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Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 780-794页

作者： Zhongyang Liu Honglei Li Zhaoyu jin Yang Li Feifei guo Yangzhige He Xinyue Liu Yaning Qi Liying Yuan Fuchu He Dong Li State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China School of Basic Medical Sciences Anhui Medical UniversityHefei 230032China College of Chemistry and Environmental Science Hebei UniversityBaoding 071002China Suzhou Geneworks Technology Co. Ltd.Suzhou 215028China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China College of Life Sciences Hebei UniversityBaoding 071002China

After decades of development,protein and peptide drugs have now grown into a major drug class in the *** identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target ***,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are ***,we systematically explore the target spaces in the human genome specifically for protein and peptide *** with other proteins,both successful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many *** on these features,we develop separate effective genome-wide target prediction models for protein and peptide ***,a user-friendly web server,Predictor Of Protein and Pept Ide drugs’therapeutic Targets(POPPIT)(http://***/),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets.

关键词： Protein drug Peptide drug Target analysis Target prediction Web server

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植物内生真菌中萜类化合物研究进展

云南民族大学学报（自然科学版） 2024年第1期33卷 1-16页

作者：郭晶刘明秀柴南南濮兴娜汪伟光李艳平云南中医药大学中药学院云南省南药可持续利用重点实验室云南昆明650500 云南民族大学民族药资源化学国家民族事务委员会-教育部重点实验室云南昆明650500

植物内生真菌中萜类化合物结构新颖,有显著的生物活性.研究表明,植物内生真菌与宿主植物生长的各阶段都有着紧密的关系,植物内生真菌特别是药用植物内生真菌的次级代谢产物更是发现具抗菌活性、抗肿瘤活性、抗炎活性等效果较好,结构丰... 详细信息

植物内生真菌中萜类化合物结构新颖,有显著的生物活性.研究表明,植物内生真菌与宿主植物生长的各阶段都有着紧密的关系,植物内生真菌特别是药用植物内生真菌的次级代谢产物更是发现具抗菌活性、抗肿瘤活性、抗炎活性等效果较好,结构丰富化合物的重要资源.本综述对植物内生真菌中萜类化合物进行研究综述,以期为这些化合物的后期研究和开发应用提供参考.

关键词：内生真菌次级代谢产物萜类生物活性

Behavior of Unbonded Flexible Risers Subject to Axial Tension

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China Ocean Engineering 2014年第2期28卷 249-258页

作者：任少飞唐文勇郭晋挺 State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Naval Architecture and Marine Engineering University of Michigan

Owing to nonlinear contact problems with slip and friction, a lot of limiting assumptions are made when developing analytical models to simulate the behavior of an unbonded flexible riser. Meanwhile, in order to avoid convergence problems and excessive calculating time associated with running the detailed finite element （FE） model of an unbonded flexible riser, interlocked carcass and zeta layers with complicated cross section shapes are replaced by simple geometrical shapes （e.g. hollow cylindrical shell） with equivalent orthotropic materials. But the simplified model does not imply the stresses equivalence of these two layers. To solve these problems, based on ABAQUS/Explicit, a numerical method that is suitable for the detailed FE model is proposed. In consideration of interaction among all component layers, the axial stiffness of an eight-layer unbonded flexible riser subjected to axial tension is predicted. Compared with analytical and experimental results, it is shown that the proposed numerical method not only has high accuracy but also can substantially reduce the calculating time. In addition, the impact of the lay angle of helical tendons on axial stiffness is discussed.

