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Review of Astragalus membranaceus polysaccharides:Extraction process,structural features, bioactivities and applications

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Chinese Herbal Medicines 2025年第1期17卷 56-69页

作者： Hongyue Tian lingzhuo An Pengwang Wang Xuemin Zhang Wenyuan Gao xia li Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency School of Pharmaceutical Science and Technology Tianjin University Key Laboratory of Modern Chinese Medicine Resources Research Enterprises College of Pharmacy Qinghai Minzu University

Astragalus membranaceus possesses the function of enhancing immunity,protecting the liver,diuretic,anti-aging,anti-stress,anti-hypertensive,and more extensive antibacterial ***,one kind of the major active ingredients of ***,are considered to be responsible for their versatile ***,a systematic summary of research progress and prospects of polysaccharides from *** polysaccharides(AMPs) is necessary to facilitate their further study and *** this review,the optimal extraction methods,structural features,biological activities,and applications of AMPs were *** structure-activity relationships are also analyzed and ***,ultrasonic,microwave,enzyme-assisted,ultra-high pressure,and combined methods have been used to extract *** them,solvent extraction is the most commonly used method because it is simple and easy to operate,but the efficiency needs to be improved *** ultra-high pressure method is the most efficient but has a low economic *** exhibited various bioactivities,including immunomodulation,antitumor,and *** structure-activity relationships revealed that different structure configurations,chain conformations,and physical properties would have different ***,the new method for purification of certain polysaccharides,detailed structure-activity relationships(SAR),mechanisms of bioactivities,and quality control of AMPs need to be extensively investigated.

关键词： antidiabetic activity antitumor applications Astragalus membranaceus (Fisch.) Bge. Astragalus membranaceus polysaccharides extraction process immunomodulation structure-activity relationship

Laser-induced phase segregation of inorganic halide perovskite alloy nanowires for optical switch

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Nano Research 2025年第2期18卷 878-886页

作者： Qihang Lv xia Shen Xuyang li Jianzhe liu Zhaohui Shan liantuan xiao Pengfei Guo Johnny CHo College of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan 030024China Huangshan Bright Semiconductor Co. Ltd.Huangshan 245021China Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong 999077China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan

Inorganic perovskitenanostructures have attracted considerable attention for their tunable band gaps and excellent optoelectronic *** is inevitable that phase segregation of halide perovskite usually occurs in mixed-halide perovskites under a focused laser llumination,which caused by photo-induced halide-ion ***,we reported an uniform perovskite alloy nanowires via a chemical vapor deposition(CvD)*** characterization reveals that these perovskite nanowires have independent linear morphology_with high-quality ***-photoluminescence(PL)spectra exhibit that these nanowire structures show a dual-wavelength emissions at 690 and 570 nm,***,time-dependent PL intensity of the emission peak at 690 nm increased by the decrease of the emission peak at 570 nm under a focused laser llumination,indicating the formation of phase segregation at the excited ***,based on these as-grown halide perovskite CsPbBr2.52lo.48 nanowires,a reasonably optical switch is designed and *** optical switch may have potential applications in timed blasting system and time-delay circuit in the future.

关键词： perovskite alloy nanowires phase segregation dual-wavelength emission optical switch nanophotonics

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肾脏体外灌流装置的研制及应用

中国现代医学杂志 2006年第13期16卷 2015-2017页

作者：袁发焕光丽霞谭红梅第三军医大学新桥医院肾内科重庆400037

目的研制离体肾脏灌流装置。方法自行设计、制造一种离体肾脏灌流装置,并进行6例新西兰白兔离体肾脏常温下灌流实验,以评估此灌流装置的工作性能。结果灌流装置能与尿量偶联自动补充灌流液,机器能持续工作,性能稳定。最长灌流保存时间达... 详细信息

