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Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: A meta-analysis

World Journal of Gastroenterology 2015年第9期21卷 2807-2815页

作者： Jian-Jun Yang Zhi-Gao Hu Wu-Xiang Shi Te Deng Song-Qing He sheng-guang yuan Laboratory of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Guilin Medical University Department of Epidemiology and Biostatistics School of Public HealthGuilin Medical University guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair

AIM:To conduct a meta-analysis evaluating theassociation between the peripheral blood neutrophil to lymphocyte ratio(NLR) and the outcome of patients with pancreatic ***:Studies evaluating the relationship between the peripheral blood NLR and outcome of patients with pancreatic cancer published up to May 2014 were searched using electronic databases, including Pub Med, Web of Science, Embase and Ovid.A meta-analysis was performed to pool the hazard ratios(HRs) or odds ratios(ORs) and their 95% confidence intervals(CIs) using either a fixed-effects model or a random-effects model to quantitatively assess the prognostic value of NLR and its association with clinicopathological ***:Eleven studies containing a total of 1804 patients were eligible according to our selection criteria, and combined hazard ratios indicated that high NLR was a poor prognostic marker for pancreatic cancer patients because it had an unfavorable impact on the overall survival(OS)(HR =2.61, 95%CI:1.68-4.06, P =0.000) and cancer specific survival(HR =1.66, 95%CI:1.08-2.57, P =0.021).Subgroup analysis revealed that high NLR was associated with poor OS in patients with mixed treatment(HR =4.36, 95%CI:2.50-7.61, P =0.000), chemotherapy(HR =2.08, 95%CI:1.49-2.9, P =0.000), or surgical resection(HR =1.2, 95%CI:1.00-1.44, P =0.048).Additionally, high NLR was significantly correlated with tumor metastasis(OR =1.69, 95%CI:1.10-2.59, P =0.016), poor tumor differentiation(OR =2.75, 95%CI:1.19-6.36, P =0.016), poor performance status(OR =2.56, 95%CI:1.63-4.03, P =0.000), high cancer antigen 199(OR =2.62, 95%CI:1.49-4.60, P =0.000), high C-reactive protein(OR =4.32, 95%CI:2.71-6.87, P =0.000), and low albumin(OR =3.56, 95%CI:1.37-9.27, P =0.009).CONCLUSION:High peripheral blood NLR suggested a poor prognosis for patients with pancreatic cancer,and it could be a novel marker of survival evaluation and could help clinicians develop therapeutic strategies for pancreatic cancer patients

关键词： Neutrophil to lymphocyte ratio Pancreatic cancer O

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Comparison of ethanol-soaked gelatin sponge and microspheres for hepatic arterioportal fistulas embolization in hepatic cellular carcinoma

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1595-1604页

作者： guang-sheng yuan Li-Li Zhang Zi-Tong Chen Cun-Jing Zhang Shu-Hui Tian Ming-Xia Gong Peng Wang Lei Guo Nan Shao Bin Liu Institute of Interventional Oncology Shandong UniversityJinan 250033Shandong ProvinceChina Department of Radiology Dongying Traditional Chinese Medicine HospitalDongying 257055Shandong ProvinceChina Department of Gastroenterology People's Hospital of Qihe CountyDezhou 251100Shandong ProvinceChina Department of Interventional Medicine The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Dean’s Office Jinan Vocational College of NursingJinan 250100Shandong ProvinceChina Department of Interventional Medicine People’s Hospital of Zouping CityBinzhou 256299Shandong ProvinceChina Department of Vascular Anomalies and Interventional Radiology Qilu Children’s Hospital of Shandong UniversityJinan 250022Shandong ProvinceChina

Hepatic arterioportal fistulas(APFs)are common in hepatocellular carcinoma(HCC).Moreover,correlated with poor prognosis,APFs often complicate antitumor treatments,including transarterial chemoembolization(TACE).AIM To compare the efficacy of ethanol-soaked gelatin sponges(ESG)and microspheres in the management of APFs and their impact on the prognosis of *** Data from patients diagnosed with HCC or hepatic APFs between June 2016 and December 2019 were retrospectively ***,APFs were embolized with ESG(group E)or microspheres(group M)during *** primary outcomes were disease control rate(DCR)and objective response rate(ORR).The secondary outcomes included immediate and first follow-up APF improvement,overall survival(OS),and progression-free survival(PFS).RESULTS Altogether,91 participants were enrolled in the study,comprising 46 in group E and 45 in group *** DCR was 93.5%and 91.1%in groups E and M,respectively(P=0.714).The ORRs were 91.3%and 66.7%in groups E and M,respectively(P=0.004).The APFs improved immediately after the procedure in 43(93.5%)patients in group E and 40(88.9%)patients in group M(P=0.485).After 2 mo,APF improvement was achieved in 37(80.4%)and 33(73.3%)participants in groups E and M,respectively(P=0.421).The OS was 26.2±1.4 and 20.6±1.1 mo in groups E and M,respectively(P=0.004),whereas the PFS was 16.6±1.0 and 13.8±0.7 mo in groups E and M,respectively(P=0.012).CONCLUSION Compared with microspheres,ESG embolization demonstrated a higher ORR and longer OS and PFS in patients of HCC with hepatic APFs.