关键词： unbonded flexible risers axis stiffness quasi-static contact friction

Comparison of Clinical Effects between Percutaneous Transluminal Septal Myocardial Ablation and Modified Morrow Septal Myectomy on Patients with Hypertrophic Cardiomyopathy

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Chinese Medical Journal 2018年第5期131卷 527-531页

作者： Hong-Chang guo jin-Hua Li Teng-Yong Jiang Chang-Wei Ren Jiang Dai Yu-Jie Zhou Yong-Qiang Lai Department of Cardiac Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background： Percutaneous transluminal septal myocardial ablation （PTSMA） and modified Morrow septal myectomy （MMSM） are two invasive strategies used to relieve obstruction in patients with hypertrophic cardiomyopathy （HCM）. This study aimed to determine the clinical outcome of these two strategies. Methods： From January 2011 to January 2015,226 patients with HCM were treated, 68 by PTSMA and 158 by MMSM. Both ultrasonic cardiograms and heart functional class were recorded before, alter operations and in the follow-up. Categorical variables were compared using Chi-square or Fisher＇s exact tests. Quantitative variables were compared using the paired samples t-test. Results： lnterventricular septal thickness was significantly reduced in both groups （21.27 ± 4.43 mm vs. 18.72 ±4.13 mm for PTSMA, t = 3.469, P 〈 0.001, and 21.83± 5.03 mm vs. 16.57 ± 3.95 mm for MMSM, t = 10.349, P 〈 0.001, respectively）. The left ventricular outflow tract （LVOT） pressure gradient （PG） significantly decreased after the operations in two groups （70.30 ± 44.79 mmHg vs. 39.78 ±22.07 mmHg for PTSMA, t = 5.041, P 〈 0.001, and 74.58 ± 45.52 mmHg vs. 13.95 ± 9.94 mmHg for MMSM, t = 16.357, P 〈 0.001, respectively）. Seven patients （10.29%） in the PTSMA group required a repeat operation in the follow-up. Eight （11.76%） patients were evaluated for New York I-lean Association （NYHA） Ill/IV in the PTSMA group, which was significantly more than the five （3.16%） in the same NYHA classes lbr the MMSM group at follow-up. Less than 15% of patients in the PTSMA group and none of the patients in the MMSM group complained of chest pain during follow-up. Conclusions： Both strategies can not only relieve LVOT PG but also improve heart function in patients with HCM. However, MMSM might provide a more reliable reduction in gradients compared to PTSMA.

关键词： Hypertrophic Cardiomyopathy Myectomy Percutaneous Translunainal Septal Myocardial Ablation

高原低氧暴露下海马中M1AChR表达对雄性大鼠学习和记忆的影响

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中国高原医学与生物学杂志 2024年第2期45卷 73-82页

作者：冯江鹏黄灵泉杨全余嘎琴李生花靳国恩青海大学医学部基础医学部西宁810016 青海大学高原医学研究中心西宁810001 教育部高原医学重点实验室西宁810001 青海省高原医学实验室西宁810001

目的考察高原低氧暴露下海马中毒蕈碱型乙酰胆碱受体M1(muscarinic acetylcholine receptor M1,M1 AChR)表达对雄性大鼠学习和记忆的影响。方法将大鼠随机分为常氧对照组(NC组)、常氧组(N组)、低氧组(H组)和低氧+TAK-071组(HT组)。采... 详细信息

目的考察高原低氧暴露下海马中毒蕈碱型乙酰胆碱受体M1(muscarinic acetylcholine receptor M1,M1 AChR)表达对雄性大鼠学习和记忆的影响。方法将大鼠随机分为常氧对照组(NC组)、常氧组(N组)、低氧组(H组)和低氧+TAK-071组(HT组)。采用定位巡航实验和空间探索实验分别考察大鼠的学习和空间记忆能力;采用苏木素-伊红染色(hematoxylin-eosin staining,H&E)技术观察大鼠额叶和海马的组织形态;采用免疫组织化学(immunohistochemical,IHC)染色和蛋白质印迹(Western Blot,WB)技术测定大鼠海马组织中M1 AchR的蛋白表达水平;采用荧光定量PCR(quantitative PCR,qPCR)技术测定大鼠海马组织中M1 AchR和叉头框蛋白P2(forkhead box protein P2,FOXP2)的基因表达水平。结果经过Morris水迷宫(morris water maze,MWM)训练后,大鼠海马组织中M1 AChR的蛋白总体表达水平明显降低(P<0.05),但在海马CA1区、CA3区显著增加(P<0.05)。低氧环境会明显改变大鼠在定位巡航实验中的表现:逃避潜伏期时长增加;明显改变大鼠在空间探索实验中的表现:在目标象限的停留时间减少(P<0.05)。激活M1AChR后,大鼠海马组织中因低氧增加的M1 AChR明显降低(P<0.05)。结论激活M1 AChR可以改善高原低氧对雄性大鼠的记忆损伤,减缓记忆衰退进程;对学习改善无影响。推测M1 AChR在雄性大鼠认知功能中的作用可能是保持已有记忆。