目的研制离体肾脏灌流装置。方法自行设计、制造一种离体肾脏灌流装置,并进行6例新西兰白兔离体肾脏常温下灌流实验,以评估此灌流装置的工作性能。结果灌流装置能与尿量偶联自动补充灌流液,机器能持续工作,性能稳定。最长灌流保存时间达80.65h。灌流24、48h,肾脏静脉流出液乳酸脱氢酶(LDH)活性、钾钠离子浓度和尿N-乙酰βD-氨基葡萄糖苷酶(NAG)活性无显著变化,肾组织形态学基本正常,当灌流65h,肾静脉流出液LDH活性和钾离子浓度显著增高,钠离子浓度显著降低,尿NAG活性显著增高,肾小管上皮细胞变性肿胀。结论该肾脏体外灌流装置操作简单,使用方便,能满足医学科研的要求。

关键词：肾脏灌流保存

Distinct Mechanisms Governing Two Types of Extreme Hourly Rainfall Rates in the Mountain Foothills of North China During the Passage of a Typhoon Remnant Vortex from 30 July to 1 August 2023

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Advances in Atmospheric Sciences 2025年第4期42卷 761-779页

作者： Rudi xia Yuqing RUAN Jisong SUN Xudong liANG Chong WU Feng li Ju li Jinfang YIN Xinghua BAO Mingxin li xiaoyu GAO State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China Research Center for Disastrous Weather over Hengduan Mountains&Low-Latitude Plateau China Meteorological AdministrationKunming 650034China

This study investigates extreme rainfall episodes along the eastern foothills of the Taihang Mountains in North China from 30 July to 1 August *** focuses on two types of extreme hourly rainfall rates(HRRs),i.e.,the maximum regionalaverage HRR and site-observed HRR,which exhibited sequential development over southern,middle,and northern key *** rainfall extremes occurred in an environment where a high-pressure barrier over North China prevented the intrusion of cold air masses from the north while a northward-moving typhoon remnant vortex and its associated low-level jet(LLJ)transported warm and moist airflow from the *** distinct echo evolution modes and convection initiation mechanisms are identified for the two types of extreme *** maximum regional-average HRR occurred when the LLJ arrived to the east of the key regions,while the maximum site-observed HRR occurred when the warmer vortex center influenced the *** the northern key region as a representation,at the time of the maximum regional-average HRR,slantwise ascent of the airflow along a warm-frontal-like boundary released energy related to symmetrical instability,resulting in stratiform rainfall with weak convective *** transport of locally initiated convection over the eastern plain region,where the atmospheric stratification was more potentially unstable,also significantly *** the maximum site-observed HRR occurred,the terrain lifting of warm and moist southeast airflow led to intense convection over the mountain ***,the passage of the warm-core typhoon remnant vortex and interaction with Taihang Mountains determined the timing and location of extreme HRRs across the key regions.

关键词： extreme rainfall hourly rainfall rate mountain vortex mechanism

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang Ni-Hui Zhang Zhi-Lai Zhan guang-Lu Chang Yan Gao xia li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 322-333页

作者： xia Chen Hai-Yan liu Wu-Bi Zhou li-li Zhang Jian Huang Da-Wei Bao Department of Pathology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223300Jiangsu ProvinceChina

BACKGROUND Esophageal squamous-cell carcinoma(ESCC)is a highly aggressive cancer,predominantly affecting populations in Eastern Asia and parts of *** pathogenesis is influenced by both genetic and environmental *** recent therapeutic advances,survival rates remain dismal,underscoring an urgent need for novel therapeutic *** To investigate the role of hypoxia-inducible factor 1-alpha(HIF1A)in the progression of ESCC and its impact on the metabolic enzyme lactate dehydrogenase A(LDHA),which is crucial for the glycolytic pathway in hypoxic tumor *** Utilizing transcriptomic data from multiple public databases,we analyzed differential gene expression and conducted gene ontology and transcription factor network *** regulatory impact of HIF1A on LDHA was specifically examined through integrative analysis with HIF1A ChIP-seq data and confirmed via siRNA-mediated knockdown experiments in ESCC cell *** Our findings reveal a significant upregulation of HIF1A in ESCC tissues,associated with poor ***1A directly regulates LDHA,enhancing glycolysis under hypoxic conditions and contributing to tumor *** of HIF1A in cell lines not only reduced LDHA expression but also altered key pathways related to cell cycle and *** The critical role of the HIF1A-LDHA axis in ESCC highlights its potential as a therapeutic target,underscoring the need for future clinical trials to validate the efficacy of HIF1A inhibitors in enhancing treatment outcomes.

