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Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, roTOR and the NO-cGMP pathway

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Asian Journal of Andrology 2013年第1期15卷 143-148页

作者： Jian Zhang Ai-Min Li Bao-Xing Liu Fei Han Feng Liu Shao-Peng Sun Xin Li Shu-Jin Cui Shao-Zhong Xian guang-qi kong Zhong-Cheng Xin Zhi-Li Ji Department of Urology Capital Medical University Luhe Hospital Beijing 101149 China Andrology Center Peking University First Hospital Beijing 100034 China Department of Andrology China-Japan Friendship Hospital Beijing 100029 China

Erectile dysfunction （ED） is a major complication of diabetes mellitus. Icariin has been shown to enhance erectile function through its bioactive form, icarisid Ih This study investigates the effects of icarisid Ⅱ on diabetic rats with ED and its potential mechanism viathe assessment of advanced glycosylation end products （AGEs）, autophagy, mTOR and the NO-cGMP pathway. Icarisid Ⅱ was extracted from icariin by an enzymatic method. In the control and diabetic ED groups, rats were administered normal saline; in the icarisid Ⅱ group, rats were administered icarisid Ⅱ intragastrically. Erectile function was evaluated by measuring intracavernosal pressure/mean arterial pressure （ICP/MAP）. AGE concentrations, nitric oxide synthase （NOS） activity and cGMP concentration were assessed by enzyme immunoassay. Cell proliferation was analysed using methyl thiazolyl tetrazolium assay and flow cytometry. Autophagosomes were observed by transmission electron microscopy, monodansylcadaverine staining and GFP-LC3 Iocalisation. The expression of NOS isoforms and key proteins in autophagy were examined by western blot. Our results have shown that Icarisid Ⅱ increased ICP/MAP values, the smooth muscle cell （SMC） growth curve, S phase and SMC/collagen fibril （SMC/CF） proportions and decreased Beclin 1 （P〈0.05）. Icarisid Ⅱ significantly increased the proliferative index and p-p70S6K（Thr389） levels and decreased the numbers of autophagosomes and the levels of LC3-11 （P〈0.01）. Icarisid Ⅱ decreased AGE concentrations and increased cGMP concentration, NOS activity （P〈0.05） and cNOS levels （P〈0.01） in the diabetic ED group. Therefore, Icarisid Ⅱ constitutes a promising compound for diabetic ED and might be involved in the upregulation of SMC proliferation and the NO-cGMP pathway and the downregulation of AGEs, autophagy and the mTOR pathway.

关键词： advanced glycosylation end products (AGEs) autophagy cell proliferation diabetes mellitus (DM) erectile dysfunction (ED) icariin icarisid II mTOR NO-cGMP NOS activity

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Assessing spatiotemporal variations of forest carbon density using bi-temporal discrete aerial laser scanning data in Chinese boreal forests

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Forest Ecosystems 2023年第5期10卷 547-560页

作者： Zhiyong qi Shiming Li Yong Pang guang Zheng Dan kong Zengyuan Li Research Institute of Forest Resource Information Techniques Chinese Academy of ForestryBeijing100091China Key Laboratory of Forestry Remote Sensing and Information System National Forestry and Grassland AdministrationBeijing100091China National Forestry and Grassland Science Data Center Beijing100091China International Institute for Earth System Science Nanjing UniversityNanjing210023China

Assessing the changes in forest carbon stocks over time is critical for monitoring carbon dynamics,estimating the balance between carbon uptake and release from forests,and providing key insights into climate change *** this study,we quantitatively characterized spatiotemporal variations in aboveground carbon density(ACD)in boreal natural forests in the Greater Khingan Mountains(GKM)region using bi-temporal discrete aerial laser scanning(ALS)data acquired in 2012 and ***,we evaluated the transferability of the proposed design model using forest field plot data and produced a wall-to-wall map of ACD changes for the entire study area from 2012 to 2016 at a grid size of 30 *** addition,we investigated the relationships between carbon dynamics and the dominant tree species,age groups,and topography of undisturbed forested areas to better understand ACD variations by employing heterogeneous forest canopy structural *** results showed that the performance of the temporally transferable model(R^(2)=0.87,rRMSE=18.25%),which included stable variables,was statistically equivalent to that obtained from the model fitted directly by the 2016 field plots(R^(2)=0.87,rRMSE=17.47%).The average rate of change in carbon sequestration across the entire study region was 1.35 Mg⋅ha^(-1)⋅year^(-1) based on the changes in ALS-based ACD values over the course of four *** relative change rates of ACD decreased as the elevation increased,with the highest and lowest ACD growth rates occurring in the middle-aged and mature forest stands,*** Gini coefficient,which represents forest canopy surface structure heterogeneity,is sensitive to carbon dynamics and is a reliable predictor of the relative change rate of *** study demonstrated the applicability of bi-temporal ALS for predicting forest carbon dynamics and fine-scale spatial change *** research contributed to a better understanding of the in-fluence of remote sensing-derive