关键词：高原低氧学习记忆海马毒蕈碱型乙酰胆碱受体M1

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某肉鸡屠宰厂生产链空气微生物监测分析

中国动物检疫 2024年第6期41卷 43-49页

作者：梁锐萍柴小冲金银姬王天坤郭江鹏北京市昌平区动物疫病预防控制中心北京102200 北京南口鸭育种科技有限公司北京102203 北京市畜牧总站北京100107

为监测某大型肉鸡屠宰厂车间内不同加工区域及不同加工时段食源性致病菌水平,从某年屠宰肉鸡3000万只的屠宰厂选取6个采样点,每个采样点每次分3个时段采样,试验周期为1年,共计采集216批1944份样品。通过细菌培养,重点监测环境中菌落总... 详细信息

为监测某大型肉鸡屠宰厂车间内不同加工区域及不同加工时段食源性致病菌水平,从某年屠宰肉鸡3000万只的屠宰厂选取6个采样点,每个采样点每次分3个时段采样,试验周期为1年,共计采集216批1944份样品。通过细菌培养,重点监测环境中菌落总数、大肠菌群、金黄色葡萄球菌、大肠杆菌、芽孢杆菌、假单胞杆菌、李斯特菌和沙门氏菌的污染情况。结果显示:在加工起始阶段的挂鸡区和浸烫打毛区,菌落总数呈现最高值,随着加工工序推进,各采样点的细菌浓度呈现下降趋势,在预冷区出现低峰值;大肠菌群浓度最高值出现在浸烫打毛区,而芽孢杆菌在挂鸡区浓度最高,假单胞杆菌、葡萄球菌、李斯特菌和沙门氏菌在预冷区、分割区和包装区浓度很低,有的甚至未被检出;在不同采样时段,浸烫打毛区和挂鸡区中大肠菌群和大肠杆菌菌落浓度变化显著,且以生产中污染最为严重。结果表明,该肉鸡屠宰厂生产链深加工区域细菌浓度整体水平较低,有利于保障鸡肉产品质量安全,但在初加工环节生产中的细菌浓度较高,易造成环境污染。同时,在屠宰操作的不同区域维持适宜的温湿度、风力和微生物颗粒密度,有利于控制环境卫生。本研究为禽类屠宰加工过程中确定污染关键控制环节及食品安全监管等方面提供了数据支持。

关键词：肉鸡屠宰厂空气微生物环境监测分析

Glycyrrhizin-Induced Pseudohyperaldosteronism:A Case Report

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Chinese Journal of Integrative Medicine 2022年第7期28卷 644-649页

作者： FAN Zong-jing LIU jin-min LI Xing-xing CUI Jie guo Bin LIN Quan ZHUANG Rui WU Zheng-bo WU Yang Department of Cardiology Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Department of Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

Licorice,also known as Radix Glycyrrhizae,is a natural sweetener and widely used as a drug,and it has been considered to be a healthy natural substance with few side effects.;Pseudo hyperaldosteronism(PsHA),which is characterized by hypertension,hypokalemia and alkalosis,should be considered when licorice or its related products are excessively ingested.