关键词： Esophageal squamous-cell carcinoma Hypoxia-inducible factor 1-alpha Lactate dehydrogenase A Metabolic reprogramming Therapeutic target

血清羟脯氨酸浓度和脯肽酶活性在判断肾纤维化病程中的意义

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第三军医大学学报 2000年第1期22卷 49-52页

作者：袁发焕刘素英光丽霞孙伟第三军医大学附属新桥医院肾内科第三军医大学附属新桥医院小儿科重庆400037 第三军医大学高原军事医学系中心实验室重庆400038

目的 :探讨血清羟脯氨酸浓度和脯肽酶活性在反映肾纤维化中的意义。方法 :经肾活检证实的有(纤维化组)和无(无纤维化组)肾小球硬化与肾间质纤维化的肾脏病人各10例 ,健康献血员(对照组)10例 ,测血清羟脯氨酸浓度、血清脯肽酶活性等指标... 详细信息

目的 :探讨血清羟脯氨酸浓度和脯肽酶活性在反映肾纤维化中的意义。方法 :经肾活检证实的有(纤维化组)和无(无纤维化组)肾小球硬化与肾间质纤维化的肾脏病人各10例 ,健康献血员(对照组)10例 ,测血清羟脯氨酸浓度、血清脯肽酶活性等指标。结果 :纤维化组血清羟脯氨酸浓度显著高于无纤维化组(P<0.001)和健康对照组(P<0.001) ,以此指标显著增高判断肾纤维化 ,敏感性100 % ,特异性91 % ,假阳性9 % ,与肾活检符合率95 %。纤维化组血清脯肽酶活性亦显著高于无纤维化组(P<0.05)和健康对照组(P<0.05) ,以此指标显著增高判断肾纤维化 ,敏感性80 % ,特异性100 % ,未发现假阳性 ,与肾活检符合率90 %。血清羟脯氨酸浓度与患者血清肌酐浓度、纤维化肾小球比率和病变肾小管、肾间质比率显著正相关。结论 :血清羟脯氨酸浓度和脯肽酶活性 ,可作为判断肾脏病人肾纤维化的无创性检查指标 ,尤其适用于有肾活检禁忌症的病人。

关键词：痉脯氨酸脯肽酶肾纤维化病理学

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng liu Changyu Zhang Zipeng li Wanying Ma Jia liu xiang xia Ning Xu Wen Sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

Endoplasmic reticulum(ER)viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF).Herein,we report the first ER-targeting viscosity-responsive near-infrared(NIR)fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT)and the excited state intramolecular proton transfer(ESIPT)are combined to endow HBT-PP with the selective response towards viscosity(~62-fold)and a super large stokes shift(~320 nm).HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living ***,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF *** note,after 10 min of stain with HBT-PP,HF lesions showed a stage-based response,indicating the potential of this probe in fast and early diagnosis of *** results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

Preparations of Mytilus edulis protein hydrolysate-iron complexes and their ameliorative effects on mice with iron deficiency anemia

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Food Science and Human Wellness 2025年

作者： guang li Xuening Yu Shuling Zhou xiaoyang liu Fawen Yin Deyang li Baocai Xu Dayong Zhou School of Food and Biological Engineering， Hefei University of Technology SKL of Marine Food Processing & Safety Control， National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， liaoning Province Key Laboratory for Marine Food Science and Technology， School of Food Science and Technology， Dalian Polytechnic University

Iron is a fundamental trace element essential for the immune system， and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration， 45 ℃ temperature， and 60 minutes of incubation， utilizing both carboxyl and amino binding sites. Compared to MEPH alone， the MEPH-Fe complexes exhibited fluorescence quenching， ultraviolet shifts， reduced X-ray diffraction peak intensities， stabilization during in vitro digestion， microstructural changes， increased particle size， and decreased absolute values of zeta potential. In the IDA mouse model， the MEPH-Fe complexes were able to restore body weight， hematological indices， organ coefficients， iron content in organs， and antioxidant capacity to normal levels. Additionally， they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion， this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.

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