关键词： Aboveground carbon density Bi-temporal ALS Carbon dynamics Temporal transferability Gini coefficient

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MILP Model for Plant-Wide Optimal By-Product Gas Scheduling in Iron and Steel Industry

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Journal of Iron and Steel Research International 2010年第7期17卷 34-37页

作者： kong Hai-ning qi Er-shi HE Shu-guang, LI Gang Management School Tianjin University Tianjin 300072 China

The scheduling of by-product gases in by-product gas system,cogeneration system and production system is *** gas-consuming users are divided into three kinds according to their different characters and then a distribution model is built.A dynamic mixed integer linear programming（MILP）model for multiperiod optimization of by-product gas is performed to optimize by-product gas distribution to achieve total cost *** study shows that 6.2% operation cost is reduced by using the proposed model.

关键词： iron and steel industry MILP by-product gas distribution scheduling

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Drop strength measurement of green pellet based on drop-rebound mechanism

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Journal of Iron and Steel Research International 2023年第11期30卷 2143-2152页

作者： Jie Lei Xu Gao Jing-shu An guang-da Bao Yu-qi kong Hong-ming Long School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resource Comprehensive Utilization Anhui University of TechnologyMa’anshan243032AnhuiChina

The construction of blast furnace charge structure based on pellet and the development of short process from non-blast furnace to electric furnace will be an efficient way to accomplish"carbon peak,carbon neutral".Since drop strength is one of the most crucial quality indexes for green pellet,the crack detection in the collision process is an indispensable segment;however,the present crack determination is basically completed *** to a series of problems including high labor intensity and poor detection conditions,it is urgent to develop an accurate,convenient and fast standardized method for drop strength *** view of the above issues,combined with plenty of experimental studies,it is found that whether rebound occurs after the collision of green ball can be used as the basis for judging if there are cracks on the surface,and the mechanism of this segment is explained by the energy conversion of collision process that the plastic deformation of the collision is a cumulative *** collision will cause a slight displacement of the iron ore particles;until the cumulative displacement exceeds the binding force between the particles,they will slip in a large range,that is,cracks will *** drop strength can be detected based on the drop-rebound mechanism determining crack generation during collision process by high-speed cameras,and the method is fully applicable to oxidized pellets with particle size of 8-16 mm though various pellet plasticities and masses increase the difficulty of bounce height *** on the drop-rebound mechanism of green pellet,three methods for automatically detecting the drop strength are proposed,which are high-speed camera,photoelectric sensor and pressure sensor methods.

关键词： Green pellet Drop strength Collision Rebound Crack

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A New Method for Electromagnetic Time Reversal in a Complex Environment

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Chinese Physics Letters 2012年第2期29卷 105-107页

作者： kong qi SHI qing-Fan YU guang-Ze ZHANG Mei School of Physics Beijing Institute of TechnologyBeijing 100081 School of Computer Guangdong Industrial UniversityGuangzhou 510006

A new time reversal method is proposed to infer the location of an unknown extending target in a complex *** our method,the wavelet analysis and scalogram of energy density are first introduced into the electromagnetic time reversal process to improve the accuracy and to eliminate *** computation results show that the new technique can refocus the unknown target better than using traditional time reversal.

关键词： Electromagnetic eliminate Complex

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Tracking the maneuvering spacecraft propelled by swing propulsion of constant magnitude

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Journal of Systems Engineering and Electronics 2020年第2期31卷 370-382页

作者： ZHAI guang WANG Yanxin ZHAO qi School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Systems Engineering Research Institute Beijing 100094China

This paper proposes partially norm-preserving filtering for a class of spacecraft in the presence of time-varying, but constant-magnitude maneuver. The augmented state Kalman filter(ASKF) is commonly used to track the maneuvering spacecraft with unknown constant propulsion;however, if the maneuver varies via time, the estimation performance will be degraded. To promote the tracking performance of the ASKF in case of time-invariant,constant-magnitude disturbance, the partially norm-preserving ASKF is developed by applying the norm constraint on the unknown maneuver. The proposed estimator, which is decomposed into two partial estimators and iteratively propagated in turns,projects the unconstrained maneuver estimation onto the Euclidian surface spanned by the norm constraint. The illustrative numerical example is provided to show the efficiency of the proposed method.

关键词： maneuvering spacecraft tracking augmented state norm-preserving Kalman filter

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Isometric Embeddings of Subsets of Boundaries of Teichmüller Spaces of Compact Hyperbolic Riemann Surfaces

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Acta Mathematica Sinica,English Series 2020年第5期36卷 605-619页

作者： guang Ming HU Yi qi College of Science Jinling Institute of TechnologyNanjing 211169P.R.China LMIB and School of Mathematics and Systems Science Beihang UniversityBeijing 100191P.R.China

It is known that every finitely unbranched holomorphic covering π:S→S of a compact Riemann surface S with genus g≥2 induces an isometric embedding Φπ:Teich(S)→Teich(S).By the mutual relations between Strebel rays in Teich(S)and their embeddings in Teich(S),we show that the 1 st-strata space of the augmented Teichmüller space Teich(S)can be embedded in the augmented Teichmüller space Teich(S)***,we show that Φπ induces an isometric embedding from the set Teich(S)B(∞)consisting of Busemann points in the horofunction boundary of Teich(S)into Teich(S)B(∞)with the detour metric.

关键词： Teichmüller space augmented Teichmüller space Strebel ray Busemann points

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Super Strong and Tough Elastomers Enabled by Sacrificial Segregated Network

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Chinese Journal of Polymer Science 2021年第3期39卷 377-386,I0008页

作者： Yong Zhu Lai-Yun Wei Xuan Fu Jun-qi Zhang Ling-Min kong guang-Su Huang Jin-Rong Wi State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

The integration of high strength and toughness concurrently is a vital requirement for elastomers from the perspective of long-term durability and reliability. Unfortunately, these properties are generally conflicting in artificial materials. In the present work, we propose a facile strategy to simultaneously toughen and strengthen elastomers by constructing 3 D segregated filler network via a simple latex mixing *** as-fabricated elastomers are featured by a microscopic 3 D interconnected segregated network of rigid graphene oxide(GO) nanosheets and a continuous soft matrix of sulfur vulcanized natural rubber(NR). We demonstrate that the interconnected segregated filler network ruptures preferentially upon deformation, and thus is more efficient in energy dissipation than the dispersed filler network. Therefore, the segregated filler network exhibits better reinforcing effects for the rubber matrix. Moreover, the excellent energy dissipating ability also contributes to the outstanding crack growth resistance through the release of concentrated stress at the crack tip. As a result, the strength, toughness and fatigue resistance of the nanocomposites are concurrently enhanced. The methodology in this work is facile and universally applicable, which may provide new insights into the design of elastomers with both extraordinary static and dynamic mechanical performance for practical applications.

关键词： Elastomers Nanocomposites Segregated network Sacrificial bonds Mechanical properties

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Optimal design for split-and-recombine-type flow distributors of microreactors based on blockage detection

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Chinese Journal of Chemical Engineering 2016年第7期24卷 897-903页

作者： Lin Wang Xianzuo kong Yongsheng qi Department of Control Engineering Inner Mongolia University of Technology

In order to increase the productivity of microreactors, the parallelization of the microreactors is required. The performances of flow distributors can affect the product yield and fault detection ability when blockage *** this research, an optimal design method to calculate the channel diameters and to determine the flow sensor location is derived based on mass balance and pressure balance models of split-and-recombine-type flow distributors(SRFDs). The model accuracy is verified by experiment data. The proposed method is applied to optimal design of SRFDs under constant flow rate operation conditions. The maximum angle difference between normal and blockage conditions at one sensor to those at the other sensors is set to be the objective function and the uniformity of flow distribution in microreactors under normal condition is also required. The diameters of each pipe in SRFDs are selected as the design variables. Simulated annealing algorithm is used to solve the optimization problem. The effectiveness of the optimal design results is demonstrated by fluid dynamics simulations. The results show that using the optimal channel diameters of SRFDs, the pressure drop in SRFD section is lower than that of the microreactor section. Meanwhile, in the case studies, only a few sensors that are located inside the SRFDs can easily detect the blockage abnormal condition in the parallelized microreactor system.

关键词： Optimal designSplit-and-recombine-type flow distributorsMicroreactorsMicrochannelsBlockage

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Influence of electronic structure on Compton scattering through comparing Cu-Ni alloys with Cu-Ni powder mixtures

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Acta Metallurgica Sinica(English Letters) 2012年第1期25卷 55-64页

作者： guang LUO Xianquan HU guangyu XIAO Chunyang kong College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 400047China

The application fields of Compton scattering have been further broadened through the studies of theories and experiments as well as the electronic structure of the scatters. The relationship between the contents of binary alloys （also binary powder mixtures） and the number of Compton scattered photons has been thoroughly examined. The linear expression of the relationship has been obtained approximately according to the Compton scattering theory. And the relationship has been validated well through the Compton scattering experiments with the scatters of Cu-Ni binary alloys or Cu- Ni binary powder mixtures. Furthermore, it is found that the slope of Cu-Ni powder mixture series is steeper than that of Cu-Ni alloy series, and through the pseudopotential plane wave theory of DFT the microscopic principles of Compton scattering of Cu-Ni alloy and Cu-Ni powder mixture series have been discussed and compared with each other. The results show that the electronic structure is the main reason for the difference of the linear slopes, and the line slope of Cu-Ni powder mixtures series is steeper than that of Cu-Ni alloy series.

关键词： Compton scattering Microscopic principle Cu-Ni Line slope

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