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Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats

World Journal of Gastroenterology 2015年第23期21卷 7155-7164页

作者： Yong-Zhan Zhen Na-Ren Li Hong-Wei He Shuang-Shuang Zhao guang-ling zhang Xiao-Fang Hao Rong-guang Shao Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases School of Basic Medical Sciences Hebei United University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College

AIM: To evaluate the protective effect of bicyclol against bile duct ligation(BDL)-induced hepatic fibrosis in ***: Sprague-Dawley male rats underwent BDL and sham-operated animals were used as healthy controls. The BDL rats were divided into two groups which received sterilized PBS or bicyclol(100 mg/kg per day) orally for two consecutive weeks. Serum, urine and bile were collected for biochemical determinations. Liver tissues were collected for histological analysis and a whole genome oligonucleotide microarray assay. Reverse transcription-polymerase chain reaction and Western blotting were used to verify the expression of liver fibrosis-related ***: Treatment with bicyclol significantly reduced liver fibrosis and bile duct proliferation after BDL. The levels of alanine aminotransferase(127.7 ± 72.3 vs 230.4 ± 69.6, P < 0.05) and aspartate amino-transferase(696.8 ± 232.6 vs 1032.6 ± 165.8, P < 0.05) were also decreased by treatment with bicyclol in comparison to PBS. The expression changes of 45 fibrogenic genes and several fibrogenesis-related pathways were reversed by bicyclol in the microarray assay. Bicyclol significantly reduced liver m RNA and/or protein expression levels of collagen 1a1, matrix metalloproteinase 2, tumor necrosis factor, tissue inhibitors of metalloproteinases 2, transforming growth factor-b1 and α-smooth muscle ***: Bicyclol significantly attenuates BDLinduced liver fibrosis by reversing fibrogenic gene expression. These findings suggest that bicyclol might be an effective anti-fibrotic drug for the treatment of cholestatic liver disease.

关键词： Bicyclol Rat Bile duct ligation Liver fibrosis Gene expression profile

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Vitamin D binding protein in psychiatric and neurological disorders:Implications for diagnosis and treatment

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Genes & Diseases 2024年第5期11卷 324-334页

作者： ling Li Bing Han Yan Kong Gaojia zhang Zhijun zhang Research Institution of Neuropsychiatry School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalNanjingJiangsu 210009China Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

Vitamin D binding protein(VDBP)serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target *** plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin *** research has shed light on its potential role in various diseases,leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological *** purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric *** examining the intricate interplay between VDBP and these disorders,this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic *** gained from the study of VDBP could pave the way for novel strategies in the diagnosis,prognosis,and treatment of psychiatric and neurological disorders.

关键词： Neurological disorder Polymorphism Psychiatric disorder Structure Vitamin D binding protein

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UAV maneuvering decision-making algorithm based on deep reinforcement learning under the guidance of expert experience

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Journal of Systems Engineering and Electronics 2024年第3期35卷 644-665页

作者： ZHAN guang zhang Kun LI Ke PIAO Haiyin School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Electro-Optic Control Laboratory Luoyang 471009China

Autonomous umanned aerial vehicle(UAV) manipulation is necessary for the defense department to execute tactical missions given by commanders in the future unmanned battlefield. A large amount of research has been devoted to improving the autonomous decision-making ability of UAV in an interactive environment, where finding the optimal maneuvering decisionmaking policy became one of the key issues for enabling the intelligence of UAV. In this paper, we propose a maneuvering decision-making algorithm for autonomous air-delivery based on deep reinforcement learning under the guidance of expert experience. Specifically, we refine the guidance towards area and guidance towards specific point tasks for the air-delivery process based on the traditional air-to-surface fire control ***, we construct the UAV maneuvering decision-making model based on Markov decision processes(MDPs). Specifically, we present a reward shaping method for the guidance towards area and guidance towards specific point tasks using potential-based function and expert-guided advice. The proposed algorithm could accelerate the convergence of the maneuvering decision-making policy and increase the stability of the policy in terms of the output during the later stage of training process. The effectiveness of the proposed maneuvering decision-making policy is illustrated by the curves of training parameters and extensive experimental results for testing the trained policy.