关键词： effects. ster ism

Value of the Ratio of Occluder Versus Atrial Septal Length for Predicting Arrhythmia Occurrence after Transcatheter Closure in Children with Ostium Secundum Atrial Septal Defect

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Chinese Medical Journal 2015年第12期128卷 1574-1578页

作者： Mei jin Wen-Hang Ding Xiao-Fang Wang Bao-jing guo Yong-Mei Liang Yan-Yan Xiao Chu-Fan Sun Department of Pediatric Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background：Transcatheter occlusion has been applied to treat ostium secundum atrial septal defect （OS ASD） since *** the clinical practice,several postoperative complications including arrhythmia have been *** study aimed to evaluate the value of the ratio of atrial septal occluder （ASO） versus atrial septal length （ASL） for predicting arrhythmia occurrence after transcatheter closure in children with OS ***：Six hundred and fifty-one children diagnosed with OS ASD underwent occlusion procedures after completing routine *** onsets and types of arrhythmia both during and after the occlusion procedures were *** were given based on the individual types of *** binary logistic regression analysis and receiver-operating characteristic （ROC） curve were used in the analysis of value of the ratio of ASO/ASL for predicting postoperative arrhythmia ***：Transcather occlusions were conducted in 651 children,among whom 7 children had different types and degrees of arrhythmia,with an incidence of 1.1%.The types of arrhythmia included sinus bradycardia,atrial premature beats,bundle branch block,and different degrees of atrioventricular *** electrocardiograph findings were resumed in these 7 patients following active therapies such as corticoids,nutrition,and *** binary logistic regression and ROC analysis suggested that the ratio of ASO/ASL exhibited an intermediate predictive value for predicting arrhythmia occurrence after occlusion procedures.A cut-offvalue of 0.576 in the ratio provided a sensitivity of 87.5% and a specificity of 76.2% with an area under the ROC curve of 0.791 （95% confidence intervals,0.655-0.926;P 〈 0.05） in predicting arrhythmia occurrence after the closure ***：The ratio of ASO/ASL might be a useful index for predicting arrhythmia occurrence after closure procedures in children with OS ASD.

关键词： Arrhythmia Atrial Septal Defect Atrial Septal Length Atrial Septal Occluder Transcatheter Closure

医院内静脉血栓栓塞症防治质量评价与管理指南(2022版)中血栓指标的解读及防治建议

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护理学报 2024年第13期31卷 35-39页

作者：代荣琴刘玉枝陈洋张金彪郭振彬李卫郭东辉高峰卢越沧州医学高等专科学校检验教研室河北沧州061001 河北省沧州中西医结合医院实验诊断科河北沧州061001 河北省沧州中西医结合医院内科河北沧州061001 河北省沧州中西医结合医院外科河北沧州061001 河北省沧州中西医结合医院超声科河北沧州061001 河北省沧州中西医结合医院护理部河北沧州061001

目的临床工作者应树立循证医学观念,用辩证思维理解和应用医院管理和临床诊疗相关指南。方法对《医院内静脉血栓栓塞症防治质量评价与管理指南(2022版)》中血栓指标内容进行解读,结合血栓指标运用提出防治建议。结果该指南提出了多项静... 详细信息

目的临床工作者应树立循证医学观念,用辩证思维理解和应用医院管理和临床诊疗相关指南。方法对《医院内静脉血栓栓塞症防治质量评价与管理指南(2022版)》中血栓指标内容进行解读,结合血栓指标运用提出防治建议。结果该指南提出了多项静脉血栓栓塞症防治的客观质量管理指标,对静脉血栓栓塞症管控实现了质化、量化,已成为临床防治静脉血栓栓塞症的重要依据和抓手。血栓指标作为客观依据在临床静脉血栓栓塞症防治中可起到关键作用。结论通过对该指南部分内容解读,从循证医学角度,结合相关检验指标,汇总国内外文献,提出的思考和建议,今后可供同行借鉴。

关键词：指南解读血栓指标静脉血栓栓塞症质量管理