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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology Research 2025年第1期33卷 225-234页

作者： WEI ZHANG WEICHENG WANG RUI WANG XIAO HAN LIJUN ZHU WENJIE guo YANHONG GU Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Effects of Grain Size and Cryogenic Temperature on the Strain Hardening Behavior of VCoNi Medium‑Entropy Alloys

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Acta Metallurgica Sinica(English Letters) 2023年第6期36卷 973-986页

作者： guo‑Dong Liu Xue‑Mei Luo Ji‑Peng Zou Bin Zhang guang‑ping Zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China

The mechanical behavior of VCoNi medium-entropy alloys with five different grain sizes at three different temperatures was *** VCoNi alloys with different grain sizes exhibit a traditional strength–ductility trade-off at 77 K,194 K and 293 *** the yield strength and the uniform elongation of the VCoNi alloys with similar grain size increase with decreasing the deformation temperature from 293 to 77 *** strain hardening rate recovery characterized by an evident up-turn behavior at stage II is observed in VCoNi alloys with the grain size above 11.1μ*** is found that the extent of the strain hardening rate recovery increases with increasing grain size or decreasing deformation *** may mainly result from the faster increase in the dislocation multiplication rate caused by the decrease in the dislocation mean free path,the decrease in the absorption of dislocations by grain boundaries and the dynamic recovery from the cross-slip with increasing grain size,as well as the suppressed dynamic recovery at cryogenic *** critical grain sizes for the occurrence of the recovery of strain hardening rate are determined to be around 9.5μm,8.3μm and 3μm for alloys deformed at 293 K,194 K and 77 K,*** basic mechanism for the strain hardening behavior of the VCoNi alloys associated with grain size and deformation temperature is analyzed.

关键词： Medium-entropy alloy Strain hardening rate Cryogenic temperature Grain size Slip band refinement

A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research International 2024年第1期31卷 74-91页

作者： Yan Yan guang-hao Shang Li-ping Zhang Shao-ying Li Han-jie guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

Mechanical performance of a double-face reinforced retaining wall in an area disturbed by mining

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Mining Science and Technology 2009年第1期19卷 36-39页

作者： YU guang-yun BAI Yong-sheng SHENG ping guo Rui-ping School of Architecture and Civil Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China State Key Laboratory for Geomechanics ＆ Deep Underground Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Atomic Energy of Canada Limited Chalk River Ontario KOJIJO Canada

The application of a double-face reinforced retaining wall during road construction can reduce engineering costs, speed road paving and have a good influence on environment. An ABAQUS numerical model of a double-face reinforced retaining wall was built. The influence of surface subsidence induced by mining was considered. A physical model test was also performed in the laboratory on a reinforced retaining wall. The influence of subsidence induced by mining was observed. The numerical results match measurements in the laboratory very well. The vertical pressure on the base of the retaining wall, the horizontal displacement of the wall and the horizontal soil pressure acting on the wall were analyzed. The differential settlement of the reinforced belt and axial forces in the wall were also studied.

关键词： double-face reinforced retaining wall underground mining finite element method physical model test

Ancient Art Retains Splendor in New Era

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China Today 2025年第1期74卷 74-75页

作者： guo QING 不详

With government support,more young people are studying Thangka art,securing its innovative *** 1,300-year-old Thangka art,religious painting on woven material,has been lauded as an illustrated encyclopedia of Tibetan *** unique artistic and cultural value earned it a place on China’s intangible cultural heritage list in *** institution tasked with preserving and developing this ancient art is the Tibet Academy of Thangka(TAT)in *** focuses on the Mansar School of Thangka *** can observe the whole process of creating a Mansar Thangka piece,from sketching to adding the final touch.

关键词： religious earned sketch

China-India: Ties that Bind

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China Today 2025年第1期74卷 59-61页

作者： guo QING 不详

From international student to professor,Tripathi Mani shares his thoughts on Chinese and Indian cultures and the beneficial exchanges between *** Vivek Mani first learned about China from bedtime stories told by his father,a Sanskrit teacher in rural Bihar,a state in east *** of the stories were about the Chinese monk Xuanzang’s adventures during his long journey to India to find Buddhist *** kindled the young boy’s interest in China and the desire to visit it one day.

关键词： India Indian desire

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming Yuan guo-Da Zhang Chao Wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

Sensitivity analysis of the surface integrity of monocrystalline silicon to grinding speed with same grain depth-of-cut

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Advances in Manufacturing 2020年第1期8卷 97-106页

作者： ping Zhou Zi-guang Wang Ying Yan Ning Huang Ren-Ke Kang Dong-Ming guo Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education.Dalian University of Technology Dalian 116024LiaoningPeople's Republic of China

Mechanisms for removal of materials during the grinding process of monocrystalline silicon have been extensively studied in the past several ***,debates over whether the cutting speed significantly affects the surface integrity are *** address this debate,this study comprehensively investigates the effects of cutting speed on surface roughness,subsurface damage,residual stress,and grinding force for a constant grain *** results illustrate that the changes in the surface roughness and subsurface damage relative to the grinding speed are less obvious when the material is removed in ductile-mode as opposed to in the brittle-ductile mixed mode.A notable finding is that there is no positive correlation between grinding force and surface *** results of this study could be useful for further investigations on fundamental and technical analysis of the precision grinding of brittle materials.

关键词： Rotational grinding Silicon wafer Surface integrity Cutting speed Residual stress