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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li Xu Huiming Xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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益母草注射液治疗急性脑梗死

中国新药与临床杂志 2002年第5期21卷 271-274页

作者：许楚芸陈少如何文贞吴育彬巫顺秀陈显光李森美汕头大学医学院第一附属医院神经内科广东汕头515041 汕头大学医学院病理生理教研室广东汕头515031

目的 :观察益母草注射液治疗急性脑梗死(ACI)的疗效。方法 :急性脑梗死 85例 ,随机分为 2组 :2组病人除给予常规治疗外 ,益母草组 4 3例给予益母草注射液 10mL加入氯化钠注射液 5 0 0mL中静脉滴注 ,qd ;复方丹参组 4 2例给予复方丹参 2 ... 详细信息

目的 :观察益母草注射液治疗急性脑梗死(ACI)的疗效。方法 :急性脑梗死 85例 ,随机分为 2组 :2组病人除给予常规治疗外 ,益母草组 4 3例给予益母草注射液 10mL加入氯化钠注射液 5 0 0mL中静脉滴注 ,qd ;复方丹参组 4 2例给予复方丹参 2 0mL加入氯化钠注射液 5 0 0mL中静脉滴注 ,qd。均治疗 15d后进行疗效评定 ,并对治疗前后凝血酶原时间、凝血因子I、血小板粘附率及血脂等生化指标进行对比分析。结果 :治疗后 ,益母草组基本治愈率70 % ,复方丹参组 31% (P <0 .0 1)。各生化指标对比提示益母草的抗凝、降纤、降脂作用突出。结论 :益母草注射液治疗ACI安全有效。

关键词：益母草注射液治疗急性脑梗死丹参中医药疗法

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Type Synthesis of Fully Decoupled Three Translational Parallel Mechanism with Closed-Loop Units and High Stifness

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Chinese Journal of Mechanical Engineering 2023年第5期36卷 231-247页

作者： Shihua li sen Wang Haoran li Yongjie Wang Shuang Chen Hebei Provincial Key Laboratory of Parallel Robot and Mechatronic Systems Yanshan UniversityQinhuangdao 066004China

In order to solve the problem of weak stifness of the existing fully decoupled parallel mechanism, a new synthesis method of fully decoupled three translational (3T) parallel mechanisms (PMs) with closed-loop units and high stifness is proposed based on screw theory. Firstly, a new criterion for the full decoupled of PMs is presented that the reciprocal product of the transmission wrench screw matrix and the output twist screw matrix of PMs is a diagonal matrix, and all elements on the main diagonal are nonzero constants. The forms of the transmission wrench screws are determined by the criterion. Secondly, the forms of the actuated and unactuated screws can be obtained according to their relationships with the transmission wrench screws. The basic decoupled limbs are generated by combination of the above actuated and unactuated screws. Finally, a closed-loop units construction method is investigated to apply the decoupled mechanisms in a better way on the high stifness occasion. The closed-loop units are constructed in the basic decoupled limbs to generate a high-stifness fully decoupled 3T PM. Kinematic and stifness analyses show that the Jacobian matrix is a diagonal matrix, and the stifness is obviously higher than that of the coupling mechanisms, which verifes the correctness of the proposed synthesis method. The mechanism synthesized by this method has a good application prospect in vehicle durability test platform.

关键词： Screw theory Three translational parallel mechanism Full decoupled Closed-loop units High stifness

Heterosis and Combining Ability for Major Yield Traits of a New Wheat Germplasm Shannong 0095 Derived from Thinopyrum intermedium

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Agricultural Sciences in China 2009年第6期8卷 753-760页

作者： BAO Yin-guang WANG sen WANG Xiu-qin WANG Yu-hai li Xing-feng WANG lin WANG Hong-gang Agronomy College Shandong Agricultural University/Tai＇an Subcentre of National Wheat Improvement Centre Tai＇an 271018 P.R. China State Key Laboratory of Crop Biology Shandong Agricultural University Tai＇an 271018 P.R.China Agronomy College Nanjing Agricultural University Nanjing 210095 P.R. China Jining Institute of Agricultural Sciences Jining 272031 P.R.China Zaozhuang University Zaozhuang 277100 P.R.China

The wheatgrass, Thinopyrum intermedium （Host） Barkworth ＆ DR Dewey, shows many beneficial characteristics, such as big spikes and high resistance to many diseases. To transfer the beneficial genes of this species, many wheat- Thinopyrum intermedium alien chromosome lines were developed. Of them, Shannong 0095 （SN0095）, a disomic substitution, has long spikes and flag-leaves, and thus may be an important genetic resource for wheat yield improvement. In order to realize its heterosis and combining ability on major yield traits, a 7 ×7 complete diallel design was made according to Griffing＇s Method-1. The results showed that heterosis for spike length （SPL）, flag-leaf area （FLA）, number of spikes per plant （NSP）, number of spikelets per spike （NSL）, kernels per spike （KPS）, 1 000-kernel weight （TKW） and grain yield per plant （GYP） existed in all the crosses by SN0095, but heterobeltiosis occurred only for KPS, TKW, and GYP. The relative mid-parent heterosis （RMH） and relative high-parent heterosis （RHH） for GYP, which valued as high as 35.32 and 29.92% respectively, were the highest among all the traits mearsured. Though additive and non-additive gene effects and cytoplasmic effects （or cytoplasmic-nuclear interaction effects） were found in governing all the traits measured above, additive gene action played a predominant role. The results also showed that SN0095 was the best-general combiner for SPL and FLA, and high-general combiner for NSP amongst all the parents. Estimates of specific combining ability （SCA） showed that SN0095 could also make high-SCA combinations for GYP, such as SN0095 × Jimai 19 （JMI9）. SN0095 could be a unique and important parent in hybrid wheat breeding programs.

关键词： Triticum aestivum Thinopyrum intermedium diallel cross combining ability heterosis

Influences of ^7li enrichment on Th-U fuel breeding for an Improved Molten Salt Fast Reactor(IMSFR)

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Nuclear Science and Techniques 2017年第7期28卷 105-113页

作者： guang-Chao li Yang Zou Cheng-Gang Yu Jian-Long Han Jin-Gen Chen Hong-Jie Xu Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China CAS Innovative Academies in TMSR Energy System Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China

The molten salt fast reactor(MSFR) shows great promise with high breeding ratio(BR),large negative temperature coefficient of reactivity,high thermal-electric conversion efficiency,inherent safety,and online *** on an improved MSFR optimized by adding axial fertile salt and a graphite reflector,the influences of ~7li enrichment on Th-U breeding are investigated,aiming to provide a feasible selection for the molten salt with high fissile breeding and a relatively low technology requirement for ~7li *** the self-developed molten salt reactor reprocessing sequence based on SCALE6.1,the burn-up calculations with online reprocessing are carried *** are explored including BR,^(233)U production,double time(DT),spectrum,~6li inventory,neutron absorption,and the tritium *** results show that the li enrichment of 99.95% is appropriate in the fast fission *** this case,BR above 1.10 can be achieved for a long time,corresponding to the ^(233)U production of130 kg per year and DT of 36 *** 80 years' operation,the tritium production for 99.5% is only about 7kg,and there is no obvious increase compared to that for 99.9995%.

关键词：繁殖率熔盐富集铀燃料裂变反应堆快堆在线处理负温度系数

A bidirectional threshold switching selector with a symmetric multilayer structure

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Science China(Information Sciences) 2021年第4期64卷 208-213页

作者： Qingjiang li Kun li Yongzhou WANG sen liU Bing SONG College of Electronic Science and Technology National University of Defense Technology

Selectors have been proposed as a highly effective tool for suppressing substantial leakage currents without sacrificing the high density of resistive random-access memory（RRAM） crossbar arrays. Among various selector types, the programmable metallization cell（PMC） selector is promising due to its simple structure and high selectivity. In this work, we demonstrate a new PMC selector that exhibits bidirectional threshold switching behavior by implementing symmetric multilayer dielectrics. The proposed Ag/SiTe/HfO2/SiTe/Ag selector device has a low off current( 10～5）, and low threshold voltage variation（< 0.05）. Upon connection to a bipolar RRAM cell via a wire, the proposed selector successfully suppresses the leakage current of an unselected device below the threshold voltage.

关键词： threshold switching selector resistive random access memory leakage current programmable metallization cell

Predict the evolution of mechanical property of Al-li alloys in a marine environment

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Defence Technology（防务技术） 2024年第1期31卷 557-566页

作者： Wei li lin Xiang guang Wu Hongli Si Jinyan Chen Yiming Jin Yan Su Jianquan Tao Chunyang Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest Technology and Engineering Research Institute Chongqing400039China

The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-li alloys in the marine *** obtained the mechanical properties of Al-li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural ***,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-li *** main conclusions are as follows:*** variation law of mechanical properties of2297-T8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-li alloy Machine learning Corrosion

Primary dolostone related to the Cretaceous lacustrine hydrothermal sedimentation in Qingxi sag, Jiuquan Basin on the northern Tibetan Plateau： Discussion

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Science China Earth Sciences 2016年第4期59卷 866-870页

作者： li Le YAO guang Qing Key Laboratory of Tectonics & Petroleum Resources of the Ministry of Education China University of Geosciences Wuhan 430074 China Faculty of Resources China University ofGeosciences Wuhan 430074 China

Recently, a mechanism of hydrothermal sedimentation about a mantel-derived source was proposed to interpret the formation of lacustrine dolostone in the Cretaceous Xiagou Formation based on systematic petrological, mineralogical, and geochemical analyses （Wen et al., 2013）. Similar to the texture found in classic hydrothermal sediments （Zhang, 1988）, the breccia texture is characterized by certain hydro- thermal sedimentation features. With detailed analysis of the data and relevant explanations, however, we found that their data are not sufficient to support the mantle-derived hydrothermal genetic theory because the formation of ex- tensive laminated micritic ferruginous dolostone is not yet fully understood. We will review the model proposed by Wen et al. （2013） focusing on the following issues.

关键词：湖相白云岩热水沉积青藏高原北部白垩系青西凹陷酒泉盆地热液沉积物地球化学分析