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Chinese Medical Journal 2020年第6期133卷 738-740页

作者： Qun Liu Jun-Xia Ruan Jing-Shu Zhang Lu-Lu Zhang guang-rong qiu Department of Medical Genetics School of Life SciencesChina Medical UniversityShenyangLiaoning 110122China Dalian Municipal Women and Children's Medical Center DalianLiaoning 116037China

To the Editor:Autosomal dominant polycystic kidney disease(ADPKD)is a common inherited kidney disease with an estimated incidence of 1 in 400 to 1 in 1000.[1] It is a late-onset systemic disorder characterized by the development and progressive enlargement of cysts in the kidney,eventually leading to end-stage renal disease.[2] Previous studies have shown that ADPKD is a heterogeneous monogenic disorder resulting from mutations in two genes:PKD1 and *** data showed that PKD1 and PKD2 mutations account for 85% and 15% of ADPKD cases,respectively.[3]

关键词： PKD1 kidney Clinical

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Modular engineering of E. coli coculture for efficient production of resveratrol from glucose and arabinose mixture

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Synthetic and Systems Biotechnology 2022年第2期7卷 718-729页

作者： Jia Li Zetian qiu guang-rong Zhao Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350China Georgia Tech Shenzhen Institute Tianjin UniversityDashi Road 1Nanshan DistrictShenzhen518055China

Resveratrol,a valuable plant-derived polyphenolic compound with various bioactivities,has been widely used in nutraceutical *** production of resveratrol suffers from metabolic burden and low malonyl-CoA availability,which is a big challenge for synthetic ***,we took advantage of coculture engineering and divided the biosynthetic pathway of resveratrol into the upstream and downstream *** enhancing the supply of malonyl-CoA via CRISPRi system and fine-tuning the expression intensity of the synthetic pathway genes,we significantly improved the resveratrol productivity of the downstream ***,we developed a resveratrol addiction circuit that coupled the growth of the upstream strain and the resveratrol production of the downstream *** bidirectional interaction stabilized the coculture system and increased the production of resveratrol by 74%.Moreover,co-utilization of glucose and arabinose by the coculture system maintained the growth advantage of the downstream strain for production of resveratrol throughout the fermentation *** optimized conditions,the engineered *** coculture system produced 204.80 mg/L of resveratrol,12.8-fold improvement over monoculture *** study demonstrates the promising potential of coculture engineering for efficient production of natural products from biomass.

关键词： Resveratrol Metabolic engineering Synthetic biology CRISPRi Coculture Resveratrol addiction

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe Wang MengXi Shi Willie Soon ShiCan qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

黑磷/黑砷异质结纳米器件热电性质应力调控研究

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原子与分子物理学报 2025年第1期42卷 69-74页

作者：戎杙邱乙峰张蓓新疆大学物理科学与技术学院乌鲁木齐830046

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形... 详细信息

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形,能够更有效抑制声子输运行为;与此同时,拉伸应变对于器件的电子输运的调控效果并不明显.在费米能附近,黑磷/黑砷异质结纳米器件在6%拉伸应变调控下热电优值达到最大值2.31.

关键词：黑磷黑砷异质结应力热电性质

非厄米PT对称多通道光波导体系的调控及动力学

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原子与分子物理学报 2025年第1期42卷 108-117页

作者：孙武叶伏秋张光成吉首大学物理与机电工程学院吉首416000

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换... 详细信息

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换为重整化参数后的等效未调制系统后,发现可以通过额外引入单频周期调制的光波导去调控体系的PT对称性,并且讨论了周期调制的非厄米三通道波导体系的能谱特性.最后通过解析和数值的方法给出了光在非厄米三通道光学波导中的动力学演化.

关键词： PT对称非厄米三通道波导

The Lapinized Chinese Strain Vaccine Against Classical Swine Fever Virus:A Retrospective Review Spanning Half A Century

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Agricultural Sciences in China 2006年第1期5卷 1-14页

作者： qiu Hua-ji SHEN rong-xian TONG guang-zhi National Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001 P.R.China

Classical swine fever （CSF）, a list A disease of Office International des Epizooties, is caused by classical swine fever virus （CSFV） belonging to the Flaviviridae family. The well-known lapinized Chinese strain of CSFV, also known as C-strain, was developed in China in the mid-1950s. In the past half a century, the vaccine has been proved to be safe and immunogenic in pigs of essentially any age. It is of high efficacy, providing immunized animals with broad-spectrum, sometimes lifelong, protection, which is contributed by both cell-mediated immunity and humoral immunity, against essentially all genotypes or subgenotypes of the virus. The maternal antibodies derived from immunized sows can confer solid protection of their offspring from disease; however, they have been proved to inhibit the successful active immunization of C-strain vaccine. The complete genomes of C-strain and dozens of established or field strains have been sequenced and annotated. Recently, the reverse genetics system of C-strain has been developed, resulting in several C- strain-derived candidate marker vaccines. Many countries manage to control or even eradicate CSF with the aid of mass vaccination with C-strain. in spite of these efforts, the eradication of the disease worldwide remains a big challenge and needs to go a long way, and provably still resorts to genetically modified C-strain vaccine. The authors present an overview of the characteristics of the vaccine, which has stood the test of half a century.

关键词： classical swine fever classical swine fever virus C-strain vaccine

Research and Application of Internal Combustion Coal-Oxygen Burner for Fluxing in EAF

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Journal of Iron and Steel Research International 1999年第1期6卷 23-26页

作者： Zhu rong Sun Yanhui qiu Yongquan Ouyang guang Chen Haiping Guo Changhua University of Science and Technology Beijing Xinyu Iron and Steel Company

The investigation shows that using internal combustion coal-oxygen burner for the intensification of melting in EAF is *** combustion coal-oxygen burner is better than external combustion coal-oxygen burner in the performance and energy saving of the *** consumption is decreased by 40 kW ? h/t,melting time is shortened by 18 *** application of internal combustion coal-oxygen burner has a significant effect on decreasing EAF energy consumption.

关键词： EAF coal-oxygen burner internal combustion energy saving

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第01期 157-162页

作者： rong-De He Yun-Lei Luo qiu-Quan Pan Qi-Wei Yao Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

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