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Cuproptosis mediates copper-induced testicular spermatogenic cell death

Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-Jun Yu Jun-Jun li Yao Xiao guang-sen li Fang Yang liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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应用瞬时波强技术评价无症状饮酒者颈总动脉弹性的研究

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中国现代医学杂志 2015年第34期25卷 64-67页

作者：王楠礼广森田燕姚方一大连医科大学附属第二医院超声科辽宁大连116027

目的探讨利用瞬时波强（WI）技术评价无症状饮酒者的颈总动脉弹性的价值。方法 62例无症状饮酒男性按酒精摄入量及饮酒时间分为B组（25例）：每日酒精摄入量≥75 ml,饮酒频率3~5 d/周,饮酒时间5~8年。C组（21例）：每日酒精摄入量≥75 ... 详细信息

目的探讨利用瞬时波强（WI）技术评价无症状饮酒者的颈总动脉弹性的价值。方法 62例无症状饮酒男性按酒精摄入量及饮酒时间分为B组（25例）：每日酒精摄入量≥75 ml,饮酒频率3~5 d/周,饮酒时间5~8年。C组（21例）：每日酒精摄入量≥75 ml,饮酒频率3~5 d/周,饮酒时间9~20年。D组（16例）：每日酒精摄入量≥125 ml,饮酒频率6~7 d/周,饮酒时间10年以上。30例年龄匹配且无饮酒史的健康志愿者作为正常对照组A组。应用WI测量受检者颈总动脉弹性相关参数。结果 B组颈动脉弹性各相关参数与A组比较差异均无统计学意义（均P〉0.05）。与A和B组比较,C和D组β、Ep、PWVβ及PWVW1均显著增高（P〈0.05或P〈0.01）,且D组较C组也明显增高（均P〈0.05）。与A和B组比较,C组W1差异无统计学意义（P〉0.05）;但C组W2和AC均明显减低（均P〈0.05）;D组W1、W2及AC均显著低于A、B和C组（P〈0.05或P〈0.01）,且D组W2和AC较C组明显减低（均P〈0.05）。4组间NA无明显差别（P〉0.05）。结论 WI可以早期、便捷及无创地评价无症状饮酒者颈总动脉弹性的异常改变。

关键词：无症状饮酒者颈总动脉弹性瞬时波强

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu guang Yang Fulun li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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Effect of Ti content on microstructures and mechanical properties of cast Al-2li-2Cu-0.5Mg alloy

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China Foundry 2023年第3期20卷 179-188页

作者： You-jie Guo Dong-chen Yang liang Zhang Guo-hua Wu Yi-xiao Wang Pei-sen li guang-xiao Ren liang-bin li Xun-man Xiong National Engineering Research Center of light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanxi Jianghuai Heavy Industry Co. Ltd.Jincheng 048000ShanxiChina Jiangxi Ganfeng lithium Co. LtdXinyu 338004JiangxiChina

Ti is regarded as one of the promising grain refiners in cast Al-li-Cu alloys,but few research works have been done on its independent *** this study,the effect of Ti on the microstructure evolution and mechanical properties of cast Al-2li-2Cu-0.5Mg base alloy was *** results revealed that the grains can be prominently refined with the increase of Ti *** adding Ti,high density TiB_(2)-Al_(3)Ti composite particles with a low lattice misfit form as heterogeneous nucleation sites for the α-Al matrix.δ’(Al3li) and T_(1)(Al_(2)Culi) precipitates that provide enhanced strength are dominated in the alloys after T6 aging *** average size of both δ’ and half-width of δ’-precipitation free zone(PFZ) decreases gradually with the increase of Ti *** is because the higher binding energy between Ti atoms and vacancies limits the diffusion efficiency of li atoms,and thus results in a higher ***,no nano-sized Al_(3)Ti or core-shell structure of Al_(3)(li,Ti) particles are *** tensile property test results indicate that the Al-2li-2Cu-0.5Mg alloy achieves optimal properties after aging at 175 °C for 32 h when 0.15wt.% Ti is *** exhibits a yield strength of 352±5 MPa,an ultimate tensile strength of 423±6 MPa,and an elongation of(3±0.4)%.These findings are expected to offer a reliable theoretical guidance for the industrial composition design of the Al-li-Cu series cast alloys.