关键词： Hepatocellular carcinoma Arterioportal fistula Ethanol Gelatin sponge Microsphere Embolization

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High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第23期21卷 7254-7263页

作者： Peng-Peng Zhu sheng-guang yuan Yan Liao Li-Ling Qin Wei-Jia Liao Laboratory of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Guilin Medical University Affiliated Hospital of Guilin Medical University Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair Disease Prevention and Control Center of Guilin

AIM: To determine the cut-off value of intercellular adhesion molecule-1(ICAM-1) and assess the correlation of ICAM-1 with clinicopathological features and the prognosis of hepatocellular carcinoma(HCC)patients who underwent surgical ***: We prospectively collected clinicopathological data from 236 HCC patients who had undergone successful hepatectomy. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off value of ICAM-1. Enzymelinked immunosorbent assay was used to measure the concentration of ICAM-1 in 236 serum samples isolated from HCC patients and the stratified analysis was used to compare the serum level of ICAM-1 in different HCC subgroups. Immunohistochemistry was performed to test the expression level of the ICAM-1 protein in76 cases of HCC tissues and their adjacent normal liver tissues(ANLT). The survival probability of HCC patients was estimated using Kaplan-Meier plots and differences between the groups were obtained using the log-rank test. Furthermore, independent indicatorsof the prognosis were acquired using a stepwise Cox proportional hazard model to analyze a series of predictors that were associated with disease-free survival(DFS) and overall survival(OS) in HCC ***: Our findings suggested that ICAM-1promotes HCC metastasis and high serum ICAM-1 is significantly associated with alpha-fetoprotein(AFP)(P = 0.022), clinical tumor-node-metastasis stage(P 684 ng/mL was an independent factor for DFS(HR = 1.643; 95

关键词： Hepatocellular carcinoma Intercellularadhesion molecule-1 Prognosis Biomarker Metastasis

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Preoperative contrast-enhanced computed tomography-based radiomics model for overall survival prediction in hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第31期28卷 4376-4389页

作者： Peng-Zhan Deng Bi-Geng Zhao Xian-Hui Huang Ting-Feng Xu Zi-Jun Chen Qiu-Feng Wei Xiao-Yi Liu Yu-Qi Guo sheng-guang yuan Wei-Jia Liao Laboratory of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy with a rising incidence *** prognosis of HCC patients after radical resection remains *** is a novel machine learning method that extracts quantitative features from medical images and provides predictive information of cancer,which can assist with cancer diagnosis,therapeutic decision-making and prognosis *** To develop and validate a contrast-enhanced computed tomography-based radiomics model for predicting the overall survival(OS)of HCC patients after radical *** A total of 150 HCC patients were randomly divided into a training cohort(n=107)and a validation cohort(n=43).Radiomics features were extracted from the entire tumour *** least absolute shrinkage and selection operator algorithm was applied for the selection of radiomics features and the construction of the radiomics *** and multivariate Cox regression analyses were used to identify the independent prognostic factors and develop the predictive nomogram,incorporating clinicopathological characteristics and the radiomics *** accuracy of the nomogram was assessed with the concordance index,receiver operating characteristic(ROC)curve and calibration *** clinical utility was evaluated by decision curve analysis(DCA).Kaplan–Meier methodology was used to compare the survival between the low-and high-risk *** In total,seven radiomics features were selected to construct the radiomics *** to the results of univariate and multivariate Cox regression analyses,alpha-fetoprotein(AFP),neutrophil-to-lymphocyte ratio(NLR)and radiomics signature were included to build the *** C-indices of the nomogram in the training and validation cohorts were 0.736 and 0.774,*** curve analysis for predicting 1-,3-,and 5-year OS confirmed satisfactory accuracy[training cohort,area under the curve(AUC)=0.850,0.791 and

关键词： Hepatocellular carcinoma Radiomics Contrast-enhanced computed tomography Survival prediction

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Gene-Ontology Analysis on the Differentially Expressed Genes in Maize （Zea mays L.） Ear Rot

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Journal of Life Sciences 2013年第3期7卷 219-226页

作者： guang-sheng yuan Jian Gao Zhi-Ming Zhang Juan Du Gui-Qing Mu guang-Tang Pan Maize Research Institute Sichuan Agricultural University Ya 'An 625014 China

To better know FM （Fusarium moniliforme） induced genes in maize ear rot, GO （gene ontology） method was performed to analyze detail physiological functions in the defensive response after pathogen infection. This gene annotation system was widely used to investigate large numbers of genes involving in real active role or regulator in cell response. First of all, differentially expressed genes were isolated by using genechip platform at 96 h post-inoculation with FM in maize inbred Bt-1. In total, 482 differentially expressed unique genes were screened out in inbred Bt-1 when compared to mock-inoculated bract tissues. Then, each gene was annotated to define functional class by GO method. Finally, these large FM-responsive genes with significant differentially change were sorted into cellular component, molecular function and biological process with complicated network by molecular annotation system. The demonstrated information in the GO analysis could provide another view for understanding the molecular mechanism and indicate a deeply complicated network with gene function underlying disease development in the host tissue. The findings in this study provide important bases to probe the molecular processes, the alteration of metabolism and the immune mechanism upon the FM infection in maize.

关键词： Ear rot genechip Fusarium moniliforme gene ontology Zea mays.

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan Yu Jing Wu guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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Clustering and Expression Analysis of Chitinases in Maize and Rice

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Journal of Life Sciences 2013年第3期7卷 244-251页

作者： Kui Xiang Wei-Tao Li Xue-Wei Chen guang-sheng yuan Wei-Lan Chen Zhi-Ming Zhang Ya-Ou Shen Hai-Jian Lin guang-Tang Pan Maize Research Institute Sichuan Agricultural University ChengDu 611130 China Rice Research Institute Sichuan Agricultural University ChengDu 611130 China

Chitinases play an important role in regulating plant growth and development, especially defending themselves from fungal pathogens. It is important to do the biological analyses in crops. In this study, the result showed that the chitinases were distributed into the whole genome in rice, and nearly the whole genome in maize expect for Chromosome 9. The clustering results showed that one out of three chitinases from maize and rice belonged to new groups, which were separated from those in the conformed Classes I-VII. The identification of most amino acid sequences was very low among the chitinases from rice and/or maize. It was inferred that the chitinases with different functions were relatively stable during plant evolution. The relationship of chitinases expression between leaf blade and anther was positively significant in maize, but not significant in rice. Additionally, the ratio of chitinases with up- or down-regulated expression in sensitive maize under Fusarium moniliforme inoculation was different from that in sensitive rice under Magnaporthe grisea inoculation. It might be result from different tissues infected by different fungi. The number of chitinases from resistant maize was less than that from sensitive maize, which inferred that the resistant pathways on F. moniliforme should be not only chitin induced Pathogen-associated molecular PTI （patterns-triggered immunity） pathway, but also might include other PTI pathways that improve tolerance to F. moniliforme. The analysis of expression pattern of chitinases from maize and rice under fungi inoculation will be contributed into further research on the defense mechanism of fungi in crops.

关键词： Chitinases fungi clustering expression maize rice.

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Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu Jiang Ziyang sheng Ruohan Feng Sihong Wang Haoyue Zhang Qianqing Xu Zijian yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

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高碘酸钠和戊二醛交联法构建的R-藻红蛋白-C-藻蓝蛋白交联物能量传递效率的比较研究

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生物化学与生物物理进展 2004年第3期31卷 273-277页

作者：王广策马圣媛曾呈奎中国科学院海洋研究所实验海洋生物学开放实验室青岛266071

从单细胞蓝藻钝顶螺旋藻中纯化C 藻蓝蛋白 ,从海洋红藻多管藻纯化R 藻红蛋白 .分别用高碘酸钠氧化法和戊二醛法将二者共价连接为R 藻红蛋白 C 藻蓝蛋白交联物 ,再用SephadexG 2 0 0柱层析纯化 .光谱分析表明 ,用两种方法构建的共价交... 详细信息

从单细胞蓝藻钝顶螺旋藻中纯化C 藻蓝蛋白 ,从海洋红藻多管藻纯化R 藻红蛋白 .分别用高碘酸钠氧化法和戊二醛法将二者共价连接为R 藻红蛋白 C 藻蓝蛋白交联物 ,再用SephadexG 2 0 0柱层析纯化 .光谱分析表明 ,用两种方法构建的共价交联物都可以将激发能从R 藻红蛋白传递到C 藻蓝蛋白 .二者相比 ,高碘酸钠氧化法构建的共价交联物的能量传递效率更高 .

关键词： R-藻红蛋白 C-藻蓝蛋白高碘酸钠氧化交联法戊二醛交联法共价交联物光谱分析传能效率

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锚杆静压桩在微波塔基础工程中的应用

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山西建筑 2006年第20期32卷 108-109页

作者：胡克旭盛光远同济大学结构工程与防灾研究所

介绍了锚杆静压桩的特点和应用范围,阐述了微波塔基础工程的设计方法,论述了微波塔锚杆静压桩的施工步骤,总结了地基加固中的关键技术及锚杆静压桩的应用优势。

关键词：锚杆静压桩基础工程地基加固

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