关键词： unmanned aerial vehicle(UAV) maneuvering decision-making autonomous air-delivery deep reinforcement learning reward shaping expert experience

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Heat transfer and temperature evolution in underground mininginduced overburden fracture and ground fissures: Optimal time window of UAV infrared monitoring

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International Journal of Mining Science and Technology 2024年第1期34卷 31-50页

作者： Yixin Zhao Kangning zhang Bo Sun Chunwei ling Jihong Guo Beijing Key Laboratory for Precise Mining of Intergrown Energy and Resources China University of Mining and Technology-BeijingBeijing 100083China School of Energy&Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China

Heat transfer and temperature evolution in overburden fracture and ground fissures are one of the essential topics for the identification of ground fissures via unmanned aerial vehicle(UAV) infrared imager. In this study, discrete element software UDEC was employed to investigate the overburden fracture field under different mining conditions. Multiphysics software COMSOL were employed to investigate heat transfer and temperature evolution of overburden fracture and ground fissures under the influence of mining condition, fissure depth, fissure width, and month alternation. The UAV infrared field measurements also provided a calibration for numerical simulation. The results showed that for ground fissures connected to underground goaf(Fissure Ⅰ), the temperature difference increased with larger mining height and shallow buried depth. In addition, Fissure Ⅰ located in the boundary of the goaf have a greater temperature difference and is easier to be identified than fissures located above the mining goaf. For ground fissures having no connection to underground goaf(Fissure Ⅱ), the heat transfer is affected by the internal resistance of the overlying strata fracture when the depth of Fissure Ⅱ is greater than10 m, the temperature of Fissure Ⅱ gradually equals to the ground temperature as the fissures’ depth increases, and the fissures are difficult to be identified. The identification effect is most obvious for fissures larger than 16 cm under the same depth. In spring and summer, UAV infrared identification of mining fissures should be carried out during nighttime. This study provides the basis for the optimal time and season for the UAV infrared identification of different types of mining ground fissures.

关键词： Heat transfer Overburden fracture Ground fissures Infrared thermal imaging Unmanned aerial vehicle(UAV) COMSOL simulation

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Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： Can-Can zhang Jun-Long Yang Ya-Jiang Huang guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

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Orientational growth behavior and mechanism of delta(δ)phase precipitation in cold-rolled Inconel 718 alloy during heat treatment

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Journal of Iron and Steel Research International 2024年第1期31卷 264-274页

作者： Neng-yong Ye guang-liang zhang Tian-yue Huang Ming Cheng Shi-hong zhang Lei Wang School of Materials Science&Engineering Taizhou UniversityTaizhou318000ZhejiangChina Institute of Metal Research Chinese Academy of SciencesShenyang110016LiaoningChina

Due to the important role ofδphase's quantity and morphology in the mechanical and fatigue properties of Inconel 718 alloy and its components,it is necessary to renew insights into the effect of cold deformation on theδphase precipitation,especially on the morphology ***,the nucleation and growth behavior ofδphase in cold-rolled Inconel 718 alloy during aging were *** results show that the precipitation rate and volume fraction ofδphase increase with increasing the cold rolling reduction from 10%to 50%.The volume fraction ofδphase reaches equilibrium after 5 h,remaining at 5.98%,6.52%,and 6.79%under different rolling reductions(10%,30%,and 50%),*** nucleation ofδphase mainly occurs on different sites(grain boundaries,new twin boundaries and old twin boundaries)under 10%rolling reduction,whileδphase mainly nucleates on the new grain boundaries of static recrystallization due to 50%rolling *** the growth ofδphase undergoes a process of alternate orientation growth from spherical(nucleation)→short rod(longitudinal orientation growth)→short rod(radial orientation growth)→dynamic *** 10%rolling reduction,δphase tends to grow into the matrix,while under 50%rolling reduction,the orientation grows faster and is easily affected by the grain boundary curvature.

关键词： Inconel 718 alloy Cold rolling δphase Orientation growth Morphology evolution

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The study of intelligent algorithm in particle identification of heavy-ion collisions at low and intermediate energies

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Nuclear Science and Techniques 2024年第2期35卷 170-182页

作者： Gao-Yi Cheng Qian-Min Su Xi-guang Cao Guo-Qiang zhang School of Electronic and Electrical Engineering Shanghai University of Engineering ScienceShanghai 201620China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

Traditional particle identification methods face timeconsuming,experience-dependent,and poor repeatability challenges in heavy-ion collisions at low and intermediate *** urgently need solutions to the dilemma of traditional particle identification *** study explores the possibility of applying intelligent learning algorithms to the particle identification of heavy-ion collisions at low and intermediate *** intelligent algorithms,including XgBoost and TabNet,were selected to test datasets from the neutron ion multi-detector for reaction-oriented dynamics(NIMROD-ISiS)and Geant4 ***-based machine learning algorithms and deep learning algorithms *** show excellent performance and generalization *** additional data features besides energy deposition can improve the algorithm’s performance when the data distribution is *** learning algorithms can be applied to solve the particle identification problem in heavy-ion collisions at low and intermediate energies.

关键词： Heavy-ion collisions at low and intermediate energies Machine learning Ensemble learning algorithm Particle identification Data imbalance

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Effect of End Shape on Flow and Heat Transfer Characteristics of Two Parallel Plates

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Journal of Thermal Science 2024年第3期33卷 815-832页

作者： zhang guang HONG Tianxiao WANG Dongrui XIN Jialin TAO Junyu LIN Zhe Key Laboratory of Fluid Transmission Technology of Zhejiang Province Zhejiang Sci-Tech UniversityHangzhou310018China

Flow around a pair of flat plates is a basic hydrodynamics *** this paper,the flow and heat transfer characteristics of two parallel plates with different edge shapes are numerically *** different inclined angles,the influence of chamfered and rounded structures with different sizes at the end-edge on unsteady flow and heat transfer characteristics of two parallel plates are *** is found that the instability and unsteadiness of flow decrease with the increase of end-edge size,and the non-uniformity of wake velocity of both rounded and chamfered plates decreases *** non-uniformity of wake temperature increases firstly and then decreases at a small inclined angle,and the amplitude becomes the largest when S_(rou)(S_(cha))=3,while it basically keeps monotonically increasing at a large inclined ***,the global heat transfer performance of the flat plate is obviously affected by the end-edge modification,especially the chamfered *** the increase of chamfered size,the global Nusselt number basically shows the decreasing *** study provides a theoretical basis for the application of plate-shape structure in engineering fields.

关键词： two parallel plates end shape flow characteristic heat transfer numerical simulation

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Nurse anesthetists’perceptions and experiences of managing emergence delirium:A qualitative study

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World Journal of Psychiatry 2024年第4期14卷 553-562页

作者： Yi Xin Fu-Cai Lin Chen Huang Bin He Ya-ling Yan Shuo Wang guang-Ming zhang Rui Li Wuxi Medical College Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Anesthesiology Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium(ED),a common and complex postoperative complication in the post-anesthesia care *** role of nurses in managing ED is critical,yet research on their understanding and management strategies for ED is *** To investigate anesthetic nurses’cognition and management experiences of ED in hopes of developing a standardized management *** This study employed a descriptive phenomenological approach from qualitative research *** sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research ***-structured interviews were conducted,and the data were organized and analyzed using Colaizzi’s seven-step analysis method,from which the final themes were *** After analyzing the interview content,four main themes and eight subthemes were distilled:Inefficient cognition hinders the identification of ED(conceptual ambiguity,empirical identification),managing diversity and challenges(patientcentered safe care,low level of medical-nursing collaboration),work responsibilities and pressure coexist(heavy work responsibilities,occupational risks and stress),demand for high-quality management(expecting the construction of predictive assessment tools and prevention strategies,and pursuing standardized management processes to enhance management effectiveness).CONCLUSION Nursing managers should prioritize the needs and suggestions of nurses in order to enhance their nursing capabilities and provide guidance for standardized management processes.

关键词： Anesthetic nurse Emergence delirium Postoperative complications Cognition Disease management Qualitative research

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Large deflection deformation behavior of a Zr-based bulk metallic glass for compliant spinal fixation application

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Journal of Materials Science & Technology 2024年第6期173卷 86-99页

作者： Diao-Feng Li Chun-guang Bai Zhi-Qiang zhang Hui-Bo zhang Nan Li Jian Zhao Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

A novel compliant spinal fixation designed based on the concept of compliant mechanisms can reduce the stress-shielding effect and adjacent segment degeneration(ASD)effectively,but propose higher requirements for the properties of the used *** metallic glasses(BMGs),as a kind of young biomaterials,exhibiting excellent comprehensive properties,which are attractive for compliant spinal ***,according to the practical service condition of the basic elements in compliant spinal fixation,large deflection deformation behaviors of Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%,ZT1)BMG beam,including elastic,yielding and plastic were investigated *** was shown that the theoretical nonlinear analytical solution curve as the benchmark not only with the capacity to predict the nonlinear load-deflection relation within the elastic deformation regime,but also assists to capture the yielding event roughly,which can be used as a powerful design tool for *** capture the beginning of the yielding event exactly,bending proof strength(σ_(p),0.05%)accompanied with tiny permanent strain of 0.05% was proposed and determined for BMGs in biomedical implant applications,which is of significance for setting the allowable operating limits of the basic flexible *** approach of interrupted loading-unloading cycles,plastic deformation driven by the bending moment can be classified into two typical stages:the initial stage which mainly characterized by the nucleation and intense interaction of abundant shear bands when the plastic strain below the critical value,and the second stage which dominated by the progressive propagation of shear bands and coupled with the emergence of shear offsets on tensile *** plasticity of BMG beam structures depends on the BMG's inherent plastic zone size(rp).When the half beam thickness less than that of the rp,the plastic deformation of BMGs will behave in a stable manner,which can be acted as the margin of safety effectiv

关键词： Metallic glasses Biomaterials Compliant spinal fixation Large deflection deformation Plastic deformation

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