关键词： cast Al-li-Cu alloy Ti content grain refiner mechanical property microstructure

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紫外线消毒系统中超声波抑垢的机制及参数优化

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土木与环境工程学报（中英文） 2025年第1期47卷 221-228页

作者：陈光赵志伟李莉重庆大学环境与生态学院重庆400045

紫外消毒技术因具有无须投加化学药剂、消毒广谱性、产生副产物少等优势越来越受重视,但石英套管结垢引起的消毒效果难以保障,成为限制紫外消毒技术发展的瓶颈。在污水厂紫外线消毒渠中搭建中试试验装置,利用超声波抑制石英套管结垢,结... 详细信息

紫外消毒技术因具有无须投加化学药剂、消毒广谱性、产生副产物少等优势越来越受重视,但石英套管结垢引起的消毒效果难以保障,成为限制紫外消毒技术发展的瓶颈。在污水厂紫外线消毒渠中搭建中试试验装置,利用超声波抑制石英套管结垢,结果表明,超声波能通过延长结垢诱导期来抑制垢的生成;以相对紫外线强度为考察对象,通过单因素试验确定超声波功率、清洗周期、超声时间合适的范围分别在500~1000 W、0.5~1.0 d、20~40 min;对于使用时间为0、0.5、1、3、5 a的石英套管,超声波均有很好的抑垢效果。为了进一步优化参数,采用Box-Behnken设计法和响应面分析方法对主要因素加以优化,得到了响应面回归模型和最优解。结果表明,超声波技术抑垢清垢的优化工艺参数为超声波功率P=965 W,清洗周期T=0.5 d,超声时间t=34 min,预测相对紫外线强度最大值为1.01。通过统计学检验,模型具有良好的拟合性,在优化工艺条件下得到的相对紫外线强度预测值与试验值接近,误差为1.00%。

关键词：超声波紫外线消毒石英套管结垢响应面法

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang Ni-Hui Zhang Zhi-Lai Zhan guang-Lu Chang Yan Gao Xia li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

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改进暗通道原理下视觉图像光晕消除算法

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现代电子技术 2025年第1期48卷 60-64页

作者：任晓楠李广中北大学山西太原030051

在光晕区域附近进行光晕消除操作可能会降低图像的对比度、清晰度和细节。因此,需要开发有效的方法来恢复和增强光晕消除后的图像细节,以确保整体图像质量的提高,为此设计一种改进暗通道原理下视觉图像光晕消除算法。建立大气散射模型... 详细信息

在光晕区域附近进行光晕消除操作可能会降低图像的对比度、清晰度和细节。因此,需要开发有效的方法来恢复和增强光晕消除后的图像细节,以确保整体图像质量的提高,为此设计一种改进暗通道原理下视觉图像光晕消除算法。建立大气散射模型深度分析光晕产生条件,根据图像中的像素强度值计算成像环境中的透射率,按照大气光照的散射系数建立光照条件研究模型。在较高的像素颜色通道条件下,根据图像中高亮度和强反射部分搭建无光晕图像亮通道定义,聚类图像亮通道特征,利用快速双边滤波器细化透射率,建立光晕图像的成像模型。在改进暗通道原理的过程中通过调整多个计算参数,包括改变权重函数,设置光晕消除的恢复指令,完成对视觉图像的光晕消除处理。经过实验分析可以证明,所提方法具备良好的光晕消除性能,光晕消除效果较好。

关键词：改进暗通道视觉图像光晕消除透射率多尺度算法大气散射模型

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