... 详细信息

目的　探讨肾上腺髓质素 (AM)及其受体CRLR在培养的大鼠肾小球上皮细胞 (GEC)和系膜细胞(MsC)的表达 ,以及AM对MsC生长的影响。方法　采用RT PCR法分别制备AM及CRLR探针 ,Northernblot法检测其在GEC和MsC的表达 ,[3H]胸腺嘧啶掺入法测定MsC增殖情况。结果　AM仅表达于GEC ,不表达于MsC ,而其受体CRLR的表达则相反。含有AM的GEC培养上清可抑制MsC生长 ,而CRLR阻断剂CGRP8-37可部分消除此抑制作用。结论　GEC可通过合成和分泌AM抑制MsC增殖 ,提示AM作为一种重要的旁分泌因子 ,以保持肾小球微环境稳定。

关键词：肾小球上皮细胞肾小球系膜细胞肾上腺髓质素聚合酶链反应 Northern blot法肾小球肾炎炎症细胞增殖

Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： chen chen Hongyu